TYW5 (tRNA-yW synthesizing protein 5)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 129450 |
| Gene name | TRNA-yW synthesizing protein 5 |
| Gene symbol | TYW5 |
| Synonyms (NCBI Gene) |
C2orf60hTYW5
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| Chromosome | 2 |
| Chromosome location | 2q33.1 |
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miRNA
miRNA information provided by mirtarbase database.
489
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
15
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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A2RUC4 | ||||||||||
| Protein name | tRNA wybutosine-synthesizing protein 5 (hTYW5) (tRNA yW-synthesizing protein 5) (EC 1.14.11.42) (tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-C(2))-hydroxylase) | ||||||||||
| Protein function | tRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the h | ||||||||||
| PDB | 3AL5 , 3AL6 | ||||||||||
| Family and domains |
Pfam
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| Sequence |
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| Sequence length | 315 | ||||||||||
| Interactions | View interactions | ||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
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Evidence Score:
★☆☆☆☆ Gene-disease association found in Text Mining only
★★☆☆☆ Found in Text Mining and Unknown/Other Associations
★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources
★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
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