KIF19 (kinesin family member 19)

Gene

• Entrez ID: 124602
• Gene name: Kinesin family member 19
• Gene symbol: KIF19
• Synonyms (NCBI Gene): KIF19A
• Chromosome: 17
• Chromosome location: 17q25.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1093484	hsa-miR-1470	CLIP-seq
MIRT1093485	hsa-miR-2355-5p	CLIP-seq
MIRT1093486	hsa-miR-3679-3p	CLIP-seq
MIRT1093487	hsa-miR-3938	CLIP-seq
MIRT1093488	hsa-miR-4446-5p	CLIP-seq
MIRT1093489	hsa-miR-4469	CLIP-seq
MIRT1093490	hsa-miR-4667-3p	CLIP-seq
MIRT1093491	hsa-miR-4766-5p	CLIP-seq
MIRT1093492	hsa-miR-495	CLIP-seq
MIRT1093493	hsa-miR-548aa	CLIP-seq
MIRT1093494	hsa-miR-642a	CLIP-seq
MIRT1093495	hsa-miR-802	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0003777	Function	Microtubule motor activity	IBA
GO:0003777	Function	Microtubule motor activity	IEA
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005871	Component	Kinesin complex	IBA
GO:0005874	Component	Microtubule	IBA
GO:0005874	Component	Microtubule	IEA
GO:0005929	Component	Cilium	IEA
GO:0005929	Component	Cilium	ISS
GO:0005930	Component	Axoneme	IEA
GO:0007018	Process	Microtubule-based movement	IBA
GO:0007018	Process	Microtubule-based movement	IEA
GO:0008017	Function	Microtubule binding	IBA
GO:0008017	Function	Microtubule binding	IEA
GO:0008574	Function	Plus-end-directed microtubule motor activity	IEA
GO:0008574	Function	Plus-end-directed microtubule motor activity	ISS
GO:0016887	Function	ATP hydrolysis activity	IBA
GO:0042995	Component	Cell projection	IEA
GO:0060404	Process	Axonemal microtubule depolymerization	IEA
GO:0060404	Process	Axonemal microtubule depolymerization	ISS
GO:0070462	Process	Plus-end specific microtubule depolymerization	IEA
GO:0070462	Process	Plus-end specific microtubule depolymerization	ISS

Other IDs

• MIM: 619610
• HGNC: 26735
• e!Ensembl: ENSG00000196169

Protein

• UniProt ID: Q2TAC6
• Protein name: Kinesin-like protein KIF19
• Protein function: Plus end-directed microtubule-dependent motor protein that regulates the length of motile cilia by mediating depolymerization of microtubules at ciliary tips.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00225	Kinesin	17 → 346	Kinesin motor domain	Domain

• Sequence:

  MKDSGDSKDQQLMVALRVRPISVAELEEGATLIAHKVDEQMVVLMDPMEDPDDILRAHRS
  REKSYLFDVAFDFTATQEMVYQATTKSLIEGVISGYNATVFAYGPTGCGKTYTMLGTDQE
  PGIYVQTLNDLFRAIEETSNDMEYEVSMSYLEIYNEMIRDLLNPSLGYLELREDSKGVIQ
  VAGITEVSTINAKEIMQLLMKGNRQRTQEPTAANQTSSRSHAVLQVTVRQRSRVKNILQE
  VRQGRLFMIDLAGSERASQTQNRGQRMKEGAHINRSLLALGNCINALSDKGSNKYINYRD
  SKLTRLLKDSLGGNSRTVMIAHISPASSAFEESRNTLTYAGRAKNIKTRVKQNLLNVSYH
  IAQYTSIIADLRGEIQRLKRKIDEQTGRGQARGRQDRGDIRHIQAEVQLHSGQGEKAGMG
  QLREQLASAFQEQMDVRRRLLELENRAMEVQIDTSRHLLTIAGWKHEKSRRALKWREEQR
  KECYAKDDSEKDSDTGDDQPDILEPPEVAAARESIAALVDEQKQLRKQKLALEQRCRELR
  ARGRRLEETLPRRIGSEEQREVLSLLCRVHELEVENTEMQSHALLRDGALRHRHEAVRRL
  EQHRSLCDEIIQGQRQIIDDYNLAVPQRLEELYEVYLRELEEGSLEQATIMDQVASRALQ
  DSSLPKITPAGTSLTPDSDLESVKTLSSDAQHLQNSALPPLSTESEGHHVFKAGTGAWQA
  KSSSVPTPPPIQLGSLVTQEAPAQDSLGSWINSSPDSSENLSEIPLSHKERKEILTGTKC
  IWVKAARRRSRALGTEGRHLLAPATERSSLSLHSLSEGDDARPPGPLACKRPPSPTLQHA
  ASEDNLSSSTGEAPSRAVGHHGDGPRPWLRGQKKSLGKKREESLEAKRRKRRSRSFEVTG
  QGLSHPKTHLLGPHQAERISDHRMPVCRHPAPGIRHLGKVTLPLAKVKLPPSQNTGPGDS
  SPLAVPPNPGGGSRRATRGPRLPHGTSTHGKDGCSRHN

• Sequence length: 998

Pathways

KEGG:

Motor proteins

Reactome:

COPI-dependent Golgi-to-ER retrograde traffic
Kinesins

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Non-immune hydrops fetalis	Pathogenic	rs538632717	RCV001844367	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
Colon adenocarcinoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYDROPS FETALIS, NON-IMMUNE	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thymoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Cakut	Congenital anomalies of the kidney and urinary tract	Pubtator	37499630	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	28901309	Associate	★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	34499727	Associate	★☆☆☆☆ Found in Text Mining only