Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	1196
Gene name	CDC like kinase 2
Gene symbol	CLK2
Synonyms (NCBI Gene)	-
Chromosome	1
Chromosome location	1q22
Summary	This gene encodes a dual specificity protein kinase that phosphorylates serine/threonine and tyrosine-containing substrates. Activity of this protein regulates serine- and arginine-rich (SR) proteins of the spliceosomal complex, thereby influencing altern

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miRTarBase ID	miRNA	Experiments
MIRT896639	hsa-miR-1193	CLIP-seq
MIRT896640	hsa-miR-1207-5p	CLIP-seq
MIRT896641	hsa-miR-125a-3p	CLIP-seq
MIRT896642	hsa-miR-1269	CLIP-seq
MIRT896643	hsa-miR-1269b	CLIP-seq
MIRT896644	hsa-miR-1279	CLIP-seq
MIRT896645	hsa-miR-1288	CLIP-seq
MIRT896646	hsa-miR-147	CLIP-seq
MIRT896647	hsa-miR-1909	CLIP-seq
MIRT896648	hsa-miR-1915	CLIP-seq
MIRT896649	hsa-miR-23a	CLIP-seq
MIRT896650	hsa-miR-23b	CLIP-seq
MIRT896651	hsa-miR-23c	CLIP-seq
MIRT896652	hsa-miR-27a	CLIP-seq
MIRT896653	hsa-miR-27b	CLIP-seq
MIRT896654	hsa-miR-2861	CLIP-seq
MIRT896655	hsa-miR-3163	CLIP-seq
MIRT896656	hsa-miR-3184	CLIP-seq
MIRT896657	hsa-miR-3616-5p	CLIP-seq
MIRT896658	hsa-miR-3647-5p	CLIP-seq
MIRT896659	hsa-miR-3654	CLIP-seq
MIRT896660	hsa-miR-3665	CLIP-seq
MIRT896661	hsa-miR-3690	CLIP-seq
MIRT896662	hsa-miR-3691-5p	CLIP-seq
MIRT896663	hsa-miR-3714	CLIP-seq
MIRT896664	hsa-miR-378	CLIP-seq
MIRT896665	hsa-miR-378b	CLIP-seq
MIRT896666	hsa-miR-378c	CLIP-seq
MIRT896667	hsa-miR-378d	CLIP-seq
MIRT896668	hsa-miR-378e	CLIP-seq
MIRT896669	hsa-miR-378f	CLIP-seq
MIRT896670	hsa-miR-378h	CLIP-seq
MIRT896671	hsa-miR-378i	CLIP-seq
MIRT896672	hsa-miR-3911	CLIP-seq
MIRT896673	hsa-miR-3918	CLIP-seq
MIRT896674	hsa-miR-3924	CLIP-seq
MIRT896675	hsa-miR-3976	CLIP-seq
MIRT896676	hsa-miR-422a	CLIP-seq
MIRT896677	hsa-miR-423-5p	CLIP-seq
MIRT896678	hsa-miR-4254	CLIP-seq
MIRT896679	hsa-miR-4261	CLIP-seq
MIRT896680	hsa-miR-4459	CLIP-seq
MIRT896681	hsa-miR-4476	CLIP-seq
MIRT896682	hsa-miR-4512	CLIP-seq
MIRT896683	hsa-miR-4515	CLIP-seq
MIRT896684	hsa-miR-4533	CLIP-seq
MIRT896685	hsa-miR-4638-3p	CLIP-seq
MIRT896686	hsa-miR-4685-5p	CLIP-seq
MIRT896687	hsa-miR-4699-3p	CLIP-seq
MIRT896688	hsa-miR-4704-5p	CLIP-seq
MIRT896689	hsa-miR-4710	CLIP-seq
MIRT896690	hsa-miR-4736	CLIP-seq
MIRT896691	hsa-miR-4738-3p	CLIP-seq
MIRT896692	hsa-miR-4740-5p	CLIP-seq
MIRT896693	hsa-miR-4752	CLIP-seq
MIRT896694	hsa-miR-4763-3p	CLIP-seq
MIRT896695	hsa-miR-4795-5p	CLIP-seq
MIRT896696	hsa-miR-486-3p	CLIP-seq
MIRT896697	hsa-miR-513a-5p	CLIP-seq
MIRT896698	hsa-miR-548g	CLIP-seq
MIRT896699	hsa-miR-573	CLIP-seq
MIRT896700	hsa-miR-624	CLIP-seq
MIRT896701	hsa-miR-644	CLIP-seq
MIRT896702	hsa-miR-665	CLIP-seq
MIRT896703	hsa-miR-892a	CLIP-seq
MIRT896704	hsa-miR-940	CLIP-seq
MIRT896639	hsa-miR-1193	CLIP-seq
MIRT896644	hsa-miR-1279	CLIP-seq
MIRT896646	hsa-miR-147	CLIP-seq
MIRT896649	hsa-miR-23a	CLIP-seq
MIRT896650	hsa-miR-23b	CLIP-seq
MIRT896651	hsa-miR-23c	CLIP-seq
MIRT896652	hsa-miR-27a	CLIP-seq
MIRT896653	hsa-miR-27b	CLIP-seq
MIRT896662	hsa-miR-3691-5p	CLIP-seq
MIRT896672	hsa-miR-3911	CLIP-seq
MIRT896679	hsa-miR-4261	CLIP-seq
MIRT896687	hsa-miR-4699-3p	CLIP-seq
MIRT896688	hsa-miR-4704-5p	CLIP-seq
MIRT1965858	hsa-miR-4719	CLIP-seq
MIRT896691	hsa-miR-4738-3p	CLIP-seq
MIRT896693	hsa-miR-4752	CLIP-seq
MIRT896697	hsa-miR-513a-5p	CLIP-seq
MIRT1965859	hsa-miR-513b	CLIP-seq
MIRT896698	hsa-miR-548g	CLIP-seq
MIRT1965860	hsa-miR-548u	CLIP-seq
MIRT896701	hsa-miR-644	CLIP-seq
MIRT896703	hsa-miR-892a	CLIP-seq
MIRT896639	hsa-miR-1193	CLIP-seq
MIRT896640	hsa-miR-1207-5p	CLIP-seq
MIRT896646	hsa-miR-147	CLIP-seq
MIRT896647	hsa-miR-1909	CLIP-seq
MIRT896649	hsa-miR-23a	CLIP-seq
MIRT896650	hsa-miR-23b	CLIP-seq
MIRT896651	hsa-miR-23c	CLIP-seq
MIRT896652	hsa-miR-27a	CLIP-seq
MIRT896653	hsa-miR-27b	CLIP-seq
MIRT896657	hsa-miR-3616-5p	CLIP-seq
MIRT896658	hsa-miR-3647-5p	CLIP-seq
MIRT896662	hsa-miR-3691-5p	CLIP-seq
MIRT896663	hsa-miR-3714	CLIP-seq
MIRT896672	hsa-miR-3911	CLIP-seq
MIRT896674	hsa-miR-3924	CLIP-seq
MIRT896693	hsa-miR-4752	CLIP-seq
MIRT896694	hsa-miR-4763-3p	CLIP-seq
MIRT896695	hsa-miR-4795-5p	CLIP-seq
MIRT896697	hsa-miR-513a-5p	CLIP-seq
MIRT896699	hsa-miR-573	CLIP-seq
MIRT896700	hsa-miR-624	CLIP-seq
MIRT896701	hsa-miR-644	CLIP-seq
MIRT896704	hsa-miR-940	CLIP-seq
MIRT896656	hsa-miR-3184	CLIP-seq
MIRT2678294	hsa-miR-409-5p	CLIP-seq
MIRT896677	hsa-miR-423-5p	CLIP-seq
MIRT2678295	hsa-miR-4715-3p	CLIP-seq
MIRT2678296	hsa-miR-4777-3p	CLIP-seq
MIRT896696	hsa-miR-486-3p	CLIP-seq

Show/Hide all (28)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IBA
GO:0004674	Function	Protein serine/threonine kinase activity	IDA	10480872
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	TAS	7990150
GO:0004712	Function	Protein serine/threonine/tyrosine kinase activity	IEA
GO:0004713	Function	Protein tyrosine kinase activity	IBA
GO:0004713	Function	Protein tyrosine kinase activity	IEA
GO:0005515	Function	Protein binding	IPI	16189514, 19282290, 20682768, 21516116, 21988832, 23602568, 25416956, 26871637, 29892012, 31515488, 32296183, 32707033, 33961781
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	9637771, 28289210
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0006468	Process	Protein phosphorylation	IDA	9637771, 20682768, 28289210
GO:0010212	Process	Response to ionizing radiation	IMP	20682768
GO:0016301	Function	Kinase activity	IEA
GO:0016604	Component	Nuclear body	IDA
GO:0016607	Component	Nuclear speck	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0042802	Function	Identical protein binding	IPI	25416956, 32296183
GO:0043484	Process	Regulation of RNA splicing	IBA
GO:0043484	Process	Regulation of RNA splicing	IDA	9637771
GO:0043484	Process	Regulation of RNA splicing	IEA
GO:0045721	Process	Negative regulation of gluconeogenesis	ISS
GO:0046777	Process	Protein autophosphorylation	ISS
GO:0106310	Function	Protein serine kinase activity	IEA

MIM	HGNC	e!Ensembl
602989	2069	ENSG00000176444

P49760

Protein name

Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2)

Protein function

Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enabl

PDB

3NR9 , 5UNP , 6FYI , 6FYK , 6FYL , 6KHE

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00069	Pkinase	163 → 479	Protein kinase domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Endothelial cells (PubMed:19168442). Expressed in androgen-dependent prostate cancer cells (PubMed:28289210). {ECO:0000269|PubMed:19168442, ECO:0000269|PubMed:28289210}.

Sequence

MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYD
DRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRR
RRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQC
VDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMC
ISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVN
SDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQ
PCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLD
WDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFA
RLRAEPPNKLWDSSRDISR

Sequence length

499

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

CLK2 (CDC like kinase 2)