Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	121599
Gene name	Spi-C transcription factor
Gene symbol	SPIC
Synonyms (NCBI Gene)	SPI-C
Chromosome	12
Chromosome location	12q23.2
Summary	The protein encoded by this gene regulates the development of red pulp macrophages, which are necessary for iron homeostasis and the recycling of red blood cells. [provided by RefSeq, Aug 2016]

Show/Hide all (89)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018368	hsa-miR-335-5p	Microarray	18185580
MIRT678022	hsa-miR-562	HITS-CLIP	23824327
MIRT678021	hsa-miR-5697	HITS-CLIP	23824327
MIRT678020	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT678019	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT678018	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT678017	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT678016	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT678015	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT678014	hsa-miR-1976	HITS-CLIP	23824327
MIRT678013	hsa-miR-5186	HITS-CLIP	23824327
MIRT678011	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT678012	hsa-miR-4279	HITS-CLIP	23824327
MIRT678010	hsa-miR-498	HITS-CLIP	23824327
MIRT525479	hsa-miR-548at-5p	HITS-CLIP	23824327
MIRT640289	hsa-miR-590-3p	HITS-CLIP	23824327
MIRT525475	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT525474	hsa-miR-4775	HITS-CLIP	23824327
MIRT525473	hsa-miR-7111-3p	HITS-CLIP	23824327
MIRT525472	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT525471	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT525470	hsa-miR-670-3p	HITS-CLIP	23824327
MIRT525469	hsa-miR-1238-3p	HITS-CLIP	23824327
MIRT617252	hsa-miR-495-5p	HITS-CLIP	23824327
MIRT617251	hsa-miR-382-5p	HITS-CLIP	23824327
MIRT617250	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT617249	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT525479	hsa-miR-548at-5p	PAR-CLIP	22012620
MIRT525478	hsa-miR-561-3p	PAR-CLIP	22012620
MIRT525477	hsa-miR-142-5p	PAR-CLIP	22012620
MIRT525476	hsa-miR-5590-3p	PAR-CLIP	22012620
MIRT525475	hsa-miR-877-3p	PAR-CLIP	22012620
MIRT525474	hsa-miR-4775	PAR-CLIP	22012620
MIRT525473	hsa-miR-7111-3p	PAR-CLIP	22012620
MIRT525472	hsa-miR-6780a-3p	PAR-CLIP	22012620
MIRT525471	hsa-miR-6881-3p	PAR-CLIP	22012620
MIRT525470	hsa-miR-670-3p	PAR-CLIP	22012620
MIRT525469	hsa-miR-1238-3p	PAR-CLIP	22012620
MIRT525468	hsa-miR-6885-3p	PAR-CLIP	22012620
MIRT678022	hsa-miR-562	HITS-CLIP	23824327
MIRT678021	hsa-miR-5697	HITS-CLIP	23824327
MIRT678020	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT678019	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT678018	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT678017	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT678016	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT678015	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT678014	hsa-miR-1976	HITS-CLIP	23824327
MIRT678013	hsa-miR-5186	HITS-CLIP	23824327
MIRT678011	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT678012	hsa-miR-4279	HITS-CLIP	23824327
MIRT678010	hsa-miR-498	HITS-CLIP	23824327
MIRT525479	hsa-miR-548at-5p	HITS-CLIP	23824327
MIRT640289	hsa-miR-590-3p	HITS-CLIP	23824327
MIRT525475	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT525474	hsa-miR-4775	HITS-CLIP	23824327
MIRT525473	hsa-miR-7111-3p	HITS-CLIP	23824327
MIRT525472	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT525471	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT525470	hsa-miR-670-3p	HITS-CLIP	23824327
MIRT525469	hsa-miR-1238-3p	HITS-CLIP	23824327
MIRT617252	hsa-miR-495-5p	HITS-CLIP	23824327
MIRT617251	hsa-miR-382-5p	HITS-CLIP	23824327
MIRT617250	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT617249	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT525479	hsa-miR-548at-5p	PAR-CLIP	22012620
MIRT525478	hsa-miR-561-3p	PAR-CLIP	22012620
MIRT525477	hsa-miR-142-5p	PAR-CLIP	22012620
MIRT525476	hsa-miR-5590-3p	PAR-CLIP	22012620
MIRT525475	hsa-miR-877-3p	PAR-CLIP	22012620
MIRT525474	hsa-miR-4775	PAR-CLIP	22012620
MIRT525473	hsa-miR-7111-3p	PAR-CLIP	22012620
MIRT525472	hsa-miR-6780a-3p	PAR-CLIP	22012620
MIRT525471	hsa-miR-6881-3p	PAR-CLIP	22012620
MIRT525470	hsa-miR-670-3p	PAR-CLIP	22012620
MIRT525469	hsa-miR-1238-3p	PAR-CLIP	22012620
MIRT525468	hsa-miR-6885-3p	PAR-CLIP	22012620
MIRT2337619	hsa-miR-1238	CLIP-seq
MIRT2440749	hsa-miR-561	CLIP-seq
MIRT2460405	hsa-miR-3148	CLIP-seq
MIRT2460406	hsa-miR-4257	CLIP-seq
MIRT2460407	hsa-miR-4311	CLIP-seq
MIRT2460408	hsa-miR-4419a	CLIP-seq
MIRT2460409	hsa-miR-4510	CLIP-seq
MIRT2460405	hsa-miR-3148	CLIP-seq
MIRT2460406	hsa-miR-4257	CLIP-seq
MIRT2460407	hsa-miR-4311	CLIP-seq
MIRT2460408	hsa-miR-4419a	CLIP-seq
MIRT2460409	hsa-miR-4510	CLIP-seq

Show/Hide all (17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IEA
GO:0001824	Process	Blastocyst development	IEA
GO:0003677	Function	DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IEA
GO:0030154	Process	Cell differentiation	IBA
GO:0043565	Function	Sequence-specific DNA binding	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA

MIM	HGNC	e!Ensembl
612568	29549	ENSG00000166211

Q8N5J4

Protein name

Transcription factor Spi-C

Protein function

Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5'-GAGGA[AT]-3') that can act as a lymphoid-specific enhance

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00178	Ets	112 → 194	Ets-domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Preferentially detected in fetal and adult spleen, lymph nodes and at lower levels in bone marrow and fetal liver. {ECO:0000269|PubMed:12459275}.

Sequence

MTCVEQDKLGQAFEDAFEVLRQHSTGDLQYSPDYRNYLALINHRPHVKGNSSCYGVLPTE
EPVYNWRTVINSAADFYFEGNIHQSLQNITENQLVQPTLLQQKGGKGRKKLRLFEYLHES
LYNPEMASCIQWVDKTKGIFQFVSKNKEKLAELWGKRKGNRKTMTYQKMARALRNYGRSG
EITKIRRKLTYQFSEAILQRLSPSYFLGKEIFYSQCVQPDQEYLSLNNWNANYNYTYANY
HELNHHDC

Sequence length

248

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
BREAST CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Clear cell carcinoma of kidney	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (3)

Disease Name	Disease (Merged)	Source	PMID	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Colitis	Colitis	BEFREE	30061415	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	21318373	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	31143160	★★★★★ ★☆☆☆☆ Found in Text Mining only

SPIC (Spi-C transcription factor)