Gene Gene information from NCBI Gene database.
Entrez ID 130574
Gene name LY6/PLAUR domain containing 6
Gene symbol LYPD6
Synonyms (NCBI Gene)
-
Chromosome 2
Chromosome location 2q23.2
Summary Members of the LY6 protein family (see SLURP1; MIM 606119), such as LYPD6, have at least one 80-amino acid LU domain that contains 10 conserved cysteines with a defined disulfide-bonding pattern (Zhang et al., 2010 [PubMed 19653121]).[supplied by OMIM, Ap
miRNA miRNA information provided by mirtarbase database.
570
miRTarBase ID miRNA Experiments Reference
MIRT026569 hsa-miR-192-5p Microarray 19074876
MIRT050622 hsa-miR-20a-5p CLASH 23622248
MIRT047643 hsa-miR-10a-5p CLASH 23622248
MIRT513061 hsa-miR-548c-3p PAR-CLIP 20371350
MIRT513059 hsa-miR-4668-3p PAR-CLIP 20371350
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
23
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 27344019, 32296183
GO:0005576 Component Extracellular region IEA
GO:0005737 Component Cytoplasm IEA
GO:0005886 Component Plasma membrane IEA
GO:0007399 Process Nervous system development IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
613359 28751 ENSG00000187123
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q86Y78
Protein name Ly6/PLAUR domain-containing protein 6
Protein function Acts as a modulator of nicotinic acetylcholine receptors (nAChRs) function in the brain (PubMed:27344019, PubMed:34631692). Inhibits nicotine-induced Ca(2+) influx through nAChRs (PubMed:27344019). In vitro, specifically inhibits alpha-3:beta-4
PDB 6GBI , 6IB6
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF16975 UPAR_LY6_2 40 145 Domain
Tissue specificity TISSUE SPECIFICITY: Detected in the temporal cortex (at protein level) (PubMed:25680266). Ubiquitous (PubMed:19653121). Highly expressed in brain and heart (PubMed:19653121). {ECO:0000269|PubMed:19653121, ECO:0000269|PubMed:25680266}.
Sequence
Sequence length 171
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG 
  Neuroactive ligand-receptor interaction  
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
2
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
GILLES DE LA TOURETTE SYNDROME Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Anxiety Anxiety Disorder BEFREE 29195920
★☆☆☆☆
Found in Text Mining only
Anxiety Disorders Anxiety Disorder BEFREE 29195920
★☆☆☆☆
Found in Text Mining only
Gilles de la Tourette syndrome Tourette Syndrome BEFREE 27862604
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Tourette Syndrome Tourette syndrome Pubtator 27862604 Associate
★☆☆☆☆
Found in Text Mining only
XX males XX Males BEFREE 27862604
★☆☆☆☆
Found in Text Mining only