Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	127707
Gene name	Kelch domain containing 7A
Gene symbol	KLHDC7A
Synonyms (NCBI Gene)	-
Chromosome	1
Chromosome location	1p36.13

106

Show/Hide all (106)

miRTarBase ID	miRNA	Experiments
MIRT1097348	hsa-miR-1208	CLIP-seq
MIRT1097349	hsa-miR-145	CLIP-seq
MIRT1097350	hsa-miR-1825	CLIP-seq
MIRT1097351	hsa-miR-1910	CLIP-seq
MIRT1097352	hsa-miR-194	CLIP-seq
MIRT1097353	hsa-miR-199a-5p	CLIP-seq
MIRT1097354	hsa-miR-199b-5p	CLIP-seq
MIRT1097355	hsa-miR-3121-5p	CLIP-seq
MIRT1097356	hsa-miR-3124-3p	CLIP-seq
MIRT1097357	hsa-miR-3180-5p	CLIP-seq
MIRT1097358	hsa-miR-330-3p	CLIP-seq
MIRT1097359	hsa-miR-370	CLIP-seq
MIRT1097360	hsa-miR-375	CLIP-seq
MIRT1097361	hsa-miR-409-3p	CLIP-seq
MIRT1097362	hsa-miR-4287	CLIP-seq
MIRT1097363	hsa-miR-4469	CLIP-seq
MIRT1097364	hsa-miR-4685-3p	CLIP-seq
MIRT1097365	hsa-miR-4778-3p	CLIP-seq
MIRT1097366	hsa-miR-494	CLIP-seq
MIRT1097367	hsa-miR-495	CLIP-seq
MIRT1097368	hsa-miR-501-5p	CLIP-seq
MIRT1097369	hsa-miR-548c-3p	CLIP-seq
MIRT1097370	hsa-miR-568	CLIP-seq
MIRT1097371	hsa-miR-643	CLIP-seq
MIRT1097372	hsa-miR-668	CLIP-seq
MIRT1097373	hsa-miR-873	CLIP-seq
MIRT1097374	hsa-miR-891b	CLIP-seq
MIRT2026406	hsa-miR-1184	CLIP-seq
MIRT2026407	hsa-miR-1205	CLIP-seq
MIRT2026408	hsa-miR-1305	CLIP-seq
MIRT2026409	hsa-miR-1324	CLIP-seq
MIRT2026410	hsa-miR-1343	CLIP-seq
MIRT1097349	hsa-miR-145	CLIP-seq
MIRT2026411	hsa-miR-150	CLIP-seq
MIRT1097350	hsa-miR-1825	CLIP-seq
MIRT1097353	hsa-miR-199a-5p	CLIP-seq
MIRT1097354	hsa-miR-199b-5p	CLIP-seq
MIRT2026412	hsa-miR-204	CLIP-seq
MIRT2026413	hsa-miR-211	CLIP-seq
MIRT1097356	hsa-miR-3124-3p	CLIP-seq
MIRT2026414	hsa-miR-3127-5p	CLIP-seq
MIRT2026415	hsa-miR-3158-5p	CLIP-seq
MIRT2026416	hsa-miR-3179	CLIP-seq
MIRT1097357	hsa-miR-3180-5p	CLIP-seq
MIRT1097358	hsa-miR-330-3p	CLIP-seq
MIRT2026417	hsa-miR-3667-3p	CLIP-seq
MIRT2026418	hsa-miR-4292	CLIP-seq
MIRT2026419	hsa-miR-4446-5p	CLIP-seq
MIRT2026420	hsa-miR-4639-3p	CLIP-seq
MIRT2026421	hsa-miR-4641	CLIP-seq
MIRT2026422	hsa-miR-4646-5p	CLIP-seq
MIRT2026423	hsa-miR-4690-3p	CLIP-seq
MIRT2026424	hsa-miR-4713-5p	CLIP-seq
MIRT2026425	hsa-miR-4728-3p	CLIP-seq
MIRT2026426	hsa-miR-4755-5p	CLIP-seq
MIRT1097366	hsa-miR-494	CLIP-seq
MIRT2026427	hsa-miR-532-3p	CLIP-seq
MIRT2026428	hsa-miR-623	CLIP-seq
MIRT1097372	hsa-miR-668	CLIP-seq
MIRT2257505	hsa-miR-1291	CLIP-seq
MIRT2026409	hsa-miR-1324	CLIP-seq
MIRT1097349	hsa-miR-145	CLIP-seq
MIRT1097350	hsa-miR-1825	CLIP-seq
MIRT1097353	hsa-miR-199a-5p	CLIP-seq
MIRT1097354	hsa-miR-199b-5p	CLIP-seq
MIRT2257506	hsa-miR-2276	CLIP-seq
MIRT2257507	hsa-miR-2355-5p	CLIP-seq
MIRT2257508	hsa-miR-3123	CLIP-seq
MIRT1097356	hsa-miR-3124-3p	CLIP-seq
MIRT1097357	hsa-miR-3180-5p	CLIP-seq
MIRT2257509	hsa-miR-328	CLIP-seq
MIRT2257510	hsa-miR-338-5p	CLIP-seq
MIRT2257511	hsa-miR-342-5p	CLIP-seq
MIRT2257512	hsa-miR-3925-5p	CLIP-seq
MIRT2257513	hsa-miR-3926	CLIP-seq
MIRT2257514	hsa-miR-3976	CLIP-seq
MIRT2257515	hsa-miR-4426	CLIP-seq
MIRT2257516	hsa-miR-4447	CLIP-seq
MIRT2257517	hsa-miR-4455	CLIP-seq
MIRT2257518	hsa-miR-4472	CLIP-seq
MIRT2257519	hsa-miR-4647	CLIP-seq
MIRT2257520	hsa-miR-4651	CLIP-seq
MIRT2257521	hsa-miR-4662b	CLIP-seq
MIRT2257522	hsa-miR-4664-5p	CLIP-seq
MIRT2257523	hsa-miR-4708-3p	CLIP-seq
MIRT2257524	hsa-miR-4729	CLIP-seq
MIRT1097366	hsa-miR-494	CLIP-seq
MIRT2257525	hsa-miR-548g	CLIP-seq
MIRT2257526	hsa-miR-548s	CLIP-seq
MIRT2257527	hsa-miR-608	CLIP-seq
MIRT2257528	hsa-miR-644	CLIP-seq
MIRT2257529	hsa-miR-663b	CLIP-seq
MIRT2257508	hsa-miR-3123	CLIP-seq
MIRT2257510	hsa-miR-338-5p	CLIP-seq
MIRT2257512	hsa-miR-3925-5p	CLIP-seq
MIRT2257514	hsa-miR-3976	CLIP-seq
MIRT1097366	hsa-miR-494	CLIP-seq
MIRT1097369	hsa-miR-548c-3p	CLIP-seq
MIRT1097373	hsa-miR-873	CLIP-seq
MIRT2257508	hsa-miR-3123	CLIP-seq
MIRT2257510	hsa-miR-338-5p	CLIP-seq
MIRT2257512	hsa-miR-3925-5p	CLIP-seq
MIRT2257514	hsa-miR-3976	CLIP-seq
MIRT1097366	hsa-miR-494	CLIP-seq
MIRT1097369	hsa-miR-548c-3p	CLIP-seq
MIRT1097373	hsa-miR-873	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0016020	Component	Membrane	IEA

MIM	HGNC	e!Ensembl
HGNC	N/A	HGNC

Q5VTJ3

Protein name

Kelch domain-containing protein 7A

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01344	Kelch_1	530 → 576	Kelch motif	Repeat
PF01344	Kelch_1	578 → 619	Kelch motif	Repeat

Sequence

MFPRGAEAQDWHLDMQLTGKVVLSAAALLLVTVAYRLYKSRPAPAQRWGGNGQAEAKEEA
EGSGQPAVQEASPGVLLRGPRRRRSSKRAEAPQGCSCENPRGPYVLVTGATSTDRKPQRK
GSGEERGGQGSDSEQVPPCCPSQETRTAVGSNPDPPHFPRLGSEPKSSPAGLIAAADGSC
AGGEPSPWQDSKPREHPGLGQLEPPHCHYVAPLQGSSDMNQSWVFTRVIGVSREEAGALE
AASDVDLTLHQQEGAPNSSYTFSSIARVRMEEHFIQKAEGVEPRLKGKVYDYYVESTSQA
IFQGRLAPRTAALTEVPSPRPPPGSLGTGAASGGQAGDTKGAAERAASPQTGPWPSTRGF
SRKESLLQIAENPELQLQPDGFRLPAPPCPDPGALPGLGRSSREPHVQPVAGTNFFHIPL
TPASAPQVRLDLGNCYEVLTLAKRQNLEALKEAAYKVMSENYLQVLRSPDIYGCLSGAER
ELILQRRLRGRQYLVVADVCPKEDSGGLCCYDDEQDVWRPLARMPPEAVSRGCAICSLFN
YLFVVSGCQGPGHQPSSRVFCYNPLTGIWSEVCPLNQARPHCRLVALDGHLYAIGGECLN
SVERYDPRLDRWDFAPPLPSDTFALAHTATVRAKEIFVTGGSLRFLLFRFSAQEQRWWAG
PTGGSKDRTAEMVAVNGFLYRFDLNRSLGIAVYRCSASTRLWYECATYRTPYPDAFQCAV
VDNLIYCVGRRSTLCFLADSVSPRFVPKELRSFPAPQGTLLPTVLTLPTPDLPQTRV

Sequence length

777

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (6)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
BREAST CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST NEOPLASMS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETIC RETINOPATHY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PELVIC ORGAN PROLAPSE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (7)

Disease Name	Disease (Merged)	Source	PMID	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Breast Carcinoma	Breast Carcinoma	CTD_human_DG	29915430	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	27607899	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetic Retinopathy	Diabetic Retinopathy	BEFREE	27607899	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant neoplasm of breast	Breast Cancer	CTD_human_DG	29915430	★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Carcinoma, Human	Marfan Syndrome	CTD_human_DG	29915430	★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	CTD_human_DG	29915430	★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms, Human	Mammary Neoplasms	CTD_human_DG	29915430	★★★★★ ★☆☆☆☆ Found in Text Mining only

KLHDC7A (kelch domain containing 7A)