Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	137964
Gene name	Glycerol-3-phosphate acyltransferase 4
Gene symbol	GPAT4
Synonyms (NCBI Gene)	1-AGPAT 6AGPAT6LPAAT-zetaLPAATZTSARG7
Chromosome	8
Chromosome location	8p11.21
Summary	Lysophosphatidic acid acyltransferases (EC 2.3.1.51) catalyze the conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA). LPA and PA are involved in signal transduction and lipid biosynthesis.[supplied by OMIM, Apr 2004]

Show/Hide all (77)

miRTarBase ID	miRNA	Experiments	Reference
MIRT721461	hsa-miR-483-3p	HITS-CLIP	19536157
MIRT721460	hsa-miR-1224-3p	HITS-CLIP	19536157
MIRT721459	hsa-miR-345-3p	HITS-CLIP	19536157
MIRT721458	hsa-miR-4732-3p	HITS-CLIP	19536157
MIRT721457	hsa-miR-125a-5p	HITS-CLIP	19536157
MIRT721456	hsa-miR-125b-5p	HITS-CLIP	19536157
MIRT721455	hsa-miR-4319	HITS-CLIP	19536157
MIRT721454	hsa-miR-532-3p	HITS-CLIP	19536157
MIRT721453	hsa-miR-7113-3p	HITS-CLIP	19536157
MIRT721452	hsa-miR-4539	HITS-CLIP	19536157
MIRT721451	hsa-miR-1260a	HITS-CLIP	19536157
MIRT052733	hsa-miR-1260b	HITS-CLIP	19536157
MIRT721450	hsa-miR-670-5p	HITS-CLIP	19536157
MIRT721449	hsa-miR-203b-3p	HITS-CLIP	19536157
MIRT716894	hsa-miR-4661-5p	HITS-CLIP	19536157
MIRT716892	hsa-miR-4301	HITS-CLIP	19536157
MIRT716891	hsa-miR-93-3p	HITS-CLIP	19536157
MIRT716890	hsa-miR-3692-5p	HITS-CLIP	19536157
MIRT716889	hsa-miR-626	HITS-CLIP	19536157
MIRT716888	hsa-miR-6876-3p	HITS-CLIP	19536157
MIRT716887	hsa-miR-3156-3p	HITS-CLIP	19536157
MIRT716886	hsa-miR-6071	HITS-CLIP	19536157
MIRT716894	hsa-miR-4661-5p	HITS-CLIP	19536157
MIRT716892	hsa-miR-4301	HITS-CLIP	19536157
MIRT716891	hsa-miR-93-3p	HITS-CLIP	19536157
MIRT716890	hsa-miR-3692-5p	HITS-CLIP	19536157
MIRT716889	hsa-miR-626	HITS-CLIP	19536157
MIRT716888	hsa-miR-6876-3p	HITS-CLIP	19536157
MIRT716887	hsa-miR-3156-3p	HITS-CLIP	19536157
MIRT716886	hsa-miR-6071	HITS-CLIP	19536157
MIRT671470	hsa-miR-5693	HITS-CLIP	23824327
MIRT671469	hsa-miR-4486	HITS-CLIP	23824327
MIRT671468	hsa-miR-4284	HITS-CLIP	23824327
MIRT671467	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT671466	hsa-miR-3178	HITS-CLIP	23824327
MIRT671470	hsa-miR-5693	HITS-CLIP	23824327
MIRT671469	hsa-miR-4486	HITS-CLIP	23824327
MIRT671468	hsa-miR-4284	HITS-CLIP	23824327
MIRT671467	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT671466	hsa-miR-3178	HITS-CLIP	23824327
MIRT487293	hsa-miR-4519	PAR-CLIP	24398324
MIRT487292	hsa-miR-1296-3p	PAR-CLIP	24398324
MIRT487291	hsa-miR-194-3p	PAR-CLIP	24398324
MIRT487288	hsa-miR-3960	PAR-CLIP	24398324
MIRT487287	hsa-miR-8072	PAR-CLIP	24398324
MIRT487286	hsa-miR-4467	PAR-CLIP	24398324
MIRT487285	hsa-miR-3180	PAR-CLIP	24398324
MIRT487284	hsa-miR-3180-3p	PAR-CLIP	24398324
MIRT487283	hsa-miR-3196	PAR-CLIP	24398324
MIRT487282	hsa-miR-6816-5p	PAR-CLIP	24398324
MIRT487281	hsa-miR-1237-5p	PAR-CLIP	24398324
MIRT487280	hsa-miR-4488	PAR-CLIP	24398324
MIRT487279	hsa-miR-4697-5p	PAR-CLIP	24398324
MIRT487278	hsa-miR-6846-5p	PAR-CLIP	24398324
MIRT487277	hsa-miR-6848-5p	PAR-CLIP	24398324
MIRT487276	hsa-miR-4447	PAR-CLIP	24398324
MIRT487275	hsa-miR-4472	PAR-CLIP	24398324
MIRT487294	hsa-miR-508-5p	PAR-CLIP	23592263
MIRT487293	hsa-miR-4519	PAR-CLIP	23592263
MIRT487292	hsa-miR-1296-3p	PAR-CLIP	23592263
MIRT487291	hsa-miR-194-3p	PAR-CLIP	23592263
MIRT487290	hsa-miR-4267	PAR-CLIP	23592263
MIRT487289	hsa-miR-766-3p	PAR-CLIP	23592263
MIRT487288	hsa-miR-3960	PAR-CLIP	23592263
MIRT487287	hsa-miR-8072	PAR-CLIP	23592263
MIRT487286	hsa-miR-4467	PAR-CLIP	23592263
MIRT487285	hsa-miR-3180	PAR-CLIP	23592263
MIRT487284	hsa-miR-3180-3p	PAR-CLIP	23592263
MIRT487283	hsa-miR-3196	PAR-CLIP	23592263
MIRT487282	hsa-miR-6816-5p	PAR-CLIP	23592263
MIRT487281	hsa-miR-1237-5p	PAR-CLIP	23592263
MIRT487280	hsa-miR-4488	PAR-CLIP	23592263
MIRT487279	hsa-miR-4697-5p	PAR-CLIP	23592263
MIRT487278	hsa-miR-6846-5p	PAR-CLIP	23592263
MIRT487277	hsa-miR-6848-5p	PAR-CLIP	23592263
MIRT487276	hsa-miR-4447	PAR-CLIP	23592263
MIRT487275	hsa-miR-4472	PAR-CLIP	23592263

Show/Hide all (37)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002071	Process	Glandular epithelial cell maturation	IEA
GO:0003841	Function	1-acylglycerol-3-phosphate O-acyltransferase activity	IDA	18238778
GO:0003841	Function	1-acylglycerol-3-phosphate O-acyltransferase activity	TAS
GO:0004366	Function	Glycerol-3-phosphate O-acyltransferase activity	IDA	18238778
GO:0004366	Function	Glycerol-3-phosphate O-acyltransferase activity	IEA
GO:0004366	Function	Glycerol-3-phosphate O-acyltransferase activity	TAS
GO:0005515	Function	Protein binding	IPI	35271311
GO:0005783	Component	Endoplasmic reticulum	IDA	18238778
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005783	Component	Endoplasmic reticulum	ISS
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006631	Process	Fatty acid metabolic process	IEA
GO:0006637	Process	Acyl-CoA metabolic process	IDA	18238778
GO:0006641	Process	Triglyceride metabolic process	IEA
GO:0006654	Process	Phosphatidic acid biosynthetic process	TAS
GO:0006656	Process	Phosphatidylcholine biosynthetic process	IDA	18238778
GO:0007595	Process	Lactation	IEA
GO:0007595	Process	Lactation	ISS
GO:0008374	Function	O-acyltransferase activity	IEA
GO:0008610	Process	Lipid biosynthetic process	IEA
GO:0008610	Process	Lipid biosynthetic process	ISS
GO:0008654	Process	Phospholipid biosynthetic process	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IDA	18238778
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	NAS	18238778
GO:0016024	Process	CDP-diacylglycerol biosynthetic process	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016746	Function	Acyltransferase activity	IEA
GO:0019432	Process	Triglyceride biosynthetic process	IDA	18238778
GO:0019432	Process	Triglyceride biosynthetic process	ISS
GO:0030879	Process	Mammary gland development	IEA
GO:0040014	Process	Regulation of multicellular organism growth	IEA
GO:0042171	Function	Lysophosphatidic acid acyltransferase activity	IEA
GO:0046339	Process	Diacylglycerol metabolic process	IEA

MIM	HGNC	e!Ensembl
608143	20880	ENSG00000158669

Q86UL3

Protein name

Glycerol-3-phosphate acyltransferase 4 (EC 2.3.1.15) (1-acylglycerol-3-phosphate O-acyltransferase 6) (1-AGP acyltransferase 6) (1-AGPAT 6) (Acyl-CoA:glycerol-3-phosphate acyltransferase 4) (Lysophosphatidic acid acyltransferase zeta) (LPAAT-zeta) (Testis

Protein function

Converts glycerol-3-phosphate to 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) by incorporating an acyl moiety at the sn-1 position of the glycerol backbone (PubMed:18238778). Active against both saturated and unsaturated long-ch

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01553	Acyltransferase	228 → 351	Acyltransferase	Family

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous. High levels in testis. Relatively high level of expression in skeletal muscle and heart. Relatively low level of expression in lung. {ECO:0000269|PubMed:12938015, ECO:0000269|PubMed:16625827, ECO:0000269|PubMed:18238778}.

Sequence

MFLLLPFDSLIVNLLGISLTVLFTLLLVFIIVPAIFGVSFGIRKLYMKSLLKIFAWATLR
MERGAKEKNHQLYKPYTNGIIAKDPTSLEEEIKEIRRSGSSKALDNTPEFELSDIFYFCR
KGMETIMDDEVTKRFSAEELESWNLLSRTNYNFQYISLRLTVLWGLGVLIRYCFLLPLRI
ALAFTGISLLVVGTTVVGYLPNGRFKEFMSKHVHLMCYRICVRALTAIITYHDRENRPRN
GGICVANHTSPIDVIILASDGYYAMVGQVHGGLMGVIQRAMVKACPHVWFERSEVKDRHL
VAKRLTEHVQDKSKLPILIFPEGTCINNTSVMMFKKGSFEIGATVYPVAIKYDPQFGDAF
WNSSKYGMVTYLLRMMTSWAIVCSVWYLPPMTREADEDAVQFANRVKSAIARQGGLVDLL
WDGGLKREKVKDTFKEEQQKLYSKMIVGNHKDRSRS

Sequence length

456

Interactions

View interactions

	KEGG		Reactome
	Glycerolipid metabolism Glycerophospholipid metabolism Metabolic pathways		Synthesis of PA

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
INSOMNIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (4)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	26040780	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	24156295		★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	BEFREE	24156295		★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	Pubtator	24156295	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

GPAT4 (glycerol-3-phosphate acyltransferase 4)