DNAJC24 (DnaJ heat shock protein family (Hsp40) member C24)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 120526 |
| Gene name | DnaJ heat shock protein family (Hsp40) member C24 |
| Gene symbol | DNAJC24 |
| Synonyms (NCBI Gene) |
DPH4JJJ3ZCSL3
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| Chromosome | 11 |
| Chromosome location | 11p13 |
| Summary | Diphthamide is a unique posttranslationally modified histidine found only in translation elongation factor-2 (EEF2; MIM 130610). This modification is conserved from archaebacteria to humans and serves as the target for ADP-ribosylation and inactivation of |
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miRNA
miRNA information provided by mirtarbase database.
619
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
12
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q6P3W2 | |||||||||||||||
| Protein name | DnaJ homolog subfamily C member 24 (CSL-type zinc finger-containing protein 3) (Diphthamide biosynthesis protein 4) | |||||||||||||||
| Protein function | Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron-binding. The iron-bound form is redox-active and can function as electron carrier. Plays a role in the diphthamide biosynthesis, a post-translation | |||||||||||||||
| PDB | 2L6L | |||||||||||||||
| Family and domains |
Pfam
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| Sequence |
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| Sequence length | 149 | |||||||||||||||
| Interactions | View interactions | |||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
4
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Evidence Score:
★☆☆☆☆ Gene-disease association found in Text Mining only
★★☆☆☆ Found in Text Mining and Unknown/Other Associations
★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources
★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
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