NXPE1 (neurexophilin and PC-esterase domain family member 1)

Gene

• Entrez ID: 120400
• Gene name: Neurexophilin and PC-esterase domain family member 1
• Gene symbol: NXPE1
• Synonyms (NCBI Gene): FAM55A
• Chromosome: 11
• Chromosome location: 11q23.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT661424	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT661423	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT661422	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT661421	hsa-miR-296-3p	HITS-CLIP	23824327
MIRT629266	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT629265	hsa-miR-1976	HITS-CLIP	23824327
MIRT629264	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT629263	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT629262	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT661424	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT661423	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT661422	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT661421	hsa-miR-296-3p	HITS-CLIP	23824327
MIRT629266	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT629265	hsa-miR-1976	HITS-CLIP	23824327
MIRT629264	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT629263	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT629262	hsa-miR-378a-5p	HITS-CLIP	23824327

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32814053
GO:0005576	Component	Extracellular region	IEA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q8N323
• Protein name: NXPE family member 1 (Protein FAM55A)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF06312	Neurexophilin	80 → 279	Neurexophilin	Family

• Sequence:

  MSSNTMLQKTLLILISFSVVTWMIFIISQNFTKLWSALNLSISVHYWNNSAKSLFPKTSL
  IPLKPLTETELRIKEIIEKLDQQIPPRPFTHVNTTTSATHSTATILNPRDTYCRGDQLDI
  LLEVRDHLGQRKQYGGDFLRARMSSPALTAGASGKVMDFNNGTYLVSFTLFWEGQVSLSL
  LLIHPSEGASALWRARNQGYDKIIFKGKFVNGTSHVFTECGLTLNSNAELCEYLDDRDQE
  AFYCMKPQHMPCEALTYMTTRNREVSYLTDKENSLFHRSKVGVEMMKDRKHIDVTNCNKR
  EKIEETCQVGMKPPVPGGYTLQGKWITTFCNQVQLDTIKINGCLKGKLIYLLGDSTLRQW
  IYYFPKVVKTLKFFDLHETGIFKKHLLLDAERHTQIQWKKHSYPFVTFQLYSLIDHDYIP
  REIDRLSGDKNTAIVITFGQHFRPFPIDIFIRRAIGVQKAIERLFLRSPATKVIIKTENI
  REMHIETERFGDFHGYIHYLIMKDIFKDLNVGIIDAWDMTIAYGTDTIHPPDHVIGNQIN
  MFLNYIC

• Sequence length: 547

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ANKYLOSING SPONDYLITIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CROHN'S DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INFLAMMATORY BOWEL DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INTRACEREBRAL HEMORRHAGE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSORIASIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCLEROSING CHOLANGITIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ULCERATIVE COLITIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Ankylosing spondylitis	Ankylosing Spondylitis	GWASCAT_DG	26974007		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cholangitis, Sclerosing	Cholangitis	GWASCAT_DG	26974007		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	29659199	Associate	★☆☆☆☆ Found in Text Mining only
Crohn Disease	Crohn Disease	GWASCAT_DG	26974007		★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory Bowel Disease	BEFREE	25766683		★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory bowel disease	Pubtator	25766683	Associate	★☆☆☆☆ Found in Text Mining only
Psoriasis	Psoriasis	GWASCAT_DG	26974007		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ulcerative Colitis	Ulcerative colitis	GWASCAT_DG	26192919, 26974007, 28067908		★★☆☆☆ Found in Text Mining + Unknown/Other Associations