Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	121457
Gene name	IKBKB interacting protein
Gene symbol	IKBIP
Synonyms (NCBI Gene)	IKIP
Chromosome	12
Chromosome location	12q23.1

275

Show/Hide all (275)

miRTarBase ID	miRNA	Experiments	Reference
MIRT005251	hsa-miR-155-5p	pSILAC	18668040
MIRT005251	hsa-miR-155-5p	Proteomics	18668040
MIRT023080	hsa-miR-124-3p	Microarray	18668037
MIRT028670	hsa-miR-30a-5p	Proteomics	18668040
MIRT045247	hsa-miR-186-5p	CLASH	23622248
MIRT044660	hsa-miR-320a	CLASH	23622248
MIRT572580	hsa-miR-4494	PAR-CLIP	20371350
MIRT572579	hsa-miR-499b-5p	PAR-CLIP	20371350
MIRT572578	hsa-miR-16-1-3p	PAR-CLIP	20371350
MIRT572577	hsa-miR-222-5p	PAR-CLIP	20371350
MIRT232802	hsa-miR-513b-3p	PAR-CLIP	22100165
MIRT445145	hsa-miR-5003-3p	PAR-CLIP	22100165
MIRT445144	hsa-miR-138-1-3p	PAR-CLIP	22100165
MIRT445143	hsa-miR-539-5p	PAR-CLIP	22100165
MIRT445142	hsa-miR-934	PAR-CLIP	22100165
MIRT445141	hsa-miR-431-5p	PAR-CLIP	22100165
MIRT445140	hsa-miR-580-3p	PAR-CLIP	22100165
MIRT232802	hsa-miR-513b-3p	PAR-CLIP	22100165
MIRT445145	hsa-miR-5003-3p	PAR-CLIP	22100165
MIRT445144	hsa-miR-138-1-3p	PAR-CLIP	22100165
MIRT445143	hsa-miR-539-5p	PAR-CLIP	22100165
MIRT445142	hsa-miR-934	PAR-CLIP	22100165
MIRT445141	hsa-miR-431-5p	PAR-CLIP	22100165
MIRT445140	hsa-miR-580-3p	PAR-CLIP	22100165
MIRT572580	hsa-miR-4494	PAR-CLIP	20371350
MIRT572579	hsa-miR-499b-5p	PAR-CLIP	20371350
MIRT572578	hsa-miR-16-1-3p	PAR-CLIP	20371350
MIRT572577	hsa-miR-222-5p	PAR-CLIP	20371350
MIRT232802	hsa-miR-513b-3p	PAR-CLIP	22100165
MIRT445145	hsa-miR-5003-3p	PAR-CLIP	22100165
MIRT445144	hsa-miR-138-1-3p	PAR-CLIP	22100165
MIRT445143	hsa-miR-539-5p	PAR-CLIP	22100165
MIRT445142	hsa-miR-934	PAR-CLIP	22100165
MIRT445141	hsa-miR-431-5p	PAR-CLIP	22100165
MIRT445140	hsa-miR-580-3p	PAR-CLIP	22100165
MIRT232802	hsa-miR-513b-3p	PAR-CLIP	22100165
MIRT445145	hsa-miR-5003-3p	PAR-CLIP	22100165
MIRT445144	hsa-miR-138-1-3p	PAR-CLIP	22100165
MIRT445143	hsa-miR-539-5p	PAR-CLIP	22100165
MIRT445142	hsa-miR-934	PAR-CLIP	22100165
MIRT445141	hsa-miR-431-5p	PAR-CLIP	22100165
MIRT445140	hsa-miR-580-3p	PAR-CLIP	22100165
MIRT1062925	hsa-miR-10a	CLIP-seq
MIRT1062926	hsa-miR-10b	CLIP-seq
MIRT1062927	hsa-miR-1200	CLIP-seq
MIRT1062928	hsa-miR-1224-3p	CLIP-seq
MIRT1062929	hsa-miR-1228	CLIP-seq
MIRT1062930	hsa-miR-1245b-5p	CLIP-seq
MIRT1062931	hsa-miR-1307	CLIP-seq
MIRT1062932	hsa-miR-1913	CLIP-seq
MIRT1062933	hsa-miR-194	CLIP-seq
MIRT1062934	hsa-miR-1976	CLIP-seq
MIRT1062935	hsa-miR-2276	CLIP-seq
MIRT1062936	hsa-miR-299-3p	CLIP-seq
MIRT1062937	hsa-miR-3142	CLIP-seq
MIRT1062938	hsa-miR-3163	CLIP-seq
MIRT1062939	hsa-miR-3194-3p	CLIP-seq
MIRT1062940	hsa-miR-3199	CLIP-seq
MIRT1062941	hsa-miR-324-3p	CLIP-seq
MIRT1062942	hsa-miR-3607-3p	CLIP-seq
MIRT1062943	hsa-miR-3620	CLIP-seq
MIRT1062944	hsa-miR-3686	CLIP-seq
MIRT1062945	hsa-miR-3691-5p	CLIP-seq
MIRT1062946	hsa-miR-377	CLIP-seq
MIRT1062947	hsa-miR-380	CLIP-seq
MIRT1062948	hsa-miR-3924	CLIP-seq
MIRT1062949	hsa-miR-411	CLIP-seq
MIRT1062950	hsa-miR-4269	CLIP-seq
MIRT1062951	hsa-miR-4279	CLIP-seq
MIRT1062952	hsa-miR-4284	CLIP-seq
MIRT1062953	hsa-miR-4324	CLIP-seq
MIRT1062954	hsa-miR-4438	CLIP-seq
MIRT1062955	hsa-miR-4491	CLIP-seq
MIRT1062956	hsa-miR-4495	CLIP-seq
MIRT1062957	hsa-miR-4511	CLIP-seq
MIRT1062958	hsa-miR-4532	CLIP-seq
MIRT1062959	hsa-miR-4634	CLIP-seq
MIRT1062960	hsa-miR-4638-5p	CLIP-seq
MIRT1062961	hsa-miR-4657	CLIP-seq
MIRT1062962	hsa-miR-4695-3p	CLIP-seq
MIRT1062963	hsa-miR-4722-3p	CLIP-seq
MIRT1062964	hsa-miR-4752	CLIP-seq
MIRT1062965	hsa-miR-5095	CLIP-seq
MIRT1062966	hsa-miR-5096	CLIP-seq
MIRT1062967	hsa-miR-544b	CLIP-seq
MIRT1062968	hsa-miR-548b-3p	CLIP-seq
MIRT1062969	hsa-miR-556-3p	CLIP-seq
MIRT1062970	hsa-miR-617	CLIP-seq
MIRT1062971	hsa-miR-889	CLIP-seq
MIRT2014823	hsa-miR-106a	CLIP-seq
MIRT2014824	hsa-miR-106b	CLIP-seq
MIRT1062927	hsa-miR-1200	CLIP-seq
MIRT2014825	hsa-miR-122	CLIP-seq
MIRT1062928	hsa-miR-1224-3p	CLIP-seq
MIRT1062929	hsa-miR-1228	CLIP-seq
MIRT2014826	hsa-miR-1234	CLIP-seq
MIRT2014827	hsa-miR-129-5p	CLIP-seq
MIRT1062931	hsa-miR-1307	CLIP-seq
MIRT2014828	hsa-miR-150	CLIP-seq
MIRT2014829	hsa-miR-17	CLIP-seq
MIRT1062932	hsa-miR-1913	CLIP-seq
MIRT1062934	hsa-miR-1976	CLIP-seq
MIRT2014830	hsa-miR-20a	CLIP-seq
MIRT2014831	hsa-miR-20b	CLIP-seq
MIRT1062935	hsa-miR-2276	CLIP-seq
MIRT2014832	hsa-miR-302a	CLIP-seq
MIRT2014833	hsa-miR-302b	CLIP-seq
MIRT2014834	hsa-miR-302c	CLIP-seq
MIRT2014835	hsa-miR-302d	CLIP-seq
MIRT2014836	hsa-miR-302e	CLIP-seq
MIRT2014837	hsa-miR-3135b	CLIP-seq
MIRT2014838	hsa-miR-3155	CLIP-seq
MIRT2014839	hsa-miR-3155b	CLIP-seq
MIRT2014840	hsa-miR-3159	CLIP-seq
MIRT2014841	hsa-miR-3176	CLIP-seq
MIRT1062939	hsa-miR-3194-3p	CLIP-seq
MIRT1062940	hsa-miR-3199	CLIP-seq
MIRT1062941	hsa-miR-324-3p	CLIP-seq
MIRT2014842	hsa-miR-3652	CLIP-seq
MIRT2014843	hsa-miR-372	CLIP-seq
MIRT2014844	hsa-miR-373	CLIP-seq
MIRT1062946	hsa-miR-377	CLIP-seq
MIRT2014845	hsa-miR-3922-3p	CLIP-seq
MIRT2014846	hsa-miR-3934	CLIP-seq
MIRT2014847	hsa-miR-4252	CLIP-seq
MIRT1062950	hsa-miR-4269	CLIP-seq
MIRT1062951	hsa-miR-4279	CLIP-seq
MIRT1062952	hsa-miR-4284	CLIP-seq
MIRT2014848	hsa-miR-4287	CLIP-seq
MIRT1062953	hsa-miR-4324	CLIP-seq
MIRT2014849	hsa-miR-4430	CLIP-seq
MIRT1062954	hsa-miR-4438	CLIP-seq
MIRT2014850	hsa-miR-4469	CLIP-seq
MIRT2014851	hsa-miR-4514	CLIP-seq
MIRT1062958	hsa-miR-4532	CLIP-seq
MIRT1062959	hsa-miR-4634	CLIP-seq
MIRT1062960	hsa-miR-4638-5p	CLIP-seq
MIRT2014852	hsa-miR-4685-3p	CLIP-seq
MIRT2014853	hsa-miR-4692	CLIP-seq
MIRT1062963	hsa-miR-4722-3p	CLIP-seq
MIRT2014854	hsa-miR-4729	CLIP-seq
MIRT2014855	hsa-miR-4735-5p	CLIP-seq
MIRT2014856	hsa-miR-4742-5p	CLIP-seq
MIRT2014857	hsa-miR-4775	CLIP-seq
MIRT2014858	hsa-miR-4794	CLIP-seq
MIRT2014859	hsa-miR-484	CLIP-seq
MIRT1062965	hsa-miR-5095	CLIP-seq
MIRT2014860	hsa-miR-510	CLIP-seq
MIRT2014861	hsa-miR-519d	CLIP-seq
MIRT2014862	hsa-miR-520a-3p	CLIP-seq
MIRT2014863	hsa-miR-520b	CLIP-seq
MIRT2014864	hsa-miR-520c-3p	CLIP-seq
MIRT2014865	hsa-miR-520d-3p	CLIP-seq
MIRT2014866	hsa-miR-520e	CLIP-seq
MIRT2014867	hsa-miR-520g	CLIP-seq
MIRT2014868	hsa-miR-520h	CLIP-seq
MIRT1062967	hsa-miR-544b	CLIP-seq
MIRT2014869	hsa-miR-552	CLIP-seq
MIRT2014870	hsa-miR-590-3p	CLIP-seq
MIRT2014871	hsa-miR-93	CLIP-seq
MIRT2014823	hsa-miR-106a	CLIP-seq
MIRT2014824	hsa-miR-106b	CLIP-seq
MIRT1062927	hsa-miR-1200	CLIP-seq
MIRT2014825	hsa-miR-122	CLIP-seq
MIRT1062928	hsa-miR-1224-3p	CLIP-seq
MIRT1062929	hsa-miR-1228	CLIP-seq
MIRT2014826	hsa-miR-1234	CLIP-seq
MIRT1062931	hsa-miR-1307	CLIP-seq
MIRT2014828	hsa-miR-150	CLIP-seq
MIRT2014829	hsa-miR-17	CLIP-seq
MIRT1062932	hsa-miR-1913	CLIP-seq
MIRT1062934	hsa-miR-1976	CLIP-seq
MIRT2014830	hsa-miR-20a	CLIP-seq
MIRT2014831	hsa-miR-20b	CLIP-seq
MIRT1062935	hsa-miR-2276	CLIP-seq
MIRT2014832	hsa-miR-302a	CLIP-seq
MIRT2014833	hsa-miR-302b	CLIP-seq
MIRT2014834	hsa-miR-302c	CLIP-seq
MIRT2014835	hsa-miR-302d	CLIP-seq
MIRT2014836	hsa-miR-302e	CLIP-seq
MIRT2014837	hsa-miR-3135b	CLIP-seq
MIRT2014838	hsa-miR-3155	CLIP-seq
MIRT2014839	hsa-miR-3155b	CLIP-seq
MIRT2014840	hsa-miR-3159	CLIP-seq
MIRT1062939	hsa-miR-3194-3p	CLIP-seq
MIRT1062940	hsa-miR-3199	CLIP-seq
MIRT1062941	hsa-miR-324-3p	CLIP-seq
MIRT2014842	hsa-miR-3652	CLIP-seq
MIRT2014843	hsa-miR-372	CLIP-seq
MIRT2014844	hsa-miR-373	CLIP-seq
MIRT1062946	hsa-miR-377	CLIP-seq
MIRT2014846	hsa-miR-3934	CLIP-seq
MIRT2014847	hsa-miR-4252	CLIP-seq
MIRT1062950	hsa-miR-4269	CLIP-seq
MIRT1062951	hsa-miR-4279	CLIP-seq
MIRT1062952	hsa-miR-4284	CLIP-seq
MIRT1062953	hsa-miR-4324	CLIP-seq
MIRT2014849	hsa-miR-4430	CLIP-seq
MIRT1062954	hsa-miR-4438	CLIP-seq
MIRT1062958	hsa-miR-4532	CLIP-seq
MIRT1062959	hsa-miR-4634	CLIP-seq
MIRT1062960	hsa-miR-4638-5p	CLIP-seq
MIRT1062963	hsa-miR-4722-3p	CLIP-seq
MIRT2014859	hsa-miR-484	CLIP-seq
MIRT1062965	hsa-miR-5095	CLIP-seq
MIRT2014860	hsa-miR-510	CLIP-seq
MIRT2014861	hsa-miR-519d	CLIP-seq
MIRT2014862	hsa-miR-520a-3p	CLIP-seq
MIRT2014863	hsa-miR-520b	CLIP-seq
MIRT2014864	hsa-miR-520c-3p	CLIP-seq
MIRT2014865	hsa-miR-520d-3p	CLIP-seq
MIRT2014866	hsa-miR-520e	CLIP-seq
MIRT2014867	hsa-miR-520g	CLIP-seq
MIRT2014868	hsa-miR-520h	CLIP-seq
MIRT1062967	hsa-miR-544b	CLIP-seq
MIRT2014869	hsa-miR-552	CLIP-seq
MIRT1062970	hsa-miR-617	CLIP-seq
MIRT2014871	hsa-miR-93	CLIP-seq
MIRT1062940	hsa-miR-3199	CLIP-seq
MIRT1062950	hsa-miR-4269	CLIP-seq
MIRT1062954	hsa-miR-4438	CLIP-seq
MIRT1062965	hsa-miR-5095	CLIP-seq
MIRT2014827	hsa-miR-129-5p	CLIP-seq
MIRT2451667	hsa-miR-3149	CLIP-seq
MIRT1062949	hsa-miR-411	CLIP-seq
MIRT2014855	hsa-miR-4735-5p	CLIP-seq
MIRT2014857	hsa-miR-4775	CLIP-seq
MIRT2014858	hsa-miR-4794	CLIP-seq
MIRT2014870	hsa-miR-590-3p	CLIP-seq
MIRT2014825	hsa-miR-122	CLIP-seq
MIRT1062928	hsa-miR-1224-3p	CLIP-seq
MIRT2014826	hsa-miR-1234	CLIP-seq
MIRT2014827	hsa-miR-129-5p	CLIP-seq
MIRT1062931	hsa-miR-1307	CLIP-seq
MIRT2014828	hsa-miR-150	CLIP-seq
MIRT1062935	hsa-miR-2276	CLIP-seq
MIRT2014837	hsa-miR-3135b	CLIP-seq
MIRT2451667	hsa-miR-3149	CLIP-seq
MIRT2014838	hsa-miR-3155	CLIP-seq
MIRT2014839	hsa-miR-3155b	CLIP-seq
MIRT1062939	hsa-miR-3194-3p	CLIP-seq
MIRT1062940	hsa-miR-3199	CLIP-seq
MIRT2014842	hsa-miR-3652	CLIP-seq
MIRT1062949	hsa-miR-411	CLIP-seq
MIRT2014847	hsa-miR-4252	CLIP-seq
MIRT1062950	hsa-miR-4269	CLIP-seq
MIRT1062952	hsa-miR-4284	CLIP-seq
MIRT2014849	hsa-miR-4430	CLIP-seq
MIRT1062954	hsa-miR-4438	CLIP-seq
MIRT1062959	hsa-miR-4634	CLIP-seq
MIRT1062960	hsa-miR-4638-5p	CLIP-seq
MIRT2014855	hsa-miR-4735-5p	CLIP-seq
MIRT2014857	hsa-miR-4775	CLIP-seq
MIRT2014858	hsa-miR-4794	CLIP-seq
MIRT2014859	hsa-miR-484	CLIP-seq
MIRT1062965	hsa-miR-5095	CLIP-seq
MIRT2014860	hsa-miR-510	CLIP-seq
MIRT2014870	hsa-miR-590-3p	CLIP-seq
MIRT2014825	hsa-miR-122	CLIP-seq
MIRT2014827	hsa-miR-129-5p	CLIP-seq
MIRT2014837	hsa-miR-3135b	CLIP-seq
MIRT2451667	hsa-miR-3149	CLIP-seq
MIRT2014838	hsa-miR-3155	CLIP-seq
MIRT2014839	hsa-miR-3155b	CLIP-seq
MIRT2014842	hsa-miR-3652	CLIP-seq
MIRT1062949	hsa-miR-411	CLIP-seq
MIRT2014847	hsa-miR-4252	CLIP-seq
MIRT2014849	hsa-miR-4430	CLIP-seq
MIRT1062959	hsa-miR-4634	CLIP-seq
MIRT2014855	hsa-miR-4735-5p	CLIP-seq
MIRT2014857	hsa-miR-4775	CLIP-seq
MIRT2014858	hsa-miR-4794	CLIP-seq
MIRT2014859	hsa-miR-484	CLIP-seq
MIRT2014860	hsa-miR-510	CLIP-seq
MIRT2014870	hsa-miR-590-3p	CLIP-seq

Show/Hide all (9)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	15389287, 25416956, 27812135, 28514442, 31515488, 32296183, 38489235
GO:0005730	Component	Nucleolus	IDA
GO:0005783	Component	Endoplasmic reticulum	IDA	15389287
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0010165	Process	Response to X-ray	TAS	15389287
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA

MIM	HGNC	e!Ensembl
609861	26430	ENSG00000166130

Q70UQ0

Protein name

Inhibitor of nuclear factor kappa-B kinase-interacting protein (I kappa-B kinase-interacting protein) (IKBKB-interacting protein) (IKK-interacting protein)

Protein function

Target of p53/TP53 with pro-apoptotic function.

Family and domains

Tissue specificity

TISSUE SPECIFICITY: Expressed in vein endothelial cells. Isoform 4 is expressed in lung, kidney, spleen, thymus and skeletal muscle. {ECO:0000269|PubMed:15389287}.

Sequence

MSEVKSRKKSGPKGAPAAEPGKRSEGGKTPVARSSGGGGWADPRTCLSLLSLGTCLGLAW
FVFQQSEKFAKVENQYQLLKLETNEFQQLQSKISLISEKWQKSEAIMEQLKSFQIIAHLK
RLQEEINEVKTWSNRITEKQDILNNSLTTLSQDITKVDQSTTSMAKDVGLKITSVKTDIR
RISGLVTDVISLTDSVQELENKIEKVEKNTVKNIGDLLSSSIDRTATLRKTASENSQRIN
SVKKTLTELKSDFDKHTDRFLSLEGDRAKVLKTVTFANDLKPKVYNLKKDFSRLEPLVND
LTLRIGRLVTDLLQREKEIAFLSEKISNLTIVQAEIKDIKDEIAHISDMN

Sequence length

350

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
BARRETT'S ESOPHAGUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (6)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Barrett Esophagus	Barrett esophagus	GWASCAT_DG	29551738		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	37454079	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Fanconi Anemia	Fanconi anemia	Pubtator	37454079	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	31761927		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	31761927, 34897031, 37454079	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	31761927		★★★★★ ★☆☆☆☆ Found in Text Mining only

IKBIP (IKBKB interacting protein)