Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	120935
Gene name	Coiled-coil domain containing 38
Gene symbol	CCDC38
Synonyms (NCBI Gene)	-
Chromosome	12
Chromosome location	12q23.1

134

Show/Hide all (134)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018106	hsa-miR-335-5p	Microarray	18185580
MIRT508325	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT514619	hsa-miR-410-3p	HITS-CLIP	21572407
MIRT508324	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT508323	hsa-miR-567	HITS-CLIP	21572407
MIRT508322	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT508321	hsa-miR-3924	HITS-CLIP	21572407
MIRT508320	hsa-miR-297	HITS-CLIP	21572407
MIRT689778	hsa-miR-4695-5p	HITS-CLIP	23313552
MIRT689777	hsa-miR-4459	HITS-CLIP	23313552
MIRT689776	hsa-miR-1273g-3p	HITS-CLIP	23313552
MIRT689775	hsa-miR-665	HITS-CLIP	23313552
MIRT689774	hsa-miR-6840-3p	HITS-CLIP	23313552
MIRT689773	hsa-miR-361-3p	HITS-CLIP	23313552
MIRT689772	hsa-miR-1273f	HITS-CLIP	23313552
MIRT689771	hsa-miR-4537	HITS-CLIP	23313552
MIRT689770	hsa-miR-6087	HITS-CLIP	23313552
MIRT689769	hsa-miR-377-5p	HITS-CLIP	23313552
MIRT689768	hsa-miR-6086	HITS-CLIP	23313552
MIRT689767	hsa-miR-6499-3p	HITS-CLIP	23313552
MIRT689766	hsa-miR-4252	HITS-CLIP	23313552
MIRT689765	hsa-miR-658	HITS-CLIP	23313552
MIRT689764	hsa-miR-25-5p	HITS-CLIP	23313552
MIRT689763	hsa-miR-1227-3p	HITS-CLIP	23313552
MIRT689762	hsa-miR-455-3p	HITS-CLIP	23313552
MIRT689761	hsa-miR-6516-5p	HITS-CLIP	23313552
MIRT508325	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT514619	hsa-miR-410-3p	PAR-CLIP	20371350
MIRT508324	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT508323	hsa-miR-567	PAR-CLIP	20371350
MIRT508322	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT508321	hsa-miR-3924	PAR-CLIP	20371350
MIRT508320	hsa-miR-297	PAR-CLIP	20371350
MIRT508325	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT514619	hsa-miR-410-3p	PAR-CLIP	20371350
MIRT508324	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT508323	hsa-miR-567	PAR-CLIP	20371350
MIRT508322	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT508321	hsa-miR-3924	PAR-CLIP	20371350
MIRT508320	hsa-miR-297	PAR-CLIP	20371350
MIRT508325	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT514621	hsa-miR-409-3p	PAR-CLIP	21572407
MIRT514620	hsa-miR-33a-3p	PAR-CLIP	21572407
MIRT514619	hsa-miR-410-3p	PAR-CLIP	21572407
MIRT508324	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT508323	hsa-miR-567	PAR-CLIP	21572407
MIRT508322	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT508321	hsa-miR-3924	PAR-CLIP	21572407
MIRT508320	hsa-miR-297	PAR-CLIP	21572407
MIRT508325	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT514621	hsa-miR-409-3p	PAR-CLIP	23446348
MIRT514620	hsa-miR-33a-3p	PAR-CLIP	23446348
MIRT514619	hsa-miR-410-3p	PAR-CLIP	23446348
MIRT508324	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT508323	hsa-miR-567	PAR-CLIP	23446348
MIRT508322	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT508321	hsa-miR-3924	PAR-CLIP	23446348
MIRT508320	hsa-miR-297	PAR-CLIP	23446348
MIRT508325	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT508324	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT508323	hsa-miR-567	PAR-CLIP	23446348
MIRT508322	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT508321	hsa-miR-3924	PAR-CLIP	23446348
MIRT508320	hsa-miR-297	PAR-CLIP	23446348
MIRT689763	hsa-miR-1227-3p	PAR-CLIP	27292025
MIRT689772	hsa-miR-1273f	PAR-CLIP	27292025
MIRT689766	hsa-miR-4252	PAR-CLIP	27292025
MIRT689771	hsa-miR-4537	PAR-CLIP	27292025
MIRT689762	hsa-miR-455-3p	PAR-CLIP	27292025
MIRT689767	hsa-miR-6499-3p	PAR-CLIP	27292025
MIRT689761	hsa-miR-6516-5p	PAR-CLIP	27292025
MIRT508325	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT514619	hsa-miR-410-3p	HITS-CLIP	21572407
MIRT508324	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT508323	hsa-miR-567	HITS-CLIP	21572407
MIRT508322	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT508321	hsa-miR-3924	HITS-CLIP	21572407
MIRT508320	hsa-miR-297	HITS-CLIP	21572407
MIRT689778	hsa-miR-4695-5p	HITS-CLIP	23313552
MIRT689777	hsa-miR-4459	HITS-CLIP	23313552
MIRT689776	hsa-miR-1273g-3p	HITS-CLIP	23313552
MIRT689775	hsa-miR-665	HITS-CLIP	23313552
MIRT689774	hsa-miR-6840-3p	HITS-CLIP	23313552
MIRT689773	hsa-miR-361-3p	HITS-CLIP	23313552
MIRT689772	hsa-miR-1273f	HITS-CLIP	23313552
MIRT689771	hsa-miR-4537	HITS-CLIP	23313552
MIRT689770	hsa-miR-6087	HITS-CLIP	23313552
MIRT689769	hsa-miR-377-5p	HITS-CLIP	23313552
MIRT689768	hsa-miR-6086	HITS-CLIP	23313552
MIRT689767	hsa-miR-6499-3p	HITS-CLIP	23313552
MIRT689766	hsa-miR-4252	HITS-CLIP	23313552
MIRT689765	hsa-miR-658	HITS-CLIP	23313552
MIRT689764	hsa-miR-25-5p	HITS-CLIP	23313552
MIRT689763	hsa-miR-1227-3p	HITS-CLIP	23313552
MIRT689762	hsa-miR-455-3p	HITS-CLIP	23313552
MIRT689761	hsa-miR-6516-5p	HITS-CLIP	23313552
MIRT508325	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT514619	hsa-miR-410-3p	PAR-CLIP	20371350
MIRT508324	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT508323	hsa-miR-567	PAR-CLIP	20371350
MIRT508322	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT508321	hsa-miR-3924	PAR-CLIP	20371350
MIRT508320	hsa-miR-297	PAR-CLIP	20371350
MIRT508325	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT514619	hsa-miR-410-3p	PAR-CLIP	20371350
MIRT508324	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT508323	hsa-miR-567	PAR-CLIP	20371350
MIRT508322	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT508321	hsa-miR-3924	PAR-CLIP	20371350
MIRT508320	hsa-miR-297	PAR-CLIP	20371350
MIRT508325	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT514621	hsa-miR-409-3p	PAR-CLIP	21572407
MIRT514620	hsa-miR-33a-3p	PAR-CLIP	21572407
MIRT514619	hsa-miR-410-3p	PAR-CLIP	21572407
MIRT508324	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT508323	hsa-miR-567	PAR-CLIP	21572407
MIRT508322	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT508321	hsa-miR-3924	PAR-CLIP	21572407
MIRT508320	hsa-miR-297	PAR-CLIP	21572407
MIRT508325	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT514621	hsa-miR-409-3p	PAR-CLIP	23446348
MIRT514620	hsa-miR-33a-3p	PAR-CLIP	23446348
MIRT514619	hsa-miR-410-3p	PAR-CLIP	23446348
MIRT508324	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT508323	hsa-miR-567	PAR-CLIP	23446348
MIRT508322	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT508321	hsa-miR-3924	PAR-CLIP	23446348
MIRT508320	hsa-miR-297	PAR-CLIP	23446348
MIRT508325	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT508324	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT508323	hsa-miR-567	PAR-CLIP	23446348
MIRT508322	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT508321	hsa-miR-3924	PAR-CLIP	23446348
MIRT508320	hsa-miR-297	PAR-CLIP	23446348

Show/Hide all (23)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001675	Process	Acrosome assembly	IEA
GO:0001675	Process	Acrosome assembly	ISS
GO:0002177	Component	Manchette	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005813	Component	Centrosome	IBA
GO:0005813	Component	Centrosome	IDA	25074808
GO:0005813	Component	Centrosome	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005929	Component	Cilium	IEA
GO:0006325	Process	Chromatin organization	IEA
GO:0007283	Process	Spermatogenesis	IEA
GO:0007283	Process	Spermatogenesis	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0031514	Component	Motile cilium	IEA
GO:0035720	Process	Intraciliary anterograde transport	IEA
GO:0036126	Component	Sperm flagellum	IEA
GO:0042995	Component	Cell projection	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0061649	Function	Ubiquitin-modified histone reader activity	IEA
GO:0061649	Function	Ubiquitin-modified histone reader activity	ISS
GO:0061827	Component	Sperm head	IEA
GO:0120316	Process	Sperm flagellum assembly	IEA
GO:0120316	Process	Sperm flagellum assembly	ISS

MIM	HGNC	e!Ensembl
HGNC	N/A	HGNC

Q502W7

Protein name

Coiled-coil domain-containing protein 38

Protein function

Essential for male fertility. Required for sperm flagellum biogenesis. Also required for acrosome biogenesis. Required for the attachment of developing acrosomes to the nucleus during spermiogenesis and may be involved in the transport of fibrou

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13863	DUF4200	112 → 230	Domain of unknown function (DUF4200)	Family

Sequence

MSSNLLPTLNSGGKVKDGSTKEDRPYKIFFRDLFLVKENEMAAKETEKFMNRNMKVYQKT
TFSSRMKSHSYLSQLAFYPKRSGRSFEKFGPGPAPIPRLIEGSDTKRTVHEFINDQRDRF
LLEYALSTKRNTIKKFEKDIAMRERQLKKAEKKLQDDALAFEEFLRENDQRSVDALKMAA
QETINKLQMTAELKKASMEVQAVKSEIAKTEFLLREYMKYGFFLLQMSPKHWQIQQALKR
AQASKSKANIILPKILAKLSLHSSNKEGILEESGRTAVLSEDASQGRDSQGKPSRSLTRT
PEKKKSNLAESFGSEDSLEFLLDDEMDVDLEPALYFKEPEELLQVLRELEEQNLTLFQYS
QDVDENLEEVNKREKVIQDKTNSNIEFLLEQEKMLKANCVREEEKAAELQLKSKLFSFGE
FNSDAQEILIDSLSKKITQVYKVCIGDAEDDGLNPIQKLVKVESRLVELCDLIESIPKEN
VEAIERMKQKEWRQKFRDEKMKEKQRHQQERLKAALEKAVAQPKKKLGRRLVFHSKPPSG
NKQQLPLVNETKTKSQEEEYFFT

Sequence length

563

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
LUPUS NEPHRITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OLIGODENDROGLIOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
URINARY BLADDER CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (1)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Pulmonary Disease Chronic Obstructive	Chronic obstructive pulmonary disease	Pubtator	24786987	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

CCDC38 (coiled-coil domain containing 38)