Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	129293
Gene name	TraB domain containing 2A
Gene symbol	TRABD2A
Synonyms (NCBI Gene)	C2orf89TIKI1
Chromosome	2
Chromosome location	2p11.2

Show/Hide all (56)

miRTarBase ID	miRNA	Experiments	Reference
MIRT721291	hsa-miR-10a-3p	HITS-CLIP	19536157
MIRT721290	hsa-miR-5002-5p	HITS-CLIP	19536157
MIRT721289	hsa-miR-520a-5p	HITS-CLIP	19536157
MIRT721288	hsa-miR-525-5p	HITS-CLIP	19536157
MIRT721287	hsa-miR-337-3p	HITS-CLIP	19536157
MIRT721286	hsa-miR-202-5p	HITS-CLIP	19536157
MIRT721285	hsa-miR-3180-5p	HITS-CLIP	19536157
MIRT721284	hsa-miR-659-3p	HITS-CLIP	19536157
MIRT716768	hsa-miR-5571-5p	HITS-CLIP	19536157
MIRT716767	hsa-miR-371b-5p	HITS-CLIP	19536157
MIRT716766	hsa-miR-373-5p	HITS-CLIP	19536157
MIRT716765	hsa-miR-616-5p	HITS-CLIP	19536157
MIRT716764	hsa-miR-371a-5p	HITS-CLIP	19536157
MIRT716763	hsa-miR-372-5p	HITS-CLIP	19536157
MIRT716762	hsa-miR-3124-3p	HITS-CLIP	19536157
MIRT716761	hsa-miR-2117	HITS-CLIP	19536157
MIRT716760	hsa-miR-513c-5p	HITS-CLIP	19536157
MIRT716759	hsa-miR-514b-5p	HITS-CLIP	19536157
MIRT716758	hsa-miR-4273	HITS-CLIP	19536157
MIRT716757	hsa-miR-7156-5p	HITS-CLIP	19536157
MIRT716756	hsa-miR-4677-5p	HITS-CLIP	19536157
MIRT716755	hsa-miR-6739-3p	HITS-CLIP	19536157
MIRT637017	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT637016	hsa-miR-1298-5p	HITS-CLIP	23824327
MIRT637015	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT637013	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT637014	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT637012	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT721291	hsa-miR-10a-3p	HITS-CLIP	19536157
MIRT721290	hsa-miR-5002-5p	HITS-CLIP	19536157
MIRT721289	hsa-miR-520a-5p	HITS-CLIP	19536157
MIRT721288	hsa-miR-525-5p	HITS-CLIP	19536157
MIRT721287	hsa-miR-337-3p	HITS-CLIP	19536157
MIRT721286	hsa-miR-202-5p	HITS-CLIP	19536157
MIRT721285	hsa-miR-3180-5p	HITS-CLIP	19536157
MIRT721284	hsa-miR-659-3p	HITS-CLIP	19536157
MIRT716768	hsa-miR-5571-5p	HITS-CLIP	19536157
MIRT716767	hsa-miR-371b-5p	HITS-CLIP	19536157
MIRT716766	hsa-miR-373-5p	HITS-CLIP	19536157
MIRT716765	hsa-miR-616-5p	HITS-CLIP	19536157
MIRT716764	hsa-miR-371a-5p	HITS-CLIP	19536157
MIRT716763	hsa-miR-372-5p	HITS-CLIP	19536157
MIRT716762	hsa-miR-3124-3p	HITS-CLIP	19536157
MIRT716761	hsa-miR-2117	HITS-CLIP	19536157
MIRT716760	hsa-miR-513c-5p	HITS-CLIP	19536157
MIRT716759	hsa-miR-514b-5p	HITS-CLIP	19536157
MIRT716758	hsa-miR-4273	HITS-CLIP	19536157
MIRT716757	hsa-miR-7156-5p	HITS-CLIP	19536157
MIRT716756	hsa-miR-4677-5p	HITS-CLIP	19536157
MIRT716755	hsa-miR-6739-3p	HITS-CLIP	19536157
MIRT637017	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT637016	hsa-miR-1298-5p	HITS-CLIP	23824327
MIRT637015	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT637013	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT637014	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT637012	hsa-miR-6809-3p	HITS-CLIP	23824327

Show/Hide all (22)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004175	Function	Endopeptidase activity	IDA	22726442
GO:0004175	Function	Endopeptidase activity	IEA
GO:0004222	Function	Metalloendopeptidase activity	IBA
GO:0004222	Function	Metalloendopeptidase activity	IDA	22726442
GO:0004222	Function	Metalloendopeptidase activity	ISS	22726442
GO:0005886	Component	Plasma membrane	IDA	22726442
GO:0005886	Component	Plasma membrane	IEA
GO:0006508	Process	Proteolysis	IDA	22726442
GO:0006508	Process	Proteolysis	IEA
GO:0008233	Function	Peptidase activity	IEA
GO:0008237	Function	Metallopeptidase activity	IEA
GO:0016020	Component	Membrane	IBA
GO:0016020	Component	Membrane	IEA
GO:0016055	Process	Wnt signaling pathway	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0017147	Function	Wnt-protein binding	IDA	22726442
GO:0030178	Process	Negative regulation of Wnt signaling pathway	IDA	22726442
GO:0030178	Process	Negative regulation of Wnt signaling pathway	IEA
GO:0031090	Component	Organelle membrane	IDA	22726442
GO:0031334	Process	Positive regulation of protein-containing complex assembly	ISS	22726442
GO:0046872	Function	Metal ion binding	IEA
GO:0060322	Process	Head development	ISS

MIM	HGNC	e!Ensembl
614912	27013	ENSG00000186854

Q86V40

Protein name

Metalloprotease TIKI1 (EC 3.4.-.-) (TRAB domain-containing protein 2A)

Protein function

Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oli

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01963	TraB	43 → 352	TraB family	Family

Sequence

MSPWSWFLLQTLCLLPTGAASRRGAPGTANCELKPQQSELNSFLWTIKRDPPSYFFGTIH
VPYTRVWDFIPDNSKEAFLQSSIVYFELDLTDPYTISALTSCQMLPQGENLQDVLPRDIY
CRLKRHLEYVKLMMPLWMTPDQRGKGLYADYLFNAIAGNWERKRPVWVMLMVNSLTEVDI
KSRGVPVLDLFLAQEAERLRKQTGAVEKVEEQCHPLNGLNFSQVIFALNQTLLQQESLRA
GSLQIPYTTEDLIKHYNCGDLSSVILSHDSSQVPNFINATLPPQERITAQEIDSYLRREL
IYKRNERIGKRVKALLEEFPDKGFFFAFGAGHFMGNNTVLDVLRREGYEVEHAPAGRPIH
KGKSKKTSTRPTLSTIFAPKVPTLEVPAPEAVSSGHSTLPPLVSRPGSADTPSEAEQRFR
KKRRRSQRRPRLRQFSDLWVRLEESDIVPQLQVPVLDRHISTELRLPRRGHSHHSQMVAS
SACLSLWTPVFWVLVLAFQTETPLL

Sequence length

505

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
RESPIRATORY TRACT INFECTIOUS DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

TRABD2A (TraB domain containing 2A)