Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	120224
Gene name	Transmembrane protein 45B
Gene symbol	TMEM45B
Synonyms (NCBI Gene)	-
Chromosome	11
Chromosome location	11q24.3

201

Show/Hide all (201)

miRTarBase ID	miRNA	Experiments	Reference
MIRT019035	hsa-miR-335-5p	Microarray	18185580
MIRT648968	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT648969	hsa-miR-6795-3p	HITS-CLIP	23824327
MIRT648967	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT648966	hsa-miR-5193	HITS-CLIP	23824327
MIRT648965	hsa-miR-3183	HITS-CLIP	23824327
MIRT648964	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT648963	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT648962	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT648961	hsa-miR-20a-3p	HITS-CLIP	23824327
MIRT648960	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT648959	hsa-miR-7111-3p	HITS-CLIP	23824327
MIRT648958	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT648968	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT648969	hsa-miR-6795-3p	HITS-CLIP	23824327
MIRT648967	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT648966	hsa-miR-5193	HITS-CLIP	23824327
MIRT648965	hsa-miR-3183	HITS-CLIP	23824327
MIRT648964	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT648963	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT648962	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT648961	hsa-miR-20a-3p	HITS-CLIP	23824327
MIRT648960	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT648959	hsa-miR-7111-3p	HITS-CLIP	23824327
MIRT648958	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT1437548	hsa-miR-1193	CLIP-seq
MIRT1437549	hsa-miR-1285	CLIP-seq
MIRT1437550	hsa-miR-1827	CLIP-seq
MIRT1437551	hsa-miR-197	CLIP-seq
MIRT1437552	hsa-miR-1976	CLIP-seq
MIRT1437553	hsa-miR-2392	CLIP-seq
MIRT1437554	hsa-miR-3117-5p	CLIP-seq
MIRT1437555	hsa-miR-3135b	CLIP-seq
MIRT1437556	hsa-miR-3152-5p	CLIP-seq
MIRT1437557	hsa-miR-3187-5p	CLIP-seq
MIRT1437558	hsa-miR-3622b-5p	CLIP-seq
MIRT1437559	hsa-miR-3652	CLIP-seq
MIRT1437560	hsa-miR-378g	CLIP-seq
MIRT1437561	hsa-miR-3929	CLIP-seq
MIRT1437562	hsa-miR-4258	CLIP-seq
MIRT1437563	hsa-miR-4284	CLIP-seq
MIRT1437564	hsa-miR-4419b	CLIP-seq
MIRT1437565	hsa-miR-4430	CLIP-seq
MIRT1437566	hsa-miR-4437	CLIP-seq
MIRT1437567	hsa-miR-4438	CLIP-seq
MIRT1437568	hsa-miR-4478	CLIP-seq
MIRT1437569	hsa-miR-4486	CLIP-seq
MIRT1437570	hsa-miR-4649-3p	CLIP-seq
MIRT1437571	hsa-miR-4662a-5p	CLIP-seq
MIRT1437572	hsa-miR-4674	CLIP-seq
MIRT1437573	hsa-miR-4676-5p	CLIP-seq
MIRT1437574	hsa-miR-4695-3p	CLIP-seq
MIRT1437575	hsa-miR-4707-3p	CLIP-seq
MIRT1437576	hsa-miR-4716-5p	CLIP-seq
MIRT1437577	hsa-miR-4740-3p	CLIP-seq
MIRT1437578	hsa-miR-4753-3p	CLIP-seq
MIRT1437579	hsa-miR-4763-5p	CLIP-seq
MIRT1437580	hsa-miR-5095	CLIP-seq
MIRT1437581	hsa-miR-5096	CLIP-seq
MIRT1437582	hsa-miR-514	CLIP-seq
MIRT1437583	hsa-miR-514b-3p	CLIP-seq
MIRT1437584	hsa-miR-575	CLIP-seq
MIRT1437585	hsa-miR-612	CLIP-seq
MIRT1437586	hsa-miR-645	CLIP-seq
MIRT2131084	hsa-miR-129-5p	CLIP-seq
MIRT1437551	hsa-miR-197	CLIP-seq
MIRT2131085	hsa-miR-199a-3p	CLIP-seq
MIRT2131086	hsa-miR-199b-3p	CLIP-seq
MIRT2131087	hsa-miR-3129-5p	CLIP-seq
MIRT1437555	hsa-miR-3135b	CLIP-seq
MIRT2131088	hsa-miR-3149	CLIP-seq
MIRT2131089	hsa-miR-3194-3p	CLIP-seq
MIRT1437558	hsa-miR-3622b-5p	CLIP-seq
MIRT1437559	hsa-miR-3652	CLIP-seq
MIRT1437561	hsa-miR-3929	CLIP-seq
MIRT1437564	hsa-miR-4419b	CLIP-seq
MIRT1437565	hsa-miR-4430	CLIP-seq
MIRT1437567	hsa-miR-4438	CLIP-seq
MIRT1437568	hsa-miR-4478	CLIP-seq
MIRT1437576	hsa-miR-4716-5p	CLIP-seq
MIRT2131090	hsa-miR-4797-5p	CLIP-seq
MIRT2131091	hsa-miR-483-5p	CLIP-seq
MIRT1437580	hsa-miR-5095	CLIP-seq
MIRT1437581	hsa-miR-5096	CLIP-seq
MIRT2131092	hsa-miR-548a-3p	CLIP-seq
MIRT2131093	hsa-miR-548e	CLIP-seq
MIRT2131094	hsa-miR-548f	CLIP-seq
MIRT1437586	hsa-miR-645	CLIP-seq
MIRT2131095	hsa-miR-936	CLIP-seq
MIRT2352365	hsa-miR-106a	CLIP-seq
MIRT2352366	hsa-miR-106b	CLIP-seq
MIRT2352367	hsa-miR-1206	CLIP-seq
MIRT2352368	hsa-miR-1234	CLIP-seq
MIRT1437549	hsa-miR-1285	CLIP-seq
MIRT2131084	hsa-miR-129-5p	CLIP-seq
MIRT2352369	hsa-miR-140-3p	CLIP-seq
MIRT2352370	hsa-miR-150	CLIP-seq
MIRT2352371	hsa-miR-17	CLIP-seq
MIRT1437551	hsa-miR-197	CLIP-seq
MIRT2131085	hsa-miR-199a-3p	CLIP-seq
MIRT2131086	hsa-miR-199b-3p	CLIP-seq
MIRT2352372	hsa-miR-20a	CLIP-seq
MIRT2352373	hsa-miR-20b	CLIP-seq
MIRT2352374	hsa-miR-214	CLIP-seq
MIRT2352375	hsa-miR-302a	CLIP-seq
MIRT2352376	hsa-miR-302b	CLIP-seq
MIRT2352377	hsa-miR-302c	CLIP-seq
MIRT2352378	hsa-miR-302d	CLIP-seq
MIRT2352379	hsa-miR-302e	CLIP-seq
MIRT2131087	hsa-miR-3129-5p	CLIP-seq
MIRT1437555	hsa-miR-3135b	CLIP-seq
MIRT2131088	hsa-miR-3149	CLIP-seq
MIRT2352380	hsa-miR-3156-5p	CLIP-seq
MIRT2352381	hsa-miR-3159	CLIP-seq
MIRT2352382	hsa-miR-3162-3p	CLIP-seq
MIRT1437557	hsa-miR-3187-5p	CLIP-seq
MIRT2131089	hsa-miR-3194-3p	CLIP-seq
MIRT2352383	hsa-miR-320a	CLIP-seq
MIRT2352384	hsa-miR-320b	CLIP-seq
MIRT2352385	hsa-miR-320c	CLIP-seq
MIRT2352386	hsa-miR-320d	CLIP-seq
MIRT2352387	hsa-miR-3619-5p	CLIP-seq
MIRT1437558	hsa-miR-3622b-5p	CLIP-seq
MIRT1437559	hsa-miR-3652	CLIP-seq
MIRT2352388	hsa-miR-372	CLIP-seq
MIRT2352389	hsa-miR-373	CLIP-seq
MIRT1437560	hsa-miR-378g	CLIP-seq
MIRT2352390	hsa-miR-383	CLIP-seq
MIRT1437561	hsa-miR-3929	CLIP-seq
MIRT1437562	hsa-miR-4258	CLIP-seq
MIRT1437564	hsa-miR-4419b	CLIP-seq
MIRT2352391	hsa-miR-4429	CLIP-seq
MIRT1437565	hsa-miR-4430	CLIP-seq
MIRT1437566	hsa-miR-4437	CLIP-seq
MIRT1437568	hsa-miR-4478	CLIP-seq
MIRT1437569	hsa-miR-4486	CLIP-seq
MIRT2352392	hsa-miR-4655-5p	CLIP-seq
MIRT1437572	hsa-miR-4674	CLIP-seq
MIRT2352393	hsa-miR-4690-5p	CLIP-seq
MIRT1437574	hsa-miR-4695-3p	CLIP-seq
MIRT1437575	hsa-miR-4707-3p	CLIP-seq
MIRT1437576	hsa-miR-4716-5p	CLIP-seq
MIRT2352394	hsa-miR-4717-5p	CLIP-seq
MIRT2352395	hsa-miR-4735-5p	CLIP-seq
MIRT1437579	hsa-miR-4763-5p	CLIP-seq
MIRT2352396	hsa-miR-4775	CLIP-seq
MIRT2131091	hsa-miR-483-5p	CLIP-seq
MIRT1437581	hsa-miR-5096	CLIP-seq
MIRT2352397	hsa-miR-519d	CLIP-seq
MIRT2352398	hsa-miR-520a-3p	CLIP-seq
MIRT2352399	hsa-miR-520b	CLIP-seq
MIRT2352400	hsa-miR-520c-3p	CLIP-seq
MIRT2352401	hsa-miR-520d-3p	CLIP-seq
MIRT2352402	hsa-miR-520e	CLIP-seq
MIRT2352403	hsa-miR-520g	CLIP-seq
MIRT2352404	hsa-miR-520h	CLIP-seq
MIRT2352405	hsa-miR-590-3p	CLIP-seq
MIRT1437585	hsa-miR-612	CLIP-seq
MIRT1437586	hsa-miR-645	CLIP-seq
MIRT2352406	hsa-miR-761	CLIP-seq
MIRT2352407	hsa-miR-93	CLIP-seq
MIRT2131095	hsa-miR-936	CLIP-seq
MIRT2352408	hsa-miR-941	CLIP-seq
MIRT2131085	hsa-miR-199a-3p	CLIP-seq
MIRT2131086	hsa-miR-199b-3p	CLIP-seq
MIRT2131087	hsa-miR-3129-5p	CLIP-seq
MIRT1437555	hsa-miR-3135b	CLIP-seq
MIRT1437558	hsa-miR-3622b-5p	CLIP-seq
MIRT1437559	hsa-miR-3652	CLIP-seq
MIRT1437561	hsa-miR-3929	CLIP-seq
MIRT1437564	hsa-miR-4419b	CLIP-seq
MIRT1437565	hsa-miR-4430	CLIP-seq
MIRT1437567	hsa-miR-4438	CLIP-seq
MIRT1437568	hsa-miR-4478	CLIP-seq
MIRT1437580	hsa-miR-5095	CLIP-seq
MIRT1437586	hsa-miR-645	CLIP-seq
MIRT2131095	hsa-miR-936	CLIP-seq
MIRT2131084	hsa-miR-129-5p	CLIP-seq
MIRT2131085	hsa-miR-199a-3p	CLIP-seq
MIRT2131086	hsa-miR-199b-3p	CLIP-seq
MIRT2131087	hsa-miR-3129-5p	CLIP-seq
MIRT2131088	hsa-miR-3149	CLIP-seq
MIRT1437562	hsa-miR-4258	CLIP-seq
MIRT1437567	hsa-miR-4438	CLIP-seq
MIRT1437575	hsa-miR-4707-3p	CLIP-seq
MIRT2352395	hsa-miR-4735-5p	CLIP-seq
MIRT2352396	hsa-miR-4775	CLIP-seq
MIRT1437580	hsa-miR-5095	CLIP-seq
MIRT2352405	hsa-miR-590-3p	CLIP-seq
MIRT2131095	hsa-miR-936	CLIP-seq
MIRT2352408	hsa-miR-941	CLIP-seq
MIRT2131084	hsa-miR-129-5p	CLIP-seq
MIRT2131088	hsa-miR-3149	CLIP-seq
MIRT1437562	hsa-miR-4258	CLIP-seq
MIRT1437567	hsa-miR-4438	CLIP-seq
MIRT1437575	hsa-miR-4707-3p	CLIP-seq
MIRT2352395	hsa-miR-4735-5p	CLIP-seq
MIRT2352396	hsa-miR-4775	CLIP-seq
MIRT1437580	hsa-miR-5095	CLIP-seq
MIRT2352405	hsa-miR-590-3p	CLIP-seq
MIRT2352408	hsa-miR-941	CLIP-seq

Show/Hide all (11)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002376	Process	Immune system process	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005764	Component	Lysosome	IEA
GO:0005765	Component	Lysosomal membrane	IEA
GO:0005768	Component	Endosome	IEA
GO:0005794	Component	Golgi apparatus	IEA
GO:0005802	Component	Trans-Golgi network	ISS
GO:0010008	Component	Endosome membrane	IEA
GO:0016020	Component	Membrane	IEA
GO:0045087	Process	Innate immune response	IEA
GO:0048265	Process	Response to pain	ISS

MIM	HGNC	e!Ensembl
621075	25194	ENSG00000151715

Q96B21

Protein name

Transmembrane protein 45B

Protein function

Plays a role in innate immunity (PubMed:35938871). Mechanistically, promotes alphaviruses RNA degradation by interacting with the viral polymerase nsP4 and the mRNA-capping enzyme nsP1 and thereby interfering with the interaction between viral R

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04819	DUF716	114 → 235	Family of unknown function (DUF716)	Family

Sequence

MANFKGHALPGSFFLIIGLCWSVKYPLKYFSHTRKNSPLHYYQRLEIVEAAIRTLFSVTG
ILAEQFVPDGPHLHLYHENHWIKLMNWQHSTMYLFFAVSGIVDMLTYLVSHVPLGVDRLV
MAVAVFMEGFLFYYHVHNRPPLDQHIHSLLLYALFGGCVSISLEVIFRDHIVLELFRTSL
IILQGTWFWQIGFVLFPPFGTPEWDQKDDANLMFITMCFCWHYLAALSIVAVNYSLVYCL
LTRMKRHGRGEIIGIQKLNSDDTYQTALLSGSDEE

Sequence length

275

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBESITY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OLIGODENDROGLIOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
WET MACULAR DEGENERATION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (19)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Benign Prostatic Hyperplasia	Benign Prostatic Hyperplasia	BEFREE	30249106		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	27225290		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	26169495	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Familial lichen amyloidosis	Lichen amyloidosis	BEFREE	30249106		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	24625834	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	27225290	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	27225290		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of pancreas	Pancreatic cancer	BEFREE	27108650		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	30249106		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	29803169		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	27225290		★★★★★ ★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	BEFREE	29229936		★★★★★ ★☆☆☆☆ Found in Text Mining only
Melanoma	Melanoma	Pubtator	29229936	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	28244852, 29803169, 30249106		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	BEFREE	28244852		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma	Pancreatic carcinoma	BEFREE	27108650		★★★★★ ★☆☆☆☆ Found in Text Mining only
Peritonitis	Peritonitis	Pubtator	29229936	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	30249106		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	29803169		★★★★★ ★☆☆☆☆ Found in Text Mining only

TMEM45B (transmembrane protein 45B)