Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	1347
Gene name	Cytochrome c oxidase subunit 7A2
Gene symbol	COX7A2
Synonyms (NCBI Gene)	COX7ALCOX7AL1COXVIIALCOXVIIa-LVIIAL
Chromosome	6
Chromosome location	6q14.1
Summary	Cytochrome c oxidase, the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of three catalytic subunits encoded by mitochondri

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miRTarBase ID	miRNA	Experiments	Reference
MIRT043577	hsa-miR-148b-3p	CLASH	23622248
MIRT040509	hsa-miR-548b-3p	CLASH	23622248
MIRT905513	hsa-miR-3136-5p	CLIP-seq
MIRT905514	hsa-miR-3160-3p	CLIP-seq
MIRT905515	hsa-miR-34a	CLIP-seq
MIRT905516	hsa-miR-34c-5p	CLIP-seq
MIRT905517	hsa-miR-361-5p	CLIP-seq
MIRT905518	hsa-miR-3976	CLIP-seq
MIRT905519	hsa-miR-423-3p	CLIP-seq
MIRT905520	hsa-miR-4439	CLIP-seq
MIRT905521	hsa-miR-449a	CLIP-seq
MIRT905522	hsa-miR-449b	CLIP-seq
MIRT905523	hsa-miR-4513	CLIP-seq
MIRT905524	hsa-miR-4731-5p	CLIP-seq
MIRT905525	hsa-miR-640	CLIP-seq
MIRT905526	hsa-miR-935	CLIP-seq
MIRT905517	hsa-miR-361-5p	CLIP-seq
MIRT905519	hsa-miR-423-3p	CLIP-seq
MIRT905525	hsa-miR-640	CLIP-seq
MIRT905515	hsa-miR-34a	CLIP-seq
MIRT905516	hsa-miR-34c-5p	CLIP-seq
MIRT905519	hsa-miR-423-3p	CLIP-seq
MIRT905521	hsa-miR-449a	CLIP-seq
MIRT905522	hsa-miR-449b	CLIP-seq
MIRT905525	hsa-miR-640	CLIP-seq
MIRT905526	hsa-miR-935	CLIP-seq
MIRT2204389	hsa-miR-1324	CLIP-seq
MIRT2204390	hsa-miR-3163	CLIP-seq
MIRT2204391	hsa-miR-330-3p	CLIP-seq
MIRT905517	hsa-miR-361-5p	CLIP-seq
MIRT905518	hsa-miR-3976	CLIP-seq
MIRT905519	hsa-miR-423-3p	CLIP-seq
MIRT2204392	hsa-miR-4422	CLIP-seq
MIRT2204393	hsa-miR-4668-3p	CLIP-seq
MIRT905525	hsa-miR-640	CLIP-seq
MIRT905513	hsa-miR-3136-5p	CLIP-seq
MIRT905520	hsa-miR-4439	CLIP-seq
MIRT905523	hsa-miR-4513	CLIP-seq
MIRT2507899	hsa-miR-4724-5p	CLIP-seq
MIRT905524	hsa-miR-4731-5p	CLIP-seq
MIRT2507900	hsa-miR-4738-3p	CLIP-seq
MIRT905513	hsa-miR-3136-5p	CLIP-seq
MIRT905520	hsa-miR-4439	CLIP-seq
MIRT905523	hsa-miR-4513	CLIP-seq
MIRT2507899	hsa-miR-4724-5p	CLIP-seq
MIRT905524	hsa-miR-4731-5p	CLIP-seq
MIRT2507900	hsa-miR-4738-3p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0004129	Function	Cytochrome-c oxidase activity	IBA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IEA
GO:0005743	Component	Mitochondrial inner membrane	IEA
GO:0005743	Component	Mitochondrial inner membrane	IEA
GO:0005743	Component	Mitochondrial inner membrane	TAS
GO:0006119	Process	Oxidative phosphorylation	IBA
GO:0006119	Process	Oxidative phosphorylation	IEA
GO:0006123	Process	Mitochondrial electron transport, cytochrome c to oxygen	IEA
GO:0006123	Process	Mitochondrial electron transport, cytochrome c to oxygen	NAS	30030519
GO:0016020	Component	Membrane	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0031966	Component	Mitochondrial membrane	IBA
GO:0031966	Component	Mitochondrial membrane	IDA	30030519
GO:0045277	Component	Respiratory chain complex IV	IEA
GO:0045333	Process	Cellular respiration	NAS	30030519
GO:0098803	Component	Respiratory chain complex	IBA
GO:1902600	Process	Proton transmembrane transport	IEA

MIM	HGNC	e!Ensembl
123996	2288	ENSG00000112695

P14406

Protein name

Cytochrome c oxidase subunit 7A2, mitochondrial (Cytochrome c oxidase subunit VIIa-liver/heart) (Cytochrome c oxidase subunit VIIa-L) (Cytochrome c oxidase subunit VIIaL)

Protein function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiqu

PDB

5Z62

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02238	COX7a	26 → 76	Cytochrome c oxidase subunit VII	Family

Sequence

MLRNLLALRQIGQRTISTASRRHFKNKVPEKQKLFQEDDEIPLYLKGGVADALLYRATMI
LTVGGTAYAIYELAVASFPKKQE

Sequence length

Interactions

View interactions

	KEGG
	Oxidative phosphorylation Metabolic pathways Cardiac muscle contraction Thermogenesis Non-alcoholic fatty liver disease Alzheimer disease Parkinson disease Amyotrophic lateral sclerosis Huntington disease Prion disease Pathways of neurodegeneration - multiple diseases Chemical carcinogenesis - reactive oxygen species Diabetic cardiomyopathy

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ASTHMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (9)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Alzheimer Disease	Alzheimer disease	Pubtator	36195955	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Basal Cell	Basal cell carcinoma	Pubtator	34278484	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	29079956		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	29079956		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	29079956		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	29079956		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mitochondrial Diseases	Mitochondrial disease	Pubtator	34278484	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	29079956		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	37482618	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

COX7A2 (cytochrome c oxidase subunit 7A2)