SPACA3 (sperm acrosome associated 3)

Gene

• Entrez ID: 124912
• Gene name: Sperm acrosome associated 3
• Gene symbol: SPACA3
• Synonyms (NCBI Gene): ALLP17, CT54, LYC3, LYZC, LYZL3, SLLP1
• Chromosome: 17
• Chromosome location: 17q11.2
• Summary: The protein encoded by this gene is a sperm surface protein that may be involved in adhesion to the egg prior to fertilization. While the encoded protein has significant similarity to lysozyme at the amino acid level, it has no detectable bacteriocidal ac

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017609	hsa-miR-335-5p	Microarray	18185580
MIRT1381645	hsa-miR-3135	CLIP-seq
MIRT1381646	hsa-miR-511	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001669	Component	Acrosomal vesicle	IBA
GO:0001669	Component	Acrosomal vesicle	IEA
GO:0002080	Component	Acrosomal membrane	IDA	12606493
GO:0002080	Component	Acrosomal membrane	IEA
GO:0003796	Function	Lysozyme activity	IDA	12606493
GO:0005515	Function	Protein binding	IPI	19945174
GO:0005576	Component	Extracellular region	IEA
GO:0007342	Process	Fusion of sperm to egg plasma membrane involved in single fertilization	IBA
GO:0007342	Process	Fusion of sperm to egg plasma membrane involved in single fertilization	IEA
GO:0007342	Process	Fusion of sperm to egg plasma membrane involved in single fertilization	IMP	15982649
GO:0016020	Component	Membrane	IEA
GO:0030141	Component	Secretory granule	IDA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0035036	Process	Sperm-egg recognition	IEA
GO:0036126	Component	Sperm flagellum	IBA
GO:0042117	Process	Monocyte activation	TAS
GO:0043032	Process	Positive regulation of macrophage activation	TAS
GO:0043159	Component	Acrosomal matrix	IDA	12606493
GO:0050766	Process	Positive regulation of phagocytosis	TAS

Other IDs

• MIM: 612749
• HGNC: 16260
• e!Ensembl: ENSG00000141316

Protein

• UniProt ID: Q8IXA5
• Protein name: Sperm acrosome membrane-associated protein 3 (Cancer/testis antigen 54) (CT54) (Lysozyme-like acrosomal sperm-specific secretory protein ALLP-17) (Lysozyme-like protein 3) (Sperm lysozyme-like protein 1) (Sperm protein reactive with antisperm antibodies)
• Protein function: Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracel
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00062	Lys	88 → 213	C-type lysozyme/alpha-lactalbumin family	Domain

• Tissue specificity: TISSUE SPECIFICITY: The processed form is expressed in sperm (at protein level). Expressed in testis, epididymis and placenta. {ECO:0000269|PubMed:12606493, ECO:0000269|PubMed:16014814}.
• Sequence:

  MVSALRGAPLIRVHSSPVSSPSVSGPRRLVSCLSSQSSALSQSGGGSTSAAGIEARSRAL
  RRRWCPAGIMLLALVCLLSCLLPSSEAKLYGRCELARVLHDFGLDGYRGYSLADWVCLAY
  FTSGFNAAALDYEADGSTNNGIFQINSRRWCSNLTPNVPNVCRMYCSDLLNPNLKDTVIC
  AMKITQEPQGLGYWEAWRHHCQGKDLTEWVDGCDF

• Sequence length: 215

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
OLIGODENDROGLIOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	35395711	Associate	★☆☆☆☆ Found in Text Mining only
Hematologic Neoplasms	Hematologic Neoplasms	BEFREE	15475442		★☆☆☆☆ Found in Text Mining only
Infertility	Infertility	Pubtator	24872021	Associate	★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	21898529	Associate	★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	BEFREE	15475442		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of testis	Malignant Neoplasm Of Testis	BEFREE	15475442		★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	Pubtator	17312182, 26088750	Associate	★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	15475442		★☆☆☆☆ Found in Text Mining only
Testicular Neoplasms	Testicular neoplasm	Pubtator	17312182	Associate	★☆☆☆☆ Found in Text Mining only