PPM1M (protein phosphatase, Mg2+/Mn2+ dependent 1M)

Gene

• Entrez ID: 132160
• Gene name: Protein phosphatase, Mg2+/Mn2+ dependent 1M
• Gene symbol: PPM1M
• Synonyms (NCBI Gene): PP2C-eta, PP2CE, PP2Ceta
• Chromosome: 3
• Chromosome location: 3p21.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT037613	hsa-miR-744-5p	CLASH	23622248
MIRT738978	hsa-miR-3174	CLIP-seq
MIRT738976	hsa-miR-4486	CLIP-seq
MIRT738977	hsa-miR-921	CLIP-seq
MIRT1254713	hsa-miR-154	CLIP-seq
MIRT1254714	hsa-miR-224	CLIP-seq
MIRT1254715	hsa-miR-3919	CLIP-seq
MIRT1254716	hsa-miR-4639-3p	CLIP-seq
MIRT1254717	hsa-miR-4727-5p	CLIP-seq
MIRT1254718	hsa-miR-4769-3p	CLIP-seq
MIRT1254719	hsa-miR-668	CLIP-seq
MIRT738978	hsa-miR-3174	CLIP-seq
MIRT738976	hsa-miR-4486	CLIP-seq
MIRT738977	hsa-miR-921	CLIP-seq
MIRT2075158	hsa-miR-4675	CLIP-seq
MIRT2075159	hsa-miR-4741	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004721	Function	Phosphoprotein phosphatase activity	IEA
GO:0004722	Function	Protein serine/threonine phosphatase activity	IEA
GO:0004741	Function	[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	ISS
GO:0005739	Component	Mitochondrion	IBA
GO:0006470	Process	Protein dephosphorylation	ISS
GO:0016787	Function	Hydrolase activity	IEA
GO:0030145	Function	Manganese ion binding	ISS
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 608979
• HGNC: 26506
• e!Ensembl: ENSG00000164088

Protein

• UniProt ID: Q96MI6
• Protein name: Protein phosphatase 1M (EC 3.1.3.16) (Protein phosphatase 2C isoform eta) (PP2C-eta) (PP2CE)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00481	PP2C	8 → 119	Protein phosphatase 2C	Family
  PF00481	PP2C	132 → 254	Protein phosphatase 2C	Family

• Sequence:

  MHLNGRCICPSDPQFVEEKGIRAEDLVIGALESAFQECDEVIGRELEASGQMGGCTALVA
  VSLQGKLYMANAGDSRAILVRRDEIRPLSFEFTPETERQRIQQLAFVYPELLAGEFTRLE
  FPRRLKGDDLGQKVLFRDHHMSGWSYKRVEKSDLKYPLIHGQGRQARLLGTLAVSRGLGD
  HQLRVLDTNIQLKPFLLSVPQVTVLDVDQLELQEDDVVVMATDGLWDVLSNEQVAWLVRS
  FLPGNQEDPHRYCSCWGPAWAWVGASSKPK

• Sequence length: 270

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
SCHIZOPHRENIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations