Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	134549
Gene name	Shroom family member 1
Gene symbol	SHROOM1
Synonyms (NCBI Gene)	APXL2
Chromosome	5
Chromosome location	5q31.1
Summary	SHROOM family members play diverse roles in the development of the nervous system and other tissues (Hagens et al., 2006 [PubMed 16615870]).[supplied by OMIM, Mar 2008]

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Show/Hide all (226)

miRTarBase ID	miRNA	Experiments	Reference
MIRT625712	hsa-miR-8485	HITS-CLIP	23824327
MIRT625711	hsa-miR-603	HITS-CLIP	23824327
MIRT625710	hsa-miR-425-5p	HITS-CLIP	23824327
MIRT625709	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT625708	hsa-miR-1245b-3p	HITS-CLIP	23824327
MIRT625707	hsa-miR-642a-3p	HITS-CLIP	23824327
MIRT625706	hsa-miR-642b-3p	HITS-CLIP	23824327
MIRT625705	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT625712	hsa-miR-8485	HITS-CLIP	23824327
MIRT625711	hsa-miR-603	HITS-CLIP	23824327
MIRT625710	hsa-miR-425-5p	HITS-CLIP	23824327
MIRT625709	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT625708	hsa-miR-1245b-3p	HITS-CLIP	23824327
MIRT625707	hsa-miR-642a-3p	HITS-CLIP	23824327
MIRT625706	hsa-miR-642b-3p	HITS-CLIP	23824327
MIRT625705	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT625712	hsa-miR-8485	HITS-CLIP	23824327
MIRT625711	hsa-miR-603	HITS-CLIP	23824327
MIRT625710	hsa-miR-425-5p	HITS-CLIP	23824327
MIRT625709	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT625708	hsa-miR-1245b-3p	HITS-CLIP	23824327
MIRT625707	hsa-miR-642a-3p	HITS-CLIP	23824327
MIRT625706	hsa-miR-642b-3p	HITS-CLIP	23824327
MIRT625705	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT625712	hsa-miR-8485	HITS-CLIP	23824327
MIRT625711	hsa-miR-603	HITS-CLIP	23824327
MIRT625710	hsa-miR-425-5p	HITS-CLIP	23824327
MIRT625709	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT625708	hsa-miR-1245b-3p	HITS-CLIP	23824327
MIRT625707	hsa-miR-642a-3p	HITS-CLIP	23824327
MIRT625706	hsa-miR-642b-3p	HITS-CLIP	23824327
MIRT625705	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT1347772	hsa-miR-1193	CLIP-seq
MIRT1347773	hsa-miR-122	CLIP-seq
MIRT1347774	hsa-miR-1915	CLIP-seq
MIRT1347775	hsa-miR-1976	CLIP-seq
MIRT1347776	hsa-miR-2276	CLIP-seq
MIRT1347777	hsa-miR-2392	CLIP-seq
MIRT1347778	hsa-miR-2964a-5p	CLIP-seq
MIRT1347779	hsa-miR-3135b	CLIP-seq
MIRT1347780	hsa-miR-3152-3p	CLIP-seq
MIRT1347781	hsa-miR-3194-3p	CLIP-seq
MIRT1347782	hsa-miR-3614-3p	CLIP-seq
MIRT1347783	hsa-miR-3652	CLIP-seq
MIRT1347784	hsa-miR-4279	CLIP-seq
MIRT1347785	hsa-miR-4294	CLIP-seq
MIRT1347786	hsa-miR-4297	CLIP-seq
MIRT1347787	hsa-miR-431	CLIP-seq
MIRT1347788	hsa-miR-4430	CLIP-seq
MIRT1347789	hsa-miR-4454	CLIP-seq
MIRT1347790	hsa-miR-4634	CLIP-seq
MIRT1347791	hsa-miR-4662a-5p	CLIP-seq
MIRT1347792	hsa-miR-4676-5p	CLIP-seq
MIRT1347793	hsa-miR-4707-3p	CLIP-seq
MIRT1347794	hsa-miR-4722-3p	CLIP-seq
MIRT1347795	hsa-miR-4726-3p	CLIP-seq
MIRT1347796	hsa-miR-483-5p	CLIP-seq
MIRT1347797	hsa-miR-5096	CLIP-seq
MIRT1347798	hsa-miR-572	CLIP-seq
MIRT1347799	hsa-miR-575	CLIP-seq
MIRT1347800	hsa-miR-924	CLIP-seq
MIRT1347772	hsa-miR-1193	CLIP-seq
MIRT1347775	hsa-miR-1976	CLIP-seq
MIRT1347777	hsa-miR-2392	CLIP-seq
MIRT1347779	hsa-miR-3135b	CLIP-seq
MIRT1347780	hsa-miR-3152-3p	CLIP-seq
MIRT1347783	hsa-miR-3652	CLIP-seq
MIRT1347801	hsa-miR-4258	CLIP-seq
MIRT1347802	hsa-miR-4269	CLIP-seq
MIRT1347788	hsa-miR-4430	CLIP-seq
MIRT1347803	hsa-miR-4438	CLIP-seq
MIRT1347789	hsa-miR-4454	CLIP-seq
MIRT1347791	hsa-miR-4662a-5p	CLIP-seq
MIRT1347792	hsa-miR-4676-5p	CLIP-seq
MIRT1347793	hsa-miR-4707-3p	CLIP-seq
MIRT1347804	hsa-miR-4735-5p	CLIP-seq
MIRT1347805	hsa-miR-4775	CLIP-seq
MIRT1347806	hsa-miR-5095	CLIP-seq
MIRT1347797	hsa-miR-5096	CLIP-seq
MIRT1347799	hsa-miR-575	CLIP-seq
MIRT1347807	hsa-miR-590-3p	CLIP-seq
MIRT1347808	hsa-miR-765	CLIP-seq
MIRT1347772	hsa-miR-1193	CLIP-seq
MIRT1347775	hsa-miR-1976	CLIP-seq
MIRT1347777	hsa-miR-2392	CLIP-seq
MIRT1347780	hsa-miR-3152-3p	CLIP-seq
MIRT1921718	hsa-miR-411	CLIP-seq
MIRT1347789	hsa-miR-4454	CLIP-seq
MIRT1347791	hsa-miR-4662a-5p	CLIP-seq
MIRT1347792	hsa-miR-4676-5p	CLIP-seq
MIRT1347793	hsa-miR-4707-3p	CLIP-seq
MIRT1347796	hsa-miR-483-5p	CLIP-seq
MIRT1347797	hsa-miR-5096	CLIP-seq
MIRT1347799	hsa-miR-575	CLIP-seq
MIRT1347772	hsa-miR-1193	CLIP-seq
MIRT1347775	hsa-miR-1976	CLIP-seq
MIRT1347777	hsa-miR-2392	CLIP-seq
MIRT1347780	hsa-miR-3152-3p	CLIP-seq
MIRT1921718	hsa-miR-411	CLIP-seq
MIRT1347789	hsa-miR-4454	CLIP-seq
MIRT1347791	hsa-miR-4662a-5p	CLIP-seq
MIRT1347792	hsa-miR-4676-5p	CLIP-seq
MIRT1347793	hsa-miR-4707-3p	CLIP-seq
MIRT1347796	hsa-miR-483-5p	CLIP-seq
MIRT1347797	hsa-miR-5096	CLIP-seq
MIRT1347799	hsa-miR-575	CLIP-seq
MIRT1347772	hsa-miR-1193	CLIP-seq
MIRT1347775	hsa-miR-1976	CLIP-seq
MIRT1347777	hsa-miR-2392	CLIP-seq
MIRT1347780	hsa-miR-3152-3p	CLIP-seq
MIRT1921718	hsa-miR-411	CLIP-seq
MIRT1347789	hsa-miR-4454	CLIP-seq
MIRT1347791	hsa-miR-4662a-5p	CLIP-seq
MIRT1347792	hsa-miR-4676-5p	CLIP-seq
MIRT1347793	hsa-miR-4707-3p	CLIP-seq
MIRT1347796	hsa-miR-483-5p	CLIP-seq
MIRT1347797	hsa-miR-5096	CLIP-seq
MIRT1347799	hsa-miR-575	CLIP-seq
MIRT1347772	hsa-miR-1193	CLIP-seq
MIRT1347775	hsa-miR-1976	CLIP-seq
MIRT1347777	hsa-miR-2392	CLIP-seq
MIRT1347780	hsa-miR-3152-3p	CLIP-seq
MIRT1921718	hsa-miR-411	CLIP-seq
MIRT1347789	hsa-miR-4454	CLIP-seq
MIRT1347791	hsa-miR-4662a-5p	CLIP-seq
MIRT1347792	hsa-miR-4676-5p	CLIP-seq
MIRT1347793	hsa-miR-4707-3p	CLIP-seq
MIRT1347796	hsa-miR-483-5p	CLIP-seq
MIRT1347797	hsa-miR-5096	CLIP-seq
MIRT1347799	hsa-miR-575	CLIP-seq
MIRT1347773	hsa-miR-122	CLIP-seq
MIRT2102980	hsa-miR-129-5p	CLIP-seq
MIRT2102981	hsa-miR-139-3p	CLIP-seq
MIRT1347775	hsa-miR-1976	CLIP-seq
MIRT1347778	hsa-miR-2964a-5p	CLIP-seq
MIRT1347779	hsa-miR-3135b	CLIP-seq
MIRT1347781	hsa-miR-3194-3p	CLIP-seq
MIRT1347782	hsa-miR-3614-3p	CLIP-seq
MIRT1347783	hsa-miR-3652	CLIP-seq
MIRT2102982	hsa-miR-3672	CLIP-seq
MIRT1347784	hsa-miR-4279	CLIP-seq
MIRT1347785	hsa-miR-4294	CLIP-seq
MIRT1347786	hsa-miR-4297	CLIP-seq
MIRT1347787	hsa-miR-431	CLIP-seq
MIRT1347788	hsa-miR-4430	CLIP-seq
MIRT1347790	hsa-miR-4634	CLIP-seq
MIRT1347794	hsa-miR-4722-3p	CLIP-seq
MIRT1347800	hsa-miR-924	CLIP-seq
MIRT2327306	hsa-miR-106a	CLIP-seq
MIRT2327307	hsa-miR-106b	CLIP-seq
MIRT1347773	hsa-miR-122	CLIP-seq
MIRT2327308	hsa-miR-1234	CLIP-seq
MIRT2327309	hsa-miR-150	CLIP-seq
MIRT2327310	hsa-miR-17	CLIP-seq
MIRT1347775	hsa-miR-1976	CLIP-seq
MIRT2327311	hsa-miR-20a	CLIP-seq
MIRT2327312	hsa-miR-20b	CLIP-seq
MIRT1347778	hsa-miR-2964a-5p	CLIP-seq
MIRT1347779	hsa-miR-3135b	CLIP-seq
MIRT1347781	hsa-miR-3194-3p	CLIP-seq
MIRT1347782	hsa-miR-3614-3p	CLIP-seq
MIRT1347783	hsa-miR-3652	CLIP-seq
MIRT1347801	hsa-miR-4258	CLIP-seq
MIRT1347802	hsa-miR-4269	CLIP-seq
MIRT1347784	hsa-miR-4279	CLIP-seq
MIRT1347785	hsa-miR-4294	CLIP-seq
MIRT1347786	hsa-miR-4297	CLIP-seq
MIRT1347787	hsa-miR-431	CLIP-seq
MIRT1347788	hsa-miR-4430	CLIP-seq
MIRT1347803	hsa-miR-4438	CLIP-seq
MIRT1347789	hsa-miR-4454	CLIP-seq
MIRT1347790	hsa-miR-4634	CLIP-seq
MIRT1347793	hsa-miR-4707-3p	CLIP-seq
MIRT1347794	hsa-miR-4722-3p	CLIP-seq
MIRT1347804	hsa-miR-4735-5p	CLIP-seq
MIRT1347806	hsa-miR-5095	CLIP-seq
MIRT2327313	hsa-miR-519d	CLIP-seq
MIRT2327314	hsa-miR-520g	CLIP-seq
MIRT2327315	hsa-miR-520h	CLIP-seq
MIRT1347800	hsa-miR-924	CLIP-seq
MIRT2327316	hsa-miR-93	CLIP-seq
MIRT1347784	hsa-miR-4279	CLIP-seq
MIRT1347773	hsa-miR-122	CLIP-seq
MIRT2102981	hsa-miR-139-3p	CLIP-seq
MIRT1347779	hsa-miR-3135b	CLIP-seq
MIRT1347781	hsa-miR-3194-3p	CLIP-seq
MIRT1347783	hsa-miR-3652	CLIP-seq
MIRT1921718	hsa-miR-411	CLIP-seq
MIRT1347801	hsa-miR-4258	CLIP-seq
MIRT1347802	hsa-miR-4269	CLIP-seq
MIRT1347785	hsa-miR-4294	CLIP-seq
MIRT1347787	hsa-miR-431	CLIP-seq
MIRT1347788	hsa-miR-4430	CLIP-seq
MIRT1347803	hsa-miR-4438	CLIP-seq
MIRT1347790	hsa-miR-4634	CLIP-seq
MIRT1347804	hsa-miR-4735-5p	CLIP-seq
MIRT1347805	hsa-miR-4775	CLIP-seq
MIRT1347796	hsa-miR-483-5p	CLIP-seq
MIRT1347806	hsa-miR-5095	CLIP-seq
MIRT1347807	hsa-miR-590-3p	CLIP-seq
MIRT1347800	hsa-miR-924	CLIP-seq
MIRT1347773	hsa-miR-122	CLIP-seq
MIRT1347779	hsa-miR-3135b	CLIP-seq
MIRT1347783	hsa-miR-3652	CLIP-seq
MIRT1347801	hsa-miR-4258	CLIP-seq
MIRT1347788	hsa-miR-4430	CLIP-seq
MIRT1347790	hsa-miR-4634	CLIP-seq
MIRT1347804	hsa-miR-4735-5p	CLIP-seq
MIRT1347805	hsa-miR-4775	CLIP-seq
MIRT1347807	hsa-miR-590-3p	CLIP-seq
MIRT1347773	hsa-miR-122	CLIP-seq
MIRT2327308	hsa-miR-1234	CLIP-seq
MIRT2102981	hsa-miR-139-3p	CLIP-seq
MIRT1347779	hsa-miR-3135b	CLIP-seq
MIRT1347781	hsa-miR-3194-3p	CLIP-seq
MIRT1347783	hsa-miR-3652	CLIP-seq
MIRT1347785	hsa-miR-4294	CLIP-seq
MIRT1347787	hsa-miR-431	CLIP-seq
MIRT1347788	hsa-miR-4430	CLIP-seq
MIRT1347789	hsa-miR-4454	CLIP-seq
MIRT1347790	hsa-miR-4634	CLIP-seq
MIRT1347793	hsa-miR-4707-3p	CLIP-seq
MIRT1347804	hsa-miR-4735-5p	CLIP-seq
MIRT1347805	hsa-miR-4775	CLIP-seq
MIRT1347807	hsa-miR-590-3p	CLIP-seq
MIRT1347800	hsa-miR-924	CLIP-seq

Show/Hide all (19)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000902	Process	Cell morphogenesis	IBA
GO:0000902	Process	Cell morphogenesis	IEA
GO:0000902	Process	Cell morphogenesis	ISS	16684770
GO:0003779	Function	Actin binding	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005874	Component	Microtubule	IEA
GO:0005912	Component	Adherens junction	IBA
GO:0016324	Component	Apical plasma membrane	IBA
GO:0030864	Component	Cortical actin cytoskeleton	IBA
GO:0043296	Component	Apical junction complex	IBA
GO:0045159	Function	Myosin II binding	IEA
GO:0045159	Function	Myosin II binding	ISS	16684770
GO:0051015	Function	Actin filament binding	IBA
GO:0051015	Function	Actin filament binding	IEA
GO:0051015	Function	Actin filament binding	ISS	16684770
GO:0051017	Process	Actin filament bundle assembly	IBA
GO:0051017	Process	Actin filament bundle assembly	IEA
GO:0051017	Process	Actin filament bundle assembly	ISS	16684770

MIM	HGNC	e!Ensembl
611179	24084	ENSG00000164403

Q2M3G4

Protein name

Protein Shroom1 (Apical protein 2)

Protein function

May be involved in the assembly of microtubule arrays during cell elongation.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF08688	ASD1	117 → 251	Apx/Shroom domain ASD1	Family
PF08687	ASD2	544 → 824	Apx/Shroom domain ASD2	Family

Sequence

MEALGPGGDRASPASSTSSLDLWHLSMRADSAYSSFSAASGGPEPRTQSPGTDLLPYLDW
DYVRVVWGGPGPAPPDAALCTSPRPRPAVAARSGPQPTEVPGTPGPLNRQATPLLYALAA
EAEAAAQAAEPPSPPASRAAYRQRLQGAQRRVLRETSFQRKELRMSLPARLRPTVPARPP
ATHPRSASLSHPGGEGEPARSRAPAPGTAGRGPLANQQRKWCFSEPGKLDRVGRGGGPAR
ECLGEACSSSGLPGPEPLEFQHPALAKFEDHEVGWLPETQPQGSMNLDSGSLKLGDAFRP
ASRSRSASGEVLGSWGGSGGTIPIVQAVPQGAETPRPLFQTKLSRFLPQKEAAVMYPAEL
PQSSPADSEQRVSETCIVPAWLPSLPDEVFLEEAPLVRMRSPPDPHASQGPPASVHASDQ
PYGTGLGQRTGQVTVPTEYPLHECPGTAGADDCWQGVNGSVGISRPTSHTPTGTANDNIP
TIDPTGLTTNPPTAAESDLLKPVPADALGLSGNDTPGPSHNTALARGTGQPGSRPTWPSQ
CLEELVQELARLDPSLCDPLASQPSPEPPLGLLDGLIPLAEVRAAMRPACGEAGEEAAST
FEPGSYQFSFTQLLPAPREETRLENPATHPVLDQPCGQGLPAPNNSIQGKKVELAARLQK
MLQDLHTEQERLQGEAQAWARRQAALEAAVRQACAPQELERFSRFMADLERVLGLLLLLG
SRLARVRRALARAASDSDPDEQASLLQRLRLLQRQEEDAKELKEHVARRERAVREVLVRA
LPVEELRVYCALLAGKAAVLAQQRNLDERIRLLQDQLDAIRDDLGHHAPSPSPARPPGTC
PPVQPPFPLLLT

Sequence length

852

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
METABOLIC SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SHROOM1-related disorder	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (2)

Disease Name	Disease (Merged)	Source	PMID	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Degenerative polyarthritis	Arthritis	BEFREE	26484395	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neural Tube Defects	Neural Tube Defect	BEFREE	29423651	★★★★★ ★☆☆☆☆ Found in Text Mining only

SHROOM1 (shroom family member 1)