UBE2QL1 (ubiquitin conjugating enzyme E2 QL1)

Gene

• Entrez ID: 134111
• Gene name: Ubiquitin conjugating enzyme E2 QL1
• Gene symbol: UBE2QL1
• Synonyms (NCBI Gene): -
• Chromosome: 5
• Chromosome location: 5p15.31

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT621680	hsa-miR-4289	HITS-CLIP	23824327
MIRT621679	hsa-miR-6758-3p	HITS-CLIP	23824327
MIRT621678	hsa-miR-1296-5p	HITS-CLIP	23824327
MIRT621677	hsa-miR-2909	HITS-CLIP	23824327
MIRT621680	hsa-miR-4289	HITS-CLIP	23824327
MIRT621679	hsa-miR-6758-3p	HITS-CLIP	23824327
MIRT621678	hsa-miR-1296-5p	HITS-CLIP	23824327
MIRT621677	hsa-miR-2909	HITS-CLIP	23824327
MIRT1468657	hsa-miR-1178	CLIP-seq
MIRT1468658	hsa-miR-1185	CLIP-seq
MIRT1468659	hsa-miR-1208	CLIP-seq
MIRT1468660	hsa-miR-124	CLIP-seq
MIRT1468661	hsa-miR-1257	CLIP-seq
MIRT1468662	hsa-miR-1270	CLIP-seq
MIRT1468663	hsa-miR-1271	CLIP-seq
MIRT1468664	hsa-miR-1286	CLIP-seq
MIRT1468665	hsa-miR-1296	CLIP-seq
MIRT1468666	hsa-miR-1299	CLIP-seq
MIRT1468667	hsa-miR-1305	CLIP-seq
MIRT1468668	hsa-miR-181a	CLIP-seq
MIRT1468669	hsa-miR-181b	CLIP-seq
MIRT1468670	hsa-miR-181c	CLIP-seq
MIRT1468671	hsa-miR-181d	CLIP-seq
MIRT1468672	hsa-miR-192	CLIP-seq
MIRT1468673	hsa-miR-210	CLIP-seq
MIRT1468674	hsa-miR-215	CLIP-seq
MIRT1468675	hsa-miR-3120-3p	CLIP-seq
MIRT1468676	hsa-miR-3144-5p	CLIP-seq
MIRT1468677	hsa-miR-3173-5p	CLIP-seq
MIRT1468678	hsa-miR-3189-3p	CLIP-seq
MIRT1468679	hsa-miR-3191	CLIP-seq
MIRT1468680	hsa-miR-3200-3p	CLIP-seq
MIRT1468681	hsa-miR-3605-5p	CLIP-seq
MIRT1468682	hsa-miR-3660	CLIP-seq
MIRT1468683	hsa-miR-3679-5p	CLIP-seq
MIRT1468684	hsa-miR-370	CLIP-seq
MIRT1468685	hsa-miR-376c	CLIP-seq
MIRT1468686	hsa-miR-3926	CLIP-seq
MIRT1468687	hsa-miR-4256	CLIP-seq
MIRT1468688	hsa-miR-4261	CLIP-seq
MIRT1468689	hsa-miR-4262	CLIP-seq
MIRT1468690	hsa-miR-4314	CLIP-seq
MIRT1468691	hsa-miR-4420	CLIP-seq
MIRT1468692	hsa-miR-4433	CLIP-seq
MIRT1468693	hsa-miR-4434	CLIP-seq
MIRT1468694	hsa-miR-4436b-3p	CLIP-seq
MIRT1468695	hsa-miR-4443	CLIP-seq
MIRT1468696	hsa-miR-4514	CLIP-seq
MIRT1468697	hsa-miR-4516	CLIP-seq
MIRT1468698	hsa-miR-4526	CLIP-seq
MIRT1468699	hsa-miR-4531	CLIP-seq
MIRT1468700	hsa-miR-4640-5p	CLIP-seq
MIRT1468701	hsa-miR-4652-5p	CLIP-seq
MIRT1468702	hsa-miR-4667-5p	CLIP-seq
MIRT1468703	hsa-miR-4692	CLIP-seq
MIRT1468704	hsa-miR-4700-5p	CLIP-seq
MIRT1468705	hsa-miR-4722-5p	CLIP-seq
MIRT1468706	hsa-miR-4726-5p	CLIP-seq
MIRT1468707	hsa-miR-4756-3p	CLIP-seq
MIRT1468708	hsa-miR-4761-3p	CLIP-seq
MIRT1468709	hsa-miR-4781-3p	CLIP-seq
MIRT1468710	hsa-miR-4790-3p	CLIP-seq
MIRT1468711	hsa-miR-4797-5p	CLIP-seq
MIRT1468712	hsa-miR-496	CLIP-seq
MIRT1468713	hsa-miR-498	CLIP-seq
MIRT1468714	hsa-miR-506	CLIP-seq
MIRT1468715	hsa-miR-511	CLIP-seq
MIRT1468716	hsa-miR-545	CLIP-seq
MIRT1468717	hsa-miR-548s	CLIP-seq
MIRT1468718	hsa-miR-549	CLIP-seq
MIRT1468719	hsa-miR-604	CLIP-seq
MIRT1468720	hsa-miR-620	CLIP-seq
MIRT1468721	hsa-miR-637	CLIP-seq
MIRT1468722	hsa-miR-642b	CLIP-seq
MIRT1468723	hsa-miR-647	CLIP-seq
MIRT1468724	hsa-miR-663b	CLIP-seq
MIRT1468725	hsa-miR-664	CLIP-seq
MIRT1468726	hsa-miR-665	CLIP-seq
MIRT1468727	hsa-miR-668	CLIP-seq
MIRT1468728	hsa-miR-767-3p	CLIP-seq
MIRT1468729	hsa-miR-875-3p	CLIP-seq
MIRT1468730	hsa-miR-9	CLIP-seq
MIRT1468731	hsa-miR-96	CLIP-seq
MIRT1921007	hsa-miR-3619-3p	CLIP-seq
MIRT1921008	hsa-miR-4799-5p	CLIP-seq
MIRT1921009	hsa-miR-591	CLIP-seq
MIRT1921007	hsa-miR-3619-3p	CLIP-seq
MIRT1921008	hsa-miR-4799-5p	CLIP-seq
MIRT1921009	hsa-miR-591	CLIP-seq
MIRT1921007	hsa-miR-3619-3p	CLIP-seq
MIRT1921008	hsa-miR-4799-5p	CLIP-seq
MIRT1921009	hsa-miR-591	CLIP-seq
MIRT1921007	hsa-miR-3619-3p	CLIP-seq
MIRT1921008	hsa-miR-4799-5p	CLIP-seq
MIRT1921009	hsa-miR-591	CLIP-seq
MIRT1468666	hsa-miR-1299	CLIP-seq
MIRT2140782	hsa-miR-15a	CLIP-seq
MIRT2140783	hsa-miR-15b	CLIP-seq
MIRT2140784	hsa-miR-16	CLIP-seq
MIRT2140785	hsa-miR-1827	CLIP-seq
MIRT2140786	hsa-miR-195	CLIP-seq
MIRT2140787	hsa-miR-3138	CLIP-seq
MIRT2140788	hsa-miR-3665	CLIP-seq
MIRT2140789	hsa-miR-3915	CLIP-seq
MIRT2140790	hsa-miR-3934	CLIP-seq
MIRT2140791	hsa-miR-424	CLIP-seq
MIRT1468688	hsa-miR-4261	CLIP-seq
MIRT2140792	hsa-miR-4310	CLIP-seq
MIRT2140793	hsa-miR-4520a-3p	CLIP-seq
MIRT2140794	hsa-miR-4659a-3p	CLIP-seq
MIRT2140795	hsa-miR-4659b-3p	CLIP-seq
MIRT2140796	hsa-miR-4719	CLIP-seq
MIRT2140797	hsa-miR-4736	CLIP-seq
MIRT2140798	hsa-miR-4800-5p	CLIP-seq
MIRT2140799	hsa-miR-497	CLIP-seq
MIRT2140800	hsa-miR-520a-5p	CLIP-seq
MIRT2140801	hsa-miR-525-5p	CLIP-seq
MIRT1468718	hsa-miR-549	CLIP-seq
MIRT1468729	hsa-miR-875-3p	CLIP-seq
MIRT2140802	hsa-miR-940	CLIP-seq
MIRT1468659	hsa-miR-1208	CLIP-seq
MIRT1468663	hsa-miR-1271	CLIP-seq
MIRT1468666	hsa-miR-1299	CLIP-seq
MIRT2140782	hsa-miR-15a	CLIP-seq
MIRT2140783	hsa-miR-15b	CLIP-seq
MIRT2140784	hsa-miR-16	CLIP-seq
MIRT2140786	hsa-miR-195	CLIP-seq
MIRT2361784	hsa-miR-204	CLIP-seq
MIRT2361785	hsa-miR-211	CLIP-seq
MIRT2361786	hsa-miR-3153	CLIP-seq
MIRT2361787	hsa-miR-3174	CLIP-seq
MIRT2361788	hsa-miR-3662	CLIP-seq
MIRT2140791	hsa-miR-424	CLIP-seq
MIRT1468688	hsa-miR-4261	CLIP-seq
MIRT1468691	hsa-miR-4420	CLIP-seq
MIRT2361789	hsa-miR-4481	CLIP-seq
MIRT2361790	hsa-miR-4505	CLIP-seq
MIRT2361791	hsa-miR-4646-5p	CLIP-seq
MIRT2361792	hsa-miR-4663	CLIP-seq
MIRT2361793	hsa-miR-4668-5p	CLIP-seq
MIRT2361794	hsa-miR-4728-3p	CLIP-seq
MIRT2361795	hsa-miR-4745-5p	CLIP-seq
MIRT2361796	hsa-miR-4758-5p	CLIP-seq
MIRT2361797	hsa-miR-4765	CLIP-seq
MIRT2140799	hsa-miR-497	CLIP-seq
MIRT2361798	hsa-miR-518d-5p	CLIP-seq
MIRT2361799	hsa-miR-519b-5p	CLIP-seq
MIRT2361800	hsa-miR-519c-5p	CLIP-seq
MIRT2361801	hsa-miR-520c-5p	CLIP-seq
MIRT2361802	hsa-miR-526a	CLIP-seq
MIRT1468718	hsa-miR-549	CLIP-seq
MIRT1468729	hsa-miR-875-3p	CLIP-seq
MIRT1468731	hsa-miR-96	CLIP-seq
MIRT1468666	hsa-miR-1299	CLIP-seq
MIRT1468688	hsa-miR-4261	CLIP-seq
MIRT1468729	hsa-miR-875-3p	CLIP-seq
MIRT2361784	hsa-miR-204	CLIP-seq
MIRT2361785	hsa-miR-211	CLIP-seq
MIRT2442816	hsa-miR-3121-5p	CLIP-seq
MIRT2442817	hsa-miR-3667-3p	CLIP-seq
MIRT2442818	hsa-miR-4279	CLIP-seq
MIRT2442819	hsa-miR-4755-5p	CLIP-seq
MIRT2442820	hsa-miR-623	CLIP-seq
MIRT2442821	hsa-miR-938	CLIP-seq
MIRT2655636	hsa-miR-3194-3p	CLIP-seq
MIRT2655637	hsa-miR-3659	CLIP-seq
MIRT2655638	hsa-miR-4658	CLIP-seq
MIRT2655639	hsa-miR-562	CLIP-seq
MIRT2655640	hsa-miR-574-5p	CLIP-seq
MIRT2655641	hsa-miR-593	CLIP-seq
MIRT1468728	hsa-miR-767-3p	CLIP-seq
MIRT2655636	hsa-miR-3194-3p	CLIP-seq
MIRT2655637	hsa-miR-3659	CLIP-seq
MIRT2655638	hsa-miR-4658	CLIP-seq
MIRT2655640	hsa-miR-574-5p	CLIP-seq
MIRT2655641	hsa-miR-593	CLIP-seq
MIRT1468728	hsa-miR-767-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000209	Process	Protein polyubiquitination	IBA
GO:0005515	Function	Protein binding	IPI	24000165
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	24000165
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005886	Component	Plasma membrane	IDA
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0061631	Function	Ubiquitin conjugating enzyme activity	IBA
GO:0061631	Function	Ubiquitin conjugating enzyme activity	IDA	24000165
GO:0061631	Function	Ubiquitin conjugating enzyme activity	IEA

Other IDs

• MIM: 615832
• HGNC: 37269
• e!Ensembl: ENSG00000215218

Protein

• UniProt ID: A1L167
• Protein name: Ubiquitin-conjugating enzyme E2Q-like protein 1 (EC 2.3.2.23) (E2Q-like ubiquitin-conjugating enzyme 1)
• Protein function: Probable E2 ubiquitin-protein ligase that catalyzes the covalent attachment of ubiquitin to target proteins. May facilitate the monoubiquitination and degradation of MTOR and CCNE1 through interaction with FBXW7.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00179	UQ_con	1 → 149	Ubiquitin-conjugating enzyme	Domain

• Sequence:

  MKELQDIARLSDRFISVELVDESLFDWNVKLHQVDKDSVLWQDMKETNTEFILLNLTFPD
  NFPFSPPFMRVLSPRLENGYVLDGGAICMELLTPRGWSSAYTVEAVMRQFAASLVKGQGR
  ICRKAGKSKKSFSRKEAEATFKSLVKTHEKYGWVTPPVSDG

• Sequence length: 161

Pathways

KEGG:

Ubiquitin mediated proteolysis

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ALZHEIMER DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Asthma	Asthma	GWASDB_DG	23181788		★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	24000165	Inhibit	★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	33510822	Associate	★☆☆☆☆ Found in Text Mining only
Conventional (Clear Cell) Renal Cell Carcinoma	Renal Carcinoma	BEFREE	24000165		★☆☆☆☆ Found in Text Mining only
Kidney Neoplasm	Kidney Neoplasm	BEFREE	24000165		★☆☆☆☆ Found in Text Mining only
Kidney Neoplasms	Kidney neoplasm	Pubtator	24000165	Inhibit	★☆☆☆☆ Found in Text Mining only
Renal Cell Carcinoma	Renal Carcinoma	BEFREE	24000165		★☆☆☆☆ Found in Text Mining only