LYPD6B (LY6/PLAUR domain containing 6B)

Gene

• Entrez ID: 130576
• Gene name: LY6/PLAUR domain containing 6B
• Gene symbol: LYPD6B
• Synonyms (NCBI Gene): CT116, LYPD7
• Chromosome: 2
• Chromosome location: 2q23.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT440301	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440301	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT1123399	hsa-miR-1279	CLIP-seq
MIRT1123400	hsa-miR-1303	CLIP-seq
MIRT1123401	hsa-miR-1827	CLIP-seq
MIRT1123402	hsa-miR-2682	CLIP-seq
MIRT1123403	hsa-miR-3121-3p	CLIP-seq
MIRT1123404	hsa-miR-3173-3p	CLIP-seq
MIRT1123405	hsa-miR-3663-5p	CLIP-seq
MIRT1123406	hsa-miR-4436b-5p	CLIP-seq
MIRT1123407	hsa-miR-449c	CLIP-seq
MIRT1123408	hsa-miR-485-5p	CLIP-seq
MIRT1123409	hsa-miR-593	CLIP-seq
MIRT1123410	hsa-miR-877	CLIP-seq
MIRT2034856	hsa-miR-582-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005576	Component	Extracellular region	TAS
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0016020	Component	Membrane	IEA
GO:0030548	Function	Acetylcholine receptor regulator activity	IBA
GO:0030548	Function	Acetylcholine receptor regulator activity	IDA	26586467
GO:0030548	Function	Acetylcholine receptor regulator activity	IEA
GO:0098552	Component	Side of membrane	IEA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q8NI32
• Protein name: Ly6/PLAUR domain-containing protein 6B
• Protein function: Likely acts as a modulator of nicotinic acetylcholine receptors (nAChRs) activity (PubMed:26586467, PubMed:34631692). In vitro acts on nAChRs in a subtype- and stoichiometry-dependent manner (PubMed:26586467). Modulates specifically alpha-3(3):b
• PDB: 6ZSO
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF16975	UPAR_LY6_2	53 → 158		Domain

• Sequence:

  MLYKSSDRPAHKVSMLLLCHALAIAVVQIVIFSESWAFAKNINFYNVRPPLDPTPFPNSF
  KCFTCENAGDNYNCNRWAEDKWCPQNTQYCLTVHHFTSHGRSTSITKKCASRSECHFVGC
  HHSRDSEHTECRSCCEGMICNVELPTNHTNAVFAVMHAQRTSGSSAPTLYLPVLAWVFVL
  PLL

• Sequence length: 183

Pathways

KEGG:

Neuroactive ligand-receptor interaction

Reactome:

Post-translational modification: synthesis of GPI-anchored proteins

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
CENTRAL NERVOUS SYSTEM CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cervical cancer	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOBLASTOMA MULTIFORME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OPTIC ATROPHY	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Stomach Neoplasms	Stomach neoplasms	Pubtator	36241983	Associate	★☆☆☆☆ Found in Text Mining only