COX15 (cytochrome c oxidase assembly factor COX15)

Gene

• Entrez ID: 1355
• Gene name: Cytochrome c oxidase assembly factor COX15
• Gene symbol: COX15
• Synonyms (NCBI Gene): CEMCOX2, HAS, MC4DN6
• Chromosome: 10
• Chromosome location: 10q24.2
• Summary: Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochond

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs28939711	G>A	Pathogenic	Missense variant, coding sequence variant, non coding transcript variant
rs149718203	G>C	Uncertain-significance, likely-pathogenic, pathogenic	Coding sequence variant, stop gained, intron variant
rs200910834	G>C	Conflicting-interpretations-of-pathogenicity, pathogenic	Intron variant
rs397514662	A>C,G	Likely-pathogenic, pathogenic	Coding sequence variant, non coding transcript variant, missense variant
rs748468371	CT>-	Pathogenic	Coding sequence variant, 5 prime UTR variant, non coding transcript variant, frameshift variant
rs863223944	T>G	Likely-pathogenic	Non coding transcript variant, coding sequence variant, 5 prime UTR variant, missense variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT659390	hsa-miR-4267	HITS-CLIP	23824327
MIRT659391	hsa-miR-153-3p	HITS-CLIP	23824327
MIRT659389	hsa-miR-448	HITS-CLIP	23824327
MIRT478958	hsa-miR-4676-5p	PAR-CLIP	23592263
MIRT478957	hsa-miR-575	PAR-CLIP	23592263
MIRT478956	hsa-miR-4717-3p	PAR-CLIP	23592263
MIRT478955	hsa-miR-199a-5p	PAR-CLIP	23592263
MIRT478954	hsa-miR-199b-5p	PAR-CLIP	23592263
MIRT478952	hsa-miR-7515	PAR-CLIP	23592263
MIRT478953	hsa-miR-3179	PAR-CLIP	23592263
MIRT478951	hsa-miR-505-5p	PAR-CLIP	23592263
MIRT478950	hsa-miR-6827-5p	PAR-CLIP	23592263
MIRT478949	hsa-miR-1343-5p	PAR-CLIP	23592263
MIRT478948	hsa-miR-939-5p	PAR-CLIP	23592263
MIRT478947	hsa-miR-4792	PAR-CLIP	23592263
MIRT478946	hsa-miR-4710	PAR-CLIP	23592263
MIRT478945	hsa-miR-597-5p	PAR-CLIP	23592263
MIRT478944	hsa-miR-6864-5p	PAR-CLIP	23592263
MIRT478942	hsa-miR-7855-5p	PAR-CLIP	23592263
MIRT478943	hsa-miR-592	PAR-CLIP	23592263
MIRT442692	hsa-miR-371b-3p	PAR-CLIP	22100165
MIRT442691	hsa-miR-371a-3p	PAR-CLIP	22100165
MIRT442690	hsa-miR-33b-3p	PAR-CLIP	22100165
MIRT442689	hsa-miR-515-3p	PAR-CLIP	22100165
MIRT442688	hsa-miR-519e-3p	PAR-CLIP	22100165
MIRT442686	hsa-miR-4480	PAR-CLIP	22100165
MIRT440905	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440905	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT659390	hsa-miR-4267	HITS-CLIP	23824327
MIRT659391	hsa-miR-153-3p	HITS-CLIP	23824327
MIRT659389	hsa-miR-448	HITS-CLIP	23824327
MIRT478958	hsa-miR-4676-5p	PAR-CLIP	23592263
MIRT478957	hsa-miR-575	PAR-CLIP	23592263
MIRT478956	hsa-miR-4717-3p	PAR-CLIP	23592263
MIRT478955	hsa-miR-199a-5p	PAR-CLIP	23592263
MIRT478954	hsa-miR-199b-5p	PAR-CLIP	23592263
MIRT478952	hsa-miR-7515	PAR-CLIP	23592263
MIRT478953	hsa-miR-3179	PAR-CLIP	23592263
MIRT478951	hsa-miR-505-5p	PAR-CLIP	23592263
MIRT478950	hsa-miR-6827-5p	PAR-CLIP	23592263
MIRT478949	hsa-miR-1343-5p	PAR-CLIP	23592263
MIRT478948	hsa-miR-939-5p	PAR-CLIP	23592263
MIRT478947	hsa-miR-4792	PAR-CLIP	23592263
MIRT478946	hsa-miR-4710	PAR-CLIP	23592263
MIRT478945	hsa-miR-597-5p	PAR-CLIP	23592263
MIRT478944	hsa-miR-6864-5p	PAR-CLIP	23592263
MIRT478942	hsa-miR-7855-5p	PAR-CLIP	23592263
MIRT478943	hsa-miR-592	PAR-CLIP	23592263
MIRT442692	hsa-miR-371b-3p	PAR-CLIP	22100165
MIRT442691	hsa-miR-371a-3p	PAR-CLIP	22100165
MIRT442690	hsa-miR-33b-3p	PAR-CLIP	22100165
MIRT442689	hsa-miR-515-3p	PAR-CLIP	22100165
MIRT442688	hsa-miR-519e-3p	PAR-CLIP	22100165
MIRT442686	hsa-miR-4480	PAR-CLIP	22100165
MIRT904939	hsa-miR-1185	CLIP-seq
MIRT904940	hsa-miR-1224-5p	CLIP-seq
MIRT904941	hsa-miR-1290	CLIP-seq
MIRT904942	hsa-miR-1294	CLIP-seq
MIRT904943	hsa-miR-1343	CLIP-seq
MIRT904944	hsa-miR-146a	CLIP-seq
MIRT904945	hsa-miR-146b-5p	CLIP-seq
MIRT904946	hsa-miR-2052	CLIP-seq
MIRT904947	hsa-miR-23a	CLIP-seq
MIRT904948	hsa-miR-23b	CLIP-seq
MIRT904949	hsa-miR-23c	CLIP-seq
MIRT904950	hsa-miR-3074-5p	CLIP-seq
MIRT904951	hsa-miR-3152-3p	CLIP-seq
MIRT904952	hsa-miR-3180-5p	CLIP-seq
MIRT904953	hsa-miR-33a	CLIP-seq
MIRT904954	hsa-miR-33b	CLIP-seq
MIRT904955	hsa-miR-3605-5p	CLIP-seq
MIRT904956	hsa-miR-3622a-3p	CLIP-seq
MIRT904957	hsa-miR-3622b-3p	CLIP-seq
MIRT904958	hsa-miR-3646	CLIP-seq
MIRT904959	hsa-miR-3664-5p	CLIP-seq
MIRT904960	hsa-miR-3679-5p	CLIP-seq
MIRT904961	hsa-miR-3915	CLIP-seq
MIRT904962	hsa-miR-3925-5p	CLIP-seq
MIRT904963	hsa-miR-3928	CLIP-seq
MIRT904964	hsa-miR-3977	CLIP-seq
MIRT904965	hsa-miR-4311	CLIP-seq
MIRT904966	hsa-miR-4316	CLIP-seq
MIRT904967	hsa-miR-4327	CLIP-seq
MIRT904968	hsa-miR-452	CLIP-seq
MIRT904969	hsa-miR-4522	CLIP-seq
MIRT904970	hsa-miR-4639-5p	CLIP-seq
MIRT904971	hsa-miR-4676-3p	CLIP-seq
MIRT904972	hsa-miR-4689	CLIP-seq
MIRT904973	hsa-miR-4694-5p	CLIP-seq
MIRT904974	hsa-miR-4766-5p	CLIP-seq
MIRT904975	hsa-miR-488	CLIP-seq
MIRT904976	hsa-miR-520a-5p	CLIP-seq
MIRT904977	hsa-miR-525-5p	CLIP-seq
MIRT904978	hsa-miR-548g	CLIP-seq
MIRT904979	hsa-miR-586	CLIP-seq
MIRT904980	hsa-miR-587	CLIP-seq
MIRT904981	hsa-miR-1225-5p	CLIP-seq
MIRT904982	hsa-miR-1266	CLIP-seq
MIRT904983	hsa-miR-1305	CLIP-seq
MIRT904984	hsa-miR-1827	CLIP-seq
MIRT904985	hsa-miR-205	CLIP-seq
MIRT904986	hsa-miR-2114	CLIP-seq
MIRT904987	hsa-miR-3125	CLIP-seq
MIRT904988	hsa-miR-3607-3p	CLIP-seq
MIRT904989	hsa-miR-362-5p	CLIP-seq
MIRT904990	hsa-miR-3664-3p	CLIP-seq
MIRT904991	hsa-miR-3686	CLIP-seq
MIRT904992	hsa-miR-3914	CLIP-seq
MIRT904993	hsa-miR-3916	CLIP-seq
MIRT904963	hsa-miR-3928	CLIP-seq
MIRT904994	hsa-miR-3929	CLIP-seq
MIRT904995	hsa-miR-3940-3p	CLIP-seq
MIRT904996	hsa-miR-421	CLIP-seq
MIRT904997	hsa-miR-4302	CLIP-seq
MIRT904998	hsa-miR-4307	CLIP-seq
MIRT904999	hsa-miR-4419b	CLIP-seq
MIRT905000	hsa-miR-4433	CLIP-seq
MIRT905001	hsa-miR-4459	CLIP-seq
MIRT905002	hsa-miR-4478	CLIP-seq
MIRT905003	hsa-miR-4518	CLIP-seq
MIRT905004	hsa-miR-4646-5p	CLIP-seq
MIRT905005	hsa-miR-4649-3p	CLIP-seq
MIRT905006	hsa-miR-4661-5p	CLIP-seq
MIRT905007	hsa-miR-4768-3p	CLIP-seq
MIRT905008	hsa-miR-485-5p	CLIP-seq
MIRT905009	hsa-miR-490-3p	CLIP-seq
MIRT905010	hsa-miR-500b	CLIP-seq
MIRT905011	hsa-miR-501-5p	CLIP-seq
MIRT905012	hsa-miR-548a-3p	CLIP-seq
MIRT905013	hsa-miR-548ac	CLIP-seq
MIRT905014	hsa-miR-548ae	CLIP-seq
MIRT905015	hsa-miR-548aj	CLIP-seq
MIRT905016	hsa-miR-548am	CLIP-seq
MIRT905017	hsa-miR-548d-3p	CLIP-seq
MIRT905018	hsa-miR-548e	CLIP-seq
MIRT905019	hsa-miR-548f	CLIP-seq
MIRT905020	hsa-miR-548x	CLIP-seq
MIRT905021	hsa-miR-548z	CLIP-seq
MIRT905022	hsa-miR-580	CLIP-seq
MIRT905023	hsa-miR-583	CLIP-seq
MIRT905024	hsa-miR-597	CLIP-seq
MIRT905025	hsa-miR-873	CLIP-seq
MIRT905026	hsa-miR-939	CLIP-seq
MIRT905027	hsa-miR-944	CLIP-seq
MIRT1920367	hsa-miR-1277	CLIP-seq
MIRT1920367	hsa-miR-1277	CLIP-seq
MIRT1920367	hsa-miR-1277	CLIP-seq
MIRT1920367	hsa-miR-1277	CLIP-seq
MIRT1968365	hsa-miR-1285	CLIP-seq
MIRT904983	hsa-miR-1305	CLIP-seq
MIRT1968366	hsa-miR-134	CLIP-seq
MIRT904944	hsa-miR-146a	CLIP-seq
MIRT904945	hsa-miR-146b-5p	CLIP-seq
MIRT1968367	hsa-miR-15a	CLIP-seq
MIRT1968368	hsa-miR-15b	CLIP-seq
MIRT1968369	hsa-miR-16	CLIP-seq
MIRT904984	hsa-miR-1827	CLIP-seq
MIRT1968370	hsa-miR-195	CLIP-seq
MIRT1968371	hsa-miR-203	CLIP-seq
MIRT904986	hsa-miR-2114	CLIP-seq
MIRT1968372	hsa-miR-214	CLIP-seq
MIRT1968373	hsa-miR-2276	CLIP-seq
MIRT1968374	hsa-miR-2467-3p	CLIP-seq
MIRT1968375	hsa-miR-2681	CLIP-seq
MIRT1968376	hsa-miR-27a	CLIP-seq
MIRT1968377	hsa-miR-27b	CLIP-seq
MIRT1968378	hsa-miR-298	CLIP-seq
MIRT1968379	hsa-miR-3118	CLIP-seq
MIRT1968380	hsa-miR-3145-5p	CLIP-seq
MIRT1968381	hsa-miR-3148	CLIP-seq
MIRT1968382	hsa-miR-3160-3p	CLIP-seq
MIRT1968383	hsa-miR-3164	CLIP-seq
MIRT1968384	hsa-miR-3166	CLIP-seq
MIRT1968385	hsa-miR-3187-5p	CLIP-seq
MIRT1968386	hsa-miR-323-3p	CLIP-seq
MIRT1968387	hsa-miR-3613-3p	CLIP-seq
MIRT1968388	hsa-miR-3616-3p	CLIP-seq
MIRT1968389	hsa-miR-3619-5p	CLIP-seq
MIRT1968390	hsa-miR-3678-3p	CLIP-seq
MIRT1968391	hsa-miR-3680	CLIP-seq
MIRT1968392	hsa-miR-3925-3p	CLIP-seq
MIRT904994	hsa-miR-3929	CLIP-seq
MIRT1968393	hsa-miR-424	CLIP-seq
MIRT1968394	hsa-miR-4291	CLIP-seq
MIRT904999	hsa-miR-4419b	CLIP-seq
MIRT905002	hsa-miR-4478	CLIP-seq
MIRT1968395	hsa-miR-4487	CLIP-seq
MIRT1968396	hsa-miR-4503	CLIP-seq
MIRT1968397	hsa-miR-4512	CLIP-seq
MIRT1968398	hsa-miR-4635	CLIP-seq
MIRT905005	hsa-miR-4649-3p	CLIP-seq
MIRT1968399	hsa-miR-4652-3p	CLIP-seq
MIRT1968400	hsa-miR-4662a-3p	CLIP-seq
MIRT1968401	hsa-miR-4668-3p	CLIP-seq
MIRT1968402	hsa-miR-4684-5p	CLIP-seq
MIRT1968403	hsa-miR-4713-3p	CLIP-seq
MIRT1968404	hsa-miR-4721	CLIP-seq
MIRT1968405	hsa-miR-4760-3p	CLIP-seq
MIRT1968406	hsa-miR-4768-5p	CLIP-seq
MIRT1968407	hsa-miR-4775	CLIP-seq
MIRT905008	hsa-miR-485-5p	CLIP-seq
MIRT1968408	hsa-miR-486-3p	CLIP-seq
MIRT1968409	hsa-miR-497	CLIP-seq
MIRT1968410	hsa-miR-508-5p	CLIP-seq
MIRT1968411	hsa-miR-513a-5p	CLIP-seq
MIRT1968412	hsa-miR-545	CLIP-seq
MIRT1968413	hsa-miR-558	CLIP-seq
MIRT905022	hsa-miR-580	CLIP-seq
MIRT1968414	hsa-miR-589	CLIP-seq
MIRT1968415	hsa-miR-590-3p	CLIP-seq
MIRT1968416	hsa-miR-607	CLIP-seq
MIRT1968417	hsa-miR-612	CLIP-seq
MIRT1968418	hsa-miR-642b	CLIP-seq
MIRT1968419	hsa-miR-661	CLIP-seq
MIRT1968420	hsa-miR-758	CLIP-seq
MIRT1968421	hsa-miR-759	CLIP-seq
MIRT1968422	hsa-miR-761	CLIP-seq
MIRT1968423	hsa-miR-766	CLIP-seq
MIRT1968424	hsa-miR-922	CLIP-seq
MIRT904939	hsa-miR-1185	CLIP-seq
MIRT1968365	hsa-miR-1285	CLIP-seq
MIRT2204189	hsa-miR-136	CLIP-seq
MIRT904944	hsa-miR-146a	CLIP-seq
MIRT904945	hsa-miR-146b-5p	CLIP-seq
MIRT1968367	hsa-miR-15a	CLIP-seq
MIRT1968368	hsa-miR-15b	CLIP-seq
MIRT1968369	hsa-miR-16	CLIP-seq
MIRT904984	hsa-miR-1827	CLIP-seq
MIRT2204190	hsa-miR-183	CLIP-seq
MIRT2204191	hsa-miR-190	CLIP-seq
MIRT2204192	hsa-miR-190b	CLIP-seq
MIRT1968370	hsa-miR-195	CLIP-seq
MIRT2204193	hsa-miR-200b	CLIP-seq
MIRT2204194	hsa-miR-200c	CLIP-seq
MIRT1968371	hsa-miR-203	CLIP-seq
MIRT2204195	hsa-miR-2054	CLIP-seq
MIRT2204196	hsa-miR-2116	CLIP-seq
MIRT2204197	hsa-miR-221	CLIP-seq
MIRT2204198	hsa-miR-222	CLIP-seq
MIRT1968373	hsa-miR-2276	CLIP-seq
MIRT1968375	hsa-miR-2681	CLIP-seq
MIRT1968378	hsa-miR-298	CLIP-seq
MIRT904950	hsa-miR-3074-5p	CLIP-seq
MIRT2204199	hsa-miR-3122	CLIP-seq
MIRT2204200	hsa-miR-3143	CLIP-seq
MIRT1968380	hsa-miR-3145-5p	CLIP-seq
MIRT1968383	hsa-miR-3164	CLIP-seq
MIRT2204201	hsa-miR-3182	CLIP-seq
MIRT1968385	hsa-miR-3187-5p	CLIP-seq
MIRT904955	hsa-miR-3605-5p	CLIP-seq
MIRT2204202	hsa-miR-3675-5p	CLIP-seq
MIRT904960	hsa-miR-3679-5p	CLIP-seq
MIRT1968391	hsa-miR-3680	CLIP-seq
MIRT2204203	hsa-miR-3913-5p	CLIP-seq
MIRT1968392	hsa-miR-3925-3p	CLIP-seq
MIRT904963	hsa-miR-3928	CLIP-seq
MIRT2204204	hsa-miR-3938	CLIP-seq
MIRT2204205	hsa-miR-3940-5p	CLIP-seq
MIRT2204206	hsa-miR-409-3p	CLIP-seq
MIRT2204207	hsa-miR-412	CLIP-seq
MIRT1968393	hsa-miR-424	CLIP-seq
MIRT2204208	hsa-miR-429	CLIP-seq
MIRT2204209	hsa-miR-4293	CLIP-seq
MIRT904997	hsa-miR-4302	CLIP-seq
MIRT905000	hsa-miR-4433	CLIP-seq
MIRT2204210	hsa-miR-4443	CLIP-seq
MIRT2204211	hsa-miR-4450	CLIP-seq
MIRT905001	hsa-miR-4459	CLIP-seq
MIRT1968395	hsa-miR-4487	CLIP-seq
MIRT1968396	hsa-miR-4503	CLIP-seq
MIRT2204212	hsa-miR-4507	CLIP-seq
MIRT1968398	hsa-miR-4635	CLIP-seq
MIRT905004	hsa-miR-4646-5p	CLIP-seq
MIRT905006	hsa-miR-4661-5p	CLIP-seq
MIRT1968401	hsa-miR-4668-3p	CLIP-seq
MIRT2204213	hsa-miR-4677-5p	CLIP-seq
MIRT2204214	hsa-miR-4735-5p	CLIP-seq
MIRT2204215	hsa-miR-4747-5p	CLIP-seq
MIRT1968405	hsa-miR-4760-3p	CLIP-seq
MIRT905007	hsa-miR-4768-3p	CLIP-seq
MIRT2204216	hsa-miR-4772-3p	CLIP-seq
MIRT2204217	hsa-miR-4789-3p	CLIP-seq
MIRT2204218	hsa-miR-4789-5p	CLIP-seq
MIRT905009	hsa-miR-490-3p	CLIP-seq
MIRT1968409	hsa-miR-497	CLIP-seq
MIRT1968410	hsa-miR-508-5p	CLIP-seq
MIRT2204219	hsa-miR-543	CLIP-seq
MIRT2204220	hsa-miR-544	CLIP-seq
MIRT2204221	hsa-miR-544b	CLIP-seq
MIRT1968412	hsa-miR-545	CLIP-seq
MIRT2204222	hsa-miR-548aa	CLIP-seq
MIRT905013	hsa-miR-548ac	CLIP-seq
MIRT905014	hsa-miR-548ae	CLIP-seq
MIRT905015	hsa-miR-548aj	CLIP-seq
MIRT905016	hsa-miR-548am	CLIP-seq
MIRT905017	hsa-miR-548d-3p	CLIP-seq
MIRT2204223	hsa-miR-548v	CLIP-seq
MIRT905020	hsa-miR-548x	CLIP-seq
MIRT905021	hsa-miR-548z	CLIP-seq
MIRT905022	hsa-miR-580	CLIP-seq
MIRT1968414	hsa-miR-589	CLIP-seq
MIRT2204224	hsa-miR-596	CLIP-seq
MIRT905024	hsa-miR-597	CLIP-seq
MIRT1968417	hsa-miR-612	CLIP-seq
MIRT2204225	hsa-miR-642a	CLIP-seq
MIRT1968418	hsa-miR-642b	CLIP-seq
MIRT2204226	hsa-miR-659	CLIP-seq
MIRT1968419	hsa-miR-661	CLIP-seq
MIRT2204227	hsa-miR-671-5p	CLIP-seq
MIRT1968423	hsa-miR-766	CLIP-seq
MIRT2204228	hsa-miR-875-5p	CLIP-seq
MIRT905026	hsa-miR-939	CLIP-seq
MIRT904950	hsa-miR-3074-5p	CLIP-seq
MIRT2507694	hsa-miR-103a	CLIP-seq
MIRT2507695	hsa-miR-107	CLIP-seq
MIRT2507696	hsa-miR-1184	CLIP-seq
MIRT2507697	hsa-miR-1202	CLIP-seq
MIRT2507698	hsa-miR-1205	CLIP-seq
MIRT2507699	hsa-miR-1208	CLIP-seq
MIRT904940	hsa-miR-1224-5p	CLIP-seq
MIRT2507700	hsa-miR-1243	CLIP-seq
MIRT2507701	hsa-miR-1247	CLIP-seq
MIRT2507702	hsa-miR-1278	CLIP-seq
MIRT2507703	hsa-miR-1279	CLIP-seq
MIRT2507704	hsa-miR-129-5p	CLIP-seq
MIRT904983	hsa-miR-1305	CLIP-seq
MIRT2507705	hsa-miR-1323	CLIP-seq
MIRT2507706	hsa-miR-139-3p	CLIP-seq
MIRT2507707	hsa-miR-139-5p	CLIP-seq
MIRT2507708	hsa-miR-145	CLIP-seq
MIRT904944	hsa-miR-146a	CLIP-seq
MIRT904945	hsa-miR-146b-5p	CLIP-seq
MIRT2507709	hsa-miR-155	CLIP-seq
MIRT1968367	hsa-miR-15a	CLIP-seq
MIRT1968368	hsa-miR-15b	CLIP-seq
MIRT1968369	hsa-miR-16	CLIP-seq
MIRT2507710	hsa-miR-1825	CLIP-seq
MIRT904984	hsa-miR-1827	CLIP-seq
MIRT2507711	hsa-miR-188-5p	CLIP-seq
MIRT2507712	hsa-miR-1912	CLIP-seq
MIRT1968370	hsa-miR-195	CLIP-seq
MIRT2507713	hsa-miR-197	CLIP-seq
MIRT1968371	hsa-miR-203	CLIP-seq
MIRT904985	hsa-miR-205	CLIP-seq
MIRT2507714	hsa-miR-21	CLIP-seq
MIRT904986	hsa-miR-2114	CLIP-seq
MIRT2204196	hsa-miR-2116	CLIP-seq
MIRT2507715	hsa-miR-2117	CLIP-seq
MIRT2507716	hsa-miR-216a	CLIP-seq
MIRT2507717	hsa-miR-216b	CLIP-seq
MIRT2507718	hsa-miR-219-1-3p	CLIP-seq
MIRT1968374	hsa-miR-2467-3p	CLIP-seq
MIRT2507719	hsa-miR-2909	CLIP-seq
MIRT2507720	hsa-miR-300	CLIP-seq
MIRT2507721	hsa-miR-3065-3p	CLIP-seq
MIRT904950	hsa-miR-3074-5p	CLIP-seq
MIRT2507722	hsa-miR-3120-5p	CLIP-seq
MIRT2507723	hsa-miR-3121-5p	CLIP-seq
MIRT2204199	hsa-miR-3122	CLIP-seq
MIRT2507724	hsa-miR-3127-3p	CLIP-seq
MIRT1968381	hsa-miR-3148	CLIP-seq
MIRT2507725	hsa-miR-3149	CLIP-seq
MIRT2507726	hsa-miR-3156-5p	CLIP-seq
MIRT2507727	hsa-miR-3157-5p	CLIP-seq
MIRT2507728	hsa-miR-3158-5p	CLIP-seq
MIRT1968382	hsa-miR-3160-3p	CLIP-seq
MIRT1968383	hsa-miR-3164	CLIP-seq
MIRT1968384	hsa-miR-3166	CLIP-seq
MIRT2204201	hsa-miR-3182	CLIP-seq
MIRT2507729	hsa-miR-3192	CLIP-seq
MIRT2507730	hsa-miR-3194-3p	CLIP-seq
MIRT2507731	hsa-miR-3194-5p	CLIP-seq
MIRT2507732	hsa-miR-3199	CLIP-seq
MIRT2507733	hsa-miR-3200-5p	CLIP-seq
MIRT1968386	hsa-miR-323-3p	CLIP-seq
MIRT2507734	hsa-miR-331-5p	CLIP-seq
MIRT2507735	hsa-miR-338-3p	CLIP-seq
MIRT2507736	hsa-miR-339-5p	CLIP-seq
MIRT1968387	hsa-miR-3613-3p	CLIP-seq
MIRT2507737	hsa-miR-3614-5p	CLIP-seq
MIRT904956	hsa-miR-3622a-3p	CLIP-seq
MIRT904957	hsa-miR-3622b-3p	CLIP-seq
MIRT2507738	hsa-miR-3622b-5p	CLIP-seq
MIRT904958	hsa-miR-3646	CLIP-seq
MIRT2507739	hsa-miR-3654	CLIP-seq
MIRT904959	hsa-miR-3664-5p	CLIP-seq
MIRT1968390	hsa-miR-3678-3p	CLIP-seq
MIRT2507740	hsa-miR-3688-3p	CLIP-seq
MIRT2507741	hsa-miR-3689d	CLIP-seq
MIRT2507742	hsa-miR-3690	CLIP-seq
MIRT2507743	hsa-miR-369-3p	CLIP-seq
MIRT2507744	hsa-miR-371-5p	CLIP-seq
MIRT2507745	hsa-miR-371b-5p	CLIP-seq
MIRT2507746	hsa-miR-374a	CLIP-seq
MIRT2507747	hsa-miR-374b	CLIP-seq
MIRT2507748	hsa-miR-381	CLIP-seq
MIRT2507749	hsa-miR-382	CLIP-seq
MIRT2204203	hsa-miR-3913-5p	CLIP-seq
MIRT2507750	hsa-miR-3919	CLIP-seq
MIRT2507751	hsa-miR-3921	CLIP-seq
MIRT1968392	hsa-miR-3925-3p	CLIP-seq
MIRT904962	hsa-miR-3925-5p	CLIP-seq
MIRT904994	hsa-miR-3929	CLIP-seq
MIRT2204204	hsa-miR-3938	CLIP-seq
MIRT904995	hsa-miR-3940-3p	CLIP-seq
MIRT2507752	hsa-miR-3972	CLIP-seq
MIRT2507753	hsa-miR-3974	CLIP-seq
MIRT2507754	hsa-miR-3978	CLIP-seq
MIRT2204207	hsa-miR-412	CLIP-seq
MIRT904996	hsa-miR-421	CLIP-seq
MIRT1968393	hsa-miR-424	CLIP-seq
MIRT2507755	hsa-miR-4251	CLIP-seq
MIRT2507756	hsa-miR-4261	CLIP-seq
MIRT2507757	hsa-miR-4263	CLIP-seq
MIRT2507758	hsa-miR-4273	CLIP-seq
MIRT2507759	hsa-miR-4274	CLIP-seq
MIRT2507760	hsa-miR-4297	CLIP-seq
MIRT2507761	hsa-miR-4308	CLIP-seq
MIRT904965	hsa-miR-4311	CLIP-seq
MIRT2507762	hsa-miR-4314	CLIP-seq
MIRT2507763	hsa-miR-4324	CLIP-seq
MIRT904999	hsa-miR-4419b	CLIP-seq
MIRT2507764	hsa-miR-4427	CLIP-seq
MIRT2204210	hsa-miR-4443	CLIP-seq
MIRT905002	hsa-miR-4478	CLIP-seq
MIRT1968395	hsa-miR-4487	CLIP-seq
MIRT1968396	hsa-miR-4503	CLIP-seq
MIRT2507765	hsa-miR-4504	CLIP-seq
MIRT2507766	hsa-miR-4530	CLIP-seq
MIRT2507767	hsa-miR-4535	CLIP-seq
MIRT2507768	hsa-miR-4637	CLIP-seq
MIRT2507769	hsa-miR-4645-5p	CLIP-seq
MIRT905004	hsa-miR-4646-5p	CLIP-seq
MIRT905005	hsa-miR-4649-3p	CLIP-seq
MIRT1968399	hsa-miR-4652-3p	CLIP-seq
MIRT2507770	hsa-miR-4653-3p	CLIP-seq
MIRT2507771	hsa-miR-4653-5p	CLIP-seq
MIRT2507772	hsa-miR-4659a-3p	CLIP-seq
MIRT2507773	hsa-miR-4659b-3p	CLIP-seq
MIRT1968400	hsa-miR-4662a-3p	CLIP-seq
MIRT2507774	hsa-miR-4662a-5p	CLIP-seq
MIRT2507775	hsa-miR-4666-3p	CLIP-seq
MIRT1968401	hsa-miR-4668-3p	CLIP-seq
MIRT2507776	hsa-miR-4673	CLIP-seq
MIRT2204213	hsa-miR-4677-5p	CLIP-seq
MIRT2507777	hsa-miR-4678	CLIP-seq
MIRT2507778	hsa-miR-4680-3p	CLIP-seq
MIRT2507779	hsa-miR-4681	CLIP-seq
MIRT1968402	hsa-miR-4684-5p	CLIP-seq
MIRT2507780	hsa-miR-4690-3p	CLIP-seq
MIRT2507781	hsa-miR-4694-3p	CLIP-seq
MIRT2507782	hsa-miR-4695-3p	CLIP-seq
MIRT2507783	hsa-miR-4704-3p	CLIP-seq
MIRT2507784	hsa-miR-4704-5p	CLIP-seq
MIRT2507785	hsa-miR-4709-3p	CLIP-seq
MIRT2507786	hsa-miR-4732-5p	CLIP-seq
MIRT2204214	hsa-miR-4735-5p	CLIP-seq
MIRT2507787	hsa-miR-4738-3p	CLIP-seq
MIRT2204215	hsa-miR-4747-5p	CLIP-seq
MIRT2507788	hsa-miR-4751	CLIP-seq
MIRT2507789	hsa-miR-4753-3p	CLIP-seq
MIRT2507790	hsa-miR-4753-5p	CLIP-seq
MIRT2507791	hsa-miR-4755-3p	CLIP-seq
MIRT2507792	hsa-miR-4756-3p	CLIP-seq
MIRT2507793	hsa-miR-4761-5p	CLIP-seq
MIRT1968406	hsa-miR-4768-5p	CLIP-seq
MIRT2204216	hsa-miR-4772-3p	CLIP-seq
MIRT1968407	hsa-miR-4775	CLIP-seq
MIRT2204218	hsa-miR-4789-5p	CLIP-seq
MIRT2507794	hsa-miR-4790-3p	CLIP-seq
MIRT2507795	hsa-miR-4795-5p	CLIP-seq
MIRT2507796	hsa-miR-4797-5p	CLIP-seq
MIRT905008	hsa-miR-485-5p	CLIP-seq
MIRT2507797	hsa-miR-487a	CLIP-seq
MIRT904975	hsa-miR-488	CLIP-seq
MIRT905009	hsa-miR-490-3p	CLIP-seq
MIRT2507798	hsa-miR-492	CLIP-seq
MIRT2507799	hsa-miR-496	CLIP-seq
MIRT1968409	hsa-miR-497	CLIP-seq
MIRT2507800	hsa-miR-513c	CLIP-seq
MIRT2507801	hsa-miR-514b-5p	CLIP-seq
MIRT2507802	hsa-miR-526b	CLIP-seq
MIRT2507803	hsa-miR-542-3p	CLIP-seq
MIRT2204220	hsa-miR-544	CLIP-seq
MIRT2204221	hsa-miR-544b	CLIP-seq
MIRT1968412	hsa-miR-545	CLIP-seq
MIRT905012	hsa-miR-548a-3p	CLIP-seq
MIRT905013	hsa-miR-548ac	CLIP-seq
MIRT2507804	hsa-miR-548c-3p	CLIP-seq
MIRT905017	hsa-miR-548d-3p	CLIP-seq
MIRT905018	hsa-miR-548e	CLIP-seq
MIRT905019	hsa-miR-548f	CLIP-seq
MIRT2507805	hsa-miR-548o	CLIP-seq
MIRT2507806	hsa-miR-548p	CLIP-seq
MIRT905021	hsa-miR-548z	CLIP-seq
MIRT2507807	hsa-miR-549	CLIP-seq
MIRT2507808	hsa-miR-550a	CLIP-seq
MIRT2507809	hsa-miR-552	CLIP-seq
MIRT1968413	hsa-miR-558	CLIP-seq
MIRT2507810	hsa-miR-567	CLIP-seq
MIRT2507811	hsa-miR-576-5p	CLIP-seq
MIRT905022	hsa-miR-580	CLIP-seq
MIRT904979	hsa-miR-586	CLIP-seq
MIRT1968415	hsa-miR-590-3p	CLIP-seq
MIRT2507812	hsa-miR-590-5p	CLIP-seq
MIRT2507813	hsa-miR-591	CLIP-seq
MIRT2507814	hsa-miR-600	CLIP-seq
MIRT2507815	hsa-miR-601	CLIP-seq
MIRT2507816	hsa-miR-605	CLIP-seq
MIRT1968416	hsa-miR-607	CLIP-seq
MIRT2507817	hsa-miR-615-5p	CLIP-seq
MIRT2507818	hsa-miR-640	CLIP-seq
MIRT2204225	hsa-miR-642a	CLIP-seq
MIRT1968418	hsa-miR-642b	CLIP-seq
MIRT2204226	hsa-miR-659	CLIP-seq
MIRT2507819	hsa-miR-668	CLIP-seq
MIRT2507820	hsa-miR-670	CLIP-seq
MIRT2204227	hsa-miR-671-5p	CLIP-seq
MIRT1968421	hsa-miR-759	CLIP-seq
MIRT1968423	hsa-miR-766	CLIP-seq
MIRT2507821	hsa-miR-767-3p	CLIP-seq
MIRT2507822	hsa-miR-885-3p	CLIP-seq
MIRT2507823	hsa-miR-890	CLIP-seq
MIRT2507824	hsa-miR-891b	CLIP-seq
MIRT2507825	hsa-miR-942	CLIP-seq
MIRT2507694	hsa-miR-103a	CLIP-seq
MIRT2507695	hsa-miR-107	CLIP-seq
MIRT2507696	hsa-miR-1184	CLIP-seq
MIRT2507697	hsa-miR-1202	CLIP-seq
MIRT2507698	hsa-miR-1205	CLIP-seq
MIRT2507699	hsa-miR-1208	CLIP-seq
MIRT2678507	hsa-miR-1224-3p	CLIP-seq
MIRT904940	hsa-miR-1224-5p	CLIP-seq
MIRT2507700	hsa-miR-1243	CLIP-seq
MIRT2507701	hsa-miR-1247	CLIP-seq
MIRT2507702	hsa-miR-1278	CLIP-seq
MIRT2507703	hsa-miR-1279	CLIP-seq
MIRT2507704	hsa-miR-129-5p	CLIP-seq
MIRT904983	hsa-miR-1305	CLIP-seq
MIRT2507705	hsa-miR-1323	CLIP-seq
MIRT2507706	hsa-miR-139-3p	CLIP-seq
MIRT2507707	hsa-miR-139-5p	CLIP-seq
MIRT2678508	hsa-miR-141	CLIP-seq
MIRT2507708	hsa-miR-145	CLIP-seq
MIRT904944	hsa-miR-146a	CLIP-seq
MIRT904945	hsa-miR-146b-5p	CLIP-seq
MIRT2507709	hsa-miR-155	CLIP-seq
MIRT1968367	hsa-miR-15a	CLIP-seq
MIRT1968368	hsa-miR-15b	CLIP-seq
MIRT1968369	hsa-miR-16	CLIP-seq
MIRT904984	hsa-miR-1827	CLIP-seq
MIRT2507711	hsa-miR-188-5p	CLIP-seq
MIRT2507712	hsa-miR-1912	CLIP-seq
MIRT1968370	hsa-miR-195	CLIP-seq
MIRT2507713	hsa-miR-197	CLIP-seq
MIRT2678509	hsa-miR-200a	CLIP-seq
MIRT1968371	hsa-miR-203	CLIP-seq
MIRT904985	hsa-miR-205	CLIP-seq
MIRT2507714	hsa-miR-21	CLIP-seq
MIRT904986	hsa-miR-2114	CLIP-seq
MIRT2204196	hsa-miR-2116	CLIP-seq
MIRT2507715	hsa-miR-2117	CLIP-seq
MIRT2507718	hsa-miR-219-1-3p	CLIP-seq
MIRT2507719	hsa-miR-2909	CLIP-seq
MIRT904950	hsa-miR-3074-5p	CLIP-seq
MIRT2507723	hsa-miR-3121-5p	CLIP-seq
MIRT2507724	hsa-miR-3127-3p	CLIP-seq
MIRT1968381	hsa-miR-3148	CLIP-seq
MIRT2507725	hsa-miR-3149	CLIP-seq
MIRT2507726	hsa-miR-3156-5p	CLIP-seq
MIRT2507728	hsa-miR-3158-5p	CLIP-seq
MIRT1968383	hsa-miR-3164	CLIP-seq
MIRT1968384	hsa-miR-3166	CLIP-seq
MIRT2204201	hsa-miR-3182	CLIP-seq
MIRT2507730	hsa-miR-3194-3p	CLIP-seq
MIRT2507731	hsa-miR-3194-5p	CLIP-seq
MIRT2507733	hsa-miR-3200-5p	CLIP-seq
MIRT1968386	hsa-miR-323-3p	CLIP-seq
MIRT2507735	hsa-miR-338-3p	CLIP-seq
MIRT2507736	hsa-miR-339-5p	CLIP-seq
MIRT1968387	hsa-miR-3613-3p	CLIP-seq
MIRT2507737	hsa-miR-3614-5p	CLIP-seq
MIRT904956	hsa-miR-3622a-3p	CLIP-seq
MIRT904957	hsa-miR-3622b-3p	CLIP-seq
MIRT2507738	hsa-miR-3622b-5p	CLIP-seq
MIRT904958	hsa-miR-3646	CLIP-seq
MIRT2507739	hsa-miR-3654	CLIP-seq
MIRT2507740	hsa-miR-3688-3p	CLIP-seq
MIRT2507743	hsa-miR-369-3p	CLIP-seq
MIRT2507744	hsa-miR-371-5p	CLIP-seq
MIRT2507745	hsa-miR-371b-5p	CLIP-seq
MIRT2507746	hsa-miR-374a	CLIP-seq
MIRT2507747	hsa-miR-374b	CLIP-seq
MIRT2507749	hsa-miR-382	CLIP-seq
MIRT2507751	hsa-miR-3921	CLIP-seq
MIRT1968392	hsa-miR-3925-3p	CLIP-seq
MIRT904962	hsa-miR-3925-5p	CLIP-seq
MIRT904994	hsa-miR-3929	CLIP-seq
MIRT2204204	hsa-miR-3938	CLIP-seq
MIRT2507752	hsa-miR-3972	CLIP-seq
MIRT2507753	hsa-miR-3974	CLIP-seq
MIRT2507754	hsa-miR-3978	CLIP-seq
MIRT2204207	hsa-miR-412	CLIP-seq
MIRT904996	hsa-miR-421	CLIP-seq
MIRT1968393	hsa-miR-424	CLIP-seq
MIRT2507755	hsa-miR-4251	CLIP-seq
MIRT2507756	hsa-miR-4261	CLIP-seq
MIRT2507757	hsa-miR-4263	CLIP-seq
MIRT2507758	hsa-miR-4273	CLIP-seq
MIRT2507760	hsa-miR-4297	CLIP-seq
MIRT904965	hsa-miR-4311	CLIP-seq
MIRT2507763	hsa-miR-4324	CLIP-seq
MIRT904999	hsa-miR-4419b	CLIP-seq
MIRT2507764	hsa-miR-4427	CLIP-seq
MIRT2204210	hsa-miR-4443	CLIP-seq
MIRT905002	hsa-miR-4478	CLIP-seq
MIRT1968396	hsa-miR-4503	CLIP-seq
MIRT2507765	hsa-miR-4504	CLIP-seq
MIRT2507766	hsa-miR-4530	CLIP-seq
MIRT2507768	hsa-miR-4637	CLIP-seq
MIRT2507769	hsa-miR-4645-5p	CLIP-seq
MIRT905004	hsa-miR-4646-5p	CLIP-seq
MIRT905005	hsa-miR-4649-3p	CLIP-seq
MIRT1968399	hsa-miR-4652-3p	CLIP-seq
MIRT2507770	hsa-miR-4653-3p	CLIP-seq
MIRT2507771	hsa-miR-4653-5p	CLIP-seq
MIRT1968400	hsa-miR-4662a-3p	CLIP-seq
MIRT2507774	hsa-miR-4662a-5p	CLIP-seq
MIRT1968401	hsa-miR-4668-3p	CLIP-seq
MIRT2507776	hsa-miR-4673	CLIP-seq
MIRT2204213	hsa-miR-4677-5p	CLIP-seq
MIRT2507778	hsa-miR-4680-3p	CLIP-seq
MIRT1968402	hsa-miR-4684-5p	CLIP-seq
MIRT2507782	hsa-miR-4695-3p	CLIP-seq
MIRT2507784	hsa-miR-4704-5p	CLIP-seq
MIRT2507785	hsa-miR-4709-3p	CLIP-seq
MIRT2204214	hsa-miR-4735-5p	CLIP-seq
MIRT2204215	hsa-miR-4747-5p	CLIP-seq
MIRT2507788	hsa-miR-4751	CLIP-seq
MIRT2507789	hsa-miR-4753-3p	CLIP-seq
MIRT2507790	hsa-miR-4753-5p	CLIP-seq
MIRT2507791	hsa-miR-4755-3p	CLIP-seq
MIRT2507793	hsa-miR-4761-5p	CLIP-seq
MIRT1968406	hsa-miR-4768-5p	CLIP-seq
MIRT2204216	hsa-miR-4772-3p	CLIP-seq
MIRT1968407	hsa-miR-4775	CLIP-seq
MIRT2507794	hsa-miR-4790-3p	CLIP-seq
MIRT2507795	hsa-miR-4795-5p	CLIP-seq
MIRT2507796	hsa-miR-4797-5p	CLIP-seq
MIRT905008	hsa-miR-485-5p	CLIP-seq
MIRT2507797	hsa-miR-487a	CLIP-seq
MIRT904975	hsa-miR-488	CLIP-seq
MIRT905009	hsa-miR-490-3p	CLIP-seq
MIRT2507799	hsa-miR-496	CLIP-seq
MIRT1968409	hsa-miR-497	CLIP-seq
MIRT2507800	hsa-miR-513c	CLIP-seq
MIRT2507801	hsa-miR-514b-5p	CLIP-seq
MIRT2507803	hsa-miR-542-3p	CLIP-seq
MIRT2204220	hsa-miR-544	CLIP-seq
MIRT2204221	hsa-miR-544b	CLIP-seq
MIRT1968412	hsa-miR-545	CLIP-seq
MIRT905012	hsa-miR-548a-3p	CLIP-seq
MIRT905013	hsa-miR-548ac	CLIP-seq
MIRT2507804	hsa-miR-548c-3p	CLIP-seq
MIRT905017	hsa-miR-548d-3p	CLIP-seq
MIRT905018	hsa-miR-548e	CLIP-seq
MIRT905019	hsa-miR-548f	CLIP-seq
MIRT2507805	hsa-miR-548o	CLIP-seq
MIRT2507806	hsa-miR-548p	CLIP-seq
MIRT905021	hsa-miR-548z	CLIP-seq
MIRT2507807	hsa-miR-549	CLIP-seq
MIRT2507808	hsa-miR-550a	CLIP-seq
MIRT2507809	hsa-miR-552	CLIP-seq
MIRT2507810	hsa-miR-567	CLIP-seq
MIRT2507811	hsa-miR-576-5p	CLIP-seq
MIRT905022	hsa-miR-580	CLIP-seq
MIRT1968415	hsa-miR-590-3p	CLIP-seq
MIRT2507812	hsa-miR-590-5p	CLIP-seq
MIRT2507813	hsa-miR-591	CLIP-seq
MIRT2507814	hsa-miR-600	CLIP-seq
MIRT2507815	hsa-miR-601	CLIP-seq
MIRT2507816	hsa-miR-605	CLIP-seq
MIRT1968416	hsa-miR-607	CLIP-seq
MIRT2507817	hsa-miR-615-5p	CLIP-seq
MIRT2204225	hsa-miR-642a	CLIP-seq
MIRT1968418	hsa-miR-642b	CLIP-seq
MIRT2204226	hsa-miR-659	CLIP-seq
MIRT2507819	hsa-miR-668	CLIP-seq
MIRT2507820	hsa-miR-670	CLIP-seq
MIRT2204227	hsa-miR-671-5p	CLIP-seq
MIRT1968423	hsa-miR-766	CLIP-seq
MIRT2507821	hsa-miR-767-3p	CLIP-seq
MIRT2507823	hsa-miR-890	CLIP-seq
MIRT2507824	hsa-miR-891b	CLIP-seq
MIRT2507825	hsa-miR-942	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	29128334
GO:0005654	Component	Nucleoplasm	IDA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IDA	9878253
GO:0005739	Component	Mitochondrion	IEA
GO:0005743	Component	Mitochondrial inner membrane	IBA
GO:0005743	Component	Mitochondrial inner membrane	IEA
GO:0005743	Component	Mitochondrial inner membrane	TAS
GO:0006783	Process	Heme biosynthetic process	IEA
GO:0006783	Process	Heme biosynthetic process	TAS
GO:0006784	Process	Heme A biosynthetic process	IBA
GO:0006784	Process	Heme A biosynthetic process	IEA
GO:0006784	Process	Heme A biosynthetic process	IGI	12474143
GO:0016020	Component	Membrane	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016627	Function	Oxidoreductase activity, acting on the CH-CH group of donors	IMP	12474143
GO:0016627	Function	Oxidoreductase activity, acting on the CH-CH group of donors	TAS
GO:0016653	Function	Oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor	IBA
GO:0017004	Process	Cytochrome complex assembly	IMP	12474143
GO:0020037	Function	Heme binding	TAS	26940873
GO:0046872	Function	Metal ion binding	IEA
GO:0070069	Component	Cytochrome complex	IDA	12474143
GO:0098803	Component	Respiratory chain complex	TAS	9878253
GO:0120547	Function	Heme A synthase activity	IEA

Other IDs

• MIM: 603646
• HGNC: 2263
• e!Ensembl: ENSG00000014919

Protein

• UniProt ID: Q7KZN9
• Protein name: Heme A synthase COX15 (HAS) (EC 1.17.99.9) (Cytochrome c oxidase assembly protein COX15 homolog)
• Protein function: Catalyzes the second reaction in the biosynthesis of heme A, a prosthetic group of mitochondrial cytochrome c oxidase (CcO) (PubMed:12474143). Heme A is synthesized from heme B by two sequential enzymatic reactions catalyzed by heme O synthase (
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02628	COX15-CtaA	70 → 399	Cytochrome oxidase assembly protein	Family

• Tissue specificity: TISSUE SPECIFICITY: Predominantly found in tissues characterized by high rates of oxidative phosphorylation (OxPhos), including muscle, heart, and brain. {ECO:0000269|PubMed:9878253}.
• Sequence:

  MQRLLFPPLRALKGRQYLPLLAPRAAPRAQCDCIRRPLRPGQYSTISEVALQSGRGTVSL
  PSKAAERVVGRWLLVCSGTVAGAVILGGVTRLTESGLSMVDWHLIKEMKPPTSQEEWEAE
  FQRYQQFPEFKILNHDMTLTEFKFIWYMEYSHRMWGRLVGLVYILPAAYFWRKGWLSRGM
  KGRVLALCGLVCFQGLLGWYMVKSGLEEKSDSHDIPRVSQYRLAAHLGSALVLYCASLWT
  SLSLLLPPHKLPETHQLLQLRRFAHGTAGLVFLTALSGAFVAGLDAGLVYNSFPKMGESW
  IPEDLFTFSPILRNVFENPTMVQFDHRILGITSVTAITVLYFLSRRIPLPRRTKMAAVTL
  LALAYTQVGLGISTLLMYVPTPLAATHQSGSLALLTGALWLMNELRRVPK

• Sequence length: 410

Pathways

KEGG:

Oxidative phosphorylation
Porphyrin metabolism
Metabolic pathways
Biosynthesis of cofactors
Thermogenesis

Reactome:

Heme biosynthesis

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Cardioencephalomyopathy, fatal infantile, due to cytochrome c oxidase deficiency 2	Likely pathogenic; Pathogenic	rs778412019, rs2492679787, rs201002908, rs2036859860, rs28939711, rs886046611, rs1409285901, rs149718203	RCV001331215 RCV002472025 RCV005025946 RCV005027974 RCV000006551 RCV003992722 RCV005030154 RCV005356552 RCV000033254	★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
COX15-related disorder	Likely pathogenic; Pathogenic	rs149718203	RCV004757251	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Leigh syndrome	Likely pathogenic; Pathogenic	rs778412019, rs2492746592, rs149718203	RCV002307728 RCV002282872 RCV000586150	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Thyroid cancer, nonmedullary, 1	Likely pathogenic; Pathogenic	rs777659902	RCV005927044	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
CARDIOENCEPHALOMYOPATHY, FATAL INFANTILE, DUE TO CYTOCHROME C OXIDASE DEFICIENCY	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARDIOMYOPATHIES	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cardiomyopathy	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cervical cancer	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CYTOCHROME-C OXIDASE DEFICIENCY	—	CTD, Disgenet CTD, Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial cancer of breast	Conflicting classifications of pathogenicity	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
FATAL INFANTILE CYTOCHROME C OXIDASE DEFICIENCY	—	Disgenet, Orphanet Disgenet, Orphanet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERTROPHIC CARDIOMYOPATHY	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LEIGH DISEASE	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LEIGH SYNDROME WITH LEUKODYSTROPHY	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Melanoma	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Mitochondrial complex IV deficiency, nuclear type 1	Uncertain significance; Benign	ClinVar ClinVar, Disgenet ClinVar, Disgenet	★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
MITOCHONDRIAL COMPLEX IV DEFICIENCY, NUCLEAR TYPE 2	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MITOCHONDRIAL COMPLEX IV DEFICIENCY, NUCLEAR TYPE 6	—	HPO	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MITOCHONDRIAL DISEASE	—	ClinGen, GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MITOCHONDRIAL DISEASES	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Anemia	Anemia	HPO_DG			★☆☆☆☆ Found in Text Mining only
Arrhythmogenic Right Ventricular Dysplasia	Arrhythmogenic right ventricular cardiomyopathy	Pubtator	28767663	Associate	★☆☆☆☆ Found in Text Mining only
Basal Cell Nevus Syndrome	Basal cell nevus syndrome	Pubtator	29081410	Associate	★☆☆☆☆ Found in Text Mining only
Blepharoptosis	Ptosis	HPO_DG			★☆☆☆☆ Found in Text Mining only
Cardioencephalomyopathy, Fatal Infantile, due to Cytochrome C Oxidase Deficiency	Cardioencephalomyopathy	ORPHANET_DG	21412973, 2175025		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cardioencephalomyopathy, Fatal Infantile, due to Cytochrome C Oxidase Deficiency	Cardioencephalomyopathy	CTD_human_DG			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARDIOENCEPHALOMYOPATHY, FATAL INFANTILE, DUE TO CYTOCHROME c OXIDASE DEFICIENCY 2	Cardioencephalomyopathy	UNIPROT_DG	12474143, 21412973		★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
CARDIOENCEPHALOMYOPATHY, FATAL INFANTILE, DUE TO CYTOCHROME c OXIDASE DEFICIENCY 2	Cardioencephalomyopathy	GENOMICS_ENGLAND_DG	15235026, 27604308		★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
CARDIOENCEPHALOMYOPATHY, FATAL INFANTILE, DUE TO CYTOCHROME c OXIDASE DEFICIENCY 2	Cardioencephalomyopathy	CLINVAR_DG			★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Cardiomyopathies	Cardiomyopathy	BEFREE	15863660		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cardiomyopathies	Cardiomyopathy	Pubtator	15863660	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cardiomyopathies	Cardiomyopathy	HPO_DG			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARDIOMYOPATHY, INFANTILE HYPERTROPHIC	Cardiomyopathy	BEFREE	12474143, 26940873, 26959537		★☆☆☆☆ Found in Text Mining only
Central nervous system demyelination	Central Nervous System Demyelination	HPO_DG			★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	35438744	Associate	★☆☆☆☆ Found in Text Mining only
Cytochrome c Oxidase Deficiency	Cytochrome c oxidase deficiency	Pubtator	15863660	Associate	★☆☆☆☆ Found in Text Mining only
Cytochrome-c Oxidase Deficiency	Cytochrome-C Oxidase Deficiency	BEFREE	12474143, 15863660		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cytochrome-c Oxidase Deficiency	Cytochrome-C Oxidase Deficiency	LHGDN	15235026		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cytochrome-c Oxidase Deficiency	Cytochrome-C Oxidase Deficiency	GENOMICS_ENGLAND_DG			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Dysarthria	Dysarthria	HPO_DG			★☆☆☆☆ Found in Text Mining only
Encephalopathies	Epileptic encephalopathy	HPO_DG			★☆☆☆☆ Found in Text Mining only
Encephalopathy, Subacute Necrotizing, Infantile	Encephalopathy	CTD_human_DG			★☆☆☆☆ Found in Text Mining only
Encephalopathy, Subacute Necrotizing, Juvenile	Encephalopathy	CTD_human_DG			★☆☆☆☆ Found in Text Mining only
Fatal infantile cytochrome C oxidase deficiency	Fatal Cytochrome C Oxidase Deficiency	Orphanet			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Fatty Liver	Fatty Liver	HPO_DG			★☆☆☆☆ Found in Text Mining only
Global developmental delay	Developmental Delay	HPO_DG			★☆☆☆☆ Found in Text Mining only
Hypertrichosis	HYPERTRICHOSIS	HPO_DG			★☆☆☆☆ Found in Text Mining only
Hypertrophic Cardiomyopathy	Hypertrophic cardiomyopathy	BEFREE	12474143, 12928484		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hypertrophic Cardiomyopathy	Hypertrophic cardiomyopathy	LHGDN	12474143		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hypertrophic Cardiomyopathy	Hypertrophic cardiomyopathy	HPO_DG			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hypertrophic obstructive cardiomyopathy	Hypertrophic cardiomyopathy	BEFREE	12474143, 12928484		★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Mental retardation	HPO_DG			★☆☆☆☆ Found in Text Mining only
Leigh Disease	Leigh Syndrome	CLINGEN_DG	11788607, 12474143, 15235026, 21723506, 25613900, 26039449		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Leigh Disease	Leigh Syndrome	LHGDN	15235026		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Leigh Disease	Leigh Syndrome	UNIPROT_DG	15235026, 15863660		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Leigh Disease	Leigh Syndrome	GENOMICS_ENGLAND_DG	15235026, 27604308		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Leigh Disease	Leigh Syndrome	BEFREE	15863660, 26940873, 26959537		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Leigh Disease	Leigh Syndrome	CLINVAR_DG	15863660, 21412973, 22310368, 26959537		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Leigh Disease	Leigh syndrome	Pubtator	15863660	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Leigh Disease	Leigh Syndrome	CTD_human_DG			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX I DEFICIENCY	Leigh Syndrome	CLINGEN_DG	11788607, 12474143, 15235026, 21723506, 25613900, 26039449		★☆☆☆☆ Found in Text Mining only
Leigh Syndrome Due To Mitochondrial Complex II Deficiency	Leigh Syndrome	CLINGEN_DG	11788607, 12474143, 15235026, 21723506, 25613900, 26039449		★☆☆☆☆ Found in Text Mining only
Leigh Syndrome due to Mitochondrial Complex III Deficiency	Leigh Syndrome	CLINGEN_DG	11788607, 12474143, 15235026, 21723506, 25613900, 26039449		★☆☆☆☆ Found in Text Mining only
Leigh Syndrome due to Mitochondrial Complex IV Deficiency	Leigh Syndrome	CLINGEN_DG	11788607, 12474143, 15235026, 21723506, 25613900, 26039449		★☆☆☆☆ Found in Text Mining only
Leigh Syndrome due to Mitochondrial Complex IV Deficiency	Leigh Syndrome	CLINVAR_DG			★☆☆☆☆ Found in Text Mining only
Leigh Syndrome due to Mitochondrial Complex V Deficiency	Leigh Syndrome	CLINGEN_DG	11788607, 12474143, 15235026, 21723506, 25613900, 26039449		★☆☆☆☆ Found in Text Mining only
Leigh syndrome with leukodystrophy	Leigh Syndrome With Leukodystrophy	Orphanet			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Leukodystrophy	Leukodystrophy	HPO_DG			★☆☆☆☆ Found in Text Mining only
Microcephaly	Microcephaly	HPO_DG			★☆☆☆☆ Found in Text Mining only
Mitochondrial Diseases	Mitochondrial Diseases	GENOMICS_ENGLAND_DG	27604308		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Mood swings	Mood swings	HPO_DG			★☆☆☆☆ Found in Text Mining only
Necrotizing encephalopathy, infantile subacute, of Leigh	Necrotizing encephalomyelopathy	CLINGEN_DG	11788607, 12474143, 15235026, 21723506, 25613900, 26039449		★☆☆☆☆ Found in Text Mining only
nervous system disorder	Nervous System Disorder	BEFREE	26940873		★☆☆☆☆ Found in Text Mining only
Nystagmus	Nystagmus	HPO_DG			★☆☆☆☆ Found in Text Mining only
Optic Atrophy	Optic Atrophy	HPO_DG			★☆☆☆☆ Found in Text Mining only
Osteoporosis	Osteoporosis	Pubtator	34743649	Associate	★☆☆☆☆ Found in Text Mining only
Peripheral Nervous System Diseases	Nervous System Diseases	HPO_DG			★☆☆☆☆ Found in Text Mining only
Progressive cerebellar ataxia	Cerebellar Ataxia	HPO_DG			★☆☆☆☆ Found in Text Mining only
Ptosis	Ptosis	HPO_DG			★☆☆☆☆ Found in Text Mining only
Pulmonary Disease Chronic Obstructive	Chronic obstructive pulmonary disease	Pubtator	17483440	Associate	★☆☆☆☆ Found in Text Mining only
Respiratory Failure	Respiratory Failure	HPO_DG			★☆☆☆☆ Found in Text Mining only
Retinitis Pigmentosa	Retinitis Pigmentosa	HPO_DG			★☆☆☆☆ Found in Text Mining only
Sensorineural Hearing Loss (disorder)	Hearing Loss	HPO_DG			★☆☆☆☆ Found in Text Mining only
Severe intellectual disability	Mental retardation	HPO_DG			★☆☆☆☆ Found in Text Mining only
Steatohepatitis	Fatty Liver	HPO_DG			★☆☆☆☆ Found in Text Mining only
Strabismus	Strabismus	HPO_DG			★☆☆☆☆ Found in Text Mining only
Ventricular Septal Defects	Ventricular septal defect	HPO_DG			★☆☆☆☆ Found in Text Mining only