Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	124599
Gene name	CD300 molecule like family member b
Gene symbol	CD300LB
Synonyms (NCBI Gene)	CD300bCLM-7CLM7CMRF35-A2IREM-3IREM3TREM-5TREM5
Chromosome	17
Chromosome location	17q25.1
Summary	CD300LB is a nonclassical activating receptor of the immunoglobulin (Ig) superfamily expressed on myeloid cells (Martinez-Barriocanal and Sayos, 2006 [PubMed 16920917]).[supplied by OMIM, Mar 2008]

154

Show/Hide all (154)

miRTarBase ID	miRNA	Experiments	Reference
MIRT497306	hsa-miR-654-3p	PAR-CLIP	22291592
MIRT497305	hsa-miR-589-5p	PAR-CLIP	22291592
MIRT497304	hsa-miR-146a-5p	PAR-CLIP	22291592
MIRT497303	hsa-miR-146b-5p	PAR-CLIP	22291592
MIRT497302	hsa-miR-7153-5p	PAR-CLIP	22291592
MIRT497301	hsa-miR-431-5p	PAR-CLIP	22291592
MIRT497300	hsa-miR-526b-5p	PAR-CLIP	22291592
MIRT497299	hsa-miR-580-3p	PAR-CLIP	22291592
MIRT497306	hsa-miR-654-3p	PAR-CLIP	22291592
MIRT497305	hsa-miR-589-5p	PAR-CLIP	22291592
MIRT497304	hsa-miR-146a-5p	PAR-CLIP	22291592
MIRT497303	hsa-miR-146b-5p	PAR-CLIP	22291592
MIRT497302	hsa-miR-7153-5p	PAR-CLIP	22291592
MIRT497301	hsa-miR-431-5p	PAR-CLIP	22291592
MIRT497300	hsa-miR-526b-5p	PAR-CLIP	22291592
MIRT497299	hsa-miR-580-3p	PAR-CLIP	22291592
MIRT874901	hsa-miR-1184	CLIP-seq
MIRT874902	hsa-miR-150	CLIP-seq
MIRT874903	hsa-miR-181a	CLIP-seq
MIRT874904	hsa-miR-181b	CLIP-seq
MIRT874905	hsa-miR-181c	CLIP-seq
MIRT874906	hsa-miR-181d	CLIP-seq
MIRT874907	hsa-miR-2110	CLIP-seq
MIRT874908	hsa-miR-2467-5p	CLIP-seq
MIRT874909	hsa-miR-3120-3p	CLIP-seq
MIRT874910	hsa-miR-3144-5p	CLIP-seq
MIRT874911	hsa-miR-3150a-3p	CLIP-seq
MIRT874912	hsa-miR-3150b-3p	CLIP-seq
MIRT874913	hsa-miR-3155	CLIP-seq
MIRT874914	hsa-miR-3155b	CLIP-seq
MIRT874915	hsa-miR-3175	CLIP-seq
MIRT874916	hsa-miR-3191	CLIP-seq
MIRT874917	hsa-miR-326	CLIP-seq
MIRT874918	hsa-miR-330-5p	CLIP-seq
MIRT874919	hsa-miR-3609	CLIP-seq
MIRT874920	hsa-miR-3909	CLIP-seq
MIRT874921	hsa-miR-421	CLIP-seq
MIRT874922	hsa-miR-4260	CLIP-seq
MIRT874923	hsa-miR-4262	CLIP-seq
MIRT874924	hsa-miR-4266	CLIP-seq
MIRT874925	hsa-miR-4292	CLIP-seq
MIRT874926	hsa-miR-4300	CLIP-seq
MIRT874927	hsa-miR-4308	CLIP-seq
MIRT874928	hsa-miR-4438	CLIP-seq
MIRT874929	hsa-miR-4633-3p	CLIP-seq
MIRT874930	hsa-miR-4652-5p	CLIP-seq
MIRT874931	hsa-miR-4659a-5p	CLIP-seq
MIRT874932	hsa-miR-4659b-5p	CLIP-seq
MIRT874933	hsa-miR-4667-5p	CLIP-seq
MIRT874934	hsa-miR-4695-5p	CLIP-seq
MIRT874935	hsa-miR-4700-5p	CLIP-seq
MIRT874936	hsa-miR-4709-5p	CLIP-seq
MIRT874937	hsa-miR-4749-3p	CLIP-seq
MIRT874938	hsa-miR-4779	CLIP-seq
MIRT874939	hsa-miR-4784	CLIP-seq
MIRT874940	hsa-miR-484	CLIP-seq
MIRT874941	hsa-miR-520g	CLIP-seq
MIRT874942	hsa-miR-520h	CLIP-seq
MIRT874943	hsa-miR-548ah	CLIP-seq
MIRT874944	hsa-miR-553	CLIP-seq
MIRT874945	hsa-miR-760	CLIP-seq
MIRT874946	hsa-miR-765	CLIP-seq
MIRT874947	hsa-miR-920	CLIP-seq
MIRT874948	hsa-miR-939	CLIP-seq
MIRT1959432	hsa-let-7a	CLIP-seq
MIRT1959433	hsa-let-7b	CLIP-seq
MIRT1959434	hsa-let-7c	CLIP-seq
MIRT1959435	hsa-let-7d	CLIP-seq
MIRT1959436	hsa-let-7e	CLIP-seq
MIRT1959437	hsa-let-7f	CLIP-seq
MIRT1959438	hsa-let-7g	CLIP-seq
MIRT1959439	hsa-let-7i	CLIP-seq
MIRT1959440	hsa-miR-1179	CLIP-seq
MIRT874901	hsa-miR-1184	CLIP-seq
MIRT1959441	hsa-miR-1291	CLIP-seq
MIRT1959442	hsa-miR-1294	CLIP-seq
MIRT1959443	hsa-miR-1296	CLIP-seq
MIRT874902	hsa-miR-150	CLIP-seq
MIRT874909	hsa-miR-3120-3p	CLIP-seq
MIRT874910	hsa-miR-3144-5p	CLIP-seq
MIRT1959444	hsa-miR-3152-5p	CLIP-seq
MIRT874916	hsa-miR-3191	CLIP-seq
MIRT874925	hsa-miR-4292	CLIP-seq
MIRT1959445	hsa-miR-4316	CLIP-seq
MIRT1959446	hsa-miR-4317	CLIP-seq
MIRT1959447	hsa-miR-4458	CLIP-seq
MIRT1959448	hsa-miR-4459	CLIP-seq
MIRT1959449	hsa-miR-4500	CLIP-seq
MIRT1959450	hsa-miR-4512	CLIP-seq
MIRT874930	hsa-miR-4652-5p	CLIP-seq
MIRT1959451	hsa-miR-4690-3p	CLIP-seq
MIRT874937	hsa-miR-4749-3p	CLIP-seq
MIRT1959452	hsa-miR-665	CLIP-seq
MIRT1959453	hsa-miR-98	CLIP-seq
MIRT2196416	hsa-miR-3158-3p	CLIP-seq
MIRT2196417	hsa-miR-361-3p	CLIP-seq
MIRT2196418	hsa-miR-3689d	CLIP-seq
MIRT2196419	hsa-miR-4446-3p	CLIP-seq
MIRT1959448	hsa-miR-4459	CLIP-seq
MIRT2196420	hsa-miR-4492	CLIP-seq
MIRT2196421	hsa-miR-4498	CLIP-seq
MIRT2196422	hsa-miR-4505	CLIP-seq
MIRT2196423	hsa-miR-4685-5p	CLIP-seq
MIRT2196424	hsa-miR-4731-5p	CLIP-seq
MIRT874941	hsa-miR-520g	CLIP-seq
MIRT874942	hsa-miR-520h	CLIP-seq
MIRT2196425	hsa-miR-637	CLIP-seq
MIRT1959452	hsa-miR-665	CLIP-seq
MIRT2196426	hsa-miR-762	CLIP-seq
MIRT2385737	hsa-miR-3919	CLIP-seq
MIRT2385738	hsa-miR-4756-3p	CLIP-seq
MIRT2442067	hsa-miR-1252	CLIP-seq
MIRT2442068	hsa-miR-4753-3p	CLIP-seq
MIRT2442069	hsa-miR-4768-5p	CLIP-seq
MIRT2442070	hsa-miR-647	CLIP-seq
MIRT2442071	hsa-miR-9	CLIP-seq
MIRT2446572	hsa-miR-146b-3p	CLIP-seq
MIRT2446573	hsa-miR-3138	CLIP-seq
MIRT1959451	hsa-miR-4690-3p	CLIP-seq
MIRT2446574	hsa-miR-4800-5p	CLIP-seq
MIRT2499355	hsa-miR-1269	CLIP-seq
MIRT2499356	hsa-miR-1269b	CLIP-seq
MIRT2499357	hsa-miR-1288	CLIP-seq
MIRT1959441	hsa-miR-1291	CLIP-seq
MIRT2499358	hsa-miR-138	CLIP-seq
MIRT2499359	hsa-miR-193a-5p	CLIP-seq
MIRT2499360	hsa-miR-3165	CLIP-seq
MIRT2499361	hsa-miR-4283	CLIP-seq
MIRT874925	hsa-miR-4292	CLIP-seq
MIRT2499362	hsa-miR-4318	CLIP-seq
MIRT2499363	hsa-miR-4456	CLIP-seq
MIRT2499364	hsa-miR-4489	CLIP-seq
MIRT2196420	hsa-miR-4492	CLIP-seq
MIRT2196421	hsa-miR-4498	CLIP-seq
MIRT2499365	hsa-miR-4515	CLIP-seq
MIRT2499366	hsa-miR-4740-5p	CLIP-seq
MIRT2196426	hsa-miR-762	CLIP-seq
MIRT2499355	hsa-miR-1269	CLIP-seq
MIRT2499356	hsa-miR-1269b	CLIP-seq
MIRT2499357	hsa-miR-1288	CLIP-seq
MIRT1959441	hsa-miR-1291	CLIP-seq
MIRT2499358	hsa-miR-138	CLIP-seq
MIRT2499359	hsa-miR-193a-5p	CLIP-seq
MIRT2499360	hsa-miR-3165	CLIP-seq
MIRT2499361	hsa-miR-4283	CLIP-seq
MIRT874925	hsa-miR-4292	CLIP-seq
MIRT2499362	hsa-miR-4318	CLIP-seq
MIRT2499363	hsa-miR-4456	CLIP-seq
MIRT2499364	hsa-miR-4489	CLIP-seq
MIRT2196420	hsa-miR-4492	CLIP-seq
MIRT2196421	hsa-miR-4498	CLIP-seq
MIRT2499365	hsa-miR-4515	CLIP-seq
MIRT2499366	hsa-miR-4740-5p	CLIP-seq
MIRT2196426	hsa-miR-762	CLIP-seq

Show/Hide all (9)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002376	Process	Immune system process	IEA
GO:0002757	Process	Immune response-activating signaling pathway	IBA
GO:0004888	Function	Transmembrane signaling receptor activity	IBA
GO:0005515	Function	Protein binding	IPI	20959446, 22291008, 29051512
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0016020	Component	Membrane	IEA
GO:0042802	Function	Identical protein binding	IPI	20959446, 29051512

MIM	HGNC	e!Ensembl
610705	30811	ENSG00000178789

A8K4G0

Protein name

CMRF35-like molecule 7 (CLM-7) (CD300 antigen-like family member B) (CMRF35-A2) (Immune receptor expressed on myeloid cells 3) (IREM-3) (Leukocyte mono-Ig-like receptor 5) (Triggering receptor expressed on myeloid cells 5) (TREM-5) (CD antigen CD300b)

Protein function

Acts as an activating immune receptor through its interaction with ITAM-bearing adapter TYROBP, and also independently by recruitment of GRB2.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07686	V-set	19 → 122	Immunoglobulin V-set domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed exclusively in myeloid lineages. {ECO:0000269|PubMed:16920917}.

Sequence

MWLPPALLLLSLSGCFSIQGPESVRAPEQGSLTVQCHYKQGWETYIKWWCRGVRWDTCKI
LIETRGSEQGEKSDRVSIKDNQKDRTFTVTMEGLRRDDADVYWCGIERRGPDLGTQVKVI
VDPEGAASTTASSPTNSNMAVFIGSHKRNHYMLLVFVKVPILLILVTAILWLKGSQRVPE
EPGEQPIYMNFSEPLTKDMAT

Sequence length

201

Interactions

View interactions

	Reactome
			Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell DAP12 interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
HEMOLYTIC ANEMIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (1)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Septicemia	Septicemia	BEFREE	27261276		★★★★★ ★☆☆☆☆ Found in Text Mining only

CD300LB (CD300 molecule like family member b)