Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	121256
Gene name	Transmembrane protein 132D
Gene symbol	TMEM132D
Synonyms (NCBI Gene)	MOLTPPP1R153
Chromosome	12
Chromosome location	12q24.33

Show/Hide all (88)

miRTarBase ID	miRNA	Experiments
MIRT1430751	hsa-miR-1273f	CLIP-seq
MIRT1430752	hsa-miR-1287	CLIP-seq
MIRT1430753	hsa-miR-1343	CLIP-seq
MIRT1430754	hsa-miR-143	CLIP-seq
MIRT1430755	hsa-miR-185	CLIP-seq
MIRT1430756	hsa-miR-2116	CLIP-seq
MIRT1430757	hsa-miR-3074-5p	CLIP-seq
MIRT1430758	hsa-miR-3124-3p	CLIP-seq
MIRT1430759	hsa-miR-3125	CLIP-seq
MIRT1430760	hsa-miR-3135b	CLIP-seq
MIRT1430761	hsa-miR-3150b-3p	CLIP-seq
MIRT1430762	hsa-miR-3173-3p	CLIP-seq
MIRT1430763	hsa-miR-3690	CLIP-seq
MIRT1430764	hsa-miR-370	CLIP-seq
MIRT1430765	hsa-miR-378g	CLIP-seq
MIRT1430766	hsa-miR-3916	CLIP-seq
MIRT1430767	hsa-miR-4252	CLIP-seq
MIRT1430768	hsa-miR-4254	CLIP-seq
MIRT1430769	hsa-miR-4270	CLIP-seq
MIRT1430770	hsa-miR-4306	CLIP-seq
MIRT1430771	hsa-miR-4441	CLIP-seq
MIRT1430772	hsa-miR-4463	CLIP-seq
MIRT1430773	hsa-miR-4534	CLIP-seq
MIRT1430774	hsa-miR-4644	CLIP-seq
MIRT1430775	hsa-miR-4677-5p	CLIP-seq
MIRT1430776	hsa-miR-4687-3p	CLIP-seq
MIRT1430777	hsa-miR-4699-3p	CLIP-seq
MIRT1430778	hsa-miR-4708-5p	CLIP-seq
MIRT1430779	hsa-miR-4770	CLIP-seq
MIRT1430780	hsa-miR-4784	CLIP-seq
MIRT1430781	hsa-miR-4797-5p	CLIP-seq
MIRT1430782	hsa-miR-516a-3p	CLIP-seq
MIRT1430783	hsa-miR-765	CLIP-seq
MIRT1430784	hsa-miR-875-3p	CLIP-seq
MIRT1430751	hsa-miR-1273f	CLIP-seq
MIRT1430752	hsa-miR-1287	CLIP-seq
MIRT1430754	hsa-miR-143	CLIP-seq
MIRT1430755	hsa-miR-185	CLIP-seq
MIRT2129170	hsa-miR-2110	CLIP-seq
MIRT2129171	hsa-miR-2355-3p	CLIP-seq
MIRT2129172	hsa-miR-2392	CLIP-seq
MIRT1430757	hsa-miR-3074-5p	CLIP-seq
MIRT1430760	hsa-miR-3135b	CLIP-seq
MIRT2129173	hsa-miR-3150a-3p	CLIP-seq
MIRT2129174	hsa-miR-3175	CLIP-seq
MIRT2129175	hsa-miR-3605-5p	CLIP-seq
MIRT1430764	hsa-miR-370	CLIP-seq
MIRT1430765	hsa-miR-378g	CLIP-seq
MIRT2129176	hsa-miR-4260	CLIP-seq
MIRT1430770	hsa-miR-4306	CLIP-seq
MIRT1430774	hsa-miR-4644	CLIP-seq
MIRT2129177	hsa-miR-4646-3p	CLIP-seq
MIRT1430778	hsa-miR-4708-5p	CLIP-seq
MIRT1430779	hsa-miR-4770	CLIP-seq
MIRT1430781	hsa-miR-4797-5p	CLIP-seq
MIRT1430782	hsa-miR-516a-3p	CLIP-seq
MIRT2129178	hsa-miR-676	CLIP-seq
MIRT2129179	hsa-miR-939	CLIP-seq
MIRT1430752	hsa-miR-1287	CLIP-seq
MIRT2350753	hsa-miR-146a	CLIP-seq
MIRT2350754	hsa-miR-146b-5p	CLIP-seq
MIRT2129170	hsa-miR-2110	CLIP-seq
MIRT2129172	hsa-miR-2392	CLIP-seq
MIRT1430757	hsa-miR-3074-5p	CLIP-seq
MIRT1430760	hsa-miR-3135b	CLIP-seq
MIRT2129173	hsa-miR-3150a-3p	CLIP-seq
MIRT2129174	hsa-miR-3175	CLIP-seq
MIRT2129175	hsa-miR-3605-5p	CLIP-seq
MIRT1430764	hsa-miR-370	CLIP-seq
MIRT1430765	hsa-miR-378g	CLIP-seq
MIRT2350755	hsa-miR-3929	CLIP-seq
MIRT2129176	hsa-miR-4260	CLIP-seq
MIRT2350756	hsa-miR-4419b	CLIP-seq
MIRT2350757	hsa-miR-4478	CLIP-seq
MIRT2350758	hsa-miR-4484	CLIP-seq
MIRT2350759	hsa-miR-4765	CLIP-seq
MIRT2350760	hsa-miR-4766-5p	CLIP-seq
MIRT2350761	hsa-miR-488	CLIP-seq
MIRT1430782	hsa-miR-516a-3p	CLIP-seq
MIRT2350762	hsa-miR-548an	CLIP-seq
MIRT2350763	hsa-miR-589	CLIP-seq
MIRT2129179	hsa-miR-939	CLIP-seq
MIRT1430752	hsa-miR-1287	CLIP-seq
MIRT1430757	hsa-miR-3074-5p	CLIP-seq
MIRT1430760	hsa-miR-3135b	CLIP-seq
MIRT1430764	hsa-miR-370	CLIP-seq
MIRT1430765	hsa-miR-378g	CLIP-seq
MIRT1430782	hsa-miR-516a-3p	CLIP-seq

Show/Hide all (3)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	19389623, 33726789
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	NAS	12966072

MIM	HGNC	e!Ensembl
611257	29411	ENSG00000151952

Q14C87

Protein name

Transmembrane protein 132D (Mature oligodendrocytes transmembrane protein) (Mature OL transmembrane protein)

Protein function

Regulate neuronals morphology via inhibition of the WAVE regulatory complex (WCR), a complex that controls F-actin cytoskeletal dynamics.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF15705	TMEM132D_N	49 → 179	Mature oligodendrocyte transmembrane protein, TMEM132D, N-term	Family
PF16070	TMEM132	436 → 779	Transmembrane protein family 132	Family
PF15706	TMEM132D_C	886 → 972	Mature oligodendrocyte transmembrane protein, TMEM132D, C-term	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in mature oligodendrocytes. Detected in the brain, lung, pancreas and testis (PubMed:12966072). Highly expressed in mature neurons of the adult nervous system (PubMed:33726789). {ECO:0000269|PubMed:12966072, ECO:0000269|PubMe

Sequence

MCPSEMGTLWHHWSPVLISLAALFSKVTEGRGILESIQRFSLLPTYLPVTYHINNADVSF
FLKEANQDIMRNSSLQSRVESFLIYKSRRLPVLNASYGPFSIEQVVPQDLMLPSNPFGFT
NKFSLNWKLKAHILRDKVYLSRPKVQVLFHIMGRDWDDRSAGEKLPCLRVFAFRETREVR
GSCRLQGDLGLCVAELELLSSWFSPPTVVAGRRKSVDQPEGTPVELYYTVHPGGERGDCV
REDARRSNGIRTGHSDIDESGPPLQRIGSIFLYQTHRKPSLRELRLDNSVAIHYIPKTVR
KGDVLTFPVSISRNSTEDRFTLRAKVKKGVNIIGVRASSPSIWDVKERTDYTGKYAPAVI
VCQKKAAGSENSADGASYEVMQIDVEVEEPGDLPATQLVTWQVEYPGEITSDLGVSKIYV
SPKDLIGVVPLAMEAEILNTAILTGKTVAVPVKVVSVEDDGTVTELLESVECRSSDEDVI
KVSDRCDYVFVNGKEMKGKVNVVVNFTYQHLSSPLEMTVWVPRLPLQIEVSDTELNQIKG
WRVPIVSSRRPAGDSEEEEDDERRGRGCTLQYQHAMVRVLTQFVAEAAGPGGHLAHLLGS
DWQVDITELINDFMQVEEPRIAKLQGGQILMGQELGMTTIQILSPLSDTILAEKTITVLD
EKVTITDLGVQLVTGLSLSLQLSPGSNRAIFATAVAQELLQRPKQEAAISCWVQFSDGSV
TPLDIYDGKDFSLMATSLDEKVVSIHQDPKFKWPIIAAETEGQGTLVKVEMVISESCQKS
KRKSVLAVGTANIKVKFGQNDANPNTSDSRHTGAGVHMENNVSDRRPKKPSQEWGSQEGQ
YYGSSSMGLMEGRGTTTDRSILQKKKGQESLLDDNSHLQTIPSDLTSFPAQVDLPRSNGE
MDGNDLMQASKGLSDLEIGMYALLGVFCLAILVFLINCVTFALKYRHKQVPFEEQEGMSH
SHDWVGLSNRTELLENHINFASSQDEQITAIDRGMDFEESKYLLSTNSQKSINGQLFKPL
GPIIIDGKDQKSEPPTSPTSKRKRVKFTTFTAVSSDDEYPTRNSIVMSSEDDIKWVCQDL
DPGDCKELHNYMERLHENV

Sequence length

1099

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (17)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ANXIETY DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ASTHMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLORECTAL CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEMENTIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INTELLECTUAL DISABILITY	—	Disgenet, GenCC Disgenet, GenCC	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LIVER NEOPLASMS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBESITY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SMALL CELL LUNG CARCINOMA	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TMEM132D-related disorder	Likely benign; Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TREATMENT-RESISTANT HYPERTENSION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Vascular endothelial growth factor (VEGF) inhibitor response	association	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (53)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Acute leukemia	Leukemia	BEFREE	12680164, 2784121		★★★★★ ★☆☆☆☆ Found in Text Mining only
Acute lymphocytic leukemia	Lymphocytic Leukemia	BEFREE	12565976, 12665628, 17999954, 18349321, 28718636, 29523024, 30813936, 31226894, 31459155, 31544515, 6586290, 8608962, 9178809		★★★★★ ★☆☆☆☆ Found in Text Mining only
Acute monocytic leukemia	Monocytic Leukemia	BEFREE	21973023		★★★★★ ★☆☆☆☆ Found in Text Mining only
Acute myelomonocytic leukemia	Myelomonocytic Leukemia	BEFREE	21973023		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adult Acute Lymphocytic Leukemia	Lymphocytic Leukemia	BEFREE	12565976, 18349321, 31459155, 31544515		★★★★★ ★☆☆☆☆ Found in Text Mining only
Anxiety	Anxiety Disorder	BEFREE	20368705, 27318301, 29317594		★★★★★ ★☆☆☆☆ Found in Text Mining only
Anxiety	Anxiety disorder	Pubtator	27318301	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Anxiety Disorders	Anxiety Disorder	BEFREE	20368705, 22911938, 24234873, 27318301, 29317594		★★★★★ ★☆☆☆☆ Found in Text Mining only
B-Cell Lymphomas	B-Cell Lymphoma	BEFREE	29523024		★★★★★ ★☆☆☆☆ Found in Text Mining only
Bipolar Disorder	Bipolar disorder	Pubtator	27112568	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	29065840, 29698921, 9619752		★★★★★ ★☆☆☆☆ Found in Text Mining only
Burkitt Lymphoma	Burkitt`s Lymphoma	BEFREE	16102592		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma	Carcinoma	BEFREE	8917402		★★★★★ ★☆☆☆☆ Found in Text Mining only
cervical cancer	Cervical Cancer	BEFREE	17151476		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cervix carcinoma	Cervix carcinoma	BEFREE	17151476, 31003438		★★★★★ ★☆☆☆☆ Found in Text Mining only
Childhood Acute Lymphoblastic Leukemia	Lymphoblastic Leukemia	BEFREE	12565976, 18349321, 31459155, 31544515		★★★★★ ★☆☆☆☆ Found in Text Mining only
Chronic Lymphocytic Leukemia	Lymphocytic Leukemia	BEFREE	21401803		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colon Carcinoma	Colon Carcinoma	BEFREE	29698921		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	24951259	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Frontotemporal Dementia	Frontotemporal dementia	Pubtator	32576262	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Impaired cognition	Impaired Cognition	GWASCAT_DG	26252872		★★★★★ ★☆☆☆☆ Found in Text Mining only
leukemia	Leukemia	BEFREE	10507318, 11485552, 11976833, 12529660, 16714776, 28181578, 28667871, 29065840, 29698921, 30488850, 30552789, 31003438, 31447082, 31751780, 7850779, 8477061, 9116294, 9292393 View all (3 more)		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	BEFREE	1954386, 21973023		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	GWASCAT_DG	27903959		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia, T-Cell	T-cell leukemia	BEFREE	15050409, 21455989, 27846451, 9408752		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver neoplasms	Liver neoplasms	CTD_human_DG	19233941		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lymphoid leukemia	Lymphoid leukemia	BEFREE	10871345, 17999954, 28718636, 9178809		★★★★★ ★☆☆☆☆ Found in Text Mining only
Major Depressive Disorder	Mental Depression	BEFREE	25974322		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant neoplasm of breast	Breast Cancer	BEFREE	29065840, 29698921, 9619752		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of kidney	Kidney Cancer	BEFREE	29698921		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of liver	Liver Cancer	CTD_human_DG	19233941		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	15517906, 17999954, 28631525, 29573314, 31078767, 31445193, 31763840, 9116294		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	BEFREE	29698921		★★★★★ ★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	BEFREE	29698921		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mental disorders	Mental Disorders	BEFREE	27318301		★★★★★ ★☆☆☆☆ Found in Text Mining only
Myeloid Leukemia	Myeloid Leukemia	BEFREE	1069137, 30552789, 31226894		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	21818556, 22751129, 30460757		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	2078479		★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	29698921		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	26448945	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Panic Disorder	Panic Disorder	BEFREE	20368705, 22911938, 22948381, 24234873, 25974322, 29317594		★★★★★ ★☆☆☆☆ Found in Text Mining only
Precursor B-cell lymphoblastic leukemia	Lymphoblastic Leukemia	BEFREE	18349321		★★★★★ ★☆☆☆☆ Found in Text Mining only
Precursor Cell Lymphoblastic Leukemia Lymphoma	Lymphoblastic Leukemia	BEFREE	17999954, 28718636, 29523024, 31226894, 6586290, 9178809		★★★★★ ★☆☆☆☆ Found in Text Mining only
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Lymphoblastic Leukemia	BEFREE	10473095, 1281665, 16102592, 17868649, 20924650, 21973023, 24628257, 28366708, 30116272, 30460757, 3529089, 8917402, 9116294, 9408752		★★★★★ ★☆☆☆☆ Found in Text Mining only
Renal carcinoma	Renal Carcinoma	BEFREE	29698921		★★★★★ ★☆☆☆☆ Found in Text Mining only
Retinal Detachment	Retinal detachment	Pubtator	37695605	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	GWASDB_DG	21926974		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Small cell carcinoma of lung	Lung carcinoma	CTD_human_DG	22941189		★★★★★ ★☆☆☆☆ Found in Text Mining only
Small cell carcinoma of lung	Lung carcinoma	BEFREE	25863124		★★★★★ ★☆☆☆☆ Found in Text Mining only
Small Cell Lung Carcinoma	Small cell lung carcinoma	Pubtator	25863124	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
T-Cell Lymphoma	T-Cell Lymphoma	BEFREE	30333864		★★★★★ ★☆☆☆☆ Found in Text Mining only
Vesicular Stomatitis	Vesicular Stomatitis	BEFREE	21521785		★★★★★ ★☆☆☆☆ Found in Text Mining only
X-linked agammaglobulinemia	Agammaglobulinemia, X-Linked	BEFREE	1849806		★★★★★ ★☆☆☆☆ Found in Text Mining only

TMEM132D (transmembrane protein 132D)