GABPB2 (GA binding protein transcription factor subunit beta 2)

Gene

• Entrez ID: 126626
• Gene name: GA binding protein transcription factor subunit beta 2
• Gene symbol: GABPB2
• Synonyms (NCBI Gene): GABPB-2
• Chromosome: 1
• Chromosome location: 1q21.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT026307	hsa-miR-192-5p	Microarray	19074876
MIRT052267	hsa-let-7b-5p	CLASH	23622248
MIRT042429	hsa-miR-425-3p	CLASH	23622248
MIRT1009744	hsa-miR-10a	CLIP-seq
MIRT1009745	hsa-miR-10b	CLIP-seq
MIRT1009746	hsa-miR-133a	CLIP-seq
MIRT1009747	hsa-miR-133b	CLIP-seq
MIRT1009748	hsa-miR-300	CLIP-seq
MIRT1009749	hsa-miR-3182	CLIP-seq
MIRT1009750	hsa-miR-328	CLIP-seq
MIRT1009751	hsa-miR-3686	CLIP-seq
MIRT1009752	hsa-miR-381	CLIP-seq
MIRT1009753	hsa-miR-4666-3p	CLIP-seq
MIRT1009754	hsa-miR-4749-3p	CLIP-seq
MIRT1009755	hsa-miR-4789-5p	CLIP-seq
MIRT1009756	hsa-miR-511	CLIP-seq
MIRT1009757	hsa-miR-548u	CLIP-seq
MIRT1009758	hsa-miR-610	CLIP-seq
MIRT1009749	hsa-miR-3182	CLIP-seq
MIRT1009751	hsa-miR-3686	CLIP-seq
MIRT2681318	hsa-miR-4742-3p	CLIP-seq
MIRT1009756	hsa-miR-511	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000976	Function	Transcription cis-regulatory region binding	IBA
GO:0000976	Function	Transcription cis-regulatory region binding	IDA	9857059
GO:0005515	Function	Protein binding	IPI	25416956, 28514442, 32296183, 32814053, 33961781
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	9857059
GO:0005634	Component	Nucleus	IEA
GO:0042802	Function	Identical protein binding	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IBA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	9857059

Other IDs

• MIM: 621284
• HGNC: 28441
• e!Ensembl: ENSG00000143458

Protein

• UniProt ID: Q8TAK5
• Protein name: GA-binding protein subunit beta-2 (GABP subunit beta-2) (GABPB-2)
• Protein function: May function as transcription factor capable of interacting with purine rich repeats (GA repeats).
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF12796	Ank_2	10 → 101	Ankyrin repeats (3 copies)	Repeat
  PF12796	Ank_2	75 → 172	Ankyrin repeats (3 copies)	Repeat

• Sequence:

  MSLVDLGKRLLEAARKGQDDEVRTLMANGAPFTTDWLGTSPLHLAAQYGHYSTAEVLLRA
  GVSRDARTKVDRTPLHMAAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVV
  ELLIKYGADVHAFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVNPERANPVTDPVSM
  AAPFIFTSGEVVNLASLISSTNTKTTSGDPHASTVQFSNSTTSVLATLAALAEASVPLSN
  SHRATANTEEIIEGNSVDSSIQQVMGSGGQRVITIVTDGVPLGNIQTSIPTGGIGQPFIV
  TVQDGQQVLTVPAGKVAEETVIKEEEEEKLPLTKKPRIGEKTNSVEESKEGNERELLQQQ
  LQEANRRAQEYRHQLLKKEQEAEQYRLKLEAIARQQPNGVDFTMVEEVAEVDAVVVTEGE
  LEERETKVTGSAGTTEPHTRVSMATVSS

• Sequence length: 448

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ATOPIC ECZEMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cervical cancer	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OLIGODENDROGLIOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Schizophrenia	Schizophrenia	Pubtator	28117656	Associate	★☆☆☆☆ Found in Text Mining only