EID2B (EP300 interacting inhibitor of differentiation 2B)

Gene

• Entrez ID: 126272
• Gene name: EP300 interacting inhibitor of differentiation 2B
• Gene symbol: EID2B
• Synonyms (NCBI Gene): EID-2B, EID-3
• Chromosome: 19
• Chromosome location: 19q13.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT620118	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT620117	hsa-miR-1256	HITS-CLIP	23824327
MIRT620116	hsa-miR-4642	HITS-CLIP	23824327
MIRT504475	hsa-miR-3938	PAR-CLIP	23446348
MIRT504474	hsa-miR-25-3p	PAR-CLIP	23446348
MIRT504473	hsa-miR-32-5p	PAR-CLIP	23446348
MIRT504472	hsa-miR-363-3p	PAR-CLIP	23446348
MIRT504471	hsa-miR-367-3p	PAR-CLIP	23446348
MIRT504470	hsa-miR-92a-3p	PAR-CLIP	23446348
MIRT504469	hsa-miR-92b-3p	PAR-CLIP	23446348
MIRT504468	hsa-miR-4317	PAR-CLIP	23446348
MIRT504467	hsa-miR-5088-3p	PAR-CLIP	23446348
MIRT504466	hsa-miR-205-5p	PAR-CLIP	23446348
MIRT504465	hsa-miR-5589-3p	PAR-CLIP	23446348
MIRT504462	hsa-miR-623	PAR-CLIP	23446348
MIRT504461	hsa-miR-204-5p	PAR-CLIP	23446348
MIRT504460	hsa-miR-211-5p	PAR-CLIP	23446348
MIRT504459	hsa-miR-4755-5p	PAR-CLIP	23446348
MIRT504458	hsa-miR-5006-3p	PAR-CLIP	23446348
MIRT504475	hsa-miR-3938	PAR-CLIP	23446348
MIRT504474	hsa-miR-25-3p	PAR-CLIP	23446348
MIRT504473	hsa-miR-32-5p	PAR-CLIP	23446348
MIRT504472	hsa-miR-363-3p	PAR-CLIP	23446348
MIRT504471	hsa-miR-367-3p	PAR-CLIP	23446348
MIRT504470	hsa-miR-92a-3p	PAR-CLIP	23446348
MIRT504469	hsa-miR-92b-3p	PAR-CLIP	23446348
MIRT504468	hsa-miR-4317	PAR-CLIP	23446348
MIRT504467	hsa-miR-5088-3p	PAR-CLIP	23446348
MIRT504466	hsa-miR-205-5p	PAR-CLIP	23446348
MIRT504465	hsa-miR-5589-3p	PAR-CLIP	23446348
MIRT504464	hsa-miR-145-5p	PAR-CLIP	23446348
MIRT504463	hsa-miR-5195-3p	PAR-CLIP	23446348
MIRT504462	hsa-miR-623	PAR-CLIP	23446348
MIRT504461	hsa-miR-204-5p	PAR-CLIP	23446348
MIRT504460	hsa-miR-211-5p	PAR-CLIP	23446348
MIRT504459	hsa-miR-4755-5p	PAR-CLIP	23446348
MIRT504458	hsa-miR-5006-3p	PAR-CLIP	23446348
MIRT440743	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440743	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT504470	hsa-miR-92a-3p	HITS-CLIP	22473208
MIRT504469	hsa-miR-92b-3p	HITS-CLIP	22473208
MIRT504473	hsa-miR-32-5p	HITS-CLIP	22473208
MIRT620118	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT620117	hsa-miR-1256	HITS-CLIP	23824327
MIRT620116	hsa-miR-4642	HITS-CLIP	23824327
MIRT504475	hsa-miR-3938	PAR-CLIP	23446348
MIRT504474	hsa-miR-25-3p	PAR-CLIP	23446348
MIRT504473	hsa-miR-32-5p	PAR-CLIP	23446348
MIRT504472	hsa-miR-363-3p	PAR-CLIP	23446348
MIRT504471	hsa-miR-367-3p	PAR-CLIP	23446348
MIRT504470	hsa-miR-92a-3p	PAR-CLIP	23446348
MIRT504469	hsa-miR-92b-3p	PAR-CLIP	23446348
MIRT504468	hsa-miR-4317	PAR-CLIP	23446348
MIRT504467	hsa-miR-5088-3p	PAR-CLIP	23446348
MIRT504466	hsa-miR-205-5p	PAR-CLIP	23446348
MIRT504465	hsa-miR-5589-3p	PAR-CLIP	23446348
MIRT504462	hsa-miR-623	PAR-CLIP	23446348
MIRT504461	hsa-miR-204-5p	PAR-CLIP	23446348
MIRT504460	hsa-miR-211-5p	PAR-CLIP	23446348
MIRT504459	hsa-miR-4755-5p	PAR-CLIP	23446348
MIRT504458	hsa-miR-5006-3p	PAR-CLIP	23446348
MIRT504475	hsa-miR-3938	PAR-CLIP	23446348
MIRT504474	hsa-miR-25-3p	PAR-CLIP	23446348
MIRT504473	hsa-miR-32-5p	PAR-CLIP	23446348
MIRT504472	hsa-miR-363-3p	PAR-CLIP	23446348
MIRT504471	hsa-miR-367-3p	PAR-CLIP	23446348
MIRT504470	hsa-miR-92a-3p	PAR-CLIP	23446348
MIRT504469	hsa-miR-92b-3p	PAR-CLIP	23446348
MIRT504468	hsa-miR-4317	PAR-CLIP	23446348
MIRT504467	hsa-miR-5088-3p	PAR-CLIP	23446348
MIRT504466	hsa-miR-205-5p	PAR-CLIP	23446348
MIRT504465	hsa-miR-5589-3p	PAR-CLIP	23446348
MIRT504464	hsa-miR-145-5p	PAR-CLIP	23446348
MIRT504463	hsa-miR-5195-3p	PAR-CLIP	23446348
MIRT504462	hsa-miR-623	PAR-CLIP	23446348
MIRT504461	hsa-miR-204-5p	PAR-CLIP	23446348
MIRT504460	hsa-miR-211-5p	PAR-CLIP	23446348
MIRT504459	hsa-miR-4755-5p	PAR-CLIP	23446348
MIRT504458	hsa-miR-5006-3p	PAR-CLIP	23446348
MIRT955868	hsa-miR-1200	CLIP-seq
MIRT955869	hsa-miR-122	CLIP-seq
MIRT955870	hsa-miR-1231	CLIP-seq
MIRT955871	hsa-miR-125a-3p	CLIP-seq
MIRT955872	hsa-miR-1281	CLIP-seq
MIRT955873	hsa-miR-1293	CLIP-seq
MIRT955874	hsa-miR-1307	CLIP-seq
MIRT955875	hsa-miR-141	CLIP-seq
MIRT955876	hsa-miR-197	CLIP-seq
MIRT955877	hsa-miR-200a	CLIP-seq
MIRT955878	hsa-miR-200b	CLIP-seq
MIRT955879	hsa-miR-200c	CLIP-seq
MIRT955880	hsa-miR-204	CLIP-seq
MIRT955881	hsa-miR-205	CLIP-seq
MIRT955882	hsa-miR-211	CLIP-seq
MIRT955883	hsa-miR-2115	CLIP-seq
MIRT955884	hsa-miR-2116	CLIP-seq
MIRT955885	hsa-miR-217	CLIP-seq
MIRT955886	hsa-miR-218	CLIP-seq
MIRT955887	hsa-miR-25	CLIP-seq
MIRT955888	hsa-miR-3129-3p	CLIP-seq
MIRT955889	hsa-miR-3170	CLIP-seq
MIRT955890	hsa-miR-3187-3p	CLIP-seq
MIRT955891	hsa-miR-32	CLIP-seq
MIRT955892	hsa-miR-323-5p	CLIP-seq
MIRT955893	hsa-miR-363	CLIP-seq
MIRT955894	hsa-miR-367	CLIP-seq
MIRT955895	hsa-miR-369-3p	CLIP-seq
MIRT955896	hsa-miR-3934	CLIP-seq
MIRT955897	hsa-miR-4288	CLIP-seq
MIRT955898	hsa-miR-429	CLIP-seq
MIRT955899	hsa-miR-4418	CLIP-seq
MIRT955900	hsa-miR-4424	CLIP-seq
MIRT955901	hsa-miR-4435	CLIP-seq
MIRT955902	hsa-miR-4452	CLIP-seq
MIRT955903	hsa-miR-4483	CLIP-seq
MIRT955904	hsa-miR-4635	CLIP-seq
MIRT955905	hsa-miR-4638-5p	CLIP-seq
MIRT955906	hsa-miR-4677-5p	CLIP-seq
MIRT955907	hsa-miR-4691-5p	CLIP-seq
MIRT955908	hsa-miR-4695-3p	CLIP-seq
MIRT955909	hsa-miR-4701-5p	CLIP-seq
MIRT955910	hsa-miR-4716-5p	CLIP-seq
MIRT955911	hsa-miR-4763-5p	CLIP-seq
MIRT955912	hsa-miR-4772-3p	CLIP-seq
MIRT955913	hsa-miR-4781-3p	CLIP-seq
MIRT955914	hsa-miR-509-3-5p	CLIP-seq
MIRT955915	hsa-miR-509-5p	CLIP-seq
MIRT955916	hsa-miR-5096	CLIP-seq
MIRT955917	hsa-miR-516a-3p	CLIP-seq
MIRT955918	hsa-miR-548g	CLIP-seq
MIRT955919	hsa-miR-548s	CLIP-seq
MIRT955920	hsa-miR-570	CLIP-seq
MIRT955921	hsa-miR-574-5p	CLIP-seq
MIRT955922	hsa-miR-587	CLIP-seq
MIRT955923	hsa-miR-588	CLIP-seq
MIRT955924	hsa-miR-596	CLIP-seq
MIRT955925	hsa-miR-632	CLIP-seq
MIRT955926	hsa-miR-636	CLIP-seq
MIRT955927	hsa-miR-640	CLIP-seq
MIRT955928	hsa-miR-648	CLIP-seq
MIRT955929	hsa-miR-764	CLIP-seq
MIRT955930	hsa-miR-92a	CLIP-seq
MIRT955931	hsa-miR-92b	CLIP-seq
MIRT955872	hsa-miR-1281	CLIP-seq
MIRT1983144	hsa-miR-1915	CLIP-seq
MIRT1983145	hsa-miR-24	CLIP-seq
MIRT1983146	hsa-miR-26a	CLIP-seq
MIRT1983147	hsa-miR-26b	CLIP-seq
MIRT1983148	hsa-miR-3178	CLIP-seq
MIRT1983149	hsa-miR-3199	CLIP-seq
MIRT1983150	hsa-miR-3607-3p	CLIP-seq
MIRT1983151	hsa-miR-4284	CLIP-seq
MIRT1983152	hsa-miR-4320	CLIP-seq
MIRT1983153	hsa-miR-4665-3p	CLIP-seq
MIRT1983154	hsa-miR-4726-3p	CLIP-seq
MIRT955912	hsa-miR-4772-3p	CLIP-seq
MIRT1983155	hsa-miR-548a-5p	CLIP-seq
MIRT1983156	hsa-miR-548ab	CLIP-seq
MIRT1983157	hsa-miR-548ak	CLIP-seq
MIRT1983158	hsa-miR-548b-5p	CLIP-seq
MIRT1983159	hsa-miR-548c-5p	CLIP-seq
MIRT1983160	hsa-miR-548d-5p	CLIP-seq
MIRT1983161	hsa-miR-548h	CLIP-seq
MIRT1983162	hsa-miR-548i	CLIP-seq
MIRT1983163	hsa-miR-548j	CLIP-seq
MIRT1983164	hsa-miR-548k	CLIP-seq
MIRT1983165	hsa-miR-548l	CLIP-seq
MIRT1983166	hsa-miR-548w	CLIP-seq
MIRT1983167	hsa-miR-548y	CLIP-seq
MIRT1983168	hsa-miR-559	CLIP-seq
MIRT2218309	hsa-miR-105	CLIP-seq
MIRT955868	hsa-miR-1200	CLIP-seq
MIRT955869	hsa-miR-122	CLIP-seq
MIRT955872	hsa-miR-1281	CLIP-seq
MIRT2218310	hsa-miR-1286	CLIP-seq
MIRT1983144	hsa-miR-1915	CLIP-seq
MIRT1983146	hsa-miR-26a	CLIP-seq
MIRT1983147	hsa-miR-26b	CLIP-seq
MIRT1983149	hsa-miR-3199	CLIP-seq
MIRT2218311	hsa-miR-33a	CLIP-seq
MIRT2218312	hsa-miR-33b	CLIP-seq
MIRT2218313	hsa-miR-412	CLIP-seq
MIRT2218314	hsa-miR-4719	CLIP-seq
MIRT2218315	hsa-miR-4722-5p	CLIP-seq
MIRT1983154	hsa-miR-4726-3p	CLIP-seq
MIRT2218316	hsa-miR-513b	CLIP-seq
MIRT955922	hsa-miR-587	CLIP-seq
MIRT955927	hsa-miR-640	CLIP-seq
MIRT955869	hsa-miR-122	CLIP-seq
MIRT955874	hsa-miR-1307	CLIP-seq
MIRT955881	hsa-miR-205	CLIP-seq
MIRT955883	hsa-miR-2115	CLIP-seq
MIRT955885	hsa-miR-217	CLIP-seq
MIRT955886	hsa-miR-218	CLIP-seq
MIRT955887	hsa-miR-25	CLIP-seq
MIRT955891	hsa-miR-32	CLIP-seq
MIRT955893	hsa-miR-363	CLIP-seq
MIRT955894	hsa-miR-367	CLIP-seq
MIRT955899	hsa-miR-4418	CLIP-seq
MIRT955905	hsa-miR-4638-5p	CLIP-seq
MIRT955907	hsa-miR-4691-5p	CLIP-seq
MIRT955912	hsa-miR-4772-3p	CLIP-seq
MIRT955914	hsa-miR-509-3-5p	CLIP-seq
MIRT955915	hsa-miR-509-5p	CLIP-seq
MIRT955917	hsa-miR-516a-3p	CLIP-seq
MIRT955926	hsa-miR-636	CLIP-seq
MIRT955928	hsa-miR-648	CLIP-seq
MIRT955930	hsa-miR-92a	CLIP-seq
MIRT955931	hsa-miR-92b	CLIP-seq
MIRT955872	hsa-miR-1281	CLIP-seq
MIRT1983144	hsa-miR-1915	CLIP-seq
MIRT1983146	hsa-miR-26a	CLIP-seq
MIRT1983147	hsa-miR-26b	CLIP-seq
MIRT1983154	hsa-miR-4726-3p	CLIP-seq
MIRT955869	hsa-miR-122	CLIP-seq
MIRT955872	hsa-miR-1281	CLIP-seq
MIRT955874	hsa-miR-1307	CLIP-seq
MIRT1983144	hsa-miR-1915	CLIP-seq
MIRT955884	hsa-miR-2116	CLIP-seq
MIRT955885	hsa-miR-217	CLIP-seq
MIRT1983146	hsa-miR-26a	CLIP-seq
MIRT1983147	hsa-miR-26b	CLIP-seq
MIRT2521884	hsa-miR-3135b	CLIP-seq
MIRT1983149	hsa-miR-3199	CLIP-seq
MIRT2521885	hsa-miR-3652	CLIP-seq
MIRT955899	hsa-miR-4418	CLIP-seq
MIRT2521886	hsa-miR-4430	CLIP-seq
MIRT955905	hsa-miR-4638-5p	CLIP-seq
MIRT955906	hsa-miR-4677-5p	CLIP-seq
MIRT955908	hsa-miR-4695-3p	CLIP-seq
MIRT2218314	hsa-miR-4719	CLIP-seq
MIRT1983154	hsa-miR-4726-3p	CLIP-seq
MIRT955911	hsa-miR-4763-5p	CLIP-seq
MIRT955912	hsa-miR-4772-3p	CLIP-seq
MIRT2521887	hsa-miR-489	CLIP-seq
MIRT955914	hsa-miR-509-3-5p	CLIP-seq
MIRT955915	hsa-miR-509-5p	CLIP-seq
MIRT955924	hsa-miR-596	CLIP-seq
MIRT955927	hsa-miR-640	CLIP-seq
MIRT2521888	hsa-miR-653	CLIP-seq
MIRT955872	hsa-miR-1281	CLIP-seq
MIRT1983144	hsa-miR-1915	CLIP-seq
MIRT1983146	hsa-miR-26a	CLIP-seq
MIRT1983147	hsa-miR-26b	CLIP-seq
MIRT1983149	hsa-miR-3199	CLIP-seq
MIRT1983154	hsa-miR-4726-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003714	Function	Transcription corepressor activity	IBA
GO:0005515	Function	Protein binding	IPI	15970276, 28514442, 32296183, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	IMP	15970276
GO:0005654	Component	Nucleoplasm	IBA
GO:0007517	Process	Muscle organ development	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0042802	Function	Identical protein binding	IPI	15970276
GO:0045662	Process	Negative regulation of myoblast differentiation	IDA	15970276
GO:0045892	Process	Negative regulation of DNA-templated transcription	IBA
GO:0045892	Process	Negative regulation of DNA-templated transcription	IDA	15970276

Other IDs

• MIM: 617355
• HGNC: 26796
• e!Ensembl: ENSG00000176401

Protein

• UniProt ID: Q96D98
• Protein name: EP300-interacting inhibitor of differentiation 2B (EID-2B) (EID-2-like inhibitor of differentiation 3) (EID-3)
• Protein function: Acts as a repressor of MYOD-dependent transcription, glucocorticoid receptor-dependent transcription, and muscle differentiation.
• Sequence:

  MAEPTGLLEMSELPGDSSVPQVGTASGVSDVLRGAVGGGVRVQEAREGPVAEAARSMARM
  PGPVPGPIPSSVPGLASAPDPHQQLAFLEINRQLLFREYLDGSSMIPVRLLRDFEERRRL
  FVEGCKAREAAFDADPPQMDFAAVAFTVALTASEALSPLAD

• Sequence length: 161

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
IRITIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UVEITIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations