Gene Gene information from NCBI Gene database.
Entrez ID 126282
Gene name TNF alpha induced protein 8 like 1
Gene symbol TNFAIP8L1
Synonyms (NCBI Gene)
TIPE1
Chromosome 19
Chromosome location 19p13.3
miRNA miRNA information provided by mirtarbase database.
829
miRTarBase ID miRNA Experiments Reference
MIRT042335 hsa-miR-484 CLASH 23622248
MIRT706880 hsa-miR-4438 HITS-CLIP 21572407
MIRT706879 hsa-miR-455-5p HITS-CLIP 21572407
MIRT706878 hsa-miR-4740-3p HITS-CLIP 21572407
MIRT529979 hsa-miR-6778-3p HITS-CLIP 21572407
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
9
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 16189514, 25416956, 32296183, 32814053
GO:0005737 Component Cytoplasm IBA
GO:0005737 Component Cytoplasm IEA
GO:0005737 Component Cytoplasm ISS
GO:0032007 Process Negative regulation of TOR signaling IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
615869 28279 ENSG00000185361
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8WVP5
Protein name Tumor necrosis factor alpha-induced protein 8-like protein 1 (TIPE1) (TNF alpha-induced protein 8-like protein 1) (TNFAIP8-like protein 1) (Oxidative stress-regulated gene-beta) (Oxy-beta)
Protein function Acts as a negative regulator of mTOR activity.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF05527 DUF758 4 184 Domain of unknown function (DUF758) Family
Tissue specificity TISSUE SPECIFICITY: High expression detected in most carcinoma cell lines, especially in cells transformed with virus genomes. {ECO:0000269|PubMed:21600655}.
Sequence
Sequence length 186
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    PI Metabolism
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
2
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
BREAST CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Ankylosing spondylitis Ankylosing Spondylitis BEFREE 27816498
★☆☆☆☆
Found in Text Mining only
Arteriosclerosis Arteriosclerosis BEFREE 31672550
★☆☆☆☆
Found in Text Mining only
Atherosclerosis Atherosclerosis BEFREE 31672550
★☆☆☆☆
Found in Text Mining only
Autoimmune Diseases Autoimmune Diseases BEFREE 27175635
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 31179241, 31559412
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Breast Neoplasms Breast neoplasm Pubtator 31559412 Associate
★☆☆☆☆
Found in Text Mining only
Carcinogenesis Carcinogenesis Pubtator 36151091 Inhibit
★☆☆☆☆
Found in Text Mining only
Carcinogenesis Carcinogenesis Pubtator 38065896 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma of lung Lung carcinoma BEFREE 29108244
★☆☆☆☆
Found in Text Mining only
cervical cancer Cervical Cancer BEFREE 30445600, 31179241
★☆☆☆☆
Found in Text Mining only