RNASE11 (ribonuclease A family member 11 (inactive))

Gene

• Entrez ID: 122651
• Gene name: Ribonuclease A family member 11 (inactive)
• Gene symbol: RNASE11
• Synonyms (NCBI Gene): C14orf6, HEL-S-84p, RAJ1
• Chromosome: 14
• Chromosome location: 14q11.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1308577	hsa-miR-1273f	CLIP-seq
MIRT1308578	hsa-miR-145	CLIP-seq
MIRT1308579	hsa-miR-3121-3p	CLIP-seq
MIRT1308580	hsa-miR-3190	CLIP-seq
MIRT1308581	hsa-miR-3925-3p	CLIP-seq
MIRT1308582	hsa-miR-3976	CLIP-seq
MIRT1308583	hsa-miR-4433	CLIP-seq
MIRT1308584	hsa-miR-4459	CLIP-seq
MIRT1308585	hsa-miR-4651	CLIP-seq
MIRT1308586	hsa-miR-4768-3p	CLIP-seq
MIRT1308587	hsa-miR-608	CLIP-seq
MIRT1308588	hsa-miR-7	CLIP-seq
MIRT2091556	hsa-miR-4286	CLIP-seq
MIRT1308582	hsa-miR-3976	CLIP-seq
MIRT2458295	hsa-miR-1245	CLIP-seq
MIRT2458296	hsa-miR-4709-3p	CLIP-seq
MIRT2458295	hsa-miR-1245	CLIP-seq
MIRT2458296	hsa-miR-4709-3p	CLIP-seq
MIRT2458295	hsa-miR-1245	CLIP-seq
MIRT2458296	hsa-miR-4709-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003676	Function	Nucleic acid binding	IEA
GO:0004540	Function	RNA nuclease activity	IBA
GO:0004540	Function	RNA nuclease activity	IKR	15676279
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005576	Component	Extracellular region	IEA
GO:0050830	Process	Defense response to Gram-positive bacterium	IBA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q8TAA1
• Protein name: Putative inactive ribonuclease 11 (RNase 11)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00074	RnaseA	73 → 189	Pancreatic ribonuclease	Domain

• Sequence:

  METFPLLLLSLGLVLAEASESTMKIIKEEFTDEEMQYDMAKSGQEKQTIEILMNPILLVK
  NTSLSMSKDDMSSTLLTFRSLHYNDPKGNSSGNDKECCNDMTVWRKVSEANGSCKWSNNF
  IRSSTEVMRRVHRAPSCKFVQNPGISCCESLELENTVCQFTTGKQFPRCQYHSVTSLEKI
  LTVLTGHSLMSWLVCGSKL

• Sequence length: 199

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
COLORECTAL CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPOTENSION	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
IGA GLOMERULONEPHRITIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations