Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	129563
Gene name	DIS3 like 3'-5' exoribonuclease 2
Gene symbol	DIS3L2
Synonyms (NCBI Gene)	FAM6APRLMNShDIS3L2
Chromosome	2
Chromosome location	2q37.1
Summary	The protein encoded by this gene is similar in sequence to 3`/5` exonucleolytic subunits of the RNA exosome. The exosome is a large multimeric ribonucleotide complex responsible for degrading various RNA substrates. Several transcript variants, some prote

Show/Hide all (11)

SNP ID	Visualize variation	Clinical significance	Consequence
rs199648534	C>T	Pathogenic	Non coding transcript variant, intron variant, stop gained, coding sequence variant, genic downstream transcript variant
rs201733073	A>G	Uncertain-significance, conflicting-interpretations-of-pathogenicity	Coding sequence variant, non coding transcript variant, missense variant
rs387907116	G>A	Pathogenic	Missense variant, coding sequence variant, non coding transcript variant, genic downstream transcript variant
rs878855224	T>-	Pathogenic	Coding sequence variant, intron variant, frameshift variant, non coding transcript variant, genic downstream transcript variant
rs1060503037	G>C	Likely-pathogenic	Splice acceptor variant, genic downstream transcript variant, intron variant
rs1201265438	G>C,T	Likely-pathogenic	Splice acceptor variant, intron variant, genic downstream transcript variant
rs1489037110	G>A	Pathogenic	Genic downstream transcript variant, intron variant
rs1553551874	GC>-	Likely-pathogenic	Genic downstream transcript variant, frameshift variant, coding sequence variant, intron variant, non coding transcript variant
rs1553610371	CT>-	Pathogenic	Genic downstream transcript variant, frameshift variant, coding sequence variant, intron variant, non coding transcript variant
rs1574980061	AGCATAGCAG>-	Pathogenic	Frameshift variant, non coding transcript variant, genic downstream transcript variant, coding sequence variant
rs1574980125	AGCAGTTA>G	Pathogenic	Frameshift variant, intron variant, non coding transcript variant, genic downstream transcript variant, coding sequence variant

Show/Hide all (39)

miRTarBase ID	miRNA	Experiments	Reference
MIRT438540	hsa-let-7a-5p	Northern blot	24141620
MIRT438540	hsa-let-7a-5p	Northern blot	24141620
MIRT440813	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440813	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT735271	hsa-miR-7-5p	Western blottingNorthern blottingImmunoprecipitaion (IP)RNA-seq	32488030
MIRT735272	hsa-miR-222-3p	Western blottingNorthern blottingImmunoprecipitaion (IP)RNA-seqqRT-PCR	32488030
MIRT735273	hsa-miR-769-3p	Western blottingNorthern blottingImmunoprecipitaion (IP)RNA-seq	32488030
MIRT937175	hsa-miR-3672	CLIP-seq
MIRT937176	hsa-miR-3925-3p	CLIP-seq
MIRT937177	hsa-miR-4269	CLIP-seq
MIRT937178	hsa-miR-4514	CLIP-seq
MIRT937179	hsa-miR-4692	CLIP-seq
MIRT937180	hsa-miR-4712-5p	CLIP-seq
MIRT937181	hsa-miR-4742-5p	CLIP-seq
MIRT937182	hsa-miR-508-5p	CLIP-seq
MIRT937183	hsa-miR-770-5p	CLIP-seq
MIRT1977444	hsa-miR-4267	CLIP-seq
MIRT1977445	hsa-miR-4427	CLIP-seq
MIRT937178	hsa-miR-4514	CLIP-seq
MIRT1977446	hsa-miR-4645-5p	CLIP-seq
MIRT1977447	hsa-miR-4673	CLIP-seq
MIRT1977448	hsa-miR-4680-3p	CLIP-seq
MIRT937179	hsa-miR-4692	CLIP-seq
MIRT1977449	hsa-miR-4727-5p	CLIP-seq
MIRT1977450	hsa-miR-4755-3p	CLIP-seq
MIRT1977451	hsa-miR-4769-3p	CLIP-seq
MIRT1977452	hsa-miR-4778-5p	CLIP-seq
MIRT2212754	hsa-miR-1285	CLIP-seq
MIRT2212755	hsa-miR-1296	CLIP-seq
MIRT2212756	hsa-miR-1343	CLIP-seq
MIRT2212757	hsa-miR-2467-3p	CLIP-seq
MIRT2212758	hsa-miR-3074-5p	CLIP-seq
MIRT2212759	hsa-miR-3187-5p	CLIP-seq
MIRT2212760	hsa-miR-3616-3p	CLIP-seq
MIRT2212761	hsa-miR-4436b-3p	CLIP-seq
MIRT2212762	hsa-miR-4512	CLIP-seq
MIRT2212763	hsa-miR-4779	CLIP-seq
MIRT2212764	hsa-miR-612	CLIP-seq
MIRT2448273	hsa-miR-3197	CLIP-seq

Show/Hide all (35)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000175	Function	3'-5'-RNA exonuclease activity	IBA
GO:0000175	Function	3'-5'-RNA exonuclease activity	IDA	23756462, 24141620
GO:0000175	Function	3'-5'-RNA exonuclease activity	IEA
GO:0000278	Process	Mitotic cell cycle	IMP	22306653
GO:0000287	Function	Magnesium ion binding	IDA	24141620
GO:0000287	Function	Magnesium ion binding	IEA
GO:0000932	Component	P-body	IBA
GO:0000932	Component	P-body	IDA	23756462
GO:0000932	Component	P-body	IEA
GO:0000956	Process	Nuclear-transcribed mRNA catabolic process	IEA
GO:0000956	Process	Nuclear-transcribed mRNA catabolic process	IMP	23756462
GO:0003723	Function	RNA binding	IEA
GO:0004518	Function	Nuclease activity	IEA
GO:0004527	Function	Exonuclease activity	IEA
GO:0004540	Function	RNA nuclease activity	IDA	22306653
GO:0004540	Function	RNA nuclease activity	IEA
GO:0005515	Function	Protein binding	IPI	23756462
GO:0005737	Component	Cytoplasm	IDA	22306653, 23756462, 24141620
GO:0005737	Component	Cytoplasm	IEA
GO:0006402	Process	MRNA catabolic process	IBA
GO:0008266	Function	Poly(U) RNA binding	IDA	24141620
GO:0008266	Function	Poly(U) RNA binding	IEA
GO:0008285	Process	Negative regulation of cell population proliferation	IMP	22306653
GO:0010587	Process	MiRNA catabolic process	IBA
GO:0010587	Process	MiRNA catabolic process	IDA	24141620
GO:0010587	Process	MiRNA catabolic process	IEA
GO:0010587	Process	MiRNA catabolic process	ISS
GO:0016787	Function	Hydrolase activity	IEA
GO:0019827	Process	Stem cell population maintenance	IEA
GO:0019827	Process	Stem cell population maintenance	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:0051301	Process	Cell division	IEA
GO:0051306	Process	Mitotic sister chromatid separation	IMP	22306653
GO:1990074	Process	Polyuridylation-dependent mRNA catabolic process	IEA
GO:1990074	Process	Polyuridylation-dependent mRNA catabolic process	ISS

MIM	HGNC	e!Ensembl
614184	28648	ENSG00000144535

Q8IYB7

Protein name

DIS3-like exonuclease 2 (hDIS3L2) (EC 3.1.13.-)

Protein function

3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been

PDB

8E27 , 8E28 , 8E29 , 8E2A

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF17216	Rrp44_CSD1	47 → 148	Rrp44-like cold shock domain	Domain
PF17849	OB_Dis3	265 → 341	Dis3-like cold-shock domain 2 (CSD2)	Domain
PF00773	RNB	371 → 721	RNB domain	Domain
PF17877	Dis3l2_C_term	766 → 855	DIS3-like exonuclease 2 C terminal	Domain

Sequence

MSHPDYRMNLRPLGTPRGVSAVAGPHDIGASPGDKKSKNRSTRGKKKSIFETYMSKEDVS
EGLKRGTLIQGVLRINPKKFHEAFIPSPDGDRDIFIDGVVARNRALNGDLVVVKLLPEEH
WKVVKPESNDKETEAAYESDIPEELCGHHLPQQSLKSYNDSPDVIVEAQFDGSDSEDGHG
ITQNVLVDGVKKLSVCVSEKGREDGDAPVTKDETTCISQDTRALSEKSLQRSAKVVYILE
KKHSRAATGFLKLLADKNSELFRKYALFSPSDHRVPRIYVPLKDCPQDFVARPKDYANTL
FICRIVDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFSSEVLECLPQGLP
WTIPPEEFSKRRDLRKDCIFTIDPSTARDLDDALSCKPLADGNFKVGVHIADVSYFVPEG
SDLDKVAAERATSVYLVQKVVPMLPRLLCEELCSLNPMSDKLTFSVIWTLTPEGKILDEW
FGRTIIRSCTKLSYEHAQSMIESPTEKIPAKELPPISPEHSSEEVHQAVLNLHGIAKQLR
QQRFVDGALRLDQLKLAFTLDHETGLPQGCHIYEYRESNKLVEEFMLLANMAVAHKIHRA
FPEQALLRRHPPPQTRMLSDLVEFCDQMGLPVDFSSAGALNKSLTQTFGDDKYSLARKEV
LTNMCSRPMQMALYFCSGLLQDPAQFRHYALNVPLYTHFTSPIRRFADVLVHRLLAAALG
YRERLDMAPDTLQKQADHCNDRRMASKRVQELSTSLFFAVLVKESGPLESEAMVMGILKQ
AFDVLVLRYGVQKRIYCNALALRSHHFQKVGKKPELTLVWEPEDMEQEPAQQVITIFSLV
EVVLQAESTALKYSAILKRPGTQGHLGPEKEEEESDGEPEDSSTS

Sequence length

885

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Causal Diseases (4)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
DIS3L2-related disorder	Likely pathogenic; Pathogenic	rs1266710900, rs1695875453, rs199648534, rs1328362747	RCV004750777 RCV003391455 RCV004751671 RCV003398929	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Familial cancer of breast	Likely pathogenic	rs747497458	RCV005925532	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Nephroblastoma	Likely pathogenic	rs1553551874	RCV000505630	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Perlman syndrome	Likely pathogenic; Pathogenic	rs2106350184, rs2106348255, rs762653147, rs2106232915, rs747734015, rs1209057640, rs2106281153, rs2106348160, rs2106221493, rs2106264887, rs747497458, rs2106220804, rs2106353572, rs2106354681, rs2106239900 View all (69 more)	RCV001379566 RCV001379082 RCV001384568 RCV001390065 RCV001382451 View all (84 more)	★★★★★ ★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (27)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Acute myeloid leukemia	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ANDROGENETIC ALOPECIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cervical cancer	Benign; Conflicting classifications of pathogenicity	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cholangiocarcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Chronic lymphocytic leukemia/small lymphocytic lymphoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colon adenocarcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETIC NEPHROPATHY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial pancreatic carcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Germ cell tumor of testis	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatoblastoma	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung cancer	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lymphoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Neurodevelopmental disorder	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEURODEVELOPMENTAL DISORDERS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Nonpapillary renal cell carcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOARTHRITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOARTHRITIS, HIP	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOARTHRITIS, KNEE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian cancer	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Benign; Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Benign; Conflicting classifications of pathogenicity	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Squamous cell carcinoma of the head and neck	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thymoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine carcinosarcoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Benign; Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (52)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Agenesis of corpus callosum	Agenesis Of Corpus Callosum	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Anaplastic thyroid carcinoma	Anaplastic thyroid cancer	BEFREE	31368081		★★★★★ ★☆☆☆☆ Found in Text Mining only
Aniridia	Aniridia	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Blepharoptosis	Ptosis	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	26080928	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cardiovascular Abnormalities	Cardiovascular Abnormalities	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	28496335		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	37340282	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Congenital chromosomal disease	Congenital Chromosomal Disease	BEFREE	30344923		★★★★★ ★☆☆☆☆ Found in Text Mining only
Congenital diaphragmatic hernia	Congenital diaphragmatic hernia	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Congenital Epicanthus	Congenital Epicanthus	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Congenital hypoplasia of penis	Congenital Hypoplasia Of Penis	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Cryptorchidism	Cryptorchidism	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Cutis marmorata telangiectatica congenita	Cutis marmorata telangiectatica congenita	Pubtator	35700413	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetic Nephropathies	Diabetic neuropathy	Pubtator	36444934	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Dwarfism	Dwarfism	BEFREE	23805197		★★★★★ ★☆☆☆☆ Found in Text Mining only
Global developmental delay	Developmental Delay	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Growth Disorders	Growth disorder	Pubtator	23805197	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hernia, Femoral	Hernia, Femoral	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Hyperinsulinism	Hyperinsulinism	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypertensive disease	Hypertension	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Mental retardation	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Interrupted aortic arch	Interrupted aortic arch	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Intestinal Volvulus	Intestinal Volvulus	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	31331910		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver neoplasms	Liver neoplasms	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Long narrow head	Dolichocephaly	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung Neoplasms	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Macrocephaly	Macrocephaly	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of liver	Liver Cancer	BEFREE	31331910		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	22306653, 30638126		★★★★★ ★☆☆☆☆ Found in Text Mining only
Micrognathism	Micrognathism	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	25018051, 29950491		★★★★★ ★☆☆☆☆ Found in Text Mining only
Nephroblastoma	Nephroblastoma	BEFREE	22306653, 23594738, 29950491, 30344923		★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Nephroblastoma	Nephroblastoma	CLINVAR_DG			★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Nephroblastoma	Nephroblastoma	ORPHANET_DG			★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Nephroblastoma	Nephroblastoma	HPO_DG			★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Nephroblastoma	Nephroblastoma	Orphanet			★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Nephroblastomatosis, fetal ascites, macrosomia and Wilms tumor	Perlman syndrome	GENOMICS_ENGLAND_DG	10508986, 22306653, 28328139		★★★★★ ★☆☆☆☆ Found in Text Mining only
Nephroblastomatosis, fetal ascites, macrosomia and Wilms tumor	Perlman syndrome	BEFREE	22306653, 23486540, 23594738, 23613427, 26809675, 27431325, 28328139, 30068702, 30275517, 30638126		★★★★★ ★☆☆☆☆ Found in Text Mining only
Nephroblastomatosis, fetal ascites, macrosomia and Wilms tumor	Perlman syndrome	ORPHANET_DG	22306653		★★★★★ ★☆☆☆☆ Found in Text Mining only
Nephroblastomatosis, fetal ascites, macrosomia and Wilms tumor	Perlman syndrome	CTD_human_DG	22306653		★★★★★ ★☆☆☆☆ Found in Text Mining only
Nephroblastomatosis, fetal ascites, macrosomia and Wilms tumor	Perlman syndrome	UNIPROT_DG	22306653, 23486540, 23613427, 28328139		★★★★★ ★☆☆☆☆ Found in Text Mining only
Nephroblastomatosis, fetal ascites, macrosomia and Wilms tumor	Perlman syndrome	CLINGEN_DG	22306653, 23486540, 28328139, 29950491		★★★★★ ★☆☆☆☆ Found in Text Mining only
Nephroblastomatosis, fetal ascites, macrosomia and Wilms tumor	Perlman syndrome	CLINVAR_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Perlman syndrome	Perlman Syndrome	Orphanet			★★★★★ ★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Posteriorly rotated ear	Posteriorly Rotated Ear	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Ptosis	Ptosis	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Specific learning disability	Specific Learning Disorder	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Status Epilepticus	Status Epilepticus	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Strawberry nevus of skin	Strawberry Nevus Of Skin	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Wilms Tumor	Wilms tumor	Pubtator	35230882, 35700413, 40340749	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

DIS3L2 (DIS3 like 3'-5' exoribonuclease 2)