PAQR4 (progestin and adipoQ receptor family member 4)

Gene

• Entrez ID: 124222
• Gene name: Progestin and adipoQ receptor family member 4
• Gene symbol: PAQR4
• Synonyms (NCBI Gene): -
• Chromosome: 16
• Chromosome location: 16p13.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT029666	hsa-miR-26b-5p	Microarray	19088304
MIRT048738	hsa-miR-96-5p	CLASH	23622248
MIRT1213368	hsa-miR-1207-5p	CLIP-seq
MIRT1213369	hsa-miR-122	CLIP-seq
MIRT738866	hsa-miR-1225-5p	CLIP-seq
MIRT1213370	hsa-miR-1234	CLIP-seq
MIRT1213371	hsa-miR-1286	CLIP-seq
MIRT1213372	hsa-miR-1910	CLIP-seq
MIRT1213373	hsa-miR-1976	CLIP-seq
MIRT1213374	hsa-miR-2467-3p	CLIP-seq
MIRT1213375	hsa-miR-3141	CLIP-seq
MIRT1213376	hsa-miR-3160-3p	CLIP-seq
MIRT1213377	hsa-miR-3166	CLIP-seq
MIRT1213378	hsa-miR-3190	CLIP-seq
MIRT1213379	hsa-miR-3194-5p	CLIP-seq
MIRT1213380	hsa-miR-3198	CLIP-seq
MIRT1213381	hsa-miR-3545-3p	CLIP-seq
MIRT1213382	hsa-miR-3678-3p	CLIP-seq
MIRT1213383	hsa-miR-370	CLIP-seq
MIRT738868	hsa-miR-4269	CLIP-seq
MIRT1213384	hsa-miR-4309	CLIP-seq
MIRT1213385	hsa-miR-432	CLIP-seq
MIRT1213386	hsa-miR-4329	CLIP-seq
MIRT1213387	hsa-miR-4330	CLIP-seq
MIRT1213388	hsa-miR-4419a	CLIP-seq
MIRT1213389	hsa-miR-4487	CLIP-seq
MIRT1213390	hsa-miR-4510	CLIP-seq
MIRT1213391	hsa-miR-451b	CLIP-seq
MIRT1213392	hsa-miR-455-3p	CLIP-seq
MIRT1213393	hsa-miR-4663	CLIP-seq
MIRT1213394	hsa-miR-4680-5p	CLIP-seq
MIRT1213395	hsa-miR-4685-5p	CLIP-seq
MIRT1213396	hsa-miR-4736	CLIP-seq
MIRT1213397	hsa-miR-4763-3p	CLIP-seq
MIRT1213398	hsa-miR-4771	CLIP-seq
MIRT738867	hsa-miR-4783-3p	CLIP-seq
MIRT1213399	hsa-miR-556-5p	CLIP-seq
MIRT1213400	hsa-miR-558	CLIP-seq
MIRT738865	hsa-miR-619	CLIP-seq
MIRT1213401	hsa-miR-671-5p	CLIP-seq
MIRT1213402	hsa-miR-7	CLIP-seq
MIRT738866	hsa-miR-1225-5p	CLIP-seq
MIRT738868	hsa-miR-4269	CLIP-seq
MIRT738867	hsa-miR-4783-3p	CLIP-seq
MIRT738865	hsa-miR-619	CLIP-seq
MIRT2061339	hsa-miR-1184	CLIP-seq
MIRT2061340	hsa-miR-1200	CLIP-seq
MIRT2061341	hsa-miR-1207-3p	CLIP-seq
MIRT1213368	hsa-miR-1207-5p	CLIP-seq
MIRT2061342	hsa-miR-1225-3p	CLIP-seq
MIRT2061343	hsa-miR-1233	CLIP-seq
MIRT2061344	hsa-miR-1252	CLIP-seq
MIRT2061345	hsa-miR-125a-5p	CLIP-seq
MIRT2061346	hsa-miR-125b	CLIP-seq
MIRT2061347	hsa-miR-1270	CLIP-seq
MIRT2061348	hsa-miR-1285	CLIP-seq
MIRT2061349	hsa-miR-1293	CLIP-seq
MIRT2061350	hsa-miR-129-3p	CLIP-seq
MIRT2061351	hsa-miR-133a	CLIP-seq
MIRT2061352	hsa-miR-133b	CLIP-seq
MIRT2061353	hsa-miR-183	CLIP-seq
MIRT1213372	hsa-miR-1910	CLIP-seq
MIRT2061354	hsa-miR-1915	CLIP-seq
MIRT1213373	hsa-miR-1976	CLIP-seq
MIRT2061355	hsa-miR-223	CLIP-seq
MIRT1213374	hsa-miR-2467-3p	CLIP-seq
MIRT2061356	hsa-miR-2467-5p	CLIP-seq
MIRT2061357	hsa-miR-28-5p	CLIP-seq
MIRT2061358	hsa-miR-2964a-5p	CLIP-seq
MIRT2061359	hsa-miR-3074-5p	CLIP-seq
MIRT2061360	hsa-miR-3139	CLIP-seq
MIRT1213375	hsa-miR-3141	CLIP-seq
MIRT1213376	hsa-miR-3160-3p	CLIP-seq
MIRT1213377	hsa-miR-3166	CLIP-seq
MIRT2061361	hsa-miR-3173-5p	CLIP-seq
MIRT2061362	hsa-miR-3177-3p	CLIP-seq
MIRT2061363	hsa-miR-3187-5p	CLIP-seq
MIRT2061364	hsa-miR-3188	CLIP-seq
MIRT1213378	hsa-miR-3190	CLIP-seq
MIRT2061365	hsa-miR-3192	CLIP-seq
MIRT1213379	hsa-miR-3194-5p	CLIP-seq
MIRT2061366	hsa-miR-3200-5p	CLIP-seq
MIRT2061367	hsa-miR-3202	CLIP-seq
MIRT2061368	hsa-miR-326	CLIP-seq
MIRT2061369	hsa-miR-330-5p	CLIP-seq
MIRT2061370	hsa-miR-339-3p	CLIP-seq
MIRT2061371	hsa-miR-339-5p	CLIP-seq
MIRT2061372	hsa-miR-3616-3p	CLIP-seq
MIRT2061373	hsa-miR-3622a-5p	CLIP-seq
MIRT2061374	hsa-miR-3659	CLIP-seq
MIRT2061375	hsa-miR-3670	CLIP-seq
MIRT1213382	hsa-miR-3678-3p	CLIP-seq
MIRT2061376	hsa-miR-3689a-3p	CLIP-seq
MIRT2061377	hsa-miR-3689c	CLIP-seq
MIRT1213383	hsa-miR-370	CLIP-seq
MIRT2061378	hsa-miR-3714	CLIP-seq
MIRT2061379	hsa-miR-378g	CLIP-seq
MIRT2061380	hsa-miR-3928	CLIP-seq
MIRT2061381	hsa-miR-3929	CLIP-seq
MIRT2061382	hsa-miR-3975	CLIP-seq
MIRT738868	hsa-miR-4269	CLIP-seq
MIRT2061383	hsa-miR-4313	CLIP-seq
MIRT2061384	hsa-miR-4319	CLIP-seq
MIRT1213385	hsa-miR-432	CLIP-seq
MIRT2061385	hsa-miR-4324	CLIP-seq
MIRT2061386	hsa-miR-4328	CLIP-seq
MIRT1213386	hsa-miR-4329	CLIP-seq
MIRT1213388	hsa-miR-4419a	CLIP-seq
MIRT2061387	hsa-miR-4419b	CLIP-seq
MIRT2061388	hsa-miR-4426	CLIP-seq
MIRT2061389	hsa-miR-4435	CLIP-seq
MIRT2061390	hsa-miR-4436b-3p	CLIP-seq
MIRT2061391	hsa-miR-4443	CLIP-seq
MIRT2061392	hsa-miR-4446-3p	CLIP-seq
MIRT2061393	hsa-miR-4453	CLIP-seq
MIRT2061394	hsa-miR-4456	CLIP-seq
MIRT2061395	hsa-miR-4474-3p	CLIP-seq
MIRT2061396	hsa-miR-4478	CLIP-seq
MIRT2061397	hsa-miR-4483	CLIP-seq
MIRT2061398	hsa-miR-4486	CLIP-seq
MIRT1213389	hsa-miR-4487	CLIP-seq
MIRT2061399	hsa-miR-4492	CLIP-seq
MIRT2061400	hsa-miR-4493	CLIP-seq
MIRT2061401	hsa-miR-4498	CLIP-seq
MIRT1213390	hsa-miR-4510	CLIP-seq
MIRT2061402	hsa-miR-4533	CLIP-seq
MIRT2061403	hsa-miR-4534	CLIP-seq
MIRT2061404	hsa-miR-4538	CLIP-seq
MIRT1213392	hsa-miR-455-3p	CLIP-seq
MIRT2061405	hsa-miR-4647	CLIP-seq
MIRT2061406	hsa-miR-4649-3p	CLIP-seq
MIRT2061407	hsa-miR-4658	CLIP-seq
MIRT2061408	hsa-miR-4662b	CLIP-seq
MIRT1213393	hsa-miR-4663	CLIP-seq
MIRT2061409	hsa-miR-4668-5p	CLIP-seq
MIRT2061410	hsa-miR-4683	CLIP-seq
MIRT1213395	hsa-miR-4685-5p	CLIP-seq
MIRT2061411	hsa-miR-4697-3p	CLIP-seq
MIRT2061412	hsa-miR-4721	CLIP-seq
MIRT2061413	hsa-miR-4726-3p	CLIP-seq
MIRT2061414	hsa-miR-4728-5p	CLIP-seq
MIRT2061415	hsa-miR-4731-5p	CLIP-seq
MIRT2061416	hsa-miR-4747-5p	CLIP-seq
MIRT2061417	hsa-miR-4761-5p	CLIP-seq
MIRT1213397	hsa-miR-4763-3p	CLIP-seq
MIRT1213398	hsa-miR-4771	CLIP-seq
MIRT2061418	hsa-miR-4772-5p	CLIP-seq
MIRT2061419	hsa-miR-4774-5p	CLIP-seq
MIRT2061420	hsa-miR-483-5p	CLIP-seq
MIRT2061421	hsa-miR-485-5p	CLIP-seq
MIRT2061422	hsa-miR-541	CLIP-seq
MIRT2061423	hsa-miR-544b	CLIP-seq
MIRT2061424	hsa-miR-548an	CLIP-seq
MIRT2061425	hsa-miR-550a	CLIP-seq
MIRT1213399	hsa-miR-556-5p	CLIP-seq
MIRT1213400	hsa-miR-558	CLIP-seq
MIRT2061426	hsa-miR-564	CLIP-seq
MIRT2061427	hsa-miR-574-5p	CLIP-seq
MIRT2061428	hsa-miR-592	CLIP-seq
MIRT2061429	hsa-miR-593	CLIP-seq
MIRT2061430	hsa-miR-597	CLIP-seq
MIRT2061431	hsa-miR-604	CLIP-seq
MIRT2061432	hsa-miR-612	CLIP-seq
MIRT2061433	hsa-miR-614	CLIP-seq
MIRT2061434	hsa-miR-615-5p	CLIP-seq
MIRT2061435	hsa-miR-620	CLIP-seq
MIRT2061436	hsa-miR-642b	CLIP-seq
MIRT2061437	hsa-miR-646	CLIP-seq
MIRT2061438	hsa-miR-647	CLIP-seq
MIRT2061439	hsa-miR-654-5p	CLIP-seq
MIRT2061440	hsa-miR-663b	CLIP-seq
MIRT2061441	hsa-miR-668	CLIP-seq
MIRT1213401	hsa-miR-671-5p	CLIP-seq
MIRT1213402	hsa-miR-7	CLIP-seq
MIRT2061442	hsa-miR-708	CLIP-seq
MIRT2061443	hsa-miR-762	CLIP-seq
MIRT2061444	hsa-miR-873	CLIP-seq
MIRT2061445	hsa-miR-940	CLIP-seq
MIRT2061347	hsa-miR-1270	CLIP-seq
MIRT2061348	hsa-miR-1285	CLIP-seq
MIRT2061349	hsa-miR-1293	CLIP-seq
MIRT1213373	hsa-miR-1976	CLIP-seq
MIRT2289883	hsa-miR-302a	CLIP-seq
MIRT2289884	hsa-miR-302b	CLIP-seq
MIRT2289885	hsa-miR-302c	CLIP-seq
MIRT2289886	hsa-miR-302d	CLIP-seq
MIRT2289887	hsa-miR-302e	CLIP-seq
MIRT2289888	hsa-miR-3160-5p	CLIP-seq
MIRT2061363	hsa-miR-3187-5p	CLIP-seq
MIRT2061365	hsa-miR-3192	CLIP-seq
MIRT2061367	hsa-miR-3202	CLIP-seq
MIRT2061368	hsa-miR-326	CLIP-seq
MIRT2061369	hsa-miR-330-5p	CLIP-seq
MIRT2061370	hsa-miR-339-3p	CLIP-seq
MIRT2061376	hsa-miR-3689a-3p	CLIP-seq
MIRT2061377	hsa-miR-3689c	CLIP-seq
MIRT2289889	hsa-miR-3691-3p	CLIP-seq
MIRT1213383	hsa-miR-370	CLIP-seq
MIRT2289890	hsa-miR-372	CLIP-seq
MIRT2289891	hsa-miR-373	CLIP-seq
MIRT2061379	hsa-miR-378g	CLIP-seq
MIRT2289892	hsa-miR-4267	CLIP-seq
MIRT1213385	hsa-miR-432	CLIP-seq
MIRT1213386	hsa-miR-4329	CLIP-seq
MIRT2061392	hsa-miR-4446-3p	CLIP-seq
MIRT2061395	hsa-miR-4474-3p	CLIP-seq
MIRT2061397	hsa-miR-4483	CLIP-seq
MIRT2061398	hsa-miR-4486	CLIP-seq
MIRT1213389	hsa-miR-4487	CLIP-seq
MIRT2061399	hsa-miR-4492	CLIP-seq
MIRT2061400	hsa-miR-4493	CLIP-seq
MIRT2061401	hsa-miR-4498	CLIP-seq
MIRT2061402	hsa-miR-4533	CLIP-seq
MIRT1213393	hsa-miR-4663	CLIP-seq
MIRT2061410	hsa-miR-4683	CLIP-seq
MIRT2061412	hsa-miR-4721	CLIP-seq
MIRT2061414	hsa-miR-4728-5p	CLIP-seq
MIRT2061415	hsa-miR-4731-5p	CLIP-seq
MIRT2061418	hsa-miR-4772-5p	CLIP-seq
MIRT2061419	hsa-miR-4774-5p	CLIP-seq
MIRT2289893	hsa-miR-512-3p	CLIP-seq
MIRT2289894	hsa-miR-520a-3p	CLIP-seq
MIRT2289895	hsa-miR-520b	CLIP-seq
MIRT2289896	hsa-miR-520c-3p	CLIP-seq
MIRT2289897	hsa-miR-520d-3p	CLIP-seq
MIRT2289898	hsa-miR-520e	CLIP-seq
MIRT2061431	hsa-miR-604	CLIP-seq
MIRT2061432	hsa-miR-612	CLIP-seq
MIRT2061435	hsa-miR-620	CLIP-seq
MIRT2061436	hsa-miR-642b	CLIP-seq
MIRT2061438	hsa-miR-647	CLIP-seq
MIRT2061443	hsa-miR-762	CLIP-seq
MIRT1213373	hsa-miR-1976	CLIP-seq
MIRT2061370	hsa-miR-339-3p	CLIP-seq
MIRT1213383	hsa-miR-370	CLIP-seq
MIRT2392119	hsa-miR-4265	CLIP-seq
MIRT2392120	hsa-miR-4296	CLIP-seq
MIRT2392121	hsa-miR-4322	CLIP-seq
MIRT1213386	hsa-miR-4329	CLIP-seq
MIRT2392122	hsa-miR-4417	CLIP-seq
MIRT1213393	hsa-miR-4663	CLIP-seq
MIRT2061421	hsa-miR-485-5p	CLIP-seq
MIRT1213379	hsa-miR-3194-5p	CLIP-seq
MIRT1213401	hsa-miR-671-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IDA	32291319
GO:0000139	Component	Golgi membrane	IEA
GO:0005794	Component	Golgi apparatus	IEA
GO:0016020	Component	Membrane	IEA
GO:0050821	Process	Protein stabilization	IDA	38961186
GO:0050821	Process	Protein stabilization	IEA
GO:0060090	Function	Molecular adaptor activity	IDA	38961186
GO:0060090	Function	Molecular adaptor activity	IEA
GO:2000303	Process	Regulation of ceramide biosynthetic process	IDA	32291319, 38961186
GO:2000303	Process	Regulation of ceramide biosynthetic process	IEA

Other IDs

• MIM: 614578
• HGNC: 26386
• e!Ensembl: ENSG00000162073

Protein

• UniProt ID: Q8N4S7
• Protein name: Progestin and adipoQ receptor family member 4 (Progestin and adipoQ receptor family member IV)
• Protein function: Plays a role in maintaining adipose tissue function through the regulation of ceramide levels (PubMed:32291319, PubMed:38961186). Mediates the stability of ceramide synthetases, CERS2 and CERS5, and their activities (Probable). {ECO:0000269|PubM
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03006	HlyIII	43 → 254	Haemolysin-III related	Family

• Tissue specificity: TISSUE SPECIFICITY: Relatively widely expressed in a range of tissues. Expressed in subcutaneous white adipose tissue (PubMed:38961186). {ECO:0000269|PubMed:16044242, ECO:0000269|PubMed:38961186}.
• Sequence:

  MAFLAGPRLLDWASSPPHLQFNKFVLTGYRPASSGSGCLRSLFYLHNELGNIYTHGLALL
  GFLVLVPMTMPWGQLGKDGWLGGTHCVACLAPPAGSVLYHLFMCHQGGSAVYARLLALDM
  CGVCLVNTLGALPIIHCTLACRPWLRPAALVGYTVLSGVAGWRALTAPSTSARLRAFGWQ
  AAARLLVFGARGVGLGSGAPGSLPCYLRMDALALLGGLVNVARLPERWGPGRFDYWGNSH
  QIMHLLSVGSILQLHAGVVPDLLWAAHHACPRD

• Sequence length: 273

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
Gastric cancer	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATIC NEOPLASMS	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Breast Carcinoma	Breast Carcinoma	BEFREE	31190865		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	36573110	Stimulate	★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	36481756	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	35240821	Stimulate	★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	36481756	Associate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	29228296, 31190865		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	CTD_human_DG	27415467		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	30322804		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	28992327, 29228296, 31190865		★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	31190865		★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic Neoplasms	CTD_human_DG	27415467		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Stomach Carcinoma	Stomach Carcinoma	BEFREE	30322804		★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	30322804	Associate	★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Urinary bladder neoplasms	Pubtator	36481756	Stimulate	★☆☆☆☆ Found in Text Mining only