Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	1353
Gene name	Cytochrome c oxidase copper chaperone COX11
Gene symbol	COX11
Synonyms (NCBI Gene)	COX11PMC4DN23
Chromosome	17
Chromosome location	17q22
Summary	Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochond

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miRTarBase ID	miRNA	Experiments
MIRT904904	hsa-miR-1224-3p	CLIP-seq
MIRT904905	hsa-miR-1245b-5p	CLIP-seq
MIRT904906	hsa-miR-1260	CLIP-seq
MIRT904907	hsa-miR-1260b	CLIP-seq
MIRT904908	hsa-miR-1280	CLIP-seq
MIRT904909	hsa-miR-1305	CLIP-seq
MIRT904910	hsa-miR-200b	CLIP-seq
MIRT904911	hsa-miR-200c	CLIP-seq
MIRT904912	hsa-miR-205	CLIP-seq
MIRT904913	hsa-miR-223	CLIP-seq
MIRT904914	hsa-miR-27a	CLIP-seq
MIRT904915	hsa-miR-27b	CLIP-seq
MIRT904916	hsa-miR-2964a-5p	CLIP-seq
MIRT904917	hsa-miR-3142	CLIP-seq
MIRT904918	hsa-miR-3180-5p	CLIP-seq
MIRT904919	hsa-miR-3667-3p	CLIP-seq
MIRT904920	hsa-miR-3685	CLIP-seq
MIRT904921	hsa-miR-412	CLIP-seq
MIRT904922	hsa-miR-421	CLIP-seq
MIRT904923	hsa-miR-429	CLIP-seq
MIRT904924	hsa-miR-4297	CLIP-seq
MIRT904925	hsa-miR-4511	CLIP-seq
MIRT904926	hsa-miR-4650-5p	CLIP-seq
MIRT904927	hsa-miR-4697-3p	CLIP-seq
MIRT904928	hsa-miR-4709-5p	CLIP-seq
MIRT904929	hsa-miR-4795-3p	CLIP-seq
MIRT904930	hsa-miR-486-5p	CLIP-seq
MIRT904931	hsa-miR-513a-5p	CLIP-seq
MIRT904932	hsa-miR-513b	CLIP-seq
MIRT904933	hsa-miR-515-3p	CLIP-seq
MIRT904934	hsa-miR-519e	CLIP-seq
MIRT904935	hsa-miR-520a-5p	CLIP-seq
MIRT904936	hsa-miR-525-5p	CLIP-seq
MIRT904937	hsa-miR-633	CLIP-seq
MIRT904938	hsa-miR-873	CLIP-seq
MIRT904910	hsa-miR-200b	CLIP-seq
MIRT904911	hsa-miR-200c	CLIP-seq
MIRT904912	hsa-miR-205	CLIP-seq
MIRT904923	hsa-miR-429	CLIP-seq
MIRT904924	hsa-miR-4297	CLIP-seq
MIRT1968363	hsa-miR-4729	CLIP-seq
MIRT904933	hsa-miR-515-3p	CLIP-seq
MIRT904934	hsa-miR-519e	CLIP-seq
MIRT1968364	hsa-miR-579	CLIP-seq
MIRT904904	hsa-miR-1224-3p	CLIP-seq
MIRT904905	hsa-miR-1245b-5p	CLIP-seq
MIRT2204158	hsa-miR-125a-3p	CLIP-seq
MIRT904906	hsa-miR-1260	CLIP-seq
MIRT904907	hsa-miR-1260b	CLIP-seq
MIRT2204159	hsa-miR-1279	CLIP-seq
MIRT904908	hsa-miR-1280	CLIP-seq
MIRT2204160	hsa-miR-139-5p	CLIP-seq
MIRT2204161	hsa-miR-181a	CLIP-seq
MIRT2204162	hsa-miR-181b	CLIP-seq
MIRT2204163	hsa-miR-181c	CLIP-seq
MIRT2204164	hsa-miR-181d	CLIP-seq
MIRT904912	hsa-miR-205	CLIP-seq
MIRT2204165	hsa-miR-2054	CLIP-seq
MIRT904913	hsa-miR-223	CLIP-seq
MIRT904914	hsa-miR-27a	CLIP-seq
MIRT904915	hsa-miR-27b	CLIP-seq
MIRT2204166	hsa-miR-3140-5p	CLIP-seq
MIRT904917	hsa-miR-3142	CLIP-seq
MIRT2204167	hsa-miR-3143	CLIP-seq
MIRT2204168	hsa-miR-3161	CLIP-seq
MIRT904918	hsa-miR-3180-5p	CLIP-seq
MIRT2204169	hsa-miR-338-5p	CLIP-seq
MIRT2204170	hsa-miR-3614-3p	CLIP-seq
MIRT904919	hsa-miR-3667-3p	CLIP-seq
MIRT904920	hsa-miR-3685	CLIP-seq
MIRT2204171	hsa-miR-3689a-5p	CLIP-seq
MIRT2204172	hsa-miR-3689b	CLIP-seq
MIRT2204173	hsa-miR-3689e	CLIP-seq
MIRT2204174	hsa-miR-3689f	CLIP-seq
MIRT2204175	hsa-miR-377	CLIP-seq
MIRT2204176	hsa-miR-3934	CLIP-seq
MIRT904921	hsa-miR-412	CLIP-seq
MIRT2204177	hsa-miR-4262	CLIP-seq
MIRT904924	hsa-miR-4297	CLIP-seq
MIRT2204178	hsa-miR-4317	CLIP-seq
MIRT904925	hsa-miR-4511	CLIP-seq
MIRT904926	hsa-miR-4650-5p	CLIP-seq
MIRT2204179	hsa-miR-4679	CLIP-seq
MIRT904927	hsa-miR-4697-3p	CLIP-seq
MIRT2204180	hsa-miR-4704-3p	CLIP-seq
MIRT2204181	hsa-miR-4718	CLIP-seq
MIRT904929	hsa-miR-4795-3p	CLIP-seq
MIRT904930	hsa-miR-486-5p	CLIP-seq
MIRT2204182	hsa-miR-490-5p	CLIP-seq
MIRT904931	hsa-miR-513a-5p	CLIP-seq
MIRT904932	hsa-miR-513b	CLIP-seq
MIRT904935	hsa-miR-520a-5p	CLIP-seq
MIRT904936	hsa-miR-525-5p	CLIP-seq
MIRT2204183	hsa-miR-543	CLIP-seq
MIRT2204184	hsa-miR-582-5p	CLIP-seq
MIRT2204185	hsa-miR-607	CLIP-seq
MIRT904937	hsa-miR-633	CLIP-seq
MIRT2204186	hsa-miR-656	CLIP-seq
MIRT2204187	hsa-miR-664	CLIP-seq
MIRT2204188	hsa-miR-764	CLIP-seq
MIRT2386394	hsa-miR-141	CLIP-seq
MIRT2386395	hsa-miR-200a	CLIP-seq
MIRT2386396	hsa-miR-665	CLIP-seq
MIRT904909	hsa-miR-1305	CLIP-seq
MIRT2447489	hsa-miR-298	CLIP-seq
MIRT904922	hsa-miR-421	CLIP-seq
MIRT2447490	hsa-miR-4540	CLIP-seq
MIRT904928	hsa-miR-4709-5p	CLIP-seq
MIRT2447491	hsa-miR-549	CLIP-seq
MIRT904909	hsa-miR-1305	CLIP-seq
MIRT904922	hsa-miR-421	CLIP-seq
MIRT2465100	hsa-miR-4699-5p	CLIP-seq
MIRT904928	hsa-miR-4709-5p	CLIP-seq
MIRT2465101	hsa-miR-544	CLIP-seq
MIRT2447491	hsa-miR-549	CLIP-seq
MIRT2507665	hsa-miR-1252	CLIP-seq
MIRT904909	hsa-miR-1305	CLIP-seq
MIRT2204160	hsa-miR-139-5p	CLIP-seq
MIRT2507666	hsa-miR-214	CLIP-seq
MIRT2447489	hsa-miR-298	CLIP-seq
MIRT2507667	hsa-miR-3619-5p	CLIP-seq
MIRT2507668	hsa-miR-3680	CLIP-seq
MIRT2507669	hsa-miR-3973	CLIP-seq
MIRT904922	hsa-miR-421	CLIP-seq
MIRT2507670	hsa-miR-4291	CLIP-seq
MIRT2507671	hsa-miR-4446-5p	CLIP-seq
MIRT2447490	hsa-miR-4540	CLIP-seq
MIRT904928	hsa-miR-4709-5p	CLIP-seq
MIRT2507672	hsa-miR-4798-3p	CLIP-seq
MIRT2507673	hsa-miR-520g	CLIP-seq
MIRT2507674	hsa-miR-520h	CLIP-seq
MIRT2507675	hsa-miR-548a-3p	CLIP-seq
MIRT2507676	hsa-miR-548a-5p	CLIP-seq
MIRT2507677	hsa-miR-548ab	CLIP-seq
MIRT2507678	hsa-miR-548ak	CLIP-seq
MIRT2507679	hsa-miR-548b-5p	CLIP-seq
MIRT2507680	hsa-miR-548c-3p	CLIP-seq
MIRT2507681	hsa-miR-548c-5p	CLIP-seq
MIRT2507682	hsa-miR-548d-5p	CLIP-seq
MIRT2507683	hsa-miR-548e	CLIP-seq
MIRT2507684	hsa-miR-548f	CLIP-seq
MIRT2507685	hsa-miR-548h	CLIP-seq
MIRT2507686	hsa-miR-548i	CLIP-seq
MIRT2507687	hsa-miR-548j	CLIP-seq
MIRT2507688	hsa-miR-548w	CLIP-seq
MIRT2507689	hsa-miR-548y	CLIP-seq
MIRT2447491	hsa-miR-549	CLIP-seq
MIRT2507690	hsa-miR-559	CLIP-seq
MIRT2204184	hsa-miR-582-5p	CLIP-seq
MIRT2204185	hsa-miR-607	CLIP-seq
MIRT2204187	hsa-miR-664	CLIP-seq
MIRT2507691	hsa-miR-761	CLIP-seq
MIRT2507692	hsa-miR-922	CLIP-seq
MIRT2507693	hsa-miR-944	CLIP-seq
MIRT2507665	hsa-miR-1252	CLIP-seq
MIRT2678502	hsa-miR-1295	CLIP-seq
MIRT904909	hsa-miR-1305	CLIP-seq
MIRT2507666	hsa-miR-214	CLIP-seq
MIRT2447489	hsa-miR-298	CLIP-seq
MIRT2507667	hsa-miR-3619-5p	CLIP-seq
MIRT2507668	hsa-miR-3680	CLIP-seq
MIRT904922	hsa-miR-421	CLIP-seq
MIRT2507670	hsa-miR-4291	CLIP-seq
MIRT2678503	hsa-miR-4418	CLIP-seq
MIRT2447490	hsa-miR-4540	CLIP-seq
MIRT904928	hsa-miR-4709-5p	CLIP-seq
MIRT2678504	hsa-miR-4717-5p	CLIP-seq
MIRT2507672	hsa-miR-4798-3p	CLIP-seq
MIRT2678505	hsa-miR-509-3-5p	CLIP-seq
MIRT2678506	hsa-miR-509-5p	CLIP-seq
MIRT2507675	hsa-miR-548a-3p	CLIP-seq
MIRT2507683	hsa-miR-548e	CLIP-seq
MIRT2507684	hsa-miR-548f	CLIP-seq
MIRT2447491	hsa-miR-549	CLIP-seq
MIRT2204187	hsa-miR-664	CLIP-seq
MIRT2507691	hsa-miR-761	CLIP-seq
MIRT2507692	hsa-miR-922	CLIP-seq

Show/Hide all (14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005507	Function	Copper ion binding	IEA
GO:0005515	Function	Protein binding	IPI	15840172, 33961781, 34400285
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IDA	9878253
GO:0005739	Component	Mitochondrion	IEA
GO:0005743	Component	Mitochondrial inner membrane	IBA
GO:0005743	Component	Mitochondrial inner membrane	IDA	15229189
GO:0005743	Component	Mitochondrial inner membrane	IEA
GO:0005743	Component	Mitochondrial inner membrane	TAS
GO:0006754	Process	ATP biosynthetic process	IMP	36030551
GO:0009055	Function	Electron transfer activity	TAS	9878253
GO:0016020	Component	Membrane	IEA
GO:0030003	Process	Intracellular monoatomic cation homeostasis	IDA	15840172
GO:0032991	Component	Protein-containing complex	IDA	15840172

MIM	HGNC	e!Ensembl
603648	2261	ENSG00000166260

Q9Y6N1

Protein name

Cytochrome c oxidase assembly protein COX11, mitochondrial

Protein function

Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04442	CtaG_Cox11	113 → 263	Cytochrome c oxidase assembly protein CtaG/Cox11	Family

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:9878253}.

Sequence

MGGLWRPGWRCVPFCGWRWIHPGSPTRAAERVEPFLRPEWSGTGGAERGLRWLGTWKRCS
LRARHPALQPPRRPKSSNPFTRAQEEERRRQNKTTLTYVAAVAVGMLGASYAAVPLYRLY
CQTTGLGGSAVAGHASDKIENMVPVKDRIIKISFNADVHASLQWNFRPQQTEIYVVPGET
ALAFYRAKNPTDKPVIGISTYNIVPFEAGQYFNKIQCFCFEEQRLNPQEEVDMPVFFYID
PEFAEDPRMIKVDLITLSYTFFEAKEGHKLPVPGYN

Sequence length

276

Interactions

View interactions

	KEGG		Reactome
	Oxidative phosphorylation Metabolic pathways Thermogenesis		TP53 Regulates Metabolic Genes Respiratory electron transport

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Mitochondrial complex IV deficiency, nuclear type 23	Pathogenic	rs1269413739, rs2509425417, rs770990177, rs2509376984	RCV003152578 RCV003152579 RCV003892098 RCV003892099	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
OBSESSIVE-COMPULSIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (12)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Breast Carcinoma	Breast Carcinoma	BEFREE	20699374, 22532573, 22863968, 28757652		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	19330027, 20699374, 21949660, 22532573, 35772352	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms Male	Male breast neoplasms	Pubtator	21949660	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of Male Breast	Breast Carcinoma, male	BEFREE	21949660		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	38078879	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Diabetes mellitus, type 2	Pubtator	21775499	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leigh Disease	Leigh syndrome	Pubtator	38068960	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	20699374, 22532573, 22863968, 28757652		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mitochondrial Diseases	Mitochondrial disease	Pubtator	38068960	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Mitochondrial encephalopathy	Mitochondrial encephalopathy	Pubtator	38068960	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	Pubtator	37405988	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pulmonary Disease Chronic Obstructive	Chronic obstructive pulmonary disease	Pubtator	17483440	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

COX11 (cytochrome c oxidase copper chaperone COX11)