Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	132789
Gene name	Glucosamine-6-phosphate deaminase 2
Gene symbol	GNPDA2
Synonyms (NCBI Gene)	GNP2SB52
Chromosome	4
Chromosome location	4p12
Summary	The protein encoded by this gene is an allosteric enzyme that catalyzes the reversible reaction converting D-glucosamine-6-phosphate into D-fructose-6-phosphate and ammonium. Variations of this gene have been reported to be associated with influencing bod

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Show/Hide all (171)

miRTarBase ID	miRNA	Experiments	Reference
MIRT002816	hsa-miR-1-3p	Microarray	15685193
MIRT020422	hsa-miR-106b-5p	Microarray	17242205
MIRT023359	hsa-miR-122-5p	Microarray	17612493
MIRT002816	hsa-miR-1-3p	Microarray	18668037
MIRT002816	hsa-miR-1-3p	Microarray	15685193
MIRT440547	hsa-miR-374a-5p	HITS-CLIP	22473208
MIRT440547	hsa-miR-374a-5p	HITS-CLIP	22473208
MIRT1025170	hsa-miR-1236	CLIP-seq
MIRT1025171	hsa-miR-1279	CLIP-seq
MIRT1025172	hsa-miR-153	CLIP-seq
MIRT1025173	hsa-miR-2052	CLIP-seq
MIRT1025174	hsa-miR-25	CLIP-seq
MIRT1025175	hsa-miR-3162-5p	CLIP-seq
MIRT1025176	hsa-miR-32	CLIP-seq
MIRT1025177	hsa-miR-320a	CLIP-seq
MIRT1025178	hsa-miR-320b	CLIP-seq
MIRT1025179	hsa-miR-320c	CLIP-seq
MIRT1025180	hsa-miR-320d	CLIP-seq
MIRT1025181	hsa-miR-3622a-5p	CLIP-seq
MIRT1025182	hsa-miR-363	CLIP-seq
MIRT1025183	hsa-miR-367	CLIP-seq
MIRT1025184	hsa-miR-3671	CLIP-seq
MIRT1025185	hsa-miR-4423-3p	CLIP-seq
MIRT1025186	hsa-miR-4429	CLIP-seq
MIRT1025187	hsa-miR-448	CLIP-seq
MIRT1025188	hsa-miR-513a-3p	CLIP-seq
MIRT1025189	hsa-miR-568	CLIP-seq
MIRT1025190	hsa-miR-607	CLIP-seq
MIRT1025191	hsa-miR-656	CLIP-seq
MIRT1025192	hsa-miR-92a	CLIP-seq
MIRT1025193	hsa-miR-92b	CLIP-seq
MIRT2004004	hsa-miR-3613-3p	CLIP-seq
MIRT2236780	hsa-miR-101	CLIP-seq
MIRT2236781	hsa-miR-144	CLIP-seq
MIRT2236782	hsa-miR-4703-3p	CLIP-seq
MIRT2236783	hsa-miR-582-5p	CLIP-seq
MIRT2540672	hsa-miR-106a	CLIP-seq
MIRT2540673	hsa-miR-106b	CLIP-seq
MIRT2540674	hsa-miR-1206	CLIP-seq
MIRT1025170	hsa-miR-1236	CLIP-seq
MIRT2540675	hsa-miR-124	CLIP-seq
MIRT2540676	hsa-miR-1265	CLIP-seq
MIRT1025171	hsa-miR-1279	CLIP-seq
MIRT2540677	hsa-miR-1298	CLIP-seq
MIRT1025172	hsa-miR-153	CLIP-seq
MIRT2540678	hsa-miR-17	CLIP-seq
MIRT1025173	hsa-miR-2052	CLIP-seq
MIRT2540679	hsa-miR-20a	CLIP-seq
MIRT2540680	hsa-miR-20b	CLIP-seq
MIRT2540681	hsa-miR-2355-5p	CLIP-seq
MIRT1025174	hsa-miR-25	CLIP-seq
MIRT2540682	hsa-miR-2964a-5p	CLIP-seq
MIRT2540683	hsa-miR-298	CLIP-seq
MIRT2540684	hsa-miR-302a	CLIP-seq
MIRT2540685	hsa-miR-302b	CLIP-seq
MIRT2540686	hsa-miR-302c	CLIP-seq
MIRT2540687	hsa-miR-302d	CLIP-seq
MIRT2540688	hsa-miR-302e	CLIP-seq
MIRT2540689	hsa-miR-30a	CLIP-seq
MIRT2540690	hsa-miR-30b	CLIP-seq
MIRT2540691	hsa-miR-30c	CLIP-seq
MIRT2540692	hsa-miR-30d	CLIP-seq
MIRT2540693	hsa-miR-30e	CLIP-seq
MIRT2540694	hsa-miR-3194-3p	CLIP-seq
MIRT1025176	hsa-miR-32	CLIP-seq
MIRT1025181	hsa-miR-3622a-5p	CLIP-seq
MIRT1025182	hsa-miR-363	CLIP-seq
MIRT2540695	hsa-miR-3647-3p	CLIP-seq
MIRT1025183	hsa-miR-367	CLIP-seq
MIRT1025184	hsa-miR-3671	CLIP-seq
MIRT2540696	hsa-miR-3714	CLIP-seq
MIRT2540697	hsa-miR-372	CLIP-seq
MIRT2540698	hsa-miR-373	CLIP-seq
MIRT2540699	hsa-miR-3907	CLIP-seq
MIRT2540700	hsa-miR-3910	CLIP-seq
MIRT2540701	hsa-miR-3941	CLIP-seq
MIRT2540702	hsa-miR-4307	CLIP-seq
MIRT1025185	hsa-miR-4423-3p	CLIP-seq
MIRT2540703	hsa-miR-4476	CLIP-seq
MIRT1025187	hsa-miR-448	CLIP-seq
MIRT2540704	hsa-miR-4495	CLIP-seq
MIRT2540705	hsa-miR-4643	CLIP-seq
MIRT2540706	hsa-miR-466	CLIP-seq
MIRT2540707	hsa-miR-4672	CLIP-seq
MIRT2540708	hsa-miR-4698	CLIP-seq
MIRT2540709	hsa-miR-4716-5p	CLIP-seq
MIRT2540710	hsa-miR-4718	CLIP-seq
MIRT2540711	hsa-miR-4760-3p	CLIP-seq
MIRT2540712	hsa-miR-4777-5p	CLIP-seq
MIRT2540713	hsa-miR-4789-3p	CLIP-seq
MIRT2540714	hsa-miR-506	CLIP-seq
MIRT1025188	hsa-miR-513a-3p	CLIP-seq
MIRT2540715	hsa-miR-519d	CLIP-seq
MIRT2540716	hsa-miR-520a-3p	CLIP-seq
MIRT2540717	hsa-miR-520b	CLIP-seq
MIRT2540718	hsa-miR-520c-3p	CLIP-seq
MIRT2540719	hsa-miR-520d-3p	CLIP-seq
MIRT2540720	hsa-miR-520e	CLIP-seq
MIRT2540721	hsa-miR-548g	CLIP-seq
MIRT2540722	hsa-miR-548t	CLIP-seq
MIRT1025190	hsa-miR-607	CLIP-seq
MIRT1025192	hsa-miR-92a	CLIP-seq
MIRT1025193	hsa-miR-92b	CLIP-seq
MIRT2540723	hsa-miR-93	CLIP-seq
MIRT2540672	hsa-miR-106a	CLIP-seq
MIRT2540673	hsa-miR-106b	CLIP-seq
MIRT1025170	hsa-miR-1236	CLIP-seq
MIRT2540675	hsa-miR-124	CLIP-seq
MIRT2540676	hsa-miR-1265	CLIP-seq
MIRT1025171	hsa-miR-1279	CLIP-seq
MIRT1025172	hsa-miR-153	CLIP-seq
MIRT2540678	hsa-miR-17	CLIP-seq
MIRT1025173	hsa-miR-2052	CLIP-seq
MIRT2540679	hsa-miR-20a	CLIP-seq
MIRT2540680	hsa-miR-20b	CLIP-seq
MIRT2540681	hsa-miR-2355-5p	CLIP-seq
MIRT1025174	hsa-miR-25	CLIP-seq
MIRT2540682	hsa-miR-2964a-5p	CLIP-seq
MIRT2540683	hsa-miR-298	CLIP-seq
MIRT2540684	hsa-miR-302a	CLIP-seq
MIRT2540685	hsa-miR-302b	CLIP-seq
MIRT2540686	hsa-miR-302c	CLIP-seq
MIRT2540687	hsa-miR-302d	CLIP-seq
MIRT2540688	hsa-miR-302e	CLIP-seq
MIRT2540689	hsa-miR-30a	CLIP-seq
MIRT2540690	hsa-miR-30b	CLIP-seq
MIRT2540691	hsa-miR-30c	CLIP-seq
MIRT2540692	hsa-miR-30d	CLIP-seq
MIRT2540693	hsa-miR-30e	CLIP-seq
MIRT2540694	hsa-miR-3194-3p	CLIP-seq
MIRT1025176	hsa-miR-32	CLIP-seq
MIRT1025181	hsa-miR-3622a-5p	CLIP-seq
MIRT1025182	hsa-miR-363	CLIP-seq
MIRT2540695	hsa-miR-3647-3p	CLIP-seq
MIRT1025183	hsa-miR-367	CLIP-seq
MIRT1025184	hsa-miR-3671	CLIP-seq
MIRT2540696	hsa-miR-3714	CLIP-seq
MIRT2540697	hsa-miR-372	CLIP-seq
MIRT2540698	hsa-miR-373	CLIP-seq
MIRT2540699	hsa-miR-3907	CLIP-seq
MIRT2540700	hsa-miR-3910	CLIP-seq
MIRT2540701	hsa-miR-3941	CLIP-seq
MIRT2540702	hsa-miR-4307	CLIP-seq
MIRT2681756	hsa-miR-4422	CLIP-seq
MIRT1025185	hsa-miR-4423-3p	CLIP-seq
MIRT2540703	hsa-miR-4476	CLIP-seq
MIRT1025187	hsa-miR-448	CLIP-seq
MIRT2540704	hsa-miR-4495	CLIP-seq
MIRT2540705	hsa-miR-4643	CLIP-seq
MIRT2540706	hsa-miR-466	CLIP-seq
MIRT2540707	hsa-miR-4672	CLIP-seq
MIRT2540708	hsa-miR-4698	CLIP-seq
MIRT2540709	hsa-miR-4716-5p	CLIP-seq
MIRT2540710	hsa-miR-4718	CLIP-seq
MIRT2540711	hsa-miR-4760-3p	CLIP-seq
MIRT2540712	hsa-miR-4777-5p	CLIP-seq
MIRT2540713	hsa-miR-4789-3p	CLIP-seq
MIRT2540714	hsa-miR-506	CLIP-seq
MIRT1025188	hsa-miR-513a-3p	CLIP-seq
MIRT2540715	hsa-miR-519d	CLIP-seq
MIRT2540716	hsa-miR-520a-3p	CLIP-seq
MIRT2540717	hsa-miR-520b	CLIP-seq
MIRT2540718	hsa-miR-520c-3p	CLIP-seq
MIRT2540719	hsa-miR-520d-3p	CLIP-seq
MIRT2540720	hsa-miR-520e	CLIP-seq
MIRT2540721	hsa-miR-548g	CLIP-seq
MIRT2540722	hsa-miR-548t	CLIP-seq
MIRT1025190	hsa-miR-607	CLIP-seq
MIRT1025192	hsa-miR-92a	CLIP-seq
MIRT1025193	hsa-miR-92b	CLIP-seq
MIRT2540723	hsa-miR-93	CLIP-seq

Show/Hide all (18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004342	Function	Glucosamine-6-phosphate deaminase activity	IBA
GO:0004342	Function	Glucosamine-6-phosphate deaminase activity	IDA	12616532
GO:0004342	Function	Glucosamine-6-phosphate deaminase activity	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 29892012, 32296183, 33961781
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005975	Process	Carbohydrate metabolic process	IEA
GO:0006043	Process	Glucosamine catabolic process	IBA
GO:0006044	Process	N-acetylglucosamine metabolic process	IEA
GO:0006046	Process	N-acetylglucosamine catabolic process	IBA
GO:0006048	Process	UDP-N-acetylglucosamine biosynthetic process	IEA
GO:0006048	Process	UDP-N-acetylglucosamine biosynthetic process	IMP	26887390
GO:0016787	Function	Hydrolase activity	IEA
GO:0016853	Function	Isomerase activity	IEA
GO:0019262	Process	N-acetylneuraminate catabolic process	IBA
GO:0042802	Function	Identical protein binding	IBA

MIM	HGNC	e!Ensembl
613222	21526	ENSG00000163281

Q8TDQ7

Protein name

Glucosamine-6-phosphate deaminase 2 (GlcN6P deaminase 2) (EC 3.5.99.6) (Glucosamine-6-phosphate isomerase 2) (Glucosamine-6-phosphate isomerase SB52)

Protein function

Catalyzes the reversible conversion of alpha-D-glucosamine 6-phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) bios

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01182	Glucosamine_iso	7 → 237	Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous, with highest expression detected in testis, ovary, placenta, and heart. {ECO:0000269|PubMed:12616532}.

Sequence

MRLVILDNYDLASEWAAKYICNRIIQFKPGQDRYFTLGLPTGSTPLGCYKKLIEYHKNGH
LSFKYVKTFNMDEYVGLPRNHPESYHSYMWNNFFKHIDIDPNNAHILDGNAADLQAECDA
FENKIKEAGGIDLFVGGIGPDGHIAFNEPGSSLVSRTRLKTLAMDTILANAKYFDGDLSK
VPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTIFVCD
EDATLELRVKTVKYFKGLMHVHNKLVDPLFSMKDGN

Sequence length

276

Interactions

View interactions

	KEGG		Reactome
	Amino sugar and nucleotide sugar metabolism Metabolic pathways		Glycolysis

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
BODY WEIGHT	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INSOMNIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBESITY	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (17)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Alzheimer Disease	Alzheimer disease	Pubtator	30342273	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Asthma	Asthma	BEFREE	20816195, 26504195		★★★★★ ★☆☆☆☆ Found in Text Mining only
Asthma	Asthma	Pubtator	20816195	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cardiovascular Diseases	Cardiovascular Diseases	BEFREE	19910641		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cardiovascular Diseases	Cardiovascular disease	Pubtator	19910641	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Diabetes mellitus, type 2	Pubtator	25093408, 30816286, 31167208	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	25093408, 30816286		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypertensive disease	Hypertension	BEFREE	23588626		★★★★★ ★☆☆☆☆ Found in Text Mining only
Metabolic Syndrome X	Metabolic Syndrome	BEFREE	21147891, 24269186		★★★★★ ★☆☆☆☆ Found in Text Mining only
Niemann-Pick Disease, Type C1	Sphingomyelinase deficiency	BEFREE	19851340		★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	CTD_human_DG	19079261		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Obesity	Obesity	Pubtator	19164386, 19910641, 20843981, 21779088, 23349760, 23375129, 23408508, 23950976, 25093408, 25890290, 27421018, 31167208, 31936053, 32228543, 33299884, 37709841 View all (1 more)	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Obesity	Obesity	BEFREE	20215397, 20843981, 21147891, 21796137, 22083549, 23375129, 23424664, 24528214, 25093408, 25890290, 26263223, 31467530		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Obesity Abdominal	Obesity	Pubtator	23424664	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	BEFREE	30342273		★★★★★ ★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	Pubtator	30342273	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pediatric Obesity	Childhood obesity	BEFREE	30816286		★★★★★ ★☆☆☆☆ Found in Text Mining only

GNPDA2 (glucosamine-6-phosphate deaminase 2)