Gene Gene information from NCBI Gene database.
Entrez ID 126433
Gene name F-box protein 27
Gene symbol FBXO27
Synonyms (NCBI Gene)
FBG5Fbx27
Chromosome 19
Chromosome location 19q13.2
Summary Members of the F-box protein family, such as FBXO27, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box pr
miRNA miRNA information provided by mirtarbase database.
453
miRTarBase ID miRNA Experiments Reference
MIRT531156 hsa-miR-5693 PAR-CLIP 22012620
MIRT523768 hsa-miR-6499-3p PAR-CLIP 22012620
MIRT523767 hsa-miR-3135b PAR-CLIP 22012620
MIRT523766 hsa-miR-4294 PAR-CLIP 22012620
MIRT523765 hsa-miR-504-3p PAR-CLIP 22012620
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
11
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IDA 18203720
GO:0005515 Function Protein binding IPI 18203720, 32296183
GO:0005737 Component Cytoplasm IBA
GO:0005737 Component Cytoplasm IEA
GO:0005829 Component Cytosol TAS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
609099 18753 ENSG00000161243
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8NI29
Protein name F-box only protein 27 (F-box/G-domain protein 5)
Protein function Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00646 F-box 24 72 F-box domain Domain
PF04300 FBA 105 278 F-box associated region Family
Tissue specificity TISSUE SPECIFICITY: Predominantly expressed in brain, heart and kidney. Expressed at lower levels in liver and lung. {ECO:0000269|PubMed:12383498}.
Sequence
Sequence length 283
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Neddylation
Antigen processing: Ubiquitination & Proteasome degradation
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
IGA GLOMERULONEPHRITIS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations