Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	126133
Gene name	Aldehyde dehydrogenase 16 family member A1
Gene symbol	ALDH16A1
Synonyms (NCBI Gene)	-
Chromosome	19
Chromosome location	19q13.33
Summary	This gene encodes a member of the aldehyde dehydrogenase superfamily. The family members act on aldehyde substrates and use nicotinamide adenine dinucleotide phosphate (NADP) as a cofactor. This gene is conserved in chimpanzee, dog, cow, mouse, rat, and z

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miRTarBase ID	miRNA	Experiments	Reference
MIRT045250	hsa-miR-186-5p	CLASH	23622248
MIRT035869	hsa-miR-1247-5p	CLASH	23622248
MIRT776895	hsa-miR-4269	CLIP-seq
MIRT776896	hsa-miR-4514	CLIP-seq
MIRT776897	hsa-miR-4692	CLIP-seq
MIRT776898	hsa-miR-4698	CLIP-seq
MIRT776899	hsa-miR-4742-5p	CLIP-seq
MIRT776900	hsa-miR-1185	CLIP-seq
MIRT776901	hsa-miR-1225-3p	CLIP-seq
MIRT776902	hsa-miR-1227	CLIP-seq
MIRT776903	hsa-miR-1233	CLIP-seq
MIRT776904	hsa-miR-1262	CLIP-seq
MIRT776905	hsa-miR-1827	CLIP-seq
MIRT776906	hsa-miR-188-5p	CLIP-seq
MIRT776907	hsa-miR-3605-5p	CLIP-seq
MIRT776908	hsa-miR-3679-5p	CLIP-seq
MIRT776909	hsa-miR-4252	CLIP-seq
MIRT776910	hsa-miR-4323	CLIP-seq
MIRT776911	hsa-miR-4661-3p	CLIP-seq
MIRT776912	hsa-miR-4701-3p	CLIP-seq
MIRT776913	hsa-miR-4780	CLIP-seq
MIRT776914	hsa-miR-542-3p	CLIP-seq
MIRT776915	hsa-miR-623	CLIP-seq
MIRT776916	hsa-miR-661	CLIP-seq
MIRT776917	hsa-miR-766	CLIP-seq
MIRT776902	hsa-miR-1227	CLIP-seq
MIRT776904	hsa-miR-1262	CLIP-seq
MIRT776909	hsa-miR-4252	CLIP-seq
MIRT776912	hsa-miR-4701-3p	CLIP-seq
MIRT776914	hsa-miR-542-3p	CLIP-seq
MIRT776916	hsa-miR-661	CLIP-seq
MIRT776917	hsa-miR-766	CLIP-seq
MIRT2170084	hsa-miR-323-5p	CLIP-seq
MIRT2170085	hsa-miR-3934	CLIP-seq
MIRT2170086	hsa-miR-485-5p	CLIP-seq
MIRT2170087	hsa-miR-654-3p	CLIP-seq
MIRT2170088	hsa-miR-876-3p	CLIP-seq
MIRT776902	hsa-miR-1227	CLIP-seq
MIRT776904	hsa-miR-1262	CLIP-seq
MIRT776909	hsa-miR-4252	CLIP-seq
MIRT776912	hsa-miR-4701-3p	CLIP-seq
MIRT776914	hsa-miR-542-3p	CLIP-seq
MIRT776916	hsa-miR-661	CLIP-seq
MIRT776917	hsa-miR-766	CLIP-seq
MIRT776904	hsa-miR-1262	CLIP-seq
MIRT776909	hsa-miR-4252	CLIP-seq
MIRT776912	hsa-miR-4701-3p	CLIP-seq
MIRT776914	hsa-miR-542-3p	CLIP-seq
MIRT776916	hsa-miR-661	CLIP-seq
MIRT776917	hsa-miR-766	CLIP-seq
MIRT776904	hsa-miR-1262	CLIP-seq
MIRT776909	hsa-miR-4252	CLIP-seq
MIRT776912	hsa-miR-4701-3p	CLIP-seq
MIRT776914	hsa-miR-542-3p	CLIP-seq
MIRT776916	hsa-miR-661	CLIP-seq
MIRT776917	hsa-miR-766	CLIP-seq
MIRT776902	hsa-miR-1227	CLIP-seq
MIRT776904	hsa-miR-1262	CLIP-seq
MIRT776909	hsa-miR-4252	CLIP-seq
MIRT776912	hsa-miR-4701-3p	CLIP-seq
MIRT776914	hsa-miR-542-3p	CLIP-seq
MIRT776916	hsa-miR-661	CLIP-seq
MIRT776917	hsa-miR-766	CLIP-seq
MIRT776904	hsa-miR-1262	CLIP-seq
MIRT776909	hsa-miR-4252	CLIP-seq
MIRT776912	hsa-miR-4701-3p	CLIP-seq
MIRT776914	hsa-miR-542-3p	CLIP-seq
MIRT776916	hsa-miR-661	CLIP-seq
MIRT776917	hsa-miR-766	CLIP-seq

Show/Hide all (5)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004029	Function	Aldehyde dehydrogenase (NAD+) activity	IBA
GO:0005515	Function	Protein binding	IPI	32296183, 33961781, 35271311
GO:0016020	Component	Membrane	HDA	19946888
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016620	Function	Oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	IEA

MIM	HGNC	e!Ensembl
613358	28114	ENSG00000161618

Q8IZ83

Protein name

Aldehyde dehydrogenase family 16 member A1

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00171	Aldedh	48 → 488	Aldehyde dehydrogenase family	Family
PF00171	Aldedh	539 → 774	Aldehyde dehydrogenase family	Family

Sequence

MAATRAGPRAREIFTSLEYGPVPESHACALAWLDTQDRCLGHYVNGKWLKPEHRNSVPCQ
DPITGENLASCLQAQAEDVAAAVEAARMAFKGWSAHPGVVRAQHLTRLAEVIQKHQRLLW
TLESLVTGRAVREVRDGDVQLAQQLLHYHAIQASTQEEALAGWEPMGVIGLILPPTFSFL
EMMWRICPALAVGCTVVALVPPASPAPLLLAQLAGELGPFPGILNVLSGPASLVPILASQ
PGIRKVAFCGAPEEGRALRRSLAGECAELGLALGTESLLLLTDTADVDSAVEGVVDAAWS
DRGPGGLRLLIQESVWDEAMRRLQERMGRLRSGRGLDGAVDMGARGAAACDLVQRFVREA
QSQGAQVFQAGDVPSERPFYPPTLVSNLPPASPCAQVEVPWPVVVASPFRTAKEALLVAN
GTPRGGSASVWSERLGQALELGYGLQVGTVWINAHGLRDPSVPTGGCKESGCSWHGGPDG
LYEYLRPSGTPARLSCLSKNLNYDTFGLAVPSTLPAGPEIGPSPAPPYGLFVGGRFQAPG
ARSSRPIRDSSGNLHGYVAEGGAKDIRGAVEAAHQAFPGWAGQSPGARAALLWALAAALE
RRKSTLASRLERQGAELKAAEAEVELSARRLRAWGARVQAQGHTLQVAGLRGPVLRLREP
LGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSAACPLLALEVCQDMATVFPAGLAN
VVTGDRDHLTRCLALHQDVQAMWYFGSAQGSQFVEWASAGNLKPVWASRGCPRAWDQEAE
GAGPELGLRVARTKALWLPMGD

Sequence length

802

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (10)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ARTHRITIS, GOUTY	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CENTRAL NERVOUS SYSTEM CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colon adenocarcinoma	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOBLASTOMA MULTIFORME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GOUT	—	CTD, Disgenet, GWAS catalog CTD, Disgenet, GWAS catalog CTD, Disgenet, GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GOUT, HPRT-RELATED	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERURICEMIA	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (7)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Glioblastoma	Glioblastoma	Pubtator	35116021	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Gout	Gout	CTD_human_DG	21983786		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gout	Gout	Pubtator	28642574	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gout, HPRT-Related	Gout	CTD_human_DG	23348497		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hyperuricemia	Hyperuricemia	BEFREE	23348497		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hyperuricemia	Hyperuricemia	CTD_human_DG	23348497		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAST SYNDROME	MAST SYNDROME	BEFREE	19184135		★★★★★ ★☆☆☆☆ Found in Text Mining only

ALDH16A1 (aldehyde dehydrogenase 16 family member A1)