Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	131601
Gene name	Transmembrane protein adipocyte associated 1
Gene symbol	TPRA1
Synonyms (NCBI Gene)	GPR175TMEM227TPRA40
Chromosome	3
Chromosome location	3q21.3

Show/Hide all (64)

miRTarBase ID	miRNA	Experiments	Reference
MIRT022414	hsa-miR-124-3p	Microarray	18668037
MIRT1450201	hsa-miR-1224-5p	CLIP-seq
MIRT1450202	hsa-miR-1304	CLIP-seq
MIRT1450203	hsa-miR-3150b-3p	CLIP-seq
MIRT1450204	hsa-miR-3165	CLIP-seq
MIRT1450205	hsa-miR-330-3p	CLIP-seq
MIRT1450206	hsa-miR-3691-5p	CLIP-seq
MIRT1450207	hsa-miR-3915	CLIP-seq
MIRT1450208	hsa-miR-3926	CLIP-seq
MIRT1450209	hsa-miR-4689	CLIP-seq
MIRT1450210	hsa-miR-4695-5p	CLIP-seq
MIRT1450211	hsa-miR-4784	CLIP-seq
MIRT2355875	hsa-miR-1292	CLIP-seq
MIRT2355876	hsa-miR-2278	CLIP-seq
MIRT2355877	hsa-miR-3202	CLIP-seq
MIRT2355878	hsa-miR-3665	CLIP-seq
MIRT2355879	hsa-miR-4468	CLIP-seq
MIRT2355880	hsa-miR-4471	CLIP-seq
MIRT2355881	hsa-miR-4712-3p	CLIP-seq
MIRT2355882	hsa-miR-541	CLIP-seq
MIRT2355883	hsa-miR-654-5p	CLIP-seq
MIRT2649375	hsa-miR-1273f	CLIP-seq
MIRT2355876	hsa-miR-2278	CLIP-seq
MIRT2649376	hsa-miR-2355-5p	CLIP-seq
MIRT2649377	hsa-miR-3179	CLIP-seq
MIRT2355877	hsa-miR-3202	CLIP-seq
MIRT2355878	hsa-miR-3665	CLIP-seq
MIRT2649378	hsa-miR-4420	CLIP-seq
MIRT2355879	hsa-miR-4468	CLIP-seq
MIRT2649379	hsa-miR-4470	CLIP-seq
MIRT2355881	hsa-miR-4712-3p	CLIP-seq
MIRT2649380	hsa-miR-4747-5p	CLIP-seq
MIRT2649381	hsa-miR-4756-3p	CLIP-seq
MIRT2649382	hsa-miR-4779	CLIP-seq
MIRT2649383	hsa-miR-668	CLIP-seq
MIRT2649384	hsa-miR-765	CLIP-seq
MIRT2693983	hsa-miR-1225-3p	CLIP-seq
MIRT2649375	hsa-miR-1273f	CLIP-seq
MIRT2693984	hsa-miR-1321	CLIP-seq
MIRT2693985	hsa-miR-1915	CLIP-seq
MIRT2355876	hsa-miR-2278	CLIP-seq
MIRT2649376	hsa-miR-2355-5p	CLIP-seq
MIRT2649377	hsa-miR-3179	CLIP-seq
MIRT2355877	hsa-miR-3202	CLIP-seq
MIRT2355878	hsa-miR-3665	CLIP-seq
MIRT2693986	hsa-miR-3689a-3p	CLIP-seq
MIRT2693987	hsa-miR-3689c	CLIP-seq
MIRT2693988	hsa-miR-4270	CLIP-seq
MIRT2693989	hsa-miR-4300	CLIP-seq
MIRT2693990	hsa-miR-4323	CLIP-seq
MIRT2649378	hsa-miR-4420	CLIP-seq
MIRT2693991	hsa-miR-4441	CLIP-seq
MIRT2693992	hsa-miR-4450	CLIP-seq
MIRT2355879	hsa-miR-4468	CLIP-seq
MIRT2649379	hsa-miR-4470	CLIP-seq
MIRT2355881	hsa-miR-4712-3p	CLIP-seq
MIRT2693993	hsa-miR-4739	CLIP-seq
MIRT2649380	hsa-miR-4747-5p	CLIP-seq
MIRT2649381	hsa-miR-4756-3p	CLIP-seq
MIRT2693994	hsa-miR-4756-5p	CLIP-seq
MIRT2649382	hsa-miR-4779	CLIP-seq
MIRT2649383	hsa-miR-668	CLIP-seq
MIRT2649384	hsa-miR-765	CLIP-seq
MIRT2693995	hsa-miR-920	CLIP-seq

Show/Hide all (10)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004930	Function	G protein-coupled receptor activity	IBA
GO:0004930	Function	G protein-coupled receptor activity	TAS	10342878
GO:0005515	Function	Protein binding	IPI	25464930, 32296183
GO:0005886	Component	Plasma membrane	IBA
GO:0006629	Process	Lipid metabolic process	TAS	10342878
GO:0007186	Process	G protein-coupled receptor signaling pathway	IBA
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	TAS	10342878
GO:0040016	Process	Embryonic cleavage	IEA
GO:1901991	Process	Negative regulation of mitotic cell cycle phase transition	IEA

MIM	HGNC	e!Ensembl
608336	30413	ENSG00000163870

Q86W33

Protein name

Transmembrane protein adipocyte-associated 1 (Integral membrane protein GPR175) (Transmembrane protein 227)

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF10160	Tmemb_40	39 → 314	Predicted membrane protein	Family

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous, with higher levels in heart, placenta and kidney. {ECO:0000269|PubMed:10342878}.

Sequence

MDTLEEVTWANGSTALPPPLAPNISVPHRCLLLLYEDIGTSRVRYWDLLLLIPNVLFLIF
LLWKLPSARAKIRITSSPIFITFYILVFVVALVGIARAVVSMTVSTSNAATVADKILWEI
TRFFLLAIELSVIILGLAFGHLESKSSIKRVLAITTVLSLAYSVTQGTLEILYPDAHLSA
EDFNIYGHGGRQFWLVSSCFFFLVYSLVVILPKTPLKERISLPSRRSFYVYAGILALLNL
LQGLGSVLLCFDIIEGLCCVDATTFLYFSFFAPLIYVAFLRGFFGSEPKILFSYKCQVDE
TEEPDVHLPQPYAVARREGLEAAGAAGASAASYSSTQFDSAGGVAYLDDIASMPCHTGSI
NSTDSERWKAINA

Sequence length

373

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
PARKINSON DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RHEUMATOID ARTHRITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (1)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Asthma	Asthma	Pubtator	30669148	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

TPRA1 (transmembrane protein adipocyte associated 1)