Gene Gene information from NCBI Gene database.
Entrez ID 129450
Gene name TRNA-yW synthesizing protein 5
Gene symbol TYW5
Synonyms (NCBI Gene)
C2orf60hTYW5
Chromosome 2
Chromosome location 2q33.1
miRNA miRNA information provided by mirtarbase database.
489
miRTarBase ID miRNA Experiments Reference
MIRT028067 hsa-miR-93-5p Sequencing 20371350
MIRT639498 hsa-miR-3121-5p HITS-CLIP 23824327
MIRT639497 hsa-miR-505-3p HITS-CLIP 23824327
MIRT639496 hsa-miR-129-5p HITS-CLIP 23824327
MIRT516867 hsa-miR-3646 PAR-CLIP 23446348
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
15
GO ID Ontology Definition Evidence Reference
GO:0000049 Function TRNA binding IBA
GO:0000049 Function TRNA binding IDA 20972222
GO:0005506 Function Iron ion binding IDA 20972222
GO:0005515 Function Protein binding IPI 28514442, 33961781
GO:0005737 Component Cytoplasm TAS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
619882 26754 ENSG00000162971
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
A2RUC4
Protein name tRNA wybutosine-synthesizing protein 5 (hTYW5) (tRNA yW-synthesizing protein 5) (EC 1.14.11.42) (tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-C(2))-hydroxylase)
Protein function tRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the h
PDB 3AL5 , 3AL6
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13621 Cupin_8 16 256 Cupin-like domain Domain
Sequence
Sequence length 315
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Synthesis of wybutosine at G37 of tRNA(Phe)
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
SCHIZOPHRENIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations