Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	137970
Gene name	Unc-5 netrin receptor D
Gene symbol	UNC5D
Synonyms (NCBI Gene)	PRO34692Unc5h4
Chromosome	8
Chromosome location	8p12

133

Show/Hide all (133)

miRTarBase ID	miRNA	Experiments	Reference
MIRT022228	hsa-miR-124-3p	Microarray	18668037
MIRT651857	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT651856	hsa-miR-4328	HITS-CLIP	23824327
MIRT651855	hsa-miR-145-5p	HITS-CLIP	23824327
MIRT651854	hsa-miR-5195-3p	HITS-CLIP	23824327
MIRT651853	hsa-miR-548aw	HITS-CLIP	23824327
MIRT651852	hsa-miR-518a-5p	HITS-CLIP	23824327
MIRT651851	hsa-miR-527	HITS-CLIP	23824327
MIRT651850	hsa-miR-450b-5p	HITS-CLIP	23824327
MIRT651849	hsa-miR-507	HITS-CLIP	23824327
MIRT651848	hsa-miR-557	HITS-CLIP	23824327
MIRT651847	hsa-miR-3680-3p	HITS-CLIP	23824327
MIRT651857	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT651856	hsa-miR-4328	HITS-CLIP	23824327
MIRT651855	hsa-miR-145-5p	HITS-CLIP	23824327
MIRT651854	hsa-miR-5195-3p	HITS-CLIP	23824327
MIRT651853	hsa-miR-548aw	HITS-CLIP	23824327
MIRT651852	hsa-miR-518a-5p	HITS-CLIP	23824327
MIRT651851	hsa-miR-527	HITS-CLIP	23824327
MIRT651850	hsa-miR-450b-5p	HITS-CLIP	23824327
MIRT651849	hsa-miR-507	HITS-CLIP	23824327
MIRT651848	hsa-miR-557	HITS-CLIP	23824327
MIRT651847	hsa-miR-3680-3p	HITS-CLIP	23824327
MIRT1475579	hsa-miR-1200	CLIP-seq
MIRT1475580	hsa-miR-1266	CLIP-seq
MIRT1475581	hsa-miR-1322	CLIP-seq
MIRT1475582	hsa-miR-182	CLIP-seq
MIRT1475583	hsa-miR-3140-5p	CLIP-seq
MIRT1475584	hsa-miR-3148	CLIP-seq
MIRT1475585	hsa-miR-3154	CLIP-seq
MIRT1475586	hsa-miR-3163	CLIP-seq
MIRT1475587	hsa-miR-325	CLIP-seq
MIRT1475588	hsa-miR-365	CLIP-seq
MIRT1475589	hsa-miR-3660	CLIP-seq
MIRT1475590	hsa-miR-3664-3p	CLIP-seq
MIRT1475591	hsa-miR-374a	CLIP-seq
MIRT1475592	hsa-miR-374b	CLIP-seq
MIRT1475593	hsa-miR-3913-3p	CLIP-seq
MIRT1475594	hsa-miR-3921	CLIP-seq
MIRT1475595	hsa-miR-3942-3p	CLIP-seq
MIRT1475596	hsa-miR-421	CLIP-seq
MIRT1475597	hsa-miR-4276	CLIP-seq
MIRT1475598	hsa-miR-4282	CLIP-seq
MIRT1475599	hsa-miR-4470	CLIP-seq
MIRT1475600	hsa-miR-4493	CLIP-seq
MIRT1475601	hsa-miR-4518	CLIP-seq
MIRT1475602	hsa-miR-4526	CLIP-seq
MIRT1475603	hsa-miR-4641	CLIP-seq
MIRT1475604	hsa-miR-4653-5p	CLIP-seq
MIRT1475605	hsa-miR-4659a-3p	CLIP-seq
MIRT1475606	hsa-miR-4659b-3p	CLIP-seq
MIRT1475607	hsa-miR-4695-3p	CLIP-seq
MIRT1475608	hsa-miR-4709-5p	CLIP-seq
MIRT1475609	hsa-miR-4714-5p	CLIP-seq
MIRT1475610	hsa-miR-4797-5p	CLIP-seq
MIRT1475611	hsa-miR-489	CLIP-seq
MIRT1475612	hsa-miR-499-3p	CLIP-seq
MIRT1475613	hsa-miR-499a-3p	CLIP-seq
MIRT1475614	hsa-miR-516a-3p	CLIP-seq
MIRT1475615	hsa-miR-548a-5p	CLIP-seq
MIRT1475616	hsa-miR-548ab	CLIP-seq
MIRT1475617	hsa-miR-548ak	CLIP-seq
MIRT1475618	hsa-miR-548b-5p	CLIP-seq
MIRT1475619	hsa-miR-548c-5p	CLIP-seq
MIRT1475620	hsa-miR-548d-5p	CLIP-seq
MIRT1475621	hsa-miR-548h	CLIP-seq
MIRT1475622	hsa-miR-548i	CLIP-seq
MIRT1475623	hsa-miR-548j	CLIP-seq
MIRT1475624	hsa-miR-548n	CLIP-seq
MIRT1475625	hsa-miR-548w	CLIP-seq
MIRT1475626	hsa-miR-548y	CLIP-seq
MIRT1475627	hsa-miR-559	CLIP-seq
MIRT1475628	hsa-miR-628-3p	CLIP-seq
MIRT1475629	hsa-miR-769-5p	CLIP-seq
MIRT1475630	hsa-miR-873	CLIP-seq
MIRT1555343	hsa-miR-3124-3p	CLIP-seq
MIRT1555344	hsa-miR-4422	CLIP-seq
MIRT1555345	hsa-miR-4757-5p	CLIP-seq
MIRT1475579	hsa-miR-1200	CLIP-seq
MIRT2143339	hsa-miR-1252	CLIP-seq
MIRT1475581	hsa-miR-1322	CLIP-seq
MIRT2143340	hsa-miR-3074-5p	CLIP-seq
MIRT2143341	hsa-miR-330-3p	CLIP-seq
MIRT2143342	hsa-miR-3646	CLIP-seq
MIRT2143343	hsa-miR-3929	CLIP-seq
MIRT2143344	hsa-miR-4325	CLIP-seq
MIRT2143345	hsa-miR-4419b	CLIP-seq
MIRT1555344	hsa-miR-4422	CLIP-seq
MIRT2143346	hsa-miR-4438	CLIP-seq
MIRT2143347	hsa-miR-4478	CLIP-seq
MIRT2143348	hsa-miR-4490	CLIP-seq
MIRT2143349	hsa-miR-4666-5p	CLIP-seq
MIRT2143350	hsa-miR-4793-3p	CLIP-seq
MIRT2143351	hsa-miR-548p	CLIP-seq
MIRT2143352	hsa-miR-548u	CLIP-seq
MIRT2143353	hsa-miR-607	CLIP-seq
MIRT2363591	hsa-miR-1290	CLIP-seq
MIRT2363592	hsa-miR-3127-5p	CLIP-seq
MIRT2143341	hsa-miR-330-3p	CLIP-seq
MIRT2363593	hsa-miR-3616-5p	CLIP-seq
MIRT2363594	hsa-miR-3647-5p	CLIP-seq
MIRT2363595	hsa-miR-3655	CLIP-seq
MIRT2363596	hsa-miR-3940-5p	CLIP-seq
MIRT2363597	hsa-miR-4270	CLIP-seq
MIRT2143344	hsa-miR-4325	CLIP-seq
MIRT1555344	hsa-miR-4422	CLIP-seq
MIRT2363598	hsa-miR-4436a	CLIP-seq
MIRT2363599	hsa-miR-4441	CLIP-seq
MIRT2363600	hsa-miR-4474-5p	CLIP-seq
MIRT2363601	hsa-miR-4506	CLIP-seq
MIRT2363602	hsa-miR-4507	CLIP-seq
MIRT1475610	hsa-miR-4797-5p	CLIP-seq
MIRT2363603	hsa-miR-485-3p	CLIP-seq
MIRT2363604	hsa-miR-513a-5p	CLIP-seq
MIRT2363605	hsa-miR-573	CLIP-seq
MIRT2143353	hsa-miR-607	CLIP-seq
MIRT2363606	hsa-miR-653	CLIP-seq
MIRT2143341	hsa-miR-330-3p	CLIP-seq
MIRT2143344	hsa-miR-4325	CLIP-seq
MIRT1555344	hsa-miR-4422	CLIP-seq
MIRT2143353	hsa-miR-607	CLIP-seq
MIRT1475588	hsa-miR-365	CLIP-seq
MIRT2462933	hsa-miR-4290	CLIP-seq
MIRT2462934	hsa-miR-4667-3p	CLIP-seq
MIRT2462935	hsa-miR-4799-5p	CLIP-seq
MIRT1475588	hsa-miR-365	CLIP-seq
MIRT2462933	hsa-miR-4290	CLIP-seq
MIRT2462934	hsa-miR-4667-3p	CLIP-seq
MIRT2462935	hsa-miR-4799-5p	CLIP-seq
MIRT1475588	hsa-miR-365	CLIP-seq
MIRT2462933	hsa-miR-4290	CLIP-seq
MIRT2462934	hsa-miR-4667-3p	CLIP-seq
MIRT2462935	hsa-miR-4799-5p	CLIP-seq

Show/Hide all (14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005042	Function	Netrin receptor activity	IBA
GO:0005042	Function	Netrin receptor activity	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006915	Process	Apoptotic process	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0007411	Process	Axon guidance	IBA
GO:0007411	Process	Axon guidance	IEA
GO:0009986	Component	Cell surface	IEA
GO:0016020	Component	Membrane	IEA
GO:0021859	Process	Pyramidal neuron differentiation	IEA
GO:0038007	Process	Netrin-activated signaling pathway	IEA
GO:0098742	Process	Cell-cell adhesion via plasma-membrane adhesion molecules	IDA	26235030
GO:2001222	Process	Regulation of neuron migration	IEA

MIM	HGNC	e!Ensembl
616466	18634	ENSG00000156687

Q6UXZ4

Protein name

Netrin receptor UNC5D (Protein unc-5 homolog 4) (Protein unc-5 homolog D)

Protein function

Receptor for the netrin NTN4 that promotes neuronal cell survival (By similarity). Plays a role in cell-cell adhesion and cell guidance. Receptor for netrin involved in cell migration. Plays a role in axon guidance by mediating axon repulsion of

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07679	I-set	159 → 249	Immunoglobulin I-set domain	Domain
PF00090	TSP_1	256 → 306	Thrombospondin type 1 domain	Domain
PF00090	TSP_1	312 → 359	Thrombospondin type 1 domain	Domain
PF00791	ZU5	543 → 639	ZU5 domain	Family
PF17217	UPA	687 → 826	UPA domain	Domain
PF00531	Death	858 → 936	Death domain	Domain

Sequence

MGRAAATAGGGGGARRWLPWLGLCFWAAGTAAARGTDNGEALPESIPSAPGTLPHFIEEP
DDAYIIKSNPIALRCKARPAMQIFFKCNGEWVHQNEHVSEETLDESSGLKVREVFINVTR
QQVEDFHGPEDYWCQCVAWSHLGTSKSRKASVRIAYLRKNFEQDPQGREVPIEGMIVLHC
RPPEGVPAAEVEWLKNEEPIDSEQDENIDTRADHNLIIRQARLSDSGNYTCMAANIVAKR
RSLSATVVVYVNGGWSSWTEWSACNVRCGRGWQKRSRTCTNPAPLNGGAFCEGMSVQKIT
CTSLCPVDGSWEVWSEWSVCSPECEHLRIRECTAPPPRNGGKFCEGLSQESENCTDGLCI
LDKKPLHEIKPQSIENASDIALYSGLGAAVVAVAVLVIGVTLYRRSQSDYGVDVIDSSAL
TGGFQTFNFKTVRQGNSLLLNSAMQPDLTVSRTYSGPICLQDPLDKELMTESSLFNPLSD
IKVKVQSSFMVSLGVSERAEYHGKNHSRTFPHGNNHSFSTMHPRNKMPYIQNLSSLPTRT
ELRTTGVFGHLGGRLVMPNTGVSLLIPHGAIPEENSWEIYMSINQGEPSLQSDGSEVLLS
PEVTCGPPDMIVTTPFALTIPHCADVSSEHWNIHLKKRTQQGKWEEVMSVEDESTSCYCL
LDPFACHVLLDSFGTYALTGEPITDCAVKQLKVAVFGCMSCNSLDYNLRVYCVDNTPCAF
QEVVSDERHQGGQLLEEPKLLHFKGNTFSLQISVLDIPPFLWRIKPFTACQEVPFSRVWC
SNRQPLHCAFSLERYTPTTTQLSCKICIRQLKGHEQILQVQTSILESERETITFFAQEDS
TFPAQTGPKAFKIPYSIRQRICATFDTPNAKGKDWQMLAQKNSINRNLSYFATQSSPSAV
ILNLWEARHQHDGDLDSLACALEEIGRTHTKLSNISESQLDEADFNYSRQNGL

Sequence length

953

Interactions

View interactions

	KEGG
	Axon guidance

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (9)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
DIABETIC FOOT	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DYSLEXIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INSOMNIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEUROPATHY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEUROTIC DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBESITY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSORIASIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (23)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Alzheimer Disease	Alzheimer disease	Pubtator	29282330	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Anisometropia	Anisometropia	BEFREE	28614238		★★★★★ ★☆☆☆☆ Found in Text Mining only
Anisometropia	Anisometropia	Pubtator	28614238	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	24519068	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cardiomyopathy Dilated	Dilated cardiomyopathy	Pubtator	19332114	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colonic Neoplasms	Colonic neoplasm	Pubtator	38235871	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	33078631, 38235871, 39186800	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Conventional (Clear Cell) Renal Cell Carcinoma	Renal Carcinoma	BEFREE	23589179		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Insulin-Dependent	Diabetes Mellitus	GWASCAT_DG	28672053		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	GWASCAT_DG	28672053		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetic Foot	Diabetic Foot	GWASCAT_DG	28672053		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hereditary and idiopathic neuropathy, unspecified	Hereditary and idiopathic neuropathy	GWASCAT_DG	28672053		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	30632669		★★★★★ ★☆☆☆☆ Found in Text Mining only
Narcolepsy	Narcolepsy	GWASDB_DG	19629137		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	23589179, 30632669		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	23778138, 24691657		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	Pubtator	24519068, 37813883	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuropathy	Neuropathy	GWASCAT_DG	28672053		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEUROPATHY, CONGENITAL HYPOMYELINATING, 2	Neuropathy	GWASCAT_DG	28672053		★★★★★ ★☆☆☆☆ Found in Text Mining only
NEUROPATHY, CONGENITAL HYPOMYELINATING, 3	Neuropathy	GWASCAT_DG	28672053		★★★★★ ★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	Pubtator	29282330	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	30632669		★★★★★ ★☆☆☆☆ Found in Text Mining only
Renal Cell Carcinoma	Renal Carcinoma	BEFREE	23589179		★★★★★ ★☆☆☆☆ Found in Text Mining only

UNC5D (unc-5 netrin receptor D)