Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	129684
Gene name	Contactin associated protein family member 5
Gene symbol	CNTNAP5
Synonyms (NCBI Gene)	caspr5
Chromosome	2
Chromosome location	2q14.3
Summary	This gene product belongs to the neurexin family, members of which function in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domai

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Show/Hide all (122)

miRTarBase ID	miRNA	Experiments	Reference
MIRT707179	hsa-miR-4789-3p	HITS-CLIP	21572407
MIRT707178	hsa-miR-4643	HITS-CLIP	21572407
MIRT707177	hsa-miR-5580-3p	HITS-CLIP	21572407
MIRT707176	hsa-miR-4798-3p	HITS-CLIP	21572407
MIRT707175	hsa-miR-3680-5p	HITS-CLIP	21572407
MIRT707174	hsa-miR-369-3p	HITS-CLIP	21572407
MIRT707173	hsa-miR-5692b	HITS-CLIP	21572407
MIRT707172	hsa-miR-5692c	HITS-CLIP	21572407
MIRT707171	hsa-miR-1285-5p	HITS-CLIP	21572407
MIRT707170	hsa-miR-16-1-3p	HITS-CLIP	21572407
MIRT707169	hsa-miR-4797-3p	HITS-CLIP	21572407
MIRT707168	hsa-miR-4264	HITS-CLIP	21572407
MIRT707167	hsa-miR-466	HITS-CLIP	21572407
MIRT707166	hsa-miR-374a-5p	HITS-CLIP	21572407
MIRT707165	hsa-miR-374b-5p	HITS-CLIP	21572407
MIRT707164	hsa-miR-4789-5p	HITS-CLIP	21572407
MIRT543637	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT707163	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT524411	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT524410	hsa-miR-511-3p	HITS-CLIP	21572407
MIRT524409	hsa-miR-223-5p	HITS-CLIP	21572407
MIRT524408	hsa-miR-6867-5p	HITS-CLIP	21572407
MIRT524407	hsa-miR-210-3p	HITS-CLIP	21572407
MIRT524406	hsa-miR-574-5p	HITS-CLIP	21572407
MIRT524411	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT524410	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT524409	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT524408	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT524407	hsa-miR-210-3p	PAR-CLIP	21572407
MIRT524406	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT524411	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT524410	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT524408	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT543637	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT524406	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT524411	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT524410	hsa-miR-511-3p	PAR-CLIP	23446348
MIRT524409	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT524408	hsa-miR-6867-5p	PAR-CLIP	23446348
MIRT524407	hsa-miR-210-3p	PAR-CLIP	23446348
MIRT524406	hsa-miR-574-5p	PAR-CLIP	23446348
MIRT707163	hsa-miR-1277-5p	HITS-CLIP	27418678
MIRT707163	hsa-miR-1277-5p	HITS-CLIP	27418678
MIRT543637	hsa-miR-190a-3p	HITS-CLIP	27418678
MIRT543637	hsa-miR-190a-3p	HITS-CLIP	27418678
MIRT524409	hsa-miR-223-5p	HITS-CLIP	27418678
MIRT524409	hsa-miR-223-5p	HITS-CLIP	27418678
MIRT524411	hsa-miR-5011-5p	HITS-CLIP	27418678
MIRT524411	hsa-miR-5011-5p	HITS-CLIP	27418678
MIRT524410	hsa-miR-511-3p	HITS-CLIP	27418678
MIRT524410	hsa-miR-511-3p	HITS-CLIP	27418678
MIRT524406	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT524406	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT524408	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT524408	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT707179	hsa-miR-4789-3p	HITS-CLIP	21572407
MIRT707178	hsa-miR-4643	HITS-CLIP	21572407
MIRT707177	hsa-miR-5580-3p	HITS-CLIP	21572407
MIRT707176	hsa-miR-4798-3p	HITS-CLIP	21572407
MIRT707175	hsa-miR-3680-5p	HITS-CLIP	21572407
MIRT707174	hsa-miR-369-3p	HITS-CLIP	21572407
MIRT707173	hsa-miR-5692b	HITS-CLIP	21572407
MIRT707172	hsa-miR-5692c	HITS-CLIP	21572407
MIRT707171	hsa-miR-1285-5p	HITS-CLIP	21572407
MIRT707170	hsa-miR-16-1-3p	HITS-CLIP	21572407
MIRT707169	hsa-miR-4797-3p	HITS-CLIP	21572407
MIRT707168	hsa-miR-4264	HITS-CLIP	21572407
MIRT707167	hsa-miR-466	HITS-CLIP	21572407
MIRT707166	hsa-miR-374a-5p	HITS-CLIP	21572407
MIRT707165	hsa-miR-374b-5p	HITS-CLIP	21572407
MIRT707164	hsa-miR-4789-5p	HITS-CLIP	21572407
MIRT543637	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT707163	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT524411	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT524410	hsa-miR-511-3p	HITS-CLIP	21572407
MIRT524409	hsa-miR-223-5p	HITS-CLIP	21572407
MIRT524408	hsa-miR-6867-5p	HITS-CLIP	21572407
MIRT524407	hsa-miR-210-3p	HITS-CLIP	21572407
MIRT524406	hsa-miR-574-5p	HITS-CLIP	21572407
MIRT524411	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT524410	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT524409	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT524408	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT524407	hsa-miR-210-3p	PAR-CLIP	21572407
MIRT524406	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT524411	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT524410	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT524408	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT543637	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT524406	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT524411	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT524410	hsa-miR-511-3p	PAR-CLIP	23446348
MIRT524409	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT524408	hsa-miR-6867-5p	PAR-CLIP	23446348
MIRT524407	hsa-miR-210-3p	PAR-CLIP	23446348
MIRT524406	hsa-miR-574-5p	PAR-CLIP	23446348
MIRT901899	hsa-miR-1276	CLIP-seq
MIRT901900	hsa-miR-3123	CLIP-seq
MIRT901901	hsa-miR-3180-5p	CLIP-seq
MIRT901902	hsa-miR-3617	CLIP-seq
MIRT901903	hsa-miR-4311	CLIP-seq
MIRT901904	hsa-miR-4724-5p	CLIP-seq
MIRT901905	hsa-miR-4738-3p	CLIP-seq
MIRT901906	hsa-miR-520a-5p	CLIP-seq
MIRT901907	hsa-miR-525-5p	CLIP-seq
MIRT901908	hsa-miR-567	CLIP-seq
MIRT901909	hsa-miR-583	CLIP-seq
MIRT901910	hsa-miR-641	CLIP-seq
MIRT1967533	hsa-miR-31	CLIP-seq
MIRT1967534	hsa-miR-330-3p	CLIP-seq
MIRT901902	hsa-miR-3617	CLIP-seq
MIRT901910	hsa-miR-641	CLIP-seq
MIRT2203269	hsa-miR-103a	CLIP-seq
MIRT2203270	hsa-miR-107	CLIP-seq
MIRT2203271	hsa-miR-1184	CLIP-seq
MIRT901904	hsa-miR-4724-5p	CLIP-seq
MIRT2203272	hsa-miR-4728-3p	CLIP-seq
MIRT2203273	hsa-miR-491-3p	CLIP-seq
MIRT2447418	hsa-miR-148a	CLIP-seq
MIRT2447419	hsa-miR-148b	CLIP-seq
MIRT2447420	hsa-miR-152	CLIP-seq
MIRT901905	hsa-miR-4738-3p	CLIP-seq

Show/Hide all (2)

GO ID	Ontology	Definition	Evidence	Reference
GO:0007155	Process	Cell adhesion	IEA
GO:0016020	Component	Membrane	IEA

MIM	HGNC	e!Ensembl
610519	18748	ENSG00000155052

Q8WYK1

Protein name

Contactin-associated protein-like 5 (Cell recognition molecule Caspr5)

Protein function

May play a role in the correct development and proper functioning of the peripheral and central nervous system and be involved in cell adhesion and intercellular communication.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00754	F5_F8_type_C	42 → 171	F5/8 type C domain	Domain
PF02210	Laminin_G_2	209 → 338	Laminin G domain	Domain
PF02210	Laminin_G_2	395 → 521	Laminin G domain	Domain
PF02210	Laminin_G_2	819 → 938	Laminin G domain	Domain
PF02210	Laminin_G_2	1044 → 1173	Laminin G domain	Domain

Sequence

MDSLPRLTSVLTLLFSGLWHLGLTATNYNCDDPLASLLSPMAFSSSSDLTGTHSPAQLNW
RVGTGGWSPADSNAQQWLQMDLGNRVEITAVATQGRYGSSDWVTSYSLMFSDTGRNWKQY
KQEDSIWTFAGNMNADSVVHHKLLHSVRARFVRFVPLEWNPSGKIGMRVEVYGCSYKSDV
ADFDGRSSLLYRFNQKLMSTLKDVISLKFKSMQGDGVLFHGEGQRGDHITLELQKGRLAL
HLNLGDSKARLSSSLPSATLGSLLDDQHWHSVLIERVGKQVNFTVDKHTQHFRTKGETDA
LDIDYELSFGGIPVPGKPGTFLKKNFHGCIENLYYNGVNIIDLAKRRKHQIYTGNVTFSC
SEPQIVPITFVNSSGSYLLLPGTPQIDGLSVSFQFRTWNKDGLLLSTELSEGSGTLLLSL
EGGILRLVIQKMTERVAEILTGSNLNDGLWHSVSINARRNRITLTLDDEAAPPAPDSTWV
QIYSGNSYYFGGCPDNLTDSQCLNPIKAFQGCMRLIFIDNQPKDLISVQQGSLGNFSDLH
IDLCSIKDRCLPNYCEHGGSCSQSWTTFYCNCSDTSYTGATCHNSIYEQSCEVYRHQGNT
AGFFYIDSDGSGPLGPLQVYCNITEDKIWTSVQHNNTELTRVRGANPEKPYAMALDYGGS
MEQLEAVIDGSEHCEQEVAYHCRRSRLLNTPDGTPFTWWIGRSNERHPYWGGSPPGVQQC
ECGLDESCLDIQHFCNCDADKDEWTNDTGFLSFKDHLPVTQIVITDTDRSNSEAAWRIGP
LRCYGDRRFWNAVSFYTEASYLHFPTFHAEFSADISFFFKTTALSGVFLENLGIKDFIRL
EISSPSEITFAIDVGNGPVELVVQSPSLLNDNQWHYVRAERNLKETSLQVDNLPRSTRET
SEEGHFRLQLNSQLFVGGTSSRQKGFLGCIRSLHLNGQKMDLEERAKVTSGVRPGCPGHC
SSYGSICHNGGKCVEKHNGYLCDCTNSPYEGPFCKKEVSAVFEAGTSVTYMFQEPYPVTK
NISLSSSAIYTDSAPSKENIALSFVTTQAPSLLLFINSSSQDFVVVLLCKNGSLQVRYHL
NKEETHVFTIDADNFANRRMHHLKINREGRELTIQMDQQLRLSYNFSPEVEFRVIRSLTL
GKVTENLGLDSEVAKANAMGFAGCMSSVQYNHIAPLKAALRHATVAPVTVHGTLTESSCG
FMVDSDVNAVTTVHSSSDPFGKTDEREPLTNAVRSDSAVIGGVIAVVIFIIFCIIGIMTR
FLYQHKQSHRTSQMKEKEYPENLDSSFRNEIDLQNTVSECKREYFI

Sequence length

1306

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (22)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ANXIETY DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CNTNAP5-associated intellectual disability	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CNTNAP5-related disorder	Uncertain significance; Likely benign; Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COMPLEX NEURODEVELOPMENTAL DISORDER	—	ClinGen	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ESSENTIAL TREMOR	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GASTROESOPHAGEAL REFLUX DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HOARDING DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INSOMNIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG ADENOCARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MOVEMENT DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NON-SPECIFIC SYNDROMIC INTELLECTUAL DISABILITY	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OVARIAN CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PERIODIC LIMB MOVEMENT DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
POST-TRAUMATIC STRESS DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSORIASIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RESTLESS LEGS SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SUBSTANCE ABUSE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (18)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Atrophy	Atrophy	Pubtator	26993346	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Autism Spectrum Disorder	Autism	Pubtator	32807774, 34553698	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Autism Spectrum Disorders	Autism Spectrum Disorder	BEFREE	20346443		★★★★★ ★☆☆☆☆ Found in Text Mining only
Autistic Disorder	Autism	BEFREE	20346443		★★★★★ ★☆☆☆☆ Found in Text Mining only
Autistic Disorder	Autism	Pubtator	20346443	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Bipolar Disorder	Bipolar disorder	Pubtator	24387768	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	32789468	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Developmental Disabilities	Developmental disability	Pubtator	34553698	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Diabetes mellitus, type 2	Pubtator	21423737	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Dyslexia	Dyslexia	BEFREE	20346443		★★★★★ ★☆☆☆☆ Found in Text Mining only
Dyslexia	Dyslexia	Pubtator	20346443	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glaucoma Angle Closure	Angle closure glaucoma	Pubtator	33737499	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Language Development Disorders	Language development disorders	Pubtator	34553698	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Major Depressive Disorder	Mental Depression	GWASCAT_DG	29662059		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
melanoma	Melanoma	BEFREE	24718909		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neurodegenerative Diseases	Neurodegenerative disorder	Pubtator	33737499	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	Pubtator	21423737, 34553698	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	GWASCAT_DG	29503163		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

CNTNAP5 (contactin associated protein family member 5)