PABPC4L (poly(A) binding protein cytoplasmic 4 like)

Gene

• Entrez ID: 132430
• Gene name: Poly(A) binding protein cytoplasmic 4 like
• Gene symbol: PABPC4L
• Synonyms (NCBI Gene): -
• Chromosome: 4
• Chromosome location: 4q28.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT563102	hsa-miR-4282	PAR-CLIP	20371350
MIRT309253	hsa-miR-455-5p	PAR-CLIP	20371350
MIRT563101	hsa-miR-16-2-3p	PAR-CLIP	20371350
MIRT563100	hsa-miR-195-3p	PAR-CLIP	20371350
MIRT563099	hsa-miR-2682-3p	PAR-CLIP	20371350
MIRT563098	hsa-miR-6781-3p	PAR-CLIP	20371350
MIRT563097	hsa-miR-19a-3p	PAR-CLIP	20371350
MIRT563096	hsa-miR-19b-3p	PAR-CLIP	20371350
MIRT563095	hsa-miR-1271-3p	PAR-CLIP	20371350
MIRT563094	hsa-miR-550a-3-5p	PAR-CLIP	20371350
MIRT563093	hsa-miR-550a-5p	PAR-CLIP	20371350
MIRT563092	hsa-miR-550b-2-5p	PAR-CLIP	20371350
MIRT441559	hsa-miR-548e-5p	PAR-CLIP	22100165
MIRT441558	hsa-miR-4803	PAR-CLIP	22100165
MIRT563102	hsa-miR-4282	PAR-CLIP	20371350
MIRT309253	hsa-miR-455-5p	PAR-CLIP	20371350
MIRT563101	hsa-miR-16-2-3p	PAR-CLIP	20371350
MIRT563100	hsa-miR-195-3p	PAR-CLIP	20371350
MIRT563099	hsa-miR-2682-3p	PAR-CLIP	20371350
MIRT563098	hsa-miR-6781-3p	PAR-CLIP	20371350
MIRT563097	hsa-miR-19a-3p	PAR-CLIP	20371350
MIRT563096	hsa-miR-19b-3p	PAR-CLIP	20371350
MIRT563095	hsa-miR-1271-3p	PAR-CLIP	20371350
MIRT563094	hsa-miR-550a-3-5p	PAR-CLIP	20371350
MIRT563093	hsa-miR-550a-5p	PAR-CLIP	20371350
MIRT563092	hsa-miR-550b-2-5p	PAR-CLIP	20371350
MIRT441559	hsa-miR-548e-5p	PAR-CLIP	22100165
MIRT441558	hsa-miR-4803	PAR-CLIP	22100165
MIRT1209592	hsa-miR-105	CLIP-seq
MIRT1209593	hsa-miR-1224-3p	CLIP-seq
MIRT1209594	hsa-miR-1260	CLIP-seq
MIRT1209595	hsa-miR-1260b	CLIP-seq
MIRT1209596	hsa-miR-1280	CLIP-seq
MIRT1209597	hsa-miR-1287	CLIP-seq
MIRT1209598	hsa-miR-145	CLIP-seq
MIRT1209599	hsa-miR-150	CLIP-seq
MIRT1209600	hsa-miR-186	CLIP-seq
MIRT1209601	hsa-miR-1911	CLIP-seq
MIRT1209602	hsa-miR-199a-3p	CLIP-seq
MIRT1209603	hsa-miR-199b-3p	CLIP-seq
MIRT1209604	hsa-miR-19a	CLIP-seq
MIRT1209605	hsa-miR-19b	CLIP-seq
MIRT1209606	hsa-miR-24	CLIP-seq
MIRT1209607	hsa-miR-3120-3p	CLIP-seq
MIRT1209608	hsa-miR-3121-3p	CLIP-seq
MIRT1209609	hsa-miR-3129-5p	CLIP-seq
MIRT1209610	hsa-miR-3135b	CLIP-seq
MIRT1209611	hsa-miR-3154	CLIP-seq
MIRT1209612	hsa-miR-3158-5p	CLIP-seq
MIRT1209613	hsa-miR-3180-5p	CLIP-seq
MIRT1209614	hsa-miR-330-3p	CLIP-seq
MIRT1209615	hsa-miR-34c-3p	CLIP-seq
MIRT1209616	hsa-miR-3647-3p	CLIP-seq
MIRT1209617	hsa-miR-3653	CLIP-seq
MIRT1209618	hsa-miR-3662	CLIP-seq
MIRT1209619	hsa-miR-3668	CLIP-seq
MIRT1209620	hsa-miR-370	CLIP-seq
MIRT1209621	hsa-miR-3714	CLIP-seq
MIRT1209622	hsa-miR-374c	CLIP-seq
MIRT1209623	hsa-miR-3910	CLIP-seq
MIRT1209624	hsa-miR-3913-3p	CLIP-seq
MIRT1209625	hsa-miR-3922-5p	CLIP-seq
MIRT1209626	hsa-miR-3978	CLIP-seq
MIRT1209627	hsa-miR-410	CLIP-seq
MIRT1209628	hsa-miR-4269	CLIP-seq
MIRT1209629	hsa-miR-4284	CLIP-seq
MIRT1209630	hsa-miR-4428	CLIP-seq
MIRT1209631	hsa-miR-4461	CLIP-seq
MIRT1209632	hsa-miR-4514	CLIP-seq
MIRT1209633	hsa-miR-4517	CLIP-seq
MIRT1209634	hsa-miR-4645-5p	CLIP-seq
MIRT1209635	hsa-miR-4661-5p	CLIP-seq
MIRT1209636	hsa-miR-4662a-3p	CLIP-seq
MIRT1209637	hsa-miR-4668-5p	CLIP-seq
MIRT1209638	hsa-miR-4673	CLIP-seq
MIRT1209639	hsa-miR-4692	CLIP-seq
MIRT1209640	hsa-miR-4713-5p	CLIP-seq
MIRT1209641	hsa-miR-4716-3p	CLIP-seq
MIRT1209642	hsa-miR-4732-5p	CLIP-seq
MIRT1209643	hsa-miR-4742-5p	CLIP-seq
MIRT1209644	hsa-miR-4753-5p	CLIP-seq
MIRT1209645	hsa-miR-4755-3p	CLIP-seq
MIRT1209646	hsa-miR-4756-3p	CLIP-seq
MIRT1209647	hsa-miR-489	CLIP-seq
MIRT1209648	hsa-miR-511	CLIP-seq
MIRT1209649	hsa-miR-518a-5p	CLIP-seq
MIRT1209650	hsa-miR-527	CLIP-seq
MIRT1209651	hsa-miR-532-3p	CLIP-seq
MIRT1209652	hsa-miR-545	CLIP-seq
MIRT1209653	hsa-miR-548c-3p	CLIP-seq
MIRT1209654	hsa-miR-548m	CLIP-seq
MIRT1209655	hsa-miR-550a	CLIP-seq
MIRT1209656	hsa-miR-576-3p	CLIP-seq
MIRT1209657	hsa-miR-579	CLIP-seq
MIRT1209658	hsa-miR-580	CLIP-seq
MIRT1209659	hsa-miR-625	CLIP-seq
MIRT1209660	hsa-miR-655	CLIP-seq
MIRT1209661	hsa-miR-875-3p	CLIP-seq
MIRT1209662	hsa-miR-936	CLIP-seq
MIRT2060122	hsa-miR-147	CLIP-seq
MIRT2060123	hsa-miR-338-5p	CLIP-seq
MIRT1209618	hsa-miR-3662	CLIP-seq
MIRT2060124	hsa-miR-3681	CLIP-seq
MIRT2060125	hsa-miR-3688-5p	CLIP-seq
MIRT1209621	hsa-miR-3714	CLIP-seq
MIRT2060126	hsa-miR-376a	CLIP-seq
MIRT2060127	hsa-miR-376b	CLIP-seq
MIRT2060128	hsa-miR-3911	CLIP-seq
MIRT1209625	hsa-miR-3922-5p	CLIP-seq
MIRT2060129	hsa-miR-4264	CLIP-seq
MIRT1209628	hsa-miR-4269	CLIP-seq
MIRT1209632	hsa-miR-4514	CLIP-seq
MIRT2060130	hsa-miR-4666-5p	CLIP-seq
MIRT2060131	hsa-miR-4672	CLIP-seq
MIRT1209639	hsa-miR-4692	CLIP-seq
MIRT1209643	hsa-miR-4742-5p	CLIP-seq
MIRT1209646	hsa-miR-4756-3p	CLIP-seq
MIRT2060132	hsa-miR-4797-3p	CLIP-seq
MIRT1209647	hsa-miR-489	CLIP-seq
MIRT2060133	hsa-miR-577	CLIP-seq
MIRT2060134	hsa-miR-606	CLIP-seq
MIRT2060135	hsa-miR-644	CLIP-seq
MIRT2060136	hsa-miR-922	CLIP-seq
MIRT2392036	hsa-miR-432	CLIP-seq
MIRT2392037	hsa-miR-548ac	CLIP-seq
MIRT2392038	hsa-miR-548d-3p	CLIP-seq
MIRT2392039	hsa-miR-548z	CLIP-seq
MIRT2392040	hsa-miR-578	CLIP-seq
MIRT1209604	hsa-miR-19a	CLIP-seq
MIRT1209605	hsa-miR-19b	CLIP-seq
MIRT2455794	hsa-miR-4698	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	IEA
GO:0003730	Function	MRNA 3'-UTR binding	IBA
GO:0005634	Component	Nucleus	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0008143	Function	Poly(A) binding	IBA
GO:0008266	Function	Poly(U) RNA binding	IBA
GO:0010494	Component	Cytoplasmic stress granule	IBA
GO:0060255	Process	Regulation of macromolecule metabolic process	IEA
GO:0080090	Process	Regulation of primary metabolic process	IEA
GO:1990904	Component	Ribonucleoprotein complex	IBA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: P0CB38
• Protein name: Polyadenylate-binding protein 4-like (PABP-4-like) (Poly(A)-binding protein 4-like)
• Protein function: May bind RNA.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00076	RRM_1	12 → 82	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain
  PF00076	RRM_1	100 → 167	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain
  PF00076	RRM_1	192 → 260	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain
  PF00076	RRM_1	295 → 363	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain

• Sequence:

  MNVAAKYRMASLYVGDLHADVTEDLLFRKFSTVGPVLSIRICRDQVTRRSLGYAYVNFLQ
  LADAQKALDTMNFDIIKGKSIRLMWSQRDAYLRRSGIGNVFIKNLDKSIDNKTLYEHFSA
  FGKILSSKVMSDDQGSKGYAFVHFQNQSAADRAIEEMNGKLLKGCKVFVGRFKNRKDREA
  ELRSKASEFTNVYIKNFGGDMDDERLKDVFSKYGKTLSVKVMTDSSGKSKGFGFVSFDSH
  EAAKKAVEEMNGRDINGQLIFVGRAQKKVERQAELKQMFEQLKRERIRGCQGVKLYIKNL
  DDTIDDEKLRNEFSSFGSISRVKVMQEEGQSKGFGLICFSSPEDATKAMTEMNGRILGSK
  PLSIALAQRH

• Sequence length: 370

Pathways

KEGG:

mRNA surveillance pathway
RNA degradation

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
HYPERTENSIVE NEPHROPATHY	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INSOMNIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TREATMENT-RESISTANT HYPERTENSION	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
VENOUS THROMBOEMBOLISM	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations