CPE (carboxypeptidase E)

Gene

• Entrez ID: 1363
• Gene name: Carboxypeptidase E
• Gene symbol: CPE
• Synonyms (NCBI Gene): BDVS, CPH, IDDHH
• Chromosome: 4
• Chromosome location: 4q32.3
• Summary: This gene encodes a member of the M14 family of metallocarboxypeptidases. The encoded preproprotein is proteolytically processed to generate the mature peptidase. This peripheral membrane protein cleaves C-terminal amino acid residues and is involved in t

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs1579283609	C>-	Pathogenic	Coding sequence variant, frameshift variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018916	hsa-miR-335-5p	Microarray	18185580
MIRT050834	hsa-miR-17-5p	CLASH	23622248
MIRT683778	hsa-miR-5197-5p	HITS-CLIP	23313552
MIRT683777	hsa-miR-4695-5p	HITS-CLIP	23313552
MIRT683776	hsa-miR-1910-3p	HITS-CLIP	23313552
MIRT683775	hsa-miR-6511a-5p	HITS-CLIP	23313552
MIRT683774	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT683773	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT683772	hsa-miR-940	HITS-CLIP	23313552
MIRT683771	hsa-miR-3929	HITS-CLIP	23313552
MIRT683770	hsa-miR-4419b	HITS-CLIP	23313552
MIRT683769	hsa-miR-4478	HITS-CLIP	23313552
MIRT683768	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT683767	hsa-miR-4459	HITS-CLIP	23313552
MIRT683766	hsa-miR-665	HITS-CLIP	23313552
MIRT683765	hsa-miR-6840-3p	HITS-CLIP	23313552
MIRT683764	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT683763	hsa-miR-1827	HITS-CLIP	23313552
MIRT683762	hsa-miR-4722-5p	HITS-CLIP	23313552
MIRT683761	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT683760	hsa-miR-4327	HITS-CLIP	23313552
MIRT683759	hsa-miR-3612	HITS-CLIP	23313552
MIRT683758	hsa-miR-650	HITS-CLIP	23313552
MIRT683757	hsa-miR-3622b-5p	HITS-CLIP	23313552
MIRT683756	hsa-miR-106a-3p	HITS-CLIP	23313552
MIRT679796	hsa-miR-4740-3p	HITS-CLIP	23824327
MIRT679795	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT679794	hsa-miR-3199	HITS-CLIP	23824327
MIRT679793	hsa-miR-8052	HITS-CLIP	23824327
MIRT679792	hsa-miR-365a-5p	HITS-CLIP	23824327
MIRT679791	hsa-miR-365b-5p	HITS-CLIP	23824327
MIRT640576	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT640575	hsa-miR-1972	HITS-CLIP	23824327
MIRT640574	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT640573	hsa-miR-6811-3p	HITS-CLIP	23824327
MIRT678956	hsa-miR-6847-3p	HITS-CLIP	23824327
MIRT640572	hsa-miR-1207-5p	HITS-CLIP	23824327
MIRT640571	hsa-miR-4763-3p	HITS-CLIP	23824327
MIRT640570	hsa-miR-4736	HITS-CLIP	23824327
MIRT640569	hsa-miR-4284	HITS-CLIP	23824327
MIRT640568	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT640567	hsa-miR-7977	HITS-CLIP	23824327
MIRT640566	hsa-miR-6514-3p	HITS-CLIP	23824327
MIRT640565	hsa-miR-7150	HITS-CLIP	23824327
MIRT640564	hsa-miR-182-5p	HITS-CLIP	23824327
MIRT640563	hsa-miR-1271-5p	HITS-CLIP	23824327
MIRT640562	hsa-miR-96-5p	HITS-CLIP	23824327
MIRT668919	hsa-miR-8485	HITS-CLIP	23824327
MIRT668918	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT668917	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT668916	hsa-miR-6801-3p	HITS-CLIP	23824327
MIRT668915	hsa-miR-6810-3p	HITS-CLIP	23824327
MIRT668914	hsa-miR-8064	HITS-CLIP	23824327
MIRT668913	hsa-miR-7703	HITS-CLIP	23824327
MIRT640576	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT640575	hsa-miR-1972	HITS-CLIP	23824327
MIRT640574	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT640573	hsa-miR-6811-3p	HITS-CLIP	23824327
MIRT640572	hsa-miR-1207-5p	HITS-CLIP	23824327
MIRT640571	hsa-miR-4763-3p	HITS-CLIP	23824327
MIRT640570	hsa-miR-4736	HITS-CLIP	23824327
MIRT640567	hsa-miR-7977	HITS-CLIP	23824327
MIRT640566	hsa-miR-6514-3p	HITS-CLIP	23824327
MIRT640565	hsa-miR-7150	HITS-CLIP	23824327
MIRT640564	hsa-miR-182-5p	HITS-CLIP	23824327
MIRT640563	hsa-miR-1271-5p	HITS-CLIP	23824327
MIRT640562	hsa-miR-96-5p	HITS-CLIP	23824327
MIRT640576	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT640575	hsa-miR-1972	HITS-CLIP	23824327
MIRT640574	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT640573	hsa-miR-6811-3p	HITS-CLIP	23824327
MIRT640572	hsa-miR-1207-5p	HITS-CLIP	23824327
MIRT640571	hsa-miR-4763-3p	HITS-CLIP	23824327
MIRT640570	hsa-miR-4736	HITS-CLIP	23824327
MIRT640569	hsa-miR-4284	HITS-CLIP	23824327
MIRT640568	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT640567	hsa-miR-7977	HITS-CLIP	23824327
MIRT640566	hsa-miR-6514-3p	HITS-CLIP	23824327
MIRT640565	hsa-miR-7150	HITS-CLIP	23824327
MIRT640564	hsa-miR-182-5p	HITS-CLIP	23824327
MIRT640563	hsa-miR-1271-5p	HITS-CLIP	23824327
MIRT640562	hsa-miR-96-5p	HITS-CLIP	23824327
MIRT638846	hsa-miR-4797-5p	HITS-CLIP	23824327
MIRT638845	hsa-miR-5007-5p	HITS-CLIP	23824327
MIRT638844	hsa-miR-6773-3p	HITS-CLIP	23824327
MIRT638843	hsa-miR-4524a-3p	HITS-CLIP	23824327
MIRT638842	hsa-miR-6879-3p	HITS-CLIP	23824327
MIRT638841	hsa-miR-3672	HITS-CLIP	23824327
MIRT638840	hsa-miR-6864-3p	HITS-CLIP	23824327
MIRT638839	hsa-miR-8055	HITS-CLIP	23824327
MIRT309648	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT570952	hsa-miR-5197-3p	PAR-CLIP	20371350
MIRT570951	hsa-miR-3154	PAR-CLIP	20371350
MIRT570950	hsa-miR-3125	PAR-CLIP	20371350
MIRT570949	hsa-miR-3916	PAR-CLIP	20371350
MIRT570948	hsa-miR-6859-5p	PAR-CLIP	20371350
MIRT570947	hsa-miR-5584-5p	PAR-CLIP	20371350
MIRT570945	hsa-miR-3185	PAR-CLIP	20371350
MIRT570946	hsa-miR-7515	PAR-CLIP	20371350
MIRT570944	hsa-miR-3150b-3p	PAR-CLIP	20371350
MIRT570943	hsa-miR-4784	PAR-CLIP	20371350
MIRT570942	hsa-miR-765	PAR-CLIP	20371350
MIRT570941	hsa-miR-3153	PAR-CLIP	20371350
MIRT570939	hsa-miR-6733-5p	PAR-CLIP	20371350
MIRT570940	hsa-miR-6739-5p	PAR-CLIP	20371350
MIRT570952	hsa-miR-5197-3p	PAR-CLIP	20371350
MIRT570951	hsa-miR-3154	PAR-CLIP	20371350
MIRT570950	hsa-miR-3125	PAR-CLIP	20371350
MIRT570949	hsa-miR-3916	PAR-CLIP	20371350
MIRT570948	hsa-miR-6859-5p	PAR-CLIP	20371350
MIRT570947	hsa-miR-5584-5p	PAR-CLIP	20371350
MIRT570945	hsa-miR-3185	PAR-CLIP	20371350
MIRT570946	hsa-miR-7515	PAR-CLIP	20371350
MIRT570944	hsa-miR-3150b-3p	PAR-CLIP	20371350
MIRT570943	hsa-miR-4784	PAR-CLIP	20371350
MIRT570942	hsa-miR-765	PAR-CLIP	20371350
MIRT570941	hsa-miR-3153	PAR-CLIP	20371350
MIRT570939	hsa-miR-6733-5p	PAR-CLIP	20371350
MIRT570940	hsa-miR-6739-5p	PAR-CLIP	20371350
MIRT440891	hsa-miR-485-5p	HITS-CLIP	24374217
MIRT440889	hsa-miR-379-3p	HITS-CLIP	24374217
MIRT440888	hsa-miR-544a	HITS-CLIP	24374217
MIRT440891	hsa-miR-485-5p	HITS-CLIP	24374217
MIRT440889	hsa-miR-379-3p	HITS-CLIP	24374217
MIRT440888	hsa-miR-544a	HITS-CLIP	24374217
MIRT309648	hsa-miR-129-5p	HITS-CLIP	27418678
MIRT309648	hsa-miR-129-5p	HITS-CLIP	27418678
MIRT638841	hsa-miR-3672	HITS-CLIP	27418678
MIRT638841	hsa-miR-3672	HITS-CLIP	27418678
MIRT638843	hsa-miR-4524a-3p	HITS-CLIP	27418678
MIRT638843	hsa-miR-4524a-3p	HITS-CLIP	27418678
MIRT638846	hsa-miR-4797-5p	HITS-CLIP	27418678
MIRT638846	hsa-miR-4797-5p	HITS-CLIP	27418678
MIRT638845	hsa-miR-5007-5p	HITS-CLIP	27418678
MIRT638845	hsa-miR-5007-5p	HITS-CLIP	27418678
MIRT638844	hsa-miR-6773-3p	HITS-CLIP	27418678
MIRT638844	hsa-miR-6773-3p	HITS-CLIP	27418678
MIRT638840	hsa-miR-6864-3p	HITS-CLIP	27418678
MIRT638840	hsa-miR-6864-3p	HITS-CLIP	27418678
MIRT638842	hsa-miR-6879-3p	HITS-CLIP	27418678
MIRT638839	hsa-miR-8055	HITS-CLIP	27418678
MIRT638839	hsa-miR-8055	HITS-CLIP	27418678
MIRT683778	hsa-miR-5197-5p	HITS-CLIP	23313552
MIRT683777	hsa-miR-4695-5p	HITS-CLIP	23313552
MIRT683776	hsa-miR-1910-3p	HITS-CLIP	23313552
MIRT683775	hsa-miR-6511a-5p	HITS-CLIP	23313552
MIRT683774	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT683773	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT683772	hsa-miR-940	HITS-CLIP	23313552
MIRT683771	hsa-miR-3929	HITS-CLIP	23313552
MIRT683770	hsa-miR-4419b	HITS-CLIP	23313552
MIRT683769	hsa-miR-4478	HITS-CLIP	23313552
MIRT683768	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT683767	hsa-miR-4459	HITS-CLIP	23313552
MIRT683766	hsa-miR-665	HITS-CLIP	23313552
MIRT683765	hsa-miR-6840-3p	HITS-CLIP	23313552
MIRT683764	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT683763	hsa-miR-1827	HITS-CLIP	23313552
MIRT683762	hsa-miR-4722-5p	HITS-CLIP	23313552
MIRT683761	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT683760	hsa-miR-4327	HITS-CLIP	23313552
MIRT683759	hsa-miR-3612	HITS-CLIP	23313552
MIRT683758	hsa-miR-650	HITS-CLIP	23313552
MIRT683757	hsa-miR-3622b-5p	HITS-CLIP	23313552
MIRT683756	hsa-miR-106a-3p	HITS-CLIP	23313552
MIRT679796	hsa-miR-4740-3p	HITS-CLIP	23824327
MIRT679795	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT679794	hsa-miR-3199	HITS-CLIP	23824327
MIRT679793	hsa-miR-8052	HITS-CLIP	23824327
MIRT679792	hsa-miR-365a-5p	HITS-CLIP	23824327
MIRT679791	hsa-miR-365b-5p	HITS-CLIP	23824327
MIRT640576	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT640575	hsa-miR-1972	HITS-CLIP	23824327
MIRT640574	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT640573	hsa-miR-6811-3p	HITS-CLIP	23824327
MIRT678956	hsa-miR-6847-3p	HITS-CLIP	23824327
MIRT640572	hsa-miR-1207-5p	HITS-CLIP	23824327
MIRT640571	hsa-miR-4763-3p	HITS-CLIP	23824327
MIRT640570	hsa-miR-4736	HITS-CLIP	23824327
MIRT640569	hsa-miR-4284	HITS-CLIP	23824327
MIRT640568	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT640567	hsa-miR-7977	HITS-CLIP	23824327
MIRT640566	hsa-miR-6514-3p	HITS-CLIP	23824327
MIRT640565	hsa-miR-7150	HITS-CLIP	23824327
MIRT640564	hsa-miR-182-5p	HITS-CLIP	23824327
MIRT640563	hsa-miR-1271-5p	HITS-CLIP	23824327
MIRT640562	hsa-miR-96-5p	HITS-CLIP	23824327
MIRT668919	hsa-miR-8485	HITS-CLIP	23824327
MIRT668918	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT668917	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT668916	hsa-miR-6801-3p	HITS-CLIP	23824327
MIRT668915	hsa-miR-6810-3p	HITS-CLIP	23824327
MIRT668914	hsa-miR-8064	HITS-CLIP	23824327
MIRT668913	hsa-miR-7703	HITS-CLIP	23824327
MIRT640576	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT640575	hsa-miR-1972	HITS-CLIP	23824327
MIRT640574	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT640573	hsa-miR-6811-3p	HITS-CLIP	23824327
MIRT640572	hsa-miR-1207-5p	HITS-CLIP	23824327
MIRT640571	hsa-miR-4763-3p	HITS-CLIP	23824327
MIRT640570	hsa-miR-4736	HITS-CLIP	23824327
MIRT640567	hsa-miR-7977	HITS-CLIP	23824327
MIRT640566	hsa-miR-6514-3p	HITS-CLIP	23824327
MIRT640565	hsa-miR-7150	HITS-CLIP	23824327
MIRT640564	hsa-miR-182-5p	HITS-CLIP	23824327
MIRT640563	hsa-miR-1271-5p	HITS-CLIP	23824327
MIRT640562	hsa-miR-96-5p	HITS-CLIP	23824327
MIRT640576	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT640575	hsa-miR-1972	HITS-CLIP	23824327
MIRT640574	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT640573	hsa-miR-6811-3p	HITS-CLIP	23824327
MIRT640572	hsa-miR-1207-5p	HITS-CLIP	23824327
MIRT640571	hsa-miR-4763-3p	HITS-CLIP	23824327
MIRT640570	hsa-miR-4736	HITS-CLIP	23824327
MIRT640569	hsa-miR-4284	HITS-CLIP	23824327
MIRT640568	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT640567	hsa-miR-7977	HITS-CLIP	23824327
MIRT640566	hsa-miR-6514-3p	HITS-CLIP	23824327
MIRT640565	hsa-miR-7150	HITS-CLIP	23824327
MIRT640564	hsa-miR-182-5p	HITS-CLIP	23824327
MIRT640563	hsa-miR-1271-5p	HITS-CLIP	23824327
MIRT640562	hsa-miR-96-5p	HITS-CLIP	23824327
MIRT638846	hsa-miR-4797-5p	HITS-CLIP	23824327
MIRT638845	hsa-miR-5007-5p	HITS-CLIP	23824327
MIRT638844	hsa-miR-6773-3p	HITS-CLIP	23824327
MIRT638843	hsa-miR-4524a-3p	HITS-CLIP	23824327
MIRT638842	hsa-miR-6879-3p	HITS-CLIP	23824327
MIRT638841	hsa-miR-3672	HITS-CLIP	23824327
MIRT638840	hsa-miR-6864-3p	HITS-CLIP	23824327
MIRT638839	hsa-miR-8055	HITS-CLIP	23824327
MIRT309648	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT570952	hsa-miR-5197-3p	PAR-CLIP	20371350
MIRT570951	hsa-miR-3154	PAR-CLIP	20371350
MIRT570950	hsa-miR-3125	PAR-CLIP	20371350
MIRT570949	hsa-miR-3916	PAR-CLIP	20371350
MIRT570948	hsa-miR-6859-5p	PAR-CLIP	20371350
MIRT570947	hsa-miR-5584-5p	PAR-CLIP	20371350
MIRT570945	hsa-miR-3185	PAR-CLIP	20371350
MIRT570946	hsa-miR-7515	PAR-CLIP	20371350
MIRT570944	hsa-miR-3150b-3p	PAR-CLIP	20371350
MIRT570943	hsa-miR-4784	PAR-CLIP	20371350
MIRT570942	hsa-miR-765	PAR-CLIP	20371350
MIRT570941	hsa-miR-3153	PAR-CLIP	20371350
MIRT570939	hsa-miR-6733-5p	PAR-CLIP	20371350
MIRT570940	hsa-miR-6739-5p	PAR-CLIP	20371350
MIRT570952	hsa-miR-5197-3p	PAR-CLIP	20371350
MIRT570951	hsa-miR-3154	PAR-CLIP	20371350
MIRT570950	hsa-miR-3125	PAR-CLIP	20371350
MIRT570949	hsa-miR-3916	PAR-CLIP	20371350
MIRT570948	hsa-miR-6859-5p	PAR-CLIP	20371350
MIRT570947	hsa-miR-5584-5p	PAR-CLIP	20371350
MIRT570945	hsa-miR-3185	PAR-CLIP	20371350
MIRT570946	hsa-miR-7515	PAR-CLIP	20371350
MIRT570944	hsa-miR-3150b-3p	PAR-CLIP	20371350
MIRT570943	hsa-miR-4784	PAR-CLIP	20371350
MIRT570942	hsa-miR-765	PAR-CLIP	20371350
MIRT570941	hsa-miR-3153	PAR-CLIP	20371350
MIRT570939	hsa-miR-6733-5p	PAR-CLIP	20371350
MIRT570940	hsa-miR-6739-5p	PAR-CLIP	20371350
MIRT905839	hsa-miR-196a	CLIP-seq
MIRT905840	hsa-miR-196b	CLIP-seq
MIRT905841	hsa-miR-3065-3p	CLIP-seq
MIRT905842	hsa-miR-30a	CLIP-seq
MIRT905843	hsa-miR-30b	CLIP-seq
MIRT905844	hsa-miR-30c	CLIP-seq
MIRT905845	hsa-miR-30d	CLIP-seq
MIRT905846	hsa-miR-30e	CLIP-seq
MIRT905847	hsa-miR-3646	CLIP-seq
MIRT905848	hsa-miR-3662	CLIP-seq
MIRT905849	hsa-miR-3927	CLIP-seq
MIRT905850	hsa-miR-4496	CLIP-seq
MIRT905851	hsa-miR-4659a-3p	CLIP-seq
MIRT905852	hsa-miR-4659b-3p	CLIP-seq
MIRT905853	hsa-miR-548aa	CLIP-seq
MIRT2204574	hsa-miR-3613-3p	CLIP-seq
MIRT905851	hsa-miR-4659a-3p	CLIP-seq
MIRT905852	hsa-miR-4659b-3p	CLIP-seq
MIRT2507965	hsa-miR-101	CLIP-seq
MIRT2507966	hsa-miR-1265	CLIP-seq
MIRT2507967	hsa-miR-1284	CLIP-seq
MIRT2507968	hsa-miR-144	CLIP-seq
MIRT2507969	hsa-miR-2392	CLIP-seq
MIRT2507970	hsa-miR-25	CLIP-seq
MIRT2507971	hsa-miR-3133	CLIP-seq
MIRT2507972	hsa-miR-3135	CLIP-seq
MIRT2507973	hsa-miR-32	CLIP-seq
MIRT2507974	hsa-miR-33a	CLIP-seq
MIRT2507975	hsa-miR-33b	CLIP-seq
MIRT2204574	hsa-miR-3613-3p	CLIP-seq
MIRT2507976	hsa-miR-363	CLIP-seq
MIRT2507977	hsa-miR-367	CLIP-seq
MIRT2507978	hsa-miR-369-3p	CLIP-seq
MIRT2507979	hsa-miR-371b-5p	CLIP-seq
MIRT2507980	hsa-miR-4275	CLIP-seq
MIRT2507981	hsa-miR-4470	CLIP-seq
MIRT2507982	hsa-miR-4503	CLIP-seq
MIRT2507983	hsa-miR-4511	CLIP-seq
MIRT2507984	hsa-miR-4735-5p	CLIP-seq
MIRT2507985	hsa-miR-4775	CLIP-seq
MIRT2507986	hsa-miR-488	CLIP-seq
MIRT2507987	hsa-miR-544	CLIP-seq
MIRT2507988	hsa-miR-582-5p	CLIP-seq
MIRT2507989	hsa-miR-590-3p	CLIP-seq
MIRT2507990	hsa-miR-888	CLIP-seq
MIRT2507991	hsa-miR-92a	CLIP-seq
MIRT2507992	hsa-miR-92b	CLIP-seq
MIRT2507965	hsa-miR-101	CLIP-seq
MIRT2507966	hsa-miR-1265	CLIP-seq
MIRT2507968	hsa-miR-144	CLIP-seq
MIRT2507969	hsa-miR-2392	CLIP-seq
MIRT2507970	hsa-miR-25	CLIP-seq
MIRT2507971	hsa-miR-3133	CLIP-seq
MIRT2507972	hsa-miR-3135	CLIP-seq
MIRT2507973	hsa-miR-32	CLIP-seq
MIRT2507974	hsa-miR-33a	CLIP-seq
MIRT2507975	hsa-miR-33b	CLIP-seq
MIRT2204574	hsa-miR-3613-3p	CLIP-seq
MIRT2507976	hsa-miR-363	CLIP-seq
MIRT2507977	hsa-miR-367	CLIP-seq
MIRT2507978	hsa-miR-369-3p	CLIP-seq
MIRT2507979	hsa-miR-371b-5p	CLIP-seq
MIRT2507980	hsa-miR-4275	CLIP-seq
MIRT2507981	hsa-miR-4470	CLIP-seq
MIRT2507982	hsa-miR-4503	CLIP-seq
MIRT2507983	hsa-miR-4511	CLIP-seq
MIRT2507984	hsa-miR-4735-5p	CLIP-seq
MIRT2507985	hsa-miR-4775	CLIP-seq
MIRT2507986	hsa-miR-488	CLIP-seq
MIRT2507987	hsa-miR-544	CLIP-seq
MIRT2507988	hsa-miR-582-5p	CLIP-seq
MIRT2507989	hsa-miR-590-3p	CLIP-seq
MIRT2507990	hsa-miR-888	CLIP-seq
MIRT2507991	hsa-miR-92a	CLIP-seq
MIRT2507992	hsa-miR-92b	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003214	Process	Cardiac left ventricle morphogenesis	IMP	19593212
GO:0004180	Function	Carboxypeptidase activity	IEA
GO:0004180	Function	Carboxypeptidase activity	TAS	9019408
GO:0004181	Function	Metallocarboxypeptidase activity	IBA
GO:0004181	Function	Metallocarboxypeptidase activity	IEA
GO:0005515	Function	Protein binding	IPI	32814053
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005794	Component	Golgi apparatus	IDA	19166515
GO:0005886	Component	Plasma membrane	TAS	9019408
GO:0006508	Process	Proteolysis	IEA
GO:0006518	Process	Peptide metabolic process	IBA
GO:0007154	Process	Cell communication	IEA
GO:0007218	Process	Neuropeptide signaling pathway	NAS	2334405
GO:0008104	Process	Intracellular protein localization	IEA
GO:0008233	Function	Peptidase activity	IEA
GO:0008237	Function	Metallopeptidase activity	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0012505	Component	Endomembrane system	IEA
GO:0016020	Component	Membrane	IEA
GO:0016055	Process	Wnt signaling pathway	IDA	22824791
GO:0016485	Process	Protein processing	IBA
GO:0016787	Function	Hydrolase activity	IEA
GO:0023052	Process	Signaling	IEA
GO:0030070	Process	Insulin processing	IEA
GO:0030072	Process	Peptide hormone secretion	IEA
GO:0030133	Component	Transport vesicle	IEA
GO:0030141	Component	Secretory granule	IEA
GO:0030658	Component	Transport vesicle membrane	IEA
GO:0030667	Component	Secretory granule membrane	IEA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0033366	Process	Protein localization to secretory granule	IEA
GO:0036211	Process	Protein modification process	NAS	2334405
GO:0042043	Function	Neurexin family protein binding	IPI	19166515
GO:0046872	Function	Metal ion binding	IEA
GO:0050839	Function	Cell adhesion molecule binding	IPI	19166515
GO:0070062	Component	Extracellular exosome	HDA	23533145
GO:0072657	Process	Protein localization to membrane	IDA	19166515

Other IDs

• MIM: 114855
• HGNC: 2303
• e!Ensembl: ENSG00000109472

Protein

• UniProt ID: P16870
• Protein name: Carboxypeptidase E (CPE) (EC 3.4.17.10) (Carboxypeptidase H) (CPH) (Enkephalin convertase) (Prohormone-processing carboxypeptidase)
• Protein function: Sorting receptor that directs prohormones to the regulated secretory pathway. Also acts as a prohormone processing enzyme in neuro/endocrine cells, removing dibasic residues from the C-terminal end of peptide hormone precursors after initial end
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00246	Peptidase_M14	59 → 364	Zinc carboxypeptidase	Domain
  PF13620	CarboxypepD_reg	375 → 450		Domain

• Sequence:

  MAGRGGSALLALCGALAACGWLLGAEAQEPGAPAAGMRRRRRLQQEDGISFEYHRYPELR
  EALVSVWLQCTAISRIYTVGRSFEGRELLVIELSDNPGVHEPGEPEFKYIGNMHGNEAVG
  RELLIFLAQYLCNEYQKGNETIVNLIHSTRIHIMPSLNPDGFEKAASQPGELKDWFVGRS
  NAQGIDLNRNFPDLDRIVYVNEKEGGPNNHLLKNMKKIVDQNTKLAPETKAVIHWIMDIP
  FVLSANLHGGDLVANYPYDETRSGSAHEYSSSPDDAIFQSLARAYSSFNPAMSDPNRPPC
  RKNDDDSSFVDGTTNGGAWYSVPGGMQDFNYLSSNCFEITVELSCEKFPPEETLKTYWED
  NKNSLISYLEQIHRGVKGFVRDLQGNPIANATISVEGIDHDVTSAKDGDYWRLLIPGNYK
  LTASAPGYLAITKKVAVPYSPAAGVDFELESFSERKEEEKEELMEWWKMMSETLNF

• Sequence length: 476

Pathways

KEGG:

Type I diabetes mellitus

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
BDV syndrome	Pathogenic	rs1298858763, rs1317332155, rs1579283609, rs768504422	RCV001418305 RCV001762730 RCV001766669 RCV001815013	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Blakemore-Durmaz-Vasileiou (BDV) syndrome	Pathogenic	rs1317332155	RCV001579305	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ATOPIC ECZEMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHRONIC ISCHEMIC HEART DISEASE	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ARTERIOSCLEROSIS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY HEART DISEASE	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CPE-related disorder	Uncertain significance; Benign; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CPE-RELATED PRADER-WILLI-LIKE SYNDROME	—	Orphanet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETES MELLITUS, NON-INSULIN-DEPENDENT	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ENDOCRINE SYSTEM DISEASES	—	CTD, Disgenet CTD, Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INSULIN RESISTANCE	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG NEOPLASMS	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYOCARDIAL ISCHEMIA	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBESITY	—	CTD, Disgenet CTD, Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PELVIC ORGAN PROLAPSE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Adrenal Gland Pheochromocytoma	Adrenal Gland Pheochromocytoma	BEFREE	21061162, 23941827		★☆☆☆☆ Found in Text Mining only
Alzheimer Disease	Alzheimer disease	Pubtator	31113950	Associate	★☆☆☆☆ Found in Text Mining only
Astrocytoma	Astrocytoma	BEFREE	21061162		★☆☆☆☆ Found in Text Mining only
Autistic Disorder	Autism	Pubtator	28316770	Associate	★☆☆☆☆ Found in Text Mining only
Bile Duct Diseases	Bile duct disease	Pubtator	40596471	Associate	★☆☆☆☆ Found in Text Mining only
Bone Diseases Metabolic	Bone disease	Pubtator	32936766	Associate	★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	35528956	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Embryonal	Embryonal carcinoma	Pubtator	27803193, 29898407	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	26803519, 35328535	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma of Endocrine Gland	Endocrine Gland cancer	BEFREE	21061162		★☆☆☆☆ Found in Text Mining only
Carcinoma, Ovarian Epithelial	Ovarian Epithelial carcinoma	BEFREE	17460774, 21123456, 29027715		★☆☆☆☆ Found in Text Mining only
Cataract	Cataract	BEFREE	19608539		★☆☆☆☆ Found in Text Mining only
cervical cancer	Cervical Cancer	BEFREE	26695643		★☆☆☆☆ Found in Text Mining only
Cervix carcinoma	Cervix carcinoma	BEFREE	26695643		★☆☆☆☆ Found in Text Mining only
Cholesterol gallstones	Cholesterol gallstones	BEFREE	26228366		★☆☆☆☆ Found in Text Mining only
Cirrhosis	Cirrhosis	BEFREE	1793464		★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	21061162, 23852859, 24006921		★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	UNIPROT_DG			★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	21061162, 23852859	Associate	★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	24006921	Stimulate	★☆☆☆☆ Found in Text Mining only
Coronary Arteriosclerosis	Coronary Arteriosclerosis	BEFREE	17957445, 18080843, 18501121		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Coronary Artery Disease	Coronary artery disease	BEFREE	17957445		★☆☆☆☆ Found in Text Mining only
Coronary heart disease	Coronary Heart Disease	BEFREE	17957445		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Coronary heart disease	Coronary Heart Disease	LHGDN	17957445		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Delirium, Dementia, Amnestic, Cognitive Disorders	Delirium, Dementia, Amnestic, Cognitive Disorders	BEFREE	29982499		★☆☆☆☆ Found in Text Mining only
Dementia	Dementia	BEFREE	27922637		★☆☆☆☆ Found in Text Mining only
Depressive disorder	Mental Depression	BEFREE	27922637, 29982499		★☆☆☆☆ Found in Text Mining only
Developmental Disabilities	Developmental disability	Pubtator	32936766	Associate	★☆☆☆☆ Found in Text Mining only
Diabetes	Diabetes	BEFREE	18550819, 28348001, 9662053		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes Mellitus	BEFREE	18550819, 28348001, 9662053		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes mellitus	Pubtator	32936766	Associate	★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 1	Diabetes mellitus, type 1	Pubtator	31442418	Associate	★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Diabetes mellitus, type 2	Pubtator	26120850, 34029697	Associate	★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Insulin-Dependent	Diabetes Mellitus	LHGDN	19120309		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Insulin-Dependent	Diabetes Mellitus	BEFREE	31442418, 7556984		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	21628999, 23776430, 26120850, 30172742, 9662053		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Diarrhea	Diarrhea	Pubtator	12682135, 16452442, 9431915	Associate	★☆☆☆☆ Found in Text Mining only
Down Syndrome	Down Syndrome	BEFREE	6459987		★☆☆☆☆ Found in Text Mining only
Endocrine System Diseases	Endocrine System Diseases	CTD_human_DG	15358678		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Endometrial Neoplasms	Endometrial Neoplasms	BEFREE	31079233		★☆☆☆☆ Found in Text Mining only
Epithelial ovarian cancer	Ovarian cancer	BEFREE	17460774, 29027715		★☆☆☆☆ Found in Text Mining only
Exfoliation Syndrome	Exfoliation Syndrome	BEFREE	30842085		★☆☆☆☆ Found in Text Mining only
Fibrosarcoma	Fibrosarcoma	BEFREE	23941827		★☆☆☆☆ Found in Text Mining only
Gallstones	Gallstones	Pubtator	26228366	Associate	★☆☆☆☆ Found in Text Mining only
Gastroenteritis	Gastroenteritis	BEFREE	18485266		★☆☆☆☆ Found in Text Mining only
Gastroenteritis	Gastroenteritis	Pubtator	31553300	Associate	★☆☆☆☆ Found in Text Mining only
Gastrointestinal Diseases	Gastrointestinal Diseases	BEFREE	10919775, 12117935, 12682135, 15819629, 18681798, 28941910		★☆☆☆☆ Found in Text Mining only
Gastrointestinal Diseases	Gastrointestinal disease	Pubtator	10919775, 11292780, 12682135, 17905877, 21464088, 9431915	Associate	★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	22249620, 28978054		★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	25356585	Inhibit	★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	39352777	Associate	★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	22249620, 28978054		★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	1764034, 23941827, 28656234		★☆☆☆☆ Found in Text Mining only
Hyperlipidemia	Hyperlipidemia	BEFREE	18550819		★☆☆☆☆ Found in Text Mining only
Hyperlipidemia	Hyperlipidemia	LHGDN	18550819		★☆☆☆☆ Found in Text Mining only
Hyperproinsulinemia	Hyperproinsulinemia	BEFREE	17957445, 18080843, 21628999, 31300553, 9662053		★☆☆☆☆ Found in Text Mining only
Hypertension	Hypertension	Pubtator	19593212	Associate	★☆☆☆☆ Found in Text Mining only
Hypogonadism	Hypogonadism	Pubtator	26120850, 32936766	Associate	★☆☆☆☆ Found in Text Mining only
Hypogonadotropic hypogonadism	Hypogonadotropic Hypogonadism	BEFREE	26120850		★☆☆☆☆ Found in Text Mining only
Hypoxia	Hypoxia	Pubtator	39352777	Associate	★☆☆☆☆ Found in Text Mining only
insulinoma	Insulinoma	BEFREE	15163304		★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Intellectual developmental disorder	Pubtator	26120850, 32936766	Associate	★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Mental retardation	BEFREE	29982499		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	21285511, 23941827, 26803519		★☆☆☆☆ Found in Text Mining only
Liver Cirrhosis	Liver Cirrhosis	BEFREE	1793464, 9062779		★☆☆☆☆ Found in Text Mining only
Liver Cirrhosis Biliary	Liver cirrhosis	Pubtator	40596471	Associate	★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung Neoplasms	CTD_human_DG	27935865		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	23852859	Stimulate	★☆☆☆☆ Found in Text Mining only
Malformations of Cortical Development, Group II	Malformation of cortical development	BEFREE	29982499		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	CTD_human_DG	27935865		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of pancreas	Pancreatic cancer	BEFREE	25374060		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	22249620, 23941827, 24006921, 25374060, 30508384		★☆☆☆☆ Found in Text Mining only
Malignant tumor of cervix	Cervical Tumor	BEFREE	26695643		★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	BEFREE	23580127		★☆☆☆☆ Found in Text Mining only
Mental Depression	Mental Depression	BEFREE	27922637, 29982499		★☆☆☆☆ Found in Text Mining only
Metabolic Diseases	Metabolic Diseases	BEFREE	20615072		★☆☆☆☆ Found in Text Mining only
Nasopharyngeal carcinoma	Nasopharyngeal Carcinoma	BEFREE	31521247		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	21061162, 21123456, 21285511, 22249620, 23580127, 23852859, 23941827, 24006921, 25374060, 26695643, 26803519, 31319379		★☆☆☆☆ Found in Text Mining only
nervous system disorder	Nervous System Disorder	BEFREE	28114332		★☆☆☆☆ Found in Text Mining only
Neurocognitive Disorders	Neurocognitive Disorders	BEFREE	29982499		★☆☆☆☆ Found in Text Mining only
Neuroendocrine Tumors	Neuroendocrine Tumors	BEFREE	15492986, 21061162		★☆☆☆☆ Found in Text Mining only
Neuroendocrine Tumors	Neuroendocrine Tumors	LHGDN	15492986		★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	BEFREE	12530526, 9207799, 9662053		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Obesity	Obesity	Pubtator	12530526, 23900445, 26120850, 32936766	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Obesity	Obesity	GENOMICS_ENGLAND_DG	15358678		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Obesity	Obesity	CTD_human_DG	15358678, 23434795		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Obesity Morbid	Obesity	Pubtator	26120850, 32936766	Associate	★☆☆☆☆ Found in Text Mining only
oligodendroglioma	Oligodendroglioma	BEFREE	21061162		★☆☆☆☆ Found in Text Mining only
Oligodendroglioma	Oligodendroglioma	Pubtator	21061162	Stimulate	★☆☆☆☆ Found in Text Mining only
Osteoporosis	Osteoporosis	BEFREE	30172742		★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	Pubtator	37663298	Associate	★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma	Pancreatic carcinoma	BEFREE	25374060		★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	31731578, 32675394, 33164330, 33253517, 35528956	Associate	★☆☆☆☆ Found in Text Mining only
Pelvic Organ Prolapse	Pelvic Organ Prolapse	BEFREE	26545240		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Pelvic Organ Prolapse	Pelvic Organ Prolapse	GWASCAT_DG	26545240		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Pelvic Organ Prolapse	Pelvic organ prolapse	Pubtator	26545240	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Pheochromocytoma	Pheochromocytoma	BEFREE	21061162, 23941827		★☆☆☆☆ Found in Text Mining only
Pheochromocytoma	Pheochromocytoma	Pubtator	21061162	Associate	★☆☆☆☆ Found in Text Mining only
Pituitary Neoplasms	Pituitary neoplasm	Pubtator	21061162	Stimulate	★☆☆☆☆ Found in Text Mining only
Presenile dementia	Senile Dementia	BEFREE	27922637		★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	34556748	Inhibit	★☆☆☆☆ Found in Text Mining only
Sarcoma	Sarcoma	BEFREE	21061162		★☆☆☆☆ Found in Text Mining only
Sarcoma Ewing	Sarcoma	Pubtator	21061162	Stimulate	★☆☆☆☆ Found in Text Mining only
Small cell carcinoma of lung	Lung carcinoma	BEFREE	11326319, 12711116		★☆☆☆☆ Found in Text Mining only
Testicular Germ Cell Tumor	Testicular germ cell tumor	Pubtator	27803193	Associate	★☆☆☆☆ Found in Text Mining only
Trigeminal Neuralgia	Trigeminal neuralgia	BEFREE	28158167		★☆☆☆☆ Found in Text Mining only
Well Differentiated Oligodendroglioma	Oligodendroglioma	BEFREE	21061162		★☆☆☆☆ Found in Text Mining only