Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	123920
Gene name	CKLF like MARVEL transmembrane domain containing 3
Gene symbol	CMTM3
Synonyms (NCBI Gene)	BNAS2CKLFSF3
Chromosome	16
Chromosome location	16q22.1
Summary	This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies of signaling molecules. This gene is one of several chemokine-like factor genes located in a cluster on

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miRTarBase ID	miRNA	Experiments	Reference
MIRT018895	hsa-miR-335-5p	Microarray	18185580
MIRT021850	hsa-miR-132-3p	Microarray	17612493
MIRT023087	hsa-miR-124-3p	Microarray	18668037
MIRT030605	hsa-miR-24-3p	Microarray	19748357
MIRT1966465	hsa-miR-29a	CLIP-seq
MIRT1966466	hsa-miR-29b	CLIP-seq
MIRT1966467	hsa-miR-29c	CLIP-seq
MIRT1966468	hsa-miR-3166	CLIP-seq
MIRT1966469	hsa-miR-3194-3p	CLIP-seq
MIRT1966470	hsa-miR-3663-3p	CLIP-seq
MIRT1966471	hsa-miR-4771	CLIP-seq
MIRT1966472	hsa-miR-519a	CLIP-seq
MIRT1966473	hsa-miR-519b-3p	CLIP-seq
MIRT1966474	hsa-miR-519c-3p	CLIP-seq
MIRT1966465	hsa-miR-29a	CLIP-seq
MIRT1966466	hsa-miR-29b	CLIP-seq
MIRT1966467	hsa-miR-29c	CLIP-seq
MIRT1966468	hsa-miR-3166	CLIP-seq
MIRT1966470	hsa-miR-3663-3p	CLIP-seq
MIRT2202349	hsa-miR-3977	CLIP-seq
MIRT2202350	hsa-miR-4265	CLIP-seq
MIRT2202351	hsa-miR-4287	CLIP-seq
MIRT2202352	hsa-miR-4296	CLIP-seq
MIRT2202353	hsa-miR-4322	CLIP-seq
MIRT2202354	hsa-miR-4417	CLIP-seq
MIRT2202355	hsa-miR-4469	CLIP-seq
MIRT2202356	hsa-miR-4685-3p	CLIP-seq
MIRT2202357	hsa-miR-4713-5p	CLIP-seq
MIRT2202358	hsa-miR-4722-5p	CLIP-seq
MIRT1966471	hsa-miR-4771	CLIP-seq
MIRT1966472	hsa-miR-519a	CLIP-seq
MIRT1966473	hsa-miR-519b-3p	CLIP-seq
MIRT1966474	hsa-miR-519c-3p	CLIP-seq
MIRT2202350	hsa-miR-4265	CLIP-seq
MIRT2202352	hsa-miR-4296	CLIP-seq
MIRT2202353	hsa-miR-4322	CLIP-seq
MIRT2202354	hsa-miR-4417	CLIP-seq
MIRT2202358	hsa-miR-4722-5p	CLIP-seq
MIRT2427370	hsa-miR-144	CLIP-seq
MIRT2427371	hsa-miR-4672	CLIP-seq
MIRT2505354	hsa-miR-105	CLIP-seq
MIRT2505355	hsa-miR-1208	CLIP-seq
MIRT2505356	hsa-miR-125a-5p	CLIP-seq
MIRT2505357	hsa-miR-125b	CLIP-seq
MIRT2505358	hsa-miR-1283	CLIP-seq
MIRT2505359	hsa-miR-1294	CLIP-seq
MIRT2505360	hsa-miR-1299	CLIP-seq
MIRT2427370	hsa-miR-144	CLIP-seq
MIRT2505361	hsa-miR-146b-3p	CLIP-seq
MIRT2505362	hsa-miR-149	CLIP-seq
MIRT2505363	hsa-miR-1976	CLIP-seq
MIRT2505364	hsa-miR-198	CLIP-seq
MIRT2505365	hsa-miR-2113	CLIP-seq
MIRT2505366	hsa-miR-3064-5p	CLIP-seq
MIRT2505367	hsa-miR-3120-5p	CLIP-seq
MIRT2505368	hsa-miR-3123	CLIP-seq
MIRT2505369	hsa-miR-3136-3p	CLIP-seq
MIRT2505370	hsa-miR-3173-5p	CLIP-seq
MIRT2505371	hsa-miR-3182	CLIP-seq
MIRT2505372	hsa-miR-3613-5p	CLIP-seq
MIRT2505373	hsa-miR-3619-3p	CLIP-seq
MIRT2505374	hsa-miR-3653	CLIP-seq
MIRT2505375	hsa-miR-3658	CLIP-seq
MIRT2505376	hsa-miR-3663-5p	CLIP-seq
MIRT2505377	hsa-miR-3677-5p	CLIP-seq
MIRT2505378	hsa-miR-3684	CLIP-seq
MIRT2505379	hsa-miR-378	CLIP-seq
MIRT2505380	hsa-miR-378b	CLIP-seq
MIRT2505381	hsa-miR-378c	CLIP-seq
MIRT2505382	hsa-miR-378d	CLIP-seq
MIRT2505383	hsa-miR-378e	CLIP-seq
MIRT2505384	hsa-miR-378f	CLIP-seq
MIRT2505385	hsa-miR-378h	CLIP-seq
MIRT2505386	hsa-miR-378i	CLIP-seq
MIRT2505387	hsa-miR-422a	CLIP-seq
MIRT2505388	hsa-miR-4252	CLIP-seq
MIRT2505389	hsa-miR-4316	CLIP-seq
MIRT2505390	hsa-miR-4319	CLIP-seq
MIRT2505391	hsa-miR-4638-3p	CLIP-seq
MIRT2427371	hsa-miR-4672	CLIP-seq
MIRT2505392	hsa-miR-4679	CLIP-seq
MIRT2505393	hsa-miR-4680-5p	CLIP-seq
MIRT2505394	hsa-miR-4776-5p	CLIP-seq
MIRT2505395	hsa-miR-4782-5p	CLIP-seq
MIRT2505396	hsa-miR-4794	CLIP-seq
MIRT2505397	hsa-miR-516b	CLIP-seq
MIRT2505398	hsa-miR-544b	CLIP-seq
MIRT2505399	hsa-miR-663b	CLIP-seq
MIRT2505400	hsa-miR-668	CLIP-seq
MIRT2505401	hsa-miR-758	CLIP-seq
MIRT2505402	hsa-miR-760	CLIP-seq
MIRT2505403	hsa-miR-874	CLIP-seq
MIRT2505404	hsa-miR-875-3p	CLIP-seq
MIRT2505354	hsa-miR-105	CLIP-seq
MIRT2505355	hsa-miR-1208	CLIP-seq
MIRT2505358	hsa-miR-1283	CLIP-seq
MIRT2505359	hsa-miR-1294	CLIP-seq
MIRT2505360	hsa-miR-1299	CLIP-seq
MIRT2427370	hsa-miR-144	CLIP-seq
MIRT2505361	hsa-miR-146b-3p	CLIP-seq
MIRT2505362	hsa-miR-149	CLIP-seq
MIRT2505363	hsa-miR-1976	CLIP-seq
MIRT2505364	hsa-miR-198	CLIP-seq
MIRT2505365	hsa-miR-2113	CLIP-seq
MIRT2505366	hsa-miR-3064-5p	CLIP-seq
MIRT2505367	hsa-miR-3120-5p	CLIP-seq
MIRT2505368	hsa-miR-3123	CLIP-seq
MIRT2505369	hsa-miR-3136-3p	CLIP-seq
MIRT2678345	hsa-miR-3140-3p	CLIP-seq
MIRT2505370	hsa-miR-3173-5p	CLIP-seq
MIRT2505371	hsa-miR-3182	CLIP-seq
MIRT2505372	hsa-miR-3613-5p	CLIP-seq
MIRT2505373	hsa-miR-3619-3p	CLIP-seq
MIRT2505374	hsa-miR-3653	CLIP-seq
MIRT2505375	hsa-miR-3658	CLIP-seq
MIRT2505376	hsa-miR-3663-5p	CLIP-seq
MIRT2678346	hsa-miR-3670	CLIP-seq
MIRT2505377	hsa-miR-3677-5p	CLIP-seq
MIRT2505378	hsa-miR-3684	CLIP-seq
MIRT2505379	hsa-miR-378	CLIP-seq
MIRT2505380	hsa-miR-378b	CLIP-seq
MIRT2505381	hsa-miR-378c	CLIP-seq
MIRT2505382	hsa-miR-378d	CLIP-seq
MIRT2505383	hsa-miR-378e	CLIP-seq
MIRT2505384	hsa-miR-378f	CLIP-seq
MIRT2505385	hsa-miR-378h	CLIP-seq
MIRT2505386	hsa-miR-378i	CLIP-seq
MIRT2505387	hsa-miR-422a	CLIP-seq
MIRT2505388	hsa-miR-4252	CLIP-seq
MIRT2505389	hsa-miR-4316	CLIP-seq
MIRT2505391	hsa-miR-4638-3p	CLIP-seq
MIRT2427371	hsa-miR-4672	CLIP-seq
MIRT2505392	hsa-miR-4679	CLIP-seq
MIRT2505393	hsa-miR-4680-5p	CLIP-seq
MIRT2505394	hsa-miR-4776-5p	CLIP-seq
MIRT2505395	hsa-miR-4782-5p	CLIP-seq
MIRT2505396	hsa-miR-4794	CLIP-seq
MIRT2505397	hsa-miR-516b	CLIP-seq
MIRT2678347	hsa-miR-556-5p	CLIP-seq
MIRT2678348	hsa-miR-622	CLIP-seq
MIRT2505399	hsa-miR-663b	CLIP-seq
MIRT2505400	hsa-miR-668	CLIP-seq
MIRT2505401	hsa-miR-758	CLIP-seq
MIRT2505402	hsa-miR-760	CLIP-seq
MIRT2505403	hsa-miR-874	CLIP-seq

Show/Hide all (13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001835	Process	Blastocyst hatching	IEA
GO:0005125	Function	Cytokine activity	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 32296183, 32814053
GO:0005615	Component	Extracellular space	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA	28428220
GO:0006935	Process	Chemotaxis	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0016020	Component	Membrane	IBA
GO:0016020	Component	Membrane	IEA
GO:0031410	Component	Cytoplasmic vesicle	IDA	28428220
GO:0031965	Component	Nuclear membrane	IEA
GO:0050861	Process	Positive regulation of B cell receptor signaling pathway	IEA

MIM	HGNC	e!Ensembl
607886	19174	ENSG00000140931

Q96MX0

Protein name

CKLF-like MARVEL transmembrane domain-containing protein 3 (Chemokine-like factor superfamily member 3)

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01284	MARVEL	36 → 149	Membrane-associating domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in the leukocytes, placenta and testis. {ECO:0000269|PubMed:12782130}.

Sequence

MWPPDPDPDPDPEPAGGSRPGPAVPGLRALLPARAFLCSLKGRLLLAESGLSFITFICYV
ASSASAFLTAPLLEFLLALYFLFADAMQLNDKWQGLCWPMMDFLRCVTAALIYFAISITA
IAKYSDGASKAAGVFGFFATIVFATDFYLIFNDVAKFLKQGDSADETTAHKTEEENSDSD
SD

Sequence length

182

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
LIVER CIRRHOSIS, EXPERIMENTAL	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (23)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Antiphospholipid Syndrome	Antiphospholipid syndrome	Pubtator	32195671	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthritis Rheumatoid	Rheumatoid arthritis	Pubtator	32195671	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma	Carcinoma	BEFREE	19509237, 24586462		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	33955330, 36975415	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal Neoplasms	BEFREE	19509237		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	25931111		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	30356407	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	25931111		★★★★★ ★☆☆☆☆ Found in Text Mining only
Laryngeal Squamous Cell Carcinoma	Laryngeal Carcinoma	BEFREE	27521994		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	27629543		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	25990505		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	24131472, 27121055, 27867015		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	25990505, 27121055, 27521994, 27867015, 29345297		★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Sclerosis	Multiple sclerosis	Pubtator	24131472	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	19509237, 24131472, 24586462, 25946973, 25990505, 27121055, 27521994, 27629543, 27867015, 28521405, 29345297		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	25990505		★★★★★ ★☆☆☆☆ Found in Text Mining only
Scleroderma Systemic	Systemic sclerosis	Pubtator	32195671	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Sjogren's Syndrome	Sjogren syndrome	Pubtator	32195671	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma	Carcinoma	BEFREE	25946973		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of esophagus	Esophagus Neoplasm	BEFREE	28521405		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	19509237, 24131472, 27121055, 27867015		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	24131472	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Testicular Neoplasms	Testicular neoplasm	Pubtator	24586462	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only

CMTM3 (CKLF like MARVEL transmembrane domain containing 3)