Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	1268
Gene name	Cannabinoid receptor 1
Gene symbol	CNR1
Synonyms (NCBI Gene)	CANN6CB-RCB1CB1ACB1K5CB1RCNR
Chromosome	6
Chromosome location	6q15
Summary	This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protei

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miRTarBase ID	miRNA	Experiments	Reference
MIRT438441	hsa-miR-494-3p	Luciferase reporter assayWestern blot	25111814
MIRT438441	hsa-miR-494-3p	Luciferase reporter assayWestern blot	25111814
MIRT438441	hsa-miR-494-3p	Luciferase reporter assayWestern blot	25111814
MIRT438441	hsa-miR-494-3p	Luciferase reporter assayWestern blot	25111814
MIRT438441	hsa-miR-494-3p	Luciferase reporter assayWestern blot	25111814
MIRT438441	hsa-miR-494-3p	Luciferase reporter assayWestern blot	25111814
MIRT755408	hsa-miR-212-5p	Luciferase reporter assayWestern blottingqRT-PCR	35978628
MIRT901338	hsa-miR-1183	CLIP-seq
MIRT901339	hsa-miR-1225-5p	CLIP-seq
MIRT901340	hsa-miR-132	CLIP-seq
MIRT901341	hsa-miR-194	CLIP-seq
MIRT901342	hsa-miR-212	CLIP-seq
MIRT901343	hsa-miR-214	CLIP-seq
MIRT901344	hsa-miR-29a	CLIP-seq
MIRT901345	hsa-miR-29b	CLIP-seq
MIRT901346	hsa-miR-29c	CLIP-seq
MIRT901347	hsa-miR-3155	CLIP-seq
MIRT901348	hsa-miR-3155b	CLIP-seq
MIRT901349	hsa-miR-323-3p	CLIP-seq
MIRT901350	hsa-miR-3591-5p	CLIP-seq
MIRT901351	hsa-miR-3619-5p	CLIP-seq
MIRT901352	hsa-miR-425	CLIP-seq
MIRT901353	hsa-miR-4473	CLIP-seq
MIRT901354	hsa-miR-4475	CLIP-seq
MIRT901355	hsa-miR-4514	CLIP-seq
MIRT901356	hsa-miR-4522	CLIP-seq
MIRT901357	hsa-miR-4530	CLIP-seq
MIRT901358	hsa-miR-4643	CLIP-seq
MIRT901359	hsa-miR-4671-3p	CLIP-seq
MIRT901360	hsa-miR-4690-5p	CLIP-seq
MIRT901361	hsa-miR-4692	CLIP-seq
MIRT901362	hsa-miR-4693-5p	CLIP-seq
MIRT901363	hsa-miR-4712-5p	CLIP-seq
MIRT901364	hsa-miR-4714-5p	CLIP-seq
MIRT901365	hsa-miR-484	CLIP-seq
MIRT901366	hsa-miR-512-3p	CLIP-seq
MIRT901367	hsa-miR-516a-5p	CLIP-seq
MIRT901368	hsa-miR-520f	CLIP-seq
MIRT901369	hsa-miR-626	CLIP-seq
MIRT901370	hsa-miR-761	CLIP-seq
MIRT901371	hsa-miR-770-5p	CLIP-seq
MIRT901372	hsa-miR-1178	CLIP-seq
MIRT901373	hsa-miR-1279	CLIP-seq
MIRT901374	hsa-miR-134	CLIP-seq
MIRT901375	hsa-miR-1343	CLIP-seq
MIRT901376	hsa-miR-137	CLIP-seq
MIRT901377	hsa-miR-141	CLIP-seq
MIRT901378	hsa-miR-200a	CLIP-seq
MIRT901379	hsa-miR-216a	CLIP-seq
MIRT901380	hsa-miR-216b	CLIP-seq
MIRT901381	hsa-miR-3074-5p	CLIP-seq
MIRT901382	hsa-miR-3118	CLIP-seq
MIRT901383	hsa-miR-3124-3p	CLIP-seq
MIRT901384	hsa-miR-3128	CLIP-seq
MIRT901385	hsa-miR-3136-5p	CLIP-seq
MIRT901350	hsa-miR-3591-5p	CLIP-seq
MIRT901386	hsa-miR-3606	CLIP-seq
MIRT901387	hsa-miR-374c	CLIP-seq
MIRT901388	hsa-miR-4265	CLIP-seq
MIRT901389	hsa-miR-4296	CLIP-seq
MIRT901390	hsa-miR-4318	CLIP-seq
MIRT901391	hsa-miR-4322	CLIP-seq
MIRT901392	hsa-miR-4417	CLIP-seq
MIRT901393	hsa-miR-4439	CLIP-seq
MIRT901394	hsa-miR-4513	CLIP-seq
MIRT901395	hsa-miR-4659a-3p	CLIP-seq
MIRT901396	hsa-miR-4659b-3p	CLIP-seq
MIRT901362	hsa-miR-4693-5p	CLIP-seq
MIRT901397	hsa-miR-4778-3p	CLIP-seq
MIRT901398	hsa-miR-578	CLIP-seq
MIRT901399	hsa-miR-643	CLIP-seq
MIRT901400	hsa-miR-655	CLIP-seq
MIRT901401	hsa-miR-892a	CLIP-seq
MIRT901402	hsa-miR-921	CLIP-seq
MIRT901381	hsa-miR-3074-5p	CLIP-seq
MIRT1967395	hsa-miR-377	CLIP-seq
MIRT2203017	hsa-miR-4700-3p	CLIP-seq
MIRT2203018	hsa-let-7a	CLIP-seq
MIRT2203019	hsa-let-7b	CLIP-seq
MIRT2203020	hsa-let-7c	CLIP-seq
MIRT2203021	hsa-let-7d	CLIP-seq
MIRT2203022	hsa-let-7e	CLIP-seq
MIRT2203023	hsa-let-7f	CLIP-seq
MIRT2203024	hsa-let-7g	CLIP-seq
MIRT2203025	hsa-let-7i	CLIP-seq
MIRT2203026	hsa-miR-1229	CLIP-seq
MIRT2203027	hsa-miR-128	CLIP-seq
MIRT2203028	hsa-miR-151-3p	CLIP-seq
MIRT901341	hsa-miR-194	CLIP-seq
MIRT2203029	hsa-miR-202	CLIP-seq
MIRT2203030	hsa-miR-2116	CLIP-seq
MIRT2203031	hsa-miR-27a	CLIP-seq
MIRT2203032	hsa-miR-27b	CLIP-seq
MIRT2203033	hsa-miR-3187-3p	CLIP-seq
MIRT901349	hsa-miR-323-3p	CLIP-seq
MIRT2203034	hsa-miR-4257	CLIP-seq
MIRT2203035	hsa-miR-4328	CLIP-seq
MIRT2203036	hsa-miR-4435	CLIP-seq
MIRT2203037	hsa-miR-4458	CLIP-seq
MIRT2203038	hsa-miR-4500	CLIP-seq
MIRT901358	hsa-miR-4643	CLIP-seq
MIRT2203039	hsa-miR-4645-5p	CLIP-seq
MIRT901395	hsa-miR-4659a-3p	CLIP-seq
MIRT901396	hsa-miR-4659b-3p	CLIP-seq
MIRT2203040	hsa-miR-4673	CLIP-seq
MIRT2203017	hsa-miR-4700-3p	CLIP-seq
MIRT2203041	hsa-miR-4701-5p	CLIP-seq
MIRT901397	hsa-miR-4778-3p	CLIP-seq
MIRT2203042	hsa-miR-548s	CLIP-seq
MIRT901398	hsa-miR-578	CLIP-seq
MIRT2203043	hsa-miR-588	CLIP-seq
MIRT2203044	hsa-miR-617	CLIP-seq
MIRT2203045	hsa-miR-653	CLIP-seq
MIRT2203046	hsa-miR-890	CLIP-seq
MIRT2203047	hsa-miR-98	CLIP-seq
MIRT2386297	hsa-miR-1289	CLIP-seq
MIRT2386298	hsa-miR-3198	CLIP-seq
MIRT2386299	hsa-miR-4294	CLIP-seq
MIRT2386300	hsa-miR-4309	CLIP-seq
MIRT2386301	hsa-miR-4790-3p	CLIP-seq
MIRT2505992	hsa-miR-3115	CLIP-seq
MIRT2505993	hsa-miR-4735-5p	CLIP-seq
MIRT2505994	hsa-miR-4777-5p	CLIP-seq
MIRT2505995	hsa-miR-518d-5p	CLIP-seq
MIRT2505996	hsa-miR-519b-5p	CLIP-seq
MIRT2505997	hsa-miR-519c-5p	CLIP-seq
MIRT2505998	hsa-miR-520c-5p	CLIP-seq
MIRT2505999	hsa-miR-526a	CLIP-seq
MIRT2506000	hsa-miR-944	CLIP-seq
MIRT2505994	hsa-miR-4777-5p	CLIP-seq
MIRT2505995	hsa-miR-518d-5p	CLIP-seq
MIRT2505996	hsa-miR-519b-5p	CLIP-seq
MIRT2505997	hsa-miR-519c-5p	CLIP-seq
MIRT2505998	hsa-miR-520c-5p	CLIP-seq
MIRT2505999	hsa-miR-526a	CLIP-seq

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Transcription factor	Regulation	Reference
STAT6	Activation	18156315

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GO ID	Ontology	Definition	Evidence	Reference
GO:0004930	Function	G protein-coupled receptor activity	IBA
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0004949	Function	Cannabinoid receptor activity	IDA	18761332
GO:0004949	Function	Cannabinoid receptor activity	IEA
GO:0004949	Function	Cannabinoid receptor activity	TAS	1718258
GO:0005515	Function	Protein binding	IPI	17356572, 17895407, 23296780, 28102227
GO:0005737	Component	Cytoplasm	IBA
GO:0005739	Component	Mitochondrion	IEA
GO:0005739	Component	Mitochondrion	IEA
GO:0005741	Component	Mitochondrial outer membrane	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	17895407
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	1718258
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007187	Process	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IEA
GO:0007187	Process	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	TAS	1718258
GO:0007188	Process	Adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IDA	18761332
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA
GO:0007413	Process	Axonal fasciculation	IEA
GO:0015629	Component	Actin cytoskeleton	IDA
GO:0016020	Component	Membrane	IEA
GO:0030424	Component	Axon	IEA
GO:0030426	Component	Growth cone	IEA
GO:0038171	Process	Cannabinoid signaling pathway	IDA	17895407
GO:0042593	Process	Glucose homeostasis	IEA
GO:0042734	Component	Presynaptic membrane	IEA
GO:0042802	Function	Identical protein binding	IPI	20590567, 28734930
GO:0042995	Component	Cell projection	IEA
GO:0045121	Component	Membrane raft	IEA
GO:0045202	Component	Synapse	IEA
GO:0098793	Component	Presynapse	IEA
GO:0098921	Process	Retrograde trans-synaptic signaling by endocannabinoid	IEA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0098982	Component	GABA-ergic synapse	IEA
GO:0099509	Process	Regulation of presynaptic cytosolic calcium ion concentration	IEA

MIM	HGNC	e!Ensembl
114610	2159	ENSG00000118432

P21554

Protein name

Cannabinoid receptor 1 (CB-R) (CB1) (CANN6)

Protein function

G-protein coupled receptor for endogenous cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG), as well as phytocannabinoids, such as delta(9)-tetrahydrocannabinol (THC) (Pub

PDB

1LVQ , 1LVR , 2B0Y , 2KOE , 2MZ2 , 2MZ3 , 2MZA , 5TGZ , 5U09 , 5XR8 , 5XRA , 6KPG , 6KQI , 6N4B , 7FEE , 7V3Z , 7WV9 , 8GAG , 8GHV , 8IKG , 8IKH , 8K8J , 8WRZ , 8WU1 , 9B54 , 9B65 , 9B9Y , 9B9Z , 9BA0 , 9ERX

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	133 → 397	7 transmembrane receptor (rhodopsin family)	Family

Tissue specificity

TISSUE SPECIFICITY: Widely expressed, with highest levels in fetal and adult brain. Expression levels of isoform 2 and isoform 3 are much lower than those of isoform 1. {ECO:0000269|PubMed:15620723}.

Sequence

MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQE
KMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIA
VLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVF
HRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLM
WTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWK
AHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLL
AIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQ
PLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL

Sequence length

472

Interactions

View interactions

	KEGG		Reactome
	Rap1 signaling pathway Neuroactive ligand-receptor interaction Thermogenesis Retrograde endocannabinoid signaling		Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (46)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ANXIETY DISORDERS	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATTENTION DEFICIT DISORDER	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BINGE-EATING DISORDER	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CANNABIS ABUSE	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CATALEPSY	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHOLESTASIS	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CNR1-related disorder	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COGNITION DISORDERS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CONDUCT DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DELIRIUM, DEMENTIA, AMNESTIC, COGNITIVE DISORDERS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEPRESSIVE DISORDER	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEVELOPMENTAL COORDINATION DISORDER	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETES MELLITUS, NON-INSULIN-DEPENDENT	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ENDOMETRIAL NEOPLASMS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ENDOMETRIOSIS	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EPILEPSY, TEMPORAL LOBE	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HUNTINGTON DISEASE	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERALGESIA	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPOTENSION	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LIVER CIRRHOSIS	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LIVER CIRRHOSIS, EXPERIMENTAL	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG ADENOCARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MELANOMA, CUTANEOUS MALIGNANT	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MEMORY DISORDERS	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MENTAL DEPRESSION	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MOTOR SKILLS DISORDERS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MOVEMENT DISORDERS	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MULTIPLE SCLEROSIS	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBESITY	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PANCREATIC NEOPLASMS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PANCREATITIS	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
POST-TRAUMATIC STRESS DISORDER	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RHABDOMYOSARCOMA	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCLERODERMA, SYSTEMIC	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SEIZURES	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SQUAMOUS CELL CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
STATUS EPILEPTICUS	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SUBSTANCE WITHDRAWAL SYNDROME	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SYSTEMIC SCLERODERMA	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UNIPOLAR DEPRESSION	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

CNR1 (cannabinoid receptor 1)