PLEKHH2 (pleckstrin homology, MyTH4 and FERM domain containing H2)

Gene

• Entrez ID: 130271
• Gene name: Pleckstrin homology, MyTH4 and FERM domain containing H2
• Gene symbol: PLEKHH2
• Synonyms (NCBI Gene): PLEKHH1L
• Chromosome: 2
• Chromosome location: 2p21

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018517	hsa-miR-335-5p	Microarray	18185580
MIRT023913	hsa-miR-1-3p	Microarray	18668037
MIRT045121	hsa-miR-186-5p	CLASH	23622248
MIRT719211	hsa-miR-483-3p	HITS-CLIP	19536157
MIRT719210	hsa-miR-6777-3p	HITS-CLIP	19536157
MIRT719209	hsa-miR-146a-3p	HITS-CLIP	19536157
MIRT719208	hsa-miR-4766-5p	HITS-CLIP	19536157
MIRT719211	hsa-miR-483-3p	HITS-CLIP	19536157
MIRT719210	hsa-miR-6777-3p	HITS-CLIP	19536157
MIRT719209	hsa-miR-146a-3p	HITS-CLIP	19536157
MIRT719208	hsa-miR-4766-5p	HITS-CLIP	19536157
MIRT1242265	hsa-miR-1	CLIP-seq
MIRT1242266	hsa-miR-1208	CLIP-seq
MIRT1242267	hsa-miR-1243	CLIP-seq
MIRT1242268	hsa-miR-1273e	CLIP-seq
MIRT1242269	hsa-miR-1285	CLIP-seq
MIRT1242270	hsa-miR-1304	CLIP-seq
MIRT1242271	hsa-miR-1321	CLIP-seq
MIRT1242272	hsa-miR-185	CLIP-seq
MIRT1242273	hsa-miR-2054	CLIP-seq
MIRT1242274	hsa-miR-206	CLIP-seq
MIRT1242275	hsa-miR-2114	CLIP-seq
MIRT1242276	hsa-miR-2277-3p	CLIP-seq
MIRT1242277	hsa-miR-24	CLIP-seq
MIRT1242278	hsa-miR-3122	CLIP-seq
MIRT1242279	hsa-miR-3136-5p	CLIP-seq
MIRT1242280	hsa-miR-3150b-3p	CLIP-seq
MIRT1242281	hsa-miR-3162-5p	CLIP-seq
MIRT1242282	hsa-miR-3187-5p	CLIP-seq
MIRT1242283	hsa-miR-335	CLIP-seq
MIRT1242284	hsa-miR-342-3p	CLIP-seq
MIRT1242285	hsa-miR-3616-5p	CLIP-seq
MIRT1242286	hsa-miR-3647-5p	CLIP-seq
MIRT1242287	hsa-miR-3654	CLIP-seq
MIRT1242288	hsa-miR-3658	CLIP-seq
MIRT1242289	hsa-miR-3660	CLIP-seq
MIRT1242290	hsa-miR-3662	CLIP-seq
MIRT1242291	hsa-miR-3673	CLIP-seq
MIRT1242292	hsa-miR-3689a-3p	CLIP-seq
MIRT1242293	hsa-miR-3689c	CLIP-seq
MIRT1242294	hsa-miR-3714	CLIP-seq
MIRT1242295	hsa-miR-378g	CLIP-seq
MIRT1242296	hsa-miR-3913-5p	CLIP-seq
MIRT1242297	hsa-miR-3929	CLIP-seq
MIRT1242298	hsa-miR-410	CLIP-seq
MIRT1242299	hsa-miR-4270	CLIP-seq
MIRT1242300	hsa-miR-4272	CLIP-seq
MIRT1242301	hsa-miR-4284	CLIP-seq
MIRT1242302	hsa-miR-4306	CLIP-seq
MIRT1242303	hsa-miR-4419b	CLIP-seq
MIRT1242304	hsa-miR-4421	CLIP-seq
MIRT1242305	hsa-miR-4427	CLIP-seq
MIRT1242306	hsa-miR-4433	CLIP-seq
MIRT1242307	hsa-miR-4434	CLIP-seq
MIRT1242308	hsa-miR-4439	CLIP-seq
MIRT1242309	hsa-miR-4441	CLIP-seq
MIRT1242310	hsa-miR-4478	CLIP-seq
MIRT1242311	hsa-miR-4486	CLIP-seq
MIRT1242312	hsa-miR-4504	CLIP-seq
MIRT1242313	hsa-miR-4513	CLIP-seq
MIRT1242314	hsa-miR-4516	CLIP-seq
MIRT1242315	hsa-miR-4517	CLIP-seq
MIRT1242316	hsa-miR-4526	CLIP-seq
MIRT1242317	hsa-miR-4644	CLIP-seq
MIRT1242318	hsa-miR-4662a-3p	CLIP-seq
MIRT1242319	hsa-miR-4672	CLIP-seq
MIRT1242320	hsa-miR-4680-3p	CLIP-seq
MIRT1242321	hsa-miR-4683	CLIP-seq
MIRT1242322	hsa-miR-4689	CLIP-seq
MIRT1242323	hsa-miR-4725-5p	CLIP-seq
MIRT1242324	hsa-miR-4728-5p	CLIP-seq
MIRT1242325	hsa-miR-4739	CLIP-seq
MIRT1242326	hsa-miR-4756-5p	CLIP-seq
MIRT1242327	hsa-miR-4784	CLIP-seq
MIRT1242328	hsa-miR-4786-5p	CLIP-seq
MIRT1242329	hsa-miR-4789-3p	CLIP-seq
MIRT1242330	hsa-miR-4790-3p	CLIP-seq
MIRT1242331	hsa-miR-4795-5p	CLIP-seq
MIRT1242332	hsa-miR-4802-5p	CLIP-seq
MIRT1242333	hsa-miR-485-5p	CLIP-seq
MIRT1242334	hsa-miR-488	CLIP-seq
MIRT1242335	hsa-miR-504	CLIP-seq
MIRT1242336	hsa-miR-542-3p	CLIP-seq
MIRT1242337	hsa-miR-545	CLIP-seq
MIRT1242338	hsa-miR-548ag	CLIP-seq
MIRT1242339	hsa-miR-548ai	CLIP-seq
MIRT1242340	hsa-miR-554	CLIP-seq
MIRT1242341	hsa-miR-573	CLIP-seq
MIRT1242342	hsa-miR-593	CLIP-seq
MIRT1242343	hsa-miR-612	CLIP-seq
MIRT1242344	hsa-miR-613	CLIP-seq
MIRT1242345	hsa-miR-642b	CLIP-seq
MIRT1242346	hsa-miR-661	CLIP-seq
MIRT1242347	hsa-miR-665	CLIP-seq
MIRT1242348	hsa-miR-758	CLIP-seq
MIRT1242349	hsa-miR-759	CLIP-seq
MIRT1242350	hsa-miR-765	CLIP-seq
MIRT1242351	hsa-miR-769-5p	CLIP-seq
MIRT1242268	hsa-miR-1273e	CLIP-seq
MIRT1242268	hsa-miR-1273e	CLIP-seq
MIRT1242269	hsa-miR-1285	CLIP-seq
MIRT1242270	hsa-miR-1304	CLIP-seq
MIRT1242272	hsa-miR-185	CLIP-seq
MIRT1242277	hsa-miR-24	CLIP-seq
MIRT2071388	hsa-miR-2467-5p	CLIP-seq
MIRT1242280	hsa-miR-3150b-3p	CLIP-seq
MIRT1242282	hsa-miR-3187-5p	CLIP-seq
MIRT1242284	hsa-miR-342-3p	CLIP-seq
MIRT2071389	hsa-miR-3613-3p	CLIP-seq
MIRT1242297	hsa-miR-3929	CLIP-seq
MIRT1242301	hsa-miR-4284	CLIP-seq
MIRT1242302	hsa-miR-4306	CLIP-seq
MIRT1242303	hsa-miR-4419b	CLIP-seq
MIRT1242306	hsa-miR-4433	CLIP-seq
MIRT1242310	hsa-miR-4478	CLIP-seq
MIRT2071390	hsa-miR-451b	CLIP-seq
MIRT1242317	hsa-miR-4644	CLIP-seq
MIRT1242322	hsa-miR-4689	CLIP-seq
MIRT2071391	hsa-miR-4763-5p	CLIP-seq
MIRT1242327	hsa-miR-4784	CLIP-seq
MIRT1242333	hsa-miR-485-5p	CLIP-seq
MIRT2071392	hsa-miR-564	CLIP-seq
MIRT1242343	hsa-miR-612	CLIP-seq
MIRT1242346	hsa-miR-661	CLIP-seq
MIRT1242347	hsa-miR-665	CLIP-seq
MIRT1242268	hsa-miR-1273e	CLIP-seq
MIRT1242269	hsa-miR-1285	CLIP-seq
MIRT1242270	hsa-miR-1304	CLIP-seq
MIRT2298647	hsa-miR-183	CLIP-seq
MIRT1242277	hsa-miR-24	CLIP-seq
MIRT1242278	hsa-miR-3122	CLIP-seq
MIRT1242280	hsa-miR-3150b-3p	CLIP-seq
MIRT1242282	hsa-miR-3187-5p	CLIP-seq
MIRT1242292	hsa-miR-3689a-3p	CLIP-seq
MIRT1242293	hsa-miR-3689c	CLIP-seq
MIRT1242296	hsa-miR-3913-5p	CLIP-seq
MIRT1242297	hsa-miR-3929	CLIP-seq
MIRT1242301	hsa-miR-4284	CLIP-seq
MIRT1242303	hsa-miR-4419b	CLIP-seq
MIRT1242306	hsa-miR-4433	CLIP-seq
MIRT1242310	hsa-miR-4478	CLIP-seq
MIRT2071390	hsa-miR-451b	CLIP-seq
MIRT1242324	hsa-miR-4728-5p	CLIP-seq
MIRT2071391	hsa-miR-4763-5p	CLIP-seq
MIRT1242327	hsa-miR-4784	CLIP-seq
MIRT2298648	hsa-miR-4793-3p	CLIP-seq
MIRT1242333	hsa-miR-485-5p	CLIP-seq
MIRT2298649	hsa-miR-508-5p	CLIP-seq
MIRT2071392	hsa-miR-564	CLIP-seq
MIRT1242343	hsa-miR-612	CLIP-seq
MIRT1242346	hsa-miR-661	CLIP-seq
MIRT1242347	hsa-miR-665	CLIP-seq
MIRT2298650	hsa-miR-766	CLIP-seq
MIRT2392675	hsa-miR-4307	CLIP-seq
MIRT1242265	hsa-miR-1	CLIP-seq
MIRT2595569	hsa-miR-1251	CLIP-seq
MIRT1242268	hsa-miR-1273e	CLIP-seq
MIRT1242269	hsa-miR-1285	CLIP-seq
MIRT1242270	hsa-miR-1304	CLIP-seq
MIRT1242271	hsa-miR-1321	CLIP-seq
MIRT2595570	hsa-miR-149	CLIP-seq
MIRT2595571	hsa-miR-1825	CLIP-seq
MIRT1242272	hsa-miR-185	CLIP-seq
MIRT2595572	hsa-miR-194	CLIP-seq
MIRT2595573	hsa-miR-199a-5p	CLIP-seq
MIRT2595574	hsa-miR-199b-5p	CLIP-seq
MIRT1242273	hsa-miR-2054	CLIP-seq
MIRT1242274	hsa-miR-206	CLIP-seq
MIRT2595575	hsa-miR-214	CLIP-seq
MIRT1242276	hsa-miR-2277-3p	CLIP-seq
MIRT1242277	hsa-miR-24	CLIP-seq
MIRT2595576	hsa-miR-3064-3p	CLIP-seq
MIRT2595577	hsa-miR-3064-5p	CLIP-seq
MIRT2595578	hsa-miR-3065-5p	CLIP-seq
MIRT1242278	hsa-miR-3122	CLIP-seq
MIRT2595579	hsa-miR-3129-3p	CLIP-seq
MIRT2595580	hsa-miR-3143	CLIP-seq
MIRT1242280	hsa-miR-3150b-3p	CLIP-seq
MIRT1242281	hsa-miR-3162-5p	CLIP-seq
MIRT2595581	hsa-miR-3163	CLIP-seq
MIRT1242282	hsa-miR-3187-5p	CLIP-seq
MIRT2595582	hsa-miR-323-5p	CLIP-seq
MIRT2071389	hsa-miR-3613-3p	CLIP-seq
MIRT2595583	hsa-miR-3619-5p	CLIP-seq
MIRT2595584	hsa-miR-3622b-5p	CLIP-seq
MIRT2595585	hsa-miR-3652	CLIP-seq
MIRT2595586	hsa-miR-3667-5p	CLIP-seq
MIRT2595587	hsa-miR-3672	CLIP-seq
MIRT1242292	hsa-miR-3689a-3p	CLIP-seq
MIRT1242293	hsa-miR-3689c	CLIP-seq
MIRT1242294	hsa-miR-3714	CLIP-seq
MIRT2595588	hsa-miR-371b-5p	CLIP-seq
MIRT2595589	hsa-miR-377	CLIP-seq
MIRT1242296	hsa-miR-3913-5p	CLIP-seq
MIRT2595590	hsa-miR-3914	CLIP-seq
MIRT2595591	hsa-miR-3925-3p	CLIP-seq
MIRT1242297	hsa-miR-3929	CLIP-seq
MIRT2595592	hsa-miR-3945	CLIP-seq
MIRT2595593	hsa-miR-409-5p	CLIP-seq
MIRT2595594	hsa-miR-4253	CLIP-seq
MIRT1242299	hsa-miR-4270	CLIP-seq
MIRT2595595	hsa-miR-4282	CLIP-seq
MIRT1242301	hsa-miR-4284	CLIP-seq
MIRT2595596	hsa-miR-4291	CLIP-seq
MIRT1242302	hsa-miR-4306	CLIP-seq
MIRT1242303	hsa-miR-4419b	CLIP-seq
MIRT1242304	hsa-miR-4421	CLIP-seq
MIRT2595597	hsa-miR-4430	CLIP-seq
MIRT1242306	hsa-miR-4433	CLIP-seq
MIRT1242307	hsa-miR-4434	CLIP-seq
MIRT1242309	hsa-miR-4441	CLIP-seq
MIRT2595598	hsa-miR-4477a	CLIP-seq
MIRT1242310	hsa-miR-4478	CLIP-seq
MIRT2595599	hsa-miR-4493	CLIP-seq
MIRT1242314	hsa-miR-4516	CLIP-seq
MIRT1242315	hsa-miR-4517	CLIP-seq
MIRT2071390	hsa-miR-451b	CLIP-seq
MIRT2595600	hsa-miR-4638-3p	CLIP-seq
MIRT1242317	hsa-miR-4644	CLIP-seq
MIRT1242321	hsa-miR-4683	CLIP-seq
MIRT2595601	hsa-miR-4684-5p	CLIP-seq
MIRT1242322	hsa-miR-4689	CLIP-seq
MIRT2595602	hsa-miR-4694-3p	CLIP-seq
MIRT2595603	hsa-miR-4696	CLIP-seq
MIRT1242323	hsa-miR-4725-5p	CLIP-seq
MIRT1242324	hsa-miR-4728-5p	CLIP-seq
MIRT1242325	hsa-miR-4739	CLIP-seq
MIRT1242326	hsa-miR-4756-5p	CLIP-seq
MIRT2595604	hsa-miR-4760-3p	CLIP-seq
MIRT2071391	hsa-miR-4763-5p	CLIP-seq
MIRT1242327	hsa-miR-4784	CLIP-seq
MIRT1242328	hsa-miR-4786-5p	CLIP-seq
MIRT1242329	hsa-miR-4789-3p	CLIP-seq
MIRT2595605	hsa-miR-4794	CLIP-seq
MIRT1242333	hsa-miR-485-5p	CLIP-seq
MIRT1242335	hsa-miR-504	CLIP-seq
MIRT2298649	hsa-miR-508-5p	CLIP-seq
MIRT2595606	hsa-miR-513a-3p	CLIP-seq
MIRT2595607	hsa-miR-522	CLIP-seq
MIRT2595608	hsa-miR-543	CLIP-seq
MIRT1242337	hsa-miR-545	CLIP-seq
MIRT2595609	hsa-miR-548c-3p	CLIP-seq
MIRT2595610	hsa-miR-590-3p	CLIP-seq
MIRT1242342	hsa-miR-593	CLIP-seq
MIRT1242343	hsa-miR-612	CLIP-seq
MIRT1242344	hsa-miR-613	CLIP-seq
MIRT2595611	hsa-miR-645	CLIP-seq
MIRT1242346	hsa-miR-661	CLIP-seq
MIRT1242347	hsa-miR-665	CLIP-seq
MIRT1242349	hsa-miR-759	CLIP-seq
MIRT2595612	hsa-miR-760	CLIP-seq
MIRT2595613	hsa-miR-761	CLIP-seq
MIRT1242351	hsa-miR-769-5p	CLIP-seq
MIRT2595614	hsa-miR-802	CLIP-seq
MIRT2595615	hsa-miR-873	CLIP-seq
MIRT2595616	hsa-miR-876-3p	CLIP-seq
MIRT2595617	hsa-miR-922	CLIP-seq
MIRT2595618	hsa-miR-944	CLIP-seq
MIRT1242265	hsa-miR-1	CLIP-seq
MIRT2688090	hsa-miR-1229	CLIP-seq
MIRT2595569	hsa-miR-1251	CLIP-seq
MIRT2688091	hsa-miR-1273d	CLIP-seq
MIRT1242268	hsa-miR-1273e	CLIP-seq
MIRT1242269	hsa-miR-1285	CLIP-seq
MIRT1242270	hsa-miR-1304	CLIP-seq
MIRT1242271	hsa-miR-1321	CLIP-seq
MIRT2688092	hsa-miR-140-3p	CLIP-seq
MIRT2595570	hsa-miR-149	CLIP-seq
MIRT2595571	hsa-miR-1825	CLIP-seq
MIRT1242272	hsa-miR-185	CLIP-seq
MIRT2595572	hsa-miR-194	CLIP-seq
MIRT2595573	hsa-miR-199a-5p	CLIP-seq
MIRT2595574	hsa-miR-199b-5p	CLIP-seq
MIRT1242273	hsa-miR-2054	CLIP-seq
MIRT1242274	hsa-miR-206	CLIP-seq
MIRT1242276	hsa-miR-2277-3p	CLIP-seq
MIRT1242277	hsa-miR-24	CLIP-seq
MIRT2071388	hsa-miR-2467-5p	CLIP-seq
MIRT2595577	hsa-miR-3064-5p	CLIP-seq
MIRT1242278	hsa-miR-3122	CLIP-seq
MIRT2595579	hsa-miR-3129-3p	CLIP-seq
MIRT1242280	hsa-miR-3150b-3p	CLIP-seq
MIRT2688093	hsa-miR-3160-5p	CLIP-seq
MIRT1242281	hsa-miR-3162-5p	CLIP-seq
MIRT2595581	hsa-miR-3163	CLIP-seq
MIRT2688094	hsa-miR-3182	CLIP-seq
MIRT1242282	hsa-miR-3187-5p	CLIP-seq
MIRT1242284	hsa-miR-342-3p	CLIP-seq
MIRT2688095	hsa-miR-3607-3p	CLIP-seq
MIRT2071389	hsa-miR-3613-3p	CLIP-seq
MIRT2595585	hsa-miR-3652	CLIP-seq
MIRT2595586	hsa-miR-3667-5p	CLIP-seq
MIRT2595587	hsa-miR-3672	CLIP-seq
MIRT2688096	hsa-miR-3686	CLIP-seq
MIRT1242292	hsa-miR-3689a-3p	CLIP-seq
MIRT1242293	hsa-miR-3689c	CLIP-seq
MIRT2688097	hsa-miR-370	CLIP-seq
MIRT2595588	hsa-miR-371b-5p	CLIP-seq
MIRT2595589	hsa-miR-377	CLIP-seq
MIRT1242296	hsa-miR-3913-5p	CLIP-seq
MIRT2595590	hsa-miR-3914	CLIP-seq
MIRT2595591	hsa-miR-3925-3p	CLIP-seq
MIRT1242297	hsa-miR-3929	CLIP-seq
MIRT2688098	hsa-miR-409-3p	CLIP-seq
MIRT2595593	hsa-miR-409-5p	CLIP-seq
MIRT2688099	hsa-miR-4263	CLIP-seq
MIRT1242301	hsa-miR-4284	CLIP-seq
MIRT1242302	hsa-miR-4306	CLIP-seq
MIRT1242303	hsa-miR-4419b	CLIP-seq
MIRT1242304	hsa-miR-4421	CLIP-seq
MIRT2595597	hsa-miR-4430	CLIP-seq
MIRT1242306	hsa-miR-4433	CLIP-seq
MIRT2688100	hsa-miR-4459	CLIP-seq
MIRT2595598	hsa-miR-4477a	CLIP-seq
MIRT1242310	hsa-miR-4478	CLIP-seq
MIRT2071390	hsa-miR-451b	CLIP-seq
MIRT2595600	hsa-miR-4638-3p	CLIP-seq
MIRT1242317	hsa-miR-4644	CLIP-seq
MIRT1242321	hsa-miR-4683	CLIP-seq
MIRT2595601	hsa-miR-4684-5p	CLIP-seq
MIRT1242322	hsa-miR-4689	CLIP-seq
MIRT2595602	hsa-miR-4694-3p	CLIP-seq
MIRT2688101	hsa-miR-4695-5p	CLIP-seq
MIRT2595603	hsa-miR-4696	CLIP-seq
MIRT1242323	hsa-miR-4725-5p	CLIP-seq
MIRT1242324	hsa-miR-4728-5p	CLIP-seq
MIRT1242325	hsa-miR-4739	CLIP-seq
MIRT1242326	hsa-miR-4756-5p	CLIP-seq
MIRT2071391	hsa-miR-4763-5p	CLIP-seq
MIRT1242327	hsa-miR-4784	CLIP-seq
MIRT1242328	hsa-miR-4786-5p	CLIP-seq
MIRT1242329	hsa-miR-4789-3p	CLIP-seq
MIRT2595605	hsa-miR-4794	CLIP-seq
MIRT1242333	hsa-miR-485-5p	CLIP-seq
MIRT1242335	hsa-miR-504	CLIP-seq
MIRT2298649	hsa-miR-508-5p	CLIP-seq
MIRT2595606	hsa-miR-513a-3p	CLIP-seq
MIRT2595607	hsa-miR-522	CLIP-seq
MIRT2595609	hsa-miR-548c-3p	CLIP-seq
MIRT2688102	hsa-miR-576-5p	CLIP-seq
MIRT2595610	hsa-miR-590-3p	CLIP-seq
MIRT1242342	hsa-miR-593	CLIP-seq
MIRT1242343	hsa-miR-612	CLIP-seq
MIRT1242344	hsa-miR-613	CLIP-seq
MIRT2595611	hsa-miR-645	CLIP-seq
MIRT1242346	hsa-miR-661	CLIP-seq
MIRT1242347	hsa-miR-665	CLIP-seq
MIRT1242349	hsa-miR-759	CLIP-seq
MIRT2595612	hsa-miR-760	CLIP-seq
MIRT1242351	hsa-miR-769-5p	CLIP-seq
MIRT2595614	hsa-miR-802	CLIP-seq
MIRT2595615	hsa-miR-873	CLIP-seq
MIRT2595618	hsa-miR-944	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003779	Function	Actin binding	IBA
GO:0003779	Function	Actin binding	IEA
GO:0003779	Function	Actin binding	ISS
GO:0005515	Function	Protein binding	IPI	25416956, 28514442, 32296183, 33961781
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	22832517
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005886	Component	Plasma membrane	IDA	22832517
GO:0005886	Component	Plasma membrane	IEA
GO:0016020	Component	Membrane	IEA
GO:0016604	Component	Nuclear body	IDA
GO:0030027	Component	Lamellipodium	IDA	22832517
GO:0030027	Component	Lamellipodium	IEA
GO:0030835	Process	Negative regulation of actin filament depolymerization	IBA
GO:0030835	Process	Negative regulation of actin filament depolymerization	IEA
GO:0030835	Process	Negative regulation of actin filament depolymerization	ISS
GO:0030864	Component	Cortical actin cytoskeleton	IEA
GO:0030864	Component	Cortical actin cytoskeleton	ISS
GO:0042995	Component	Cell projection	IEA
GO:0071944	Component	Cell periphery	IEA

Other IDs

• MIM: 612723
• HGNC: 30506
• e!Ensembl: ENSG00000152527

Protein

• UniProt ID: Q8IVE3
• Protein name: Pleckstrin homology domain-containing family H member 2
• Protein function: In the kidney glomerulus may play a role in linking podocyte foot processes to the glomerular basement membrane. May be involved in stabilization of F-actin by attenuating its depolymerization. Can recruit TGFB1I1 from focal adhesions to podocyt
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00169	PH	704 → 797	PH domain	Domain
  PF00784	MyTH4	1000 → 1109	MyTH4 domain	Family
  PF00373	FERM_M	1226 → 1354	FERM central domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Kidney. Reduced expression in patients with focal segmental glomerulosclerosis. {ECO:0000269|PubMed:22832517}.
• Sequence:

  MAELSEPEGPVDWKERCVALESQLMKFRVQASKIRELLAEKMQQLERQVIDAERQAEKAF
  QQVQVMEDKLKAANIQTSESETRLYNKCQDLESLIQEKDDVIQNLELQLEEQKQIRIQEA
  KIIEEKAAKIKEWVTVKLNELELENQNLRLINQNQTEEIRTMQSKLQEVQGKKSSTVSTL
  KLSEGQRLSSLTFGCFLSRARSPPQVVKSEEMSKISSKEPEFTEGKDMEEMEIPEKSVDN
  QVLENNRGQRTLHQTPCGSEQNRKTRTSFATDGGISQNSGAPVSDWSSDEEDGSKGRSKS
  RCTSTLSSHTSEEGVQCSRMGSEMYLTASDDSSSIFEEETFGIKRPEHKKLYSWQQEAQW
  KALNSPLGKGNSELSKKEQDSSSDELNKKFQSQRLDYSSSSSEANTPSPILTPALMPKHP
  NSLSGKGTQLVPSSHLPPPKLRIPNVFSISVALAKRHLSQPQLSSDRMFGTNRNAISMIR
  PLRPQETDLDLVDGDSTEVLENMDTSCDDGLFSYDSLDSPNSDDQEHCDSAKKVAYSKPP
  TPPLHRFPSWESRIYAVAKSGIRMSEAFNMESVNKNSAATLSYTTSGLYTSLIYKNMTTP
  VYTTLKGKATQISSSPFLDDSSGSEEEDSSRSSSRTSESDSRSRSGPGSPRAMKRGVSLS
  SVASESDYAIPPDAYSTDTEYSQPEQKLPKTCSSSSDNGKNEPLEKSGYLLKMSGKVKSW
  KRRWFVLKGGELLYYKSPSDVIRKPQGHIELSASCSILRGDNKQTVQLTTEKHTYYLTAD
  SPNILEEWIKVLQNVLRVQAANPLSLQPEGKPTMKGLLTKVKHGYSKRVWCTLIGKTLYY
  FRSQEDKFPLGQIKLWEAKVEEVDRSCDSDEDYEASGRSLLSTHYTIVIHPKDQGPTYLL
  IGSKHEKDTWLYHLTVAAGSNNVNVGSEFEQLVCKLLNIDGEPSSQIWRHPTLCHSKEGI
  ISPLTTLPSEALQTEAIKLFKTCQLFINAAVDSPAIDYHISLAQSALQICLTHPELQNEI
  CCQLIKQTRRRQPQNQPGPLQGWQLLALCVGLFLPHHPFLWLLRLHLKRNADSRTEFGKY
  AIYCQRCVERTQQNGDREARPSRMEILSTLLRNPYHHSLPFSIPVHFMNGIYQVVGFDAS
  TTVEEFLNTLNQDTGMRKPAQSGFALFTDDPSGRDLEHCLQGNIKICDIISKWEQASKEQ
  QPGKCEGTRTVRLTYKNRLYFSVQARGETDREKLLLMYQTNDQIINGLFPLNKDLALEMA
  ALLSQVEIGDFERPFSTPAGHVTNQCKVNQTLKQVIEKFYPKRYRDGCSEEQLRQLCQRL
  STRWMALRGHSAADCVRIYLTVARKWPFFGAKLFLAKPITPSSLGSTFLWLAVHEDGLSL
  LEYNSMRLIVSYVYKSLMTFGGYQDDFMVVINNTHSKDKPTEKLLFAMAKPKILEITLLI
  ASYINNFHQQKAAFHHLSAPALLSAQTRGPQARMMGSQPLLSSSRPTKGPTLL

• Sequence length: 1493

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
CHOLELITHIASIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INFLAMMATORY BOWEL DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Diabetes	Diabetes	GWASCAT_DG	27670767		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes Mellitus	GWASCAT_DG	27670767		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Diabetic Nephropathy	Diabetic Nephropathy	BEFREE	18752002		★☆☆☆☆ Found in Text Mining only
Diabetic Nephropathy	Diabetic Nephropathy	LHGDN	18752002		★☆☆☆☆ Found in Text Mining only
Focal glomerulosclerosis	Glomerulosclerosis	BEFREE	22832517		★☆☆☆☆ Found in Text Mining only
Hypertensive disease	Hypertension	GWASCAT_DG	27670767		★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	36209201	Associate	★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	36209201	Stimulate	★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	Pubtator	31959813	Associate	★☆☆☆☆ Found in Text Mining only
Venous Thromboembolism	Venous thromboembolism	Pubtator	29117201	Associate	★☆☆☆☆ Found in Text Mining only