Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	135250
Gene name	Retinoic acid early transcript 1E
Gene symbol	RAET1E
Synonyms (NCBI Gene)	LETALN2DL-4NKG2DL4RAET1E2RL-4ULBP4bA350J20.7
Chromosome	6
Chromosome location	6q25.1
Summary	This gene belong to the RAET1 family, which consists of major histocompatibility complex (MHC) class I-related genes located in a cluster on chromosome 6q24.2-q25.3. This and RAET1G protein differ from other RAET1 proteins in that they have type I membran

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miRTarBase ID	miRNA	Experiments	Reference
MIRT022530	hsa-miR-124-3p	Microarray	18668037
MIRT669882	hsa-miR-512-5p	HITS-CLIP	23824327
MIRT669881	hsa-miR-510-5p	HITS-CLIP	23824327
MIRT669880	hsa-miR-5690	HITS-CLIP	23824327
MIRT669879	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT669878	hsa-miR-6811-3p	HITS-CLIP	23824327
MIRT669877	hsa-miR-6847-3p	HITS-CLIP	23824327
MIRT669876	hsa-miR-4284	HITS-CLIP	23824327
MIRT669875	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT669874	hsa-miR-1268a	HITS-CLIP	23824327
MIRT669873	hsa-miR-1268b	HITS-CLIP	23824327
MIRT669872	hsa-miR-7977	HITS-CLIP	23824327
MIRT669871	hsa-miR-6514-3p	HITS-CLIP	23824327
MIRT669870	hsa-miR-6821-5p	HITS-CLIP	23824327
MIRT634914	hsa-miR-8485	HITS-CLIP	23824327
MIRT634910	hsa-miR-33a-5p	HITS-CLIP	23824327
MIRT634909	hsa-miR-33b-5p	HITS-CLIP	23824327
MIRT634908	hsa-miR-450b-5p	HITS-CLIP	23824327
MIRT634907	hsa-miR-507	HITS-CLIP	23824327
MIRT634906	hsa-miR-557	HITS-CLIP	23824327
MIRT634905	hsa-miR-3680-3p	HITS-CLIP	23824327
MIRT634904	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT634913	hsa-miR-6733-3p	HITS-CLIP	23824327
MIRT634912	hsa-miR-4302	HITS-CLIP	23824327
MIRT634911	hsa-miR-4276	HITS-CLIP	23824327
MIRT634910	hsa-miR-33a-5p	HITS-CLIP	23824327
MIRT634909	hsa-miR-33b-5p	HITS-CLIP	23824327
MIRT634908	hsa-miR-450b-5p	HITS-CLIP	23824327
MIRT634907	hsa-miR-507	HITS-CLIP	23824327
MIRT634906	hsa-miR-557	HITS-CLIP	23824327
MIRT634905	hsa-miR-3680-3p	HITS-CLIP	23824327
MIRT634904	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT634914	hsa-miR-8485	HITS-CLIP	23824327
MIRT634913	hsa-miR-6733-3p	HITS-CLIP	23824327
MIRT634912	hsa-miR-4302	HITS-CLIP	23824327
MIRT634911	hsa-miR-4276	HITS-CLIP	23824327
MIRT634910	hsa-miR-33a-5p	HITS-CLIP	23824327
MIRT634909	hsa-miR-33b-5p	HITS-CLIP	23824327
MIRT634908	hsa-miR-450b-5p	HITS-CLIP	23824327
MIRT634907	hsa-miR-507	HITS-CLIP	23824327
MIRT634906	hsa-miR-557	HITS-CLIP	23824327
MIRT634905	hsa-miR-3680-3p	HITS-CLIP	23824327
MIRT634904	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT669882	hsa-miR-512-5p	HITS-CLIP	23824327
MIRT669881	hsa-miR-510-5p	HITS-CLIP	23824327
MIRT669880	hsa-miR-5690	HITS-CLIP	23824327
MIRT669879	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT669878	hsa-miR-6811-3p	HITS-CLIP	23824327
MIRT669877	hsa-miR-6847-3p	HITS-CLIP	23824327
MIRT669876	hsa-miR-4284	HITS-CLIP	23824327
MIRT669875	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT669874	hsa-miR-1268a	HITS-CLIP	23824327
MIRT669873	hsa-miR-1268b	HITS-CLIP	23824327
MIRT669872	hsa-miR-7977	HITS-CLIP	23824327
MIRT669871	hsa-miR-6514-3p	HITS-CLIP	23824327
MIRT669870	hsa-miR-6821-5p	HITS-CLIP	23824327
MIRT634914	hsa-miR-8485	HITS-CLIP	23824327
MIRT634910	hsa-miR-33a-5p	HITS-CLIP	23824327
MIRT634909	hsa-miR-33b-5p	HITS-CLIP	23824327
MIRT634908	hsa-miR-450b-5p	HITS-CLIP	23824327
MIRT634907	hsa-miR-507	HITS-CLIP	23824327
MIRT634906	hsa-miR-557	HITS-CLIP	23824327
MIRT634905	hsa-miR-3680-3p	HITS-CLIP	23824327
MIRT634904	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT634913	hsa-miR-6733-3p	HITS-CLIP	23824327
MIRT634912	hsa-miR-4302	HITS-CLIP	23824327
MIRT634911	hsa-miR-4276	HITS-CLIP	23824327
MIRT634910	hsa-miR-33a-5p	HITS-CLIP	23824327
MIRT634909	hsa-miR-33b-5p	HITS-CLIP	23824327
MIRT634908	hsa-miR-450b-5p	HITS-CLIP	23824327
MIRT634907	hsa-miR-507	HITS-CLIP	23824327
MIRT634906	hsa-miR-557	HITS-CLIP	23824327
MIRT634905	hsa-miR-3680-3p	HITS-CLIP	23824327
MIRT634904	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT634914	hsa-miR-8485	HITS-CLIP	23824327
MIRT634913	hsa-miR-6733-3p	HITS-CLIP	23824327
MIRT634912	hsa-miR-4302	HITS-CLIP	23824327
MIRT634911	hsa-miR-4276	HITS-CLIP	23824327
MIRT634910	hsa-miR-33a-5p	HITS-CLIP	23824327
MIRT634909	hsa-miR-33b-5p	HITS-CLIP	23824327
MIRT634908	hsa-miR-450b-5p	HITS-CLIP	23824327
MIRT634907	hsa-miR-507	HITS-CLIP	23824327
MIRT634906	hsa-miR-557	HITS-CLIP	23824327
MIRT634905	hsa-miR-3680-3p	HITS-CLIP	23824327
MIRT634904	hsa-miR-129-5p	HITS-CLIP	23824327

Show/Hide all (16)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001916	Process	Positive regulation of T cell mediated cytotoxicity	IBA
GO:0002376	Process	Immune system process	IEA
GO:0002476	Process	Antigen processing and presentation of endogenous peptide antigen via MHC class Ib	IBA
GO:0002486	Process	Antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent	IBA
GO:0005515	Function	Protein binding	IPI	18544572, 19436053, 19658097, 28559451
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	IBA
GO:0005886	Component	Plasma membrane	NAS	15240696
GO:0005886	Component	Plasma membrane	TAS
GO:0006955	Process	Immune response	IBA
GO:0009897	Component	External side of plasma membrane	IBA
GO:0016020	Component	Membrane	IEA
GO:0042267	Process	Natural killer cell mediated cytotoxicity	IDA	15240696
GO:0045954	Process	Positive regulation of natural killer cell mediated cytotoxicity	IDA	18544572
GO:0046703	Function	Natural killer cell lectin-like receptor binding	IEA
GO:0046703	Function	Natural killer cell lectin-like receptor binding	IPI	15240696

MIM	HGNC	e!Ensembl
609243	16793	ENSG00000164520

Q8TD07

Protein name

Retinoic acid early transcript 1E (Lymphocyte effector toxicity activation ligand) (NKG2D ligand 4) (N2DL-4) (NKG2DL4) (RAE-1-like transcript 4) (UL16-binding protein 4)

Protein function

Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00129	MHC_I	29 → 202	Class I Histocompatibility antigen, domains alpha 1 and 2	Domain

Tissue specificity

TISSUE SPECIFICITY: Predominantly expressed in the skin, but also expressed in testis and trachea. Up-regulated in tumor cells of different origins. Expression progressively decreased after treatment of tumor cells with retinoic acid. {ECO:0000269|PubMed:

Sequence

MRRISLTSSPVRLLLFLLLLLIALEIMVGGHSLCFNFTIKSLSRPGQPWCEAQVFLNKNL
FLQYNSDNNMVKPLGLLGKKVYATSTWGELTQTLGEVGRDLRMLLCDIKPQIKTSDPSTL
QVEMFCQREAERCTGASWQFATNGEKSLLFDAMNMTWTVINHEASKIKETWKKDRGLEKY
FRKLSKGDCDHWLREFLGHWEAMPEPTVSPVNASDIHWSSSSLPDRWIILGAFILLVLMG
IVLICVWWQNGEWQAGLWPLRTS

Sequence length

263

Interactions

View interactions

	KEGG		Reactome
	Natural killer cell mediated cytotoxicity		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
AUTISM SPECTRUM DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (16)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adenocarcinoma	Adenocarcinoma	BEFREE	31827723		★★★★★ ★☆☆☆☆ Found in Text Mining only
Atherosclerosis	Atherosclerosis	Pubtator	30662365	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	22257486, 25803781	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	36353638	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	35936986	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma, Ovarian Epithelial	Ovarian Epithelial carcinoma	BEFREE	19436053		★★★★★ ★☆☆☆☆ Found in Text Mining only
Coronary Artery Disease	Coronary artery disease	Pubtator	30662365	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Crohn Disease	Crohn disease	Pubtator	28684217	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypertension	Hypertension	Pubtator	30662365	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypoalphalipoproteinemias	Hypoalphalipoproteinemia	Pubtator	30662365	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Sclerosis	Multiple sclerosis	Pubtator	34873031	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Nasopharyngeal carcinoma	Nasopharyngeal Carcinoma	BEFREE	28159927		★★★★★ ★☆☆☆☆ Found in Text Mining only
Nasopharyngeal Carcinoma	Nasopharyngeal carcinoma	Pubtator	28159927	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	17470428, 19436053		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	23297870	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Uterine neoplasm	Pubtator	25510288	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

RAET1E (retinoic acid early transcript 1E)