Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	132724
Gene name	Transmembrane serine protease 11B
Gene symbol	TMPRSS11B
Synonyms (NCBI Gene)	HATL5
Chromosome	4
Chromosome location	4q13.2

173

Show/Hide all (173)

miRTarBase ID	miRNA	Experiments	Reference
MIRT718320	hsa-miR-6845-3p	HITS-CLIP	19536157
MIRT718319	hsa-miR-942-5p	HITS-CLIP	19536157
MIRT718318	hsa-miR-6873-3p	HITS-CLIP	19536157
MIRT718317	hsa-miR-4768-5p	HITS-CLIP	19536157
MIRT718316	hsa-miR-6833-3p	HITS-CLIP	19536157
MIRT718315	hsa-miR-6875-3p	HITS-CLIP	19536157
MIRT718314	hsa-miR-4659a-3p	HITS-CLIP	19536157
MIRT718313	hsa-miR-4659b-3p	HITS-CLIP	19536157
MIRT718312	hsa-miR-6809-3p	HITS-CLIP	19536157
MIRT718311	hsa-miR-6830-3p	HITS-CLIP	19536157
MIRT718320	hsa-miR-6845-3p	HITS-CLIP	19536157
MIRT718319	hsa-miR-942-5p	HITS-CLIP	19536157
MIRT718318	hsa-miR-6873-3p	HITS-CLIP	19536157
MIRT718317	hsa-miR-4768-5p	HITS-CLIP	19536157
MIRT718316	hsa-miR-6833-3p	HITS-CLIP	19536157
MIRT718315	hsa-miR-6875-3p	HITS-CLIP	19536157
MIRT718314	hsa-miR-4659a-3p	HITS-CLIP	19536157
MIRT718313	hsa-miR-4659b-3p	HITS-CLIP	19536157
MIRT718312	hsa-miR-6809-3p	HITS-CLIP	19536157
MIRT718311	hsa-miR-6830-3p	HITS-CLIP	19536157
MIRT1440861	hsa-miR-106a	CLIP-seq
MIRT1440862	hsa-miR-106b	CLIP-seq
MIRT1440863	hsa-miR-1182	CLIP-seq
MIRT1440864	hsa-miR-1234	CLIP-seq
MIRT1440865	hsa-miR-1267	CLIP-seq
MIRT1440866	hsa-miR-129-5p	CLIP-seq
MIRT1440867	hsa-miR-140-3p	CLIP-seq
MIRT1440868	hsa-miR-155	CLIP-seq
MIRT1440869	hsa-miR-17	CLIP-seq
MIRT1440870	hsa-miR-20a	CLIP-seq
MIRT1440871	hsa-miR-20b	CLIP-seq
MIRT1440872	hsa-miR-2117	CLIP-seq
MIRT1440873	hsa-miR-23a	CLIP-seq
MIRT1440874	hsa-miR-23b	CLIP-seq
MIRT1440875	hsa-miR-23c	CLIP-seq
MIRT1440876	hsa-miR-302a	CLIP-seq
MIRT1440877	hsa-miR-302b	CLIP-seq
MIRT1440878	hsa-miR-302c	CLIP-seq
MIRT1440879	hsa-miR-302d	CLIP-seq
MIRT1440880	hsa-miR-302e	CLIP-seq
MIRT1440881	hsa-miR-3148	CLIP-seq
MIRT1440882	hsa-miR-3159	CLIP-seq
MIRT1440883	hsa-miR-3647-3p	CLIP-seq
MIRT1440884	hsa-miR-365	CLIP-seq
MIRT1440885	hsa-miR-3664-5p	CLIP-seq
MIRT1440886	hsa-miR-3672	CLIP-seq
MIRT1440887	hsa-miR-3674	CLIP-seq
MIRT1440888	hsa-miR-370	CLIP-seq
MIRT1440889	hsa-miR-371-5p	CLIP-seq
MIRT1440890	hsa-miR-371b-5p	CLIP-seq
MIRT1440891	hsa-miR-372	CLIP-seq
MIRT1440892	hsa-miR-373	CLIP-seq
MIRT1440893	hsa-miR-378g	CLIP-seq
MIRT1440894	hsa-miR-3973	CLIP-seq
MIRT1440895	hsa-miR-3978	CLIP-seq
MIRT1440896	hsa-miR-4273	CLIP-seq
MIRT1440897	hsa-miR-4437	CLIP-seq
MIRT1440898	hsa-miR-4438	CLIP-seq
MIRT1440899	hsa-miR-4639-3p	CLIP-seq
MIRT1440900	hsa-miR-4674	CLIP-seq
MIRT1440901	hsa-miR-4714-3p	CLIP-seq
MIRT1440902	hsa-miR-4731-5p	CLIP-seq
MIRT1440903	hsa-miR-4732-5p	CLIP-seq
MIRT1440904	hsa-miR-4757-5p	CLIP-seq
MIRT1440905	hsa-miR-5095	CLIP-seq
MIRT1440906	hsa-miR-519d	CLIP-seq
MIRT1440907	hsa-miR-520a-3p	CLIP-seq
MIRT1440908	hsa-miR-520b	CLIP-seq
MIRT1440909	hsa-miR-520c-3p	CLIP-seq
MIRT1440910	hsa-miR-520d-3p	CLIP-seq
MIRT1440911	hsa-miR-520d-5p	CLIP-seq
MIRT1440912	hsa-miR-520e	CLIP-seq
MIRT1440913	hsa-miR-520g	CLIP-seq
MIRT1440914	hsa-miR-520h	CLIP-seq
MIRT1440915	hsa-miR-524-5p	CLIP-seq
MIRT1440916	hsa-miR-532-5p	CLIP-seq
MIRT1440917	hsa-miR-93	CLIP-seq
MIRT1440918	hsa-miR-944	CLIP-seq
MIRT1440863	hsa-miR-1182	CLIP-seq
MIRT2131990	hsa-miR-122	CLIP-seq
MIRT2131991	hsa-miR-1248	CLIP-seq
MIRT1440865	hsa-miR-1267	CLIP-seq
MIRT1440866	hsa-miR-129-5p	CLIP-seq
MIRT1440868	hsa-miR-155	CLIP-seq
MIRT2131992	hsa-miR-2276	CLIP-seq
MIRT2131993	hsa-miR-3135	CLIP-seq
MIRT2131994	hsa-miR-3135b	CLIP-seq
MIRT1440884	hsa-miR-365	CLIP-seq
MIRT2131995	hsa-miR-3652	CLIP-seq
MIRT1440885	hsa-miR-3664-5p	CLIP-seq
MIRT1440886	hsa-miR-3672	CLIP-seq
MIRT1440893	hsa-miR-378g	CLIP-seq
MIRT2131996	hsa-miR-4328	CLIP-seq
MIRT2131997	hsa-miR-4423-5p	CLIP-seq
MIRT2131998	hsa-miR-4430	CLIP-seq
MIRT1440897	hsa-miR-4437	CLIP-seq
MIRT1440899	hsa-miR-4639-3p	CLIP-seq
MIRT1440900	hsa-miR-4674	CLIP-seq
MIRT2131999	hsa-miR-4696	CLIP-seq
MIRT2132000	hsa-miR-4735-5p	CLIP-seq
MIRT2132001	hsa-miR-4775	CLIP-seq
MIRT2132002	hsa-miR-513a-3p	CLIP-seq
MIRT1440916	hsa-miR-532-5p	CLIP-seq
MIRT2132003	hsa-miR-590-3p	CLIP-seq
MIRT2132004	hsa-miR-942	CLIP-seq
MIRT1440863	hsa-miR-1182	CLIP-seq
MIRT2131990	hsa-miR-122	CLIP-seq
MIRT2353141	hsa-miR-1224-3p	CLIP-seq
MIRT2353142	hsa-miR-1260	CLIP-seq
MIRT2353143	hsa-miR-1260b	CLIP-seq
MIRT1440865	hsa-miR-1267	CLIP-seq
MIRT2353144	hsa-miR-1280	CLIP-seq
MIRT1440866	hsa-miR-129-5p	CLIP-seq
MIRT2131994	hsa-miR-3135b	CLIP-seq
MIRT2353145	hsa-miR-3140-5p	CLIP-seq
MIRT2131995	hsa-miR-3652	CLIP-seq
MIRT1440885	hsa-miR-3664-5p	CLIP-seq
MIRT1440886	hsa-miR-3672	CLIP-seq
MIRT2131997	hsa-miR-4423-5p	CLIP-seq
MIRT2353146	hsa-miR-4427	CLIP-seq
MIRT2131998	hsa-miR-4430	CLIP-seq
MIRT1440899	hsa-miR-4639-3p	CLIP-seq
MIRT2353147	hsa-miR-532-3p	CLIP-seq
MIRT1440863	hsa-miR-1182	CLIP-seq
MIRT2131990	hsa-miR-122	CLIP-seq
MIRT1440865	hsa-miR-1267	CLIP-seq
MIRT2131994	hsa-miR-3135b	CLIP-seq
MIRT2131995	hsa-miR-3652	CLIP-seq
MIRT1440885	hsa-miR-3664-5p	CLIP-seq
MIRT2131997	hsa-miR-4423-5p	CLIP-seq
MIRT2131998	hsa-miR-4430	CLIP-seq
MIRT1440899	hsa-miR-4639-3p	CLIP-seq
MIRT1440863	hsa-miR-1182	CLIP-seq
MIRT2131990	hsa-miR-122	CLIP-seq
MIRT2353141	hsa-miR-1224-3p	CLIP-seq
MIRT2131991	hsa-miR-1248	CLIP-seq
MIRT2353142	hsa-miR-1260	CLIP-seq
MIRT2353143	hsa-miR-1260b	CLIP-seq
MIRT1440865	hsa-miR-1267	CLIP-seq
MIRT2353144	hsa-miR-1280	CLIP-seq
MIRT1440866	hsa-miR-129-5p	CLIP-seq
MIRT2131993	hsa-miR-3135	CLIP-seq
MIRT2131994	hsa-miR-3135b	CLIP-seq
MIRT2353145	hsa-miR-3140-5p	CLIP-seq
MIRT2646806	hsa-miR-3149	CLIP-seq
MIRT2646807	hsa-miR-3199	CLIP-seq
MIRT2646808	hsa-miR-3614-3p	CLIP-seq
MIRT2131995	hsa-miR-3652	CLIP-seq
MIRT1440885	hsa-miR-3664-5p	CLIP-seq
MIRT2131997	hsa-miR-4423-5p	CLIP-seq
MIRT2353146	hsa-miR-4427	CLIP-seq
MIRT2131998	hsa-miR-4430	CLIP-seq
MIRT1440899	hsa-miR-4639-3p	CLIP-seq
MIRT2132000	hsa-miR-4735-5p	CLIP-seq
MIRT2132001	hsa-miR-4775	CLIP-seq
MIRT2353147	hsa-miR-532-3p	CLIP-seq
MIRT2132003	hsa-miR-590-3p	CLIP-seq
MIRT2132004	hsa-miR-942	CLIP-seq
MIRT1440863	hsa-miR-1182	CLIP-seq
MIRT2131990	hsa-miR-122	CLIP-seq
MIRT1440865	hsa-miR-1267	CLIP-seq
MIRT1440866	hsa-miR-129-5p	CLIP-seq
MIRT2131993	hsa-miR-3135	CLIP-seq
MIRT2131994	hsa-miR-3135b	CLIP-seq
MIRT2646806	hsa-miR-3149	CLIP-seq
MIRT2131995	hsa-miR-3652	CLIP-seq
MIRT1440885	hsa-miR-3664-5p	CLIP-seq
MIRT2131997	hsa-miR-4423-5p	CLIP-seq
MIRT2131998	hsa-miR-4430	CLIP-seq
MIRT1440899	hsa-miR-4639-3p	CLIP-seq
MIRT2132000	hsa-miR-4735-5p	CLIP-seq
MIRT2132001	hsa-miR-4775	CLIP-seq
MIRT2132003	hsa-miR-590-3p	CLIP-seq

Show/Hide all (13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004252	Function	Serine-type endopeptidase activity	IEA
GO:0005576	Component	Extracellular region	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	24498351
GO:0005886	Component	Plasma membrane	IEA
GO:0006508	Process	Proteolysis	IEA
GO:0008233	Function	Peptidase activity	IEA
GO:0008236	Function	Serine-type peptidase activity	IBA
GO:0008236	Function	Serine-type peptidase activity	IDA	24498351
GO:0008236	Function	Serine-type peptidase activity	IEA
GO:0016020	Component	Membrane	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0070062	Component	Extracellular exosome	HDA	19199708

MIM	HGNC	e!Ensembl
HGNC	N/A	HGNC

Q86T26

Protein name

Transmembrane protease serine 11B (EC 3.4.21.-) (Airway trypsin-like protease 5)

Protein function

Serine protease.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01390	SEA	45 → 148	SEA domain	Family
PF00089	Trypsin	185 → 410	Trypsin	Domain

Sequence

MYRHGISSQRSWPLWTTIFIFLGVAAILGVTIGLLVHFLAVEKTYYYQGDFHISGVTYND
NCENAASQASTNLSKDIETKMLNAFQNSSIYKEYVKSEVIKLLPNANGSNVQLQLKFKFP
PAEGVSMRTKIKAKLHQMLKNNMASWNAVPASIKLMEISKAASEMLTNNCCGRQVANSII
TGNKIVNGKSSLEGAWPWQASMQWKGRHYCGASLISSRWLLSAAHCFAKKNNSKDWTVNF
GIVVNKPYMTRKVQNIIFHENYSSPGLHDDIALVQLAEEVSFTEYIRKICLPEAKMKLSE
NDNVVVTGWGTLYMNGSFPVILQEDFLKIIDNKICNASYAYSGFVTDTMLCAGFMSGEAD
ACQNDSGGPLAYPDSRNIWHLVGIVSWGDGCGKKNKPGVYTRVTSYRNWITSKTGL

Sequence length

416

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
OBESITY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
VENOUS THROMBOEMBOLISM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (6)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Carcinogenesis	Carcinogenesis	Pubtator	30463017	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	30463017		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Squamous Cell	Squamous cell carcinoma	Pubtator	30463017	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	30463017	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	30463017		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	30463017		★★★★★ ★☆☆☆☆ Found in Text Mining only

TMPRSS11B (transmembrane serine protease 11B)