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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q7Z7C8 |
| Protein name |
Transcription initiation factor TFIID subunit 8 (Protein taube nuss) (TBP-associated factor 43 kDa) (TBP-associated factor 8) (Transcription initiation factor TFIID 43 kDa subunit) (TAFII-43) (TAFII43) (hTAFII43) |
| Protein function |
The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TAT |
| PDB |
4WV4
, 4WV6
, 5FUR
, 6MZC
, 6MZL
, 6MZM
, 7EDX
, 7EG7
, 7EG8
, 7EG9
, 7EGA
, 7EGB
, 7EGC
, 7EGD
, 7EGE
, 7EGG
, 7EGH
, 7EGI
, 7EGJ
, 7ENA
, 7ENC
, 8GXQ
, 8GXS
, 8WAK
, 8WAL
, 8WAN
, 8WAO
, 8WAP
, 8WAQ
, 8WAR
, 8WAS
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| Family and domains |
Pfam
| Accession |
ID |
Position in sequence |
Description |
Type |
| PF07524 |
Bromo_TP |
29 → 106 |
Bromodomain associated |
Domain |
| PF10406 |
TAF8_C |
145 → 193 |
Transcription factor TFIID complex subunit 8 C-term |
Domain |
|
| Sequence |
|
| Sequence length |
310 |
| Interactions |
View interactions |
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Evidence Score:
★☆☆☆☆ Gene-disease association found in Text Mining only
★★☆☆☆ Found in Text Mining and Unknown/Other Associations
★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources
★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
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|
| Phenotype Name |
Clinical Significance |
Source |
Evidence Score |
| HYPERPITUITARISM |
— |
GWAS catalog
| ★★★★★★★☆☆☆ Found in Text Mining + Unknown/Other Associations |
| NEURODEVELOPMENTAL DISORDERS |
— |
Disgenet
| ★★★★★★★☆☆☆ Found in Text Mining + Unknown/Other Associations |
| PARTIAL AGENESIS OF CORPUS CALLOSUM |
— |
Disgenet
| ★★★★★★★☆☆☆ Found in Text Mining + Unknown/Other Associations |
| SEBORRHEIC DERMATITIS |
— |
GWAS catalog
| ★★★★★★★☆☆☆ Found in Text Mining + Unknown/Other Associations |
| SPORADIC AMYOTROPHIC LATERAL SCLEROSIS |
— |
GWAS catalog
| ★★★★★★★☆☆☆ Found in Text Mining + Unknown/Other Associations |
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| Disease Name |
Disease (Merged) |
Source |
PMID |
Relationship Type |
Evidence Score |
| Acute leukemia |
Leukemia |
BEFREE |
31611934 |
|
★★★★★★☆☆☆☆ Found in Text Mining only |
| Adenocarcinoma of lung (disorder) |
Lung adenocarcinoma |
BEFREE |
31176779 |
|
★★★★★★☆☆☆☆ Found in Text Mining only |
| Brain Infarction |
Brain Infarction |
BEFREE |
29411248 |
|
★★★★★★☆☆☆☆ Found in Text Mining only |
| Colonic Neoplasms |
Colonic neoplasm |
Pubtator |
18567809 |
Associate |
★★★★★★☆☆☆☆ Found in Text Mining only |
| Down Syndrome |
Down Syndrome |
BEFREE |
10328528 |
|
★★★★★★☆☆☆☆ Found in Text Mining only |
| Glaucoma |
Glaucoma |
BEFREE |
28160291 |
|
★★★★★★☆☆☆☆ Found in Text Mining only |
| Intellectual Disability |
Mental retardation |
BEFREE |
29648665 |
|
★★★★★★☆☆☆☆ Found in Text Mining only |
| Ischemic stroke |
Ischemic Stroke |
BEFREE |
29411248 |
|
★★★★★★☆☆☆☆ Found in Text Mining only |
| Leukemia, T-Cell |
T-cell leukemia |
BEFREE |
3019203 |
|
★★★★★★☆☆☆☆ Found in Text Mining only |
| Malignant neoplasm of breast |
Breast Cancer |
BEFREE |
12168092 |
|
★★★★★★☆☆☆☆ Found in Text Mining only |
| Neoplasms |
Neoplasms |
BEFREE |
31176779 |
|
★★★★★★☆☆☆☆ Found in Text Mining only |
|