WDR88 (WD repeat domain 88)

Gene

• Entrez ID: 126248
• Gene name: WD repeat domain 88
• Gene symbol: WDR88
• Synonyms (NCBI Gene): PQWD
• Chromosome: 19
• Chromosome location: 19q13.11

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1491897	hsa-miR-3136-3p	CLIP-seq
MIRT1491898	hsa-miR-3184	CLIP-seq
MIRT1491899	hsa-miR-3192	CLIP-seq
MIRT1491900	hsa-miR-3660	CLIP-seq
MIRT1491901	hsa-miR-3689a-3p	CLIP-seq
MIRT1491902	hsa-miR-3689c	CLIP-seq
MIRT1491903	hsa-miR-370	CLIP-seq
MIRT1491904	hsa-miR-423-5p	CLIP-seq
MIRT1491905	hsa-miR-4526	CLIP-seq
MIRT1491906	hsa-miR-4650-5p	CLIP-seq
MIRT1491907	hsa-miR-4663	CLIP-seq
MIRT1491908	hsa-miR-4728-5p	CLIP-seq
MIRT1491909	hsa-miR-661	CLIP-seq
MIRT1491897	hsa-miR-3136-3p	CLIP-seq
MIRT1491898	hsa-miR-3184	CLIP-seq
MIRT1491899	hsa-miR-3192	CLIP-seq
MIRT1491901	hsa-miR-3689a-3p	CLIP-seq
MIRT1491902	hsa-miR-3689c	CLIP-seq
MIRT1491903	hsa-miR-370	CLIP-seq
MIRT1491904	hsa-miR-423-5p	CLIP-seq
MIRT1491906	hsa-miR-4650-5p	CLIP-seq
MIRT1491907	hsa-miR-4663	CLIP-seq
MIRT1491908	hsa-miR-4728-5p	CLIP-seq
MIRT2463482	hsa-miR-518a-5p	CLIP-seq
MIRT2463483	hsa-miR-527	CLIP-seq
MIRT1491909	hsa-miR-661	CLIP-seq
MIRT2662295	hsa-miR-1287	CLIP-seq
MIRT2662296	hsa-miR-1289	CLIP-seq
MIRT2662297	hsa-miR-1914	CLIP-seq
MIRT2662298	hsa-miR-196a	CLIP-seq
MIRT2662299	hsa-miR-196b	CLIP-seq
MIRT2662300	hsa-miR-3135b	CLIP-seq
MIRT2662301	hsa-miR-3198	CLIP-seq
MIRT2662302	hsa-miR-3927	CLIP-seq
MIRT2662303	hsa-miR-4293	CLIP-seq
MIRT2662304	hsa-miR-4294	CLIP-seq
MIRT2662305	hsa-miR-4309	CLIP-seq
MIRT2662306	hsa-miR-596	CLIP-seq
MIRT2662307	hsa-miR-668	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32814053

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q6ZMY6
• Protein name: WD repeat-containing protein 88 (PQQ repeat and WD repeat-containing protein)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00400	WD40	93 → 130	WD domain, G-beta repeat	Repeat
  PF01011	PQQ	159 → 191	PQQ enzyme repeat	Repeat
  PF00400	WD40	219 → 258	WD domain, G-beta repeat	Repeat
  PF00400	WD40	263 → 301	WD domain, G-beta repeat	Repeat
  PF00400	WD40	311 → 349	WD domain, G-beta repeat	Repeat
  PF00400	WD40	354 → 391	WD domain, G-beta repeat	Repeat

• Sequence:

  MASPPRCSPTAHDRECKLPPPSAPASEYCPGKLSWGTMARALGRFKLSIPHTHLLATLDP
  LALDREPPPHLLPEKHQVPEKLIWGDQDPLSKIPFKILSGHEHAVSTCHFCVDDTKLLSG
  SYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDSSRVIAASYDKTVRAWDLETGKLL
  WKVRYDTFIVSCKFSPDGKYVVSGFDVDHGICIMDAENITTVSVIKDHHTRSITSCCFDP
  DSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIW
  NVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLK
  GHNDWVMDVAISNNKKWILSASKDRTMRLWNIEEIDEIPLVIKYKKAVGLKLKQCERCDR
  PFSIFKSDTSSEMFTQCVFCRIDTRGLPADTSSSSSSSERENSPPPRGSKDD

• Sequence length: 472

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ALZHEIMER DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEMENTIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Malignant neoplasm of breast	Breast Cancer	UNIPROT_DG			★☆☆☆☆ Found in Text Mining only