Gene Gene information from NCBI Gene database.
Entrez ID 137886
Gene name UBX domain protein 2B
Gene symbol UBXN2B
Synonyms (NCBI Gene)
p37
Chromosome 8
Chromosome location 8q12.1
miRNA miRNA information provided by mirtarbase database.
1009
miRTarBase ID miRNA Experiments Reference
MIRT051130 hsa-miR-16-5p CLASH 23622248
MIRT048564 hsa-miR-100-5p CLASH 23622248
MIRT621642 hsa-miR-124-3p HITS-CLIP 23824327
MIRT621657 hsa-miR-3714 HITS-CLIP 23824327
MIRT621656 hsa-miR-3910 HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
23
GO ID Ontology Definition Evidence Reference
GO:0000045 Process Autophagosome assembly IBA
GO:0000132 Process Establishment of mitotic spindle orientation IEA
GO:0000132 Process Establishment of mitotic spindle orientation IGI 23649807
GO:0005515 Function Protein binding IPI 25416956, 28514442, 29997244, 31515488, 32296183, 33961781, 35271311
GO:0005634 Component Nucleus IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
610686 27035 ENSG00000215114
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q14CS0
Protein name UBX domain-containing protein 2B (NSFL1 cofactor p37) (p97 cofactor p37)
Protein function Adapter protein required for Golgi and endoplasmic reticulum biogenesis (PubMed:17141156). Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis (PubMed:17141156). The complex for
PDB 8B5R
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF08059 SEP 146 220 SEP domain Domain
PF00789 UBX 251 330 UBX domain Domain
Sequence
MAEGGGPEPGEQERRSSGPRPPSARDLQLALAELYEDEVKCKSSKSNRPKATVFKSPRTP
PQRFYSSEHEYSGLNIVRPSTGKIVNELFKEAREHGAVPLNEATRASGDDKSKSFTGGGY
RLGSSFCKRSEYIYGENQLQDVQILLKLWSNGFSLDDGELRPYNEPTNAQFLESVKRGEI
PLELQRLVHGGQVNLDMEDHQDQEYIKPRLRFKAFSGEGQ
KLGSLTPEIVSTPSSPEEED
KSILNAVVLIDDSVPTTKIQIRLADGSRLIQRFNSTHRILDVRNFIVQSRPEFAALDFIL
VTSFPNKELTDESLTLLEADILNTVLLQQL
K
Sequence length 331
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
12
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
CARDIOVASCULAR DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CHOLELITHIASIS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ESOPHAGEAL SQUAMOUS CELL CARCINOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
FAMILIAL HYPERLIPIDEMIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Cataplexy Cataplexy BEFREE 23496005
★☆☆☆☆
Found in Text Mining only
Liver carcinoma Liver carcinoma BEFREE 28036384, 28976984, 30980864
★☆☆☆☆
Found in Text Mining only
Malignant neoplasm of stomach Stomach Neoplasms BEFREE 21062494
★☆☆☆☆
Found in Text Mining only
Malignant Neoplasms Malignant Neoplasm BEFREE 28036384
★☆☆☆☆
Found in Text Mining only
Narcolepsy Narcolepsy GWASCAT_DG 23496005
★☆☆☆☆
Found in Text Mining only
Narcolepsy-Cataplexy Syndrome Narcolepsy-Cataplexy Syndrome GWASDB_DG 23496005
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Schizophrenia Schizophrenia BEFREE 31211828
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Stomach Carcinoma Stomach Carcinoma BEFREE 21062494
★☆☆☆☆
Found in Text Mining only
Uveal melanoma Uveal melanoma Pubtator 38246894 Associate
★☆☆☆☆
Found in Text Mining only