Gene Gene information from NCBI Gene database.
Entrez ID 122786
Gene name FERM domain containing 6
Gene symbol FRMD6
Synonyms (NCBI Gene)
C14orf31EX1Willinc14_5320
Chromosome 14
Chromosome location 14q22.1
miRNA miRNA information provided by mirtarbase database.
681
miRTarBase ID miRNA Experiments Reference
MIRT022571 hsa-miR-124-3p Microarray 18668037
MIRT027277 hsa-miR-101-3p Sequencing 20371350
MIRT070247 hsa-miR-5197-3p HITS-CLIP 23824327
MIRT644413 hsa-miR-3123 HITS-CLIP 23824327
MIRT644414 hsa-miR-141-5p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
12
GO ID Ontology Definition Evidence Reference
GO:0003383 Process Apical constriction IEA
GO:0005515 Function Protein binding IPI 16189514, 25416956, 28514442, 29892012, 31515488, 32296183, 32814053, 33961781
GO:0005737 Component Cytoplasm IDA 16137681
GO:0005737 Component Cytoplasm IEA
GO:0005886 Component Plasma membrane IDA 16137681
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
614555 19839 ENSG00000139926
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q96NE9
Protein name FERM domain-containing protein 6 (Willin)
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF09379 FERM_N 20 82 FERM N-terminal domain Domain
PF00373 FERM_M 118 234 FERM central domain Domain
PF09380 FERM_C 239 332 FERM C-terminal PH-like domain Domain
Sequence
MNKLNFHNNRVMQDRRSVCIFLPNDESLNIIINVKILCHQLLVQVCDLLRLKDCHLFGLS
VIQNNEHVYMELSQKLYKYCPK
EWKKEASKVRQYEVTWGIDQFGPPMIIHFRVQYYVENG
RLISDRAARYYYYWHLRKQVLHSQCVLREEAYFLLAAFALQADLGNFKRNKHYGKYFEPE
AYFPSWVVSKRGKDYILKHIPNMHKDQFALTASEAHLKYIKEAVRLDDVAVHYY
RLYKDK
REIEASLTLGLTMRGIQIFQNLDEEKQLLYDFPWTNVGKLVFVGKKFEILPDGLPSARKL
IYYTGCPMRSRHLLQLLSNSHRLYMNLQPVLR
HIRKLEENEEKKQYRESYISDNLDLDMD
QLEKRSRASGSSAGSMKHKRLSRHSTASHSSSHTSGIEADTKPRDTGPEDSYSSSAIHRK
LKTCSSMTSHGSSHTSGVESGGKDRLEEDLQDDEIEMLVDDPRDLEQMNEESLEVSPDMC
IYITEDMLMSRKLNGHSGLIVKEIGSSTSSSSETVVKLRGQSTDSLPQTICRKPKTSTDR
HSLSLDDIRLYQKDFLRIAGLCQDTAQSYTFGCGHELDEEGLYCNSCLAQQCINIQDAFP
VKRTSKYFSLDLTHDEVPEFVV
Sequence length 622
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG 
  Hippo signaling pathway
Hippo signaling pathway - multiple species
 
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
2
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
PANCREATIC CARCINOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
SQUAMOUS CELL LUNG CARCINOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Alzheimer Disease Alzheimer disease Pubtator 22190428 Associate
★☆☆☆☆
Found in Text Mining only
Aortic Aneurysm Thoracic Thoracic aortic aneurysm Pubtator 34469433 Associate
★☆☆☆☆
Found in Text Mining only
Asthma Asthma BEFREE 22432035, 28293931
★☆☆☆☆
Found in Text Mining only
Asthma Asthma Pubtator 22432035 Associate
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 39199284 Associate
★☆☆☆☆
Found in Text Mining only
Colorectal Neoplasms Colorectal neoplasm Pubtator 27609023 Associate
★☆☆☆☆
Found in Text Mining only
Congenital myasthenic syndrome ib Congenital myasthenic syndrome Pubtator 33721619 Associate
★☆☆☆☆
Found in Text Mining only
Liver carcinoma Liver carcinoma BEFREE 31128910
★☆☆☆☆
Found in Text Mining only
Metabolic Syndrome X Metabolic Syndrome GWASCAT_DG 30621171
★☆☆☆☆
Found in Text Mining only
Multiple Sclerosis Multiple sclerosis Pubtator 27454520 Associate
★☆☆☆☆
Found in Text Mining only