CLCN3 (chloride voltage-gated channel 3)

Gene

• Entrez ID: 1182
• Gene name: Chloride voltage-gated channel 3
• Gene symbol: CLCN3
• Synonyms (NCBI Gene): CLC3, ClC-3, NEDHYBA, NEDSBA
• Chromosome: 4
• Chromosome location: 4q33
• Summary: This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domai

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT002737	hsa-miR-1-3p	Microarray	15685193
MIRT006176	hsa-miR-15a-5p	Luciferase reporter assay, Microarray, Northern blot, qRT-PCR, Western blot	21880628
MIRT006176	hsa-miR-15a-5p	Luciferase reporter assay, Microarray, Northern blot, qRT-PCR, Western blot	21880628
MIRT006176	hsa-miR-15a-5p	Luciferase reporter assay, Microarray, Northern blot, qRT-PCR, Western blot	21880628
MIRT006176	hsa-miR-15a-5p	Luciferase reporter assay, Microarray, Northern blot, qRT-PCR, Western blot	21880628
MIRT006176	hsa-miR-15a-5p	Luciferase reporter assay, Microarray, Northern blot, qRT-PCR, Western blot	21880628
MIRT006176	hsa-miR-15a-5p	Luciferase reporter assay, Microarray, Northern blot, qRT-PCR, Western blot	21880628
MIRT018874	hsa-miR-335-5p	Microarray	18185580
MIRT019489	hsa-miR-148b-3p	Microarray	17612493
MIRT002737	hsa-miR-1-3p	Microarray;Other	15685193
MIRT040507	hsa-miR-548b-3p	CLASH	23622248
MIRT668981	hsa-miR-548an	HITS-CLIP	23824327
MIRT668980	hsa-miR-6768-3p	HITS-CLIP	23824327
MIRT668979	hsa-miR-4484	HITS-CLIP	23824327
MIRT668978	hsa-miR-539-5p	HITS-CLIP	23824327
MIRT212150	hsa-miR-130a-3p	PAR-CLIP	21572407
MIRT212152	hsa-miR-130b-3p	PAR-CLIP	21572407
MIRT212156	hsa-miR-3666	PAR-CLIP	21572407
MIRT212153	hsa-miR-454-3p	PAR-CLIP	21572407
MIRT212155	hsa-miR-4295	PAR-CLIP	21572407
MIRT212151	hsa-miR-301a-3p	PAR-CLIP	21572407
MIRT212154	hsa-miR-301b-3p	PAR-CLIP	21572407
MIRT212157	hsa-miR-4671-3p	PAR-CLIP	21572407
MIRT558716	hsa-miR-4473	PAR-CLIP	21572407
MIRT212149	hsa-miR-183-3p	PAR-CLIP	21572407
MIRT558715	hsa-miR-3591-5p	PAR-CLIP	21572407
MIRT212150	hsa-miR-130a-3p	PAR-CLIP	22012620
MIRT212152	hsa-miR-130b-3p	PAR-CLIP	22012620
MIRT212156	hsa-miR-3666	PAR-CLIP	22012620
MIRT212153	hsa-miR-454-3p	PAR-CLIP	22012620
MIRT212155	hsa-miR-4295	PAR-CLIP	22012620
MIRT212151	hsa-miR-301a-3p	PAR-CLIP	22012620
MIRT212154	hsa-miR-301b-3p	PAR-CLIP	22012620
MIRT212148	hsa-miR-4282	PAR-CLIP	22012620
MIRT212139	hsa-miR-548m	PAR-CLIP	22012620
MIRT212141	hsa-miR-548ag	PAR-CLIP	22012620
MIRT212142	hsa-miR-548ai	PAR-CLIP	22012620
MIRT212146	hsa-miR-548ba	PAR-CLIP	22012620
MIRT212136	hsa-miR-570-5p	PAR-CLIP	22012620
MIRT538527	hsa-miR-519a-3p	PAR-CLIP	22012620
MIRT538526	hsa-miR-519b-3p	PAR-CLIP	22012620
MIRT538525	hsa-miR-519c-3p	PAR-CLIP	22012620
MIRT538524	hsa-miR-302a-3p	PAR-CLIP	22012620
MIRT538523	hsa-miR-302b-3p	PAR-CLIP	22012620
MIRT538522	hsa-miR-302c-3p	PAR-CLIP	22012620
MIRT538521	hsa-miR-302d-3p	PAR-CLIP	22012620
MIRT538520	hsa-miR-302e	PAR-CLIP	22012620
MIRT538519	hsa-miR-372-3p	PAR-CLIP	22012620
MIRT538518	hsa-miR-373-3p	PAR-CLIP	22012620
MIRT538517	hsa-miR-520a-3p	PAR-CLIP	22012620
MIRT538516	hsa-miR-520b	PAR-CLIP	22012620
MIRT538515	hsa-miR-520c-3p	PAR-CLIP	22012620
MIRT538514	hsa-miR-520d-3p	PAR-CLIP	22012620
MIRT538513	hsa-miR-520e	PAR-CLIP	22012620
MIRT538512	hsa-miR-16-2-3p	PAR-CLIP	22012620
MIRT538511	hsa-miR-195-3p	PAR-CLIP	22012620
MIRT444300	hsa-miR-5582-3p	PAR-CLIP	22100165
MIRT444299	hsa-miR-4635	PAR-CLIP	22100165
MIRT444297	hsa-miR-3185	PAR-CLIP	22100165
MIRT444298	hsa-miR-3616-5p	PAR-CLIP	22100165
MIRT444296	hsa-miR-573	PAR-CLIP	22100165
MIRT444295	hsa-miR-3201	PAR-CLIP	22100165
MIRT444300	hsa-miR-5582-3p	PAR-CLIP	22100165
MIRT444299	hsa-miR-4635	PAR-CLIP	22100165
MIRT444297	hsa-miR-3185	PAR-CLIP	22100165
MIRT444298	hsa-miR-3616-5p	PAR-CLIP	22100165
MIRT444296	hsa-miR-573	PAR-CLIP	22100165
MIRT444295	hsa-miR-3201	PAR-CLIP	22100165
MIRT440938	ebv-miR-BART7-3p	HITS-CLIP	22473208
MIRT440938	ebv-miR-BART7-3p	HITS-CLIP	22473208
MIRT002737	hsa-miR-1-3p	PAR-CLIP	27292025
MIRT668979	hsa-miR-4484	PAR-CLIP	27292025
MIRT668978	hsa-miR-539-5p	PAR-CLIP	27292025
MIRT668981	hsa-miR-548an	PAR-CLIP	27292025
MIRT668980	hsa-miR-6768-3p	PAR-CLIP	27292025
MIRT002737	hsa-miR-1-3p	HITS-CLIP	27418678
MIRT668979	hsa-miR-4484	HITS-CLIP	27418678
MIRT668978	hsa-miR-539-5p	HITS-CLIP	27418678
MIRT668981	hsa-miR-548an	HITS-CLIP	27418678
MIRT668980	hsa-miR-6768-3p	HITS-CLIP	27418678
MIRT668981	hsa-miR-548an	HITS-CLIP	23824327
MIRT668980	hsa-miR-6768-3p	HITS-CLIP	23824327
MIRT668979	hsa-miR-4484	HITS-CLIP	23824327
MIRT668978	hsa-miR-539-5p	HITS-CLIP	23824327
MIRT212150	hsa-miR-130a-3p	PAR-CLIP	21572407
MIRT212152	hsa-miR-130b-3p	PAR-CLIP	21572407
MIRT212156	hsa-miR-3666	PAR-CLIP	21572407
MIRT212153	hsa-miR-454-3p	PAR-CLIP	21572407
MIRT212155	hsa-miR-4295	PAR-CLIP	21572407
MIRT212151	hsa-miR-301a-3p	PAR-CLIP	21572407
MIRT212154	hsa-miR-301b-3p	PAR-CLIP	21572407
MIRT212157	hsa-miR-4671-3p	PAR-CLIP	21572407
MIRT558716	hsa-miR-4473	PAR-CLIP	21572407
MIRT212149	hsa-miR-183-3p	PAR-CLIP	21572407
MIRT558715	hsa-miR-3591-5p	PAR-CLIP	21572407
MIRT212150	hsa-miR-130a-3p	PAR-CLIP	22012620
MIRT212152	hsa-miR-130b-3p	PAR-CLIP	22012620
MIRT212156	hsa-miR-3666	PAR-CLIP	22012620
MIRT212153	hsa-miR-454-3p	PAR-CLIP	22012620
MIRT212155	hsa-miR-4295	PAR-CLIP	22012620
MIRT212151	hsa-miR-301a-3p	PAR-CLIP	22012620
MIRT212154	hsa-miR-301b-3p	PAR-CLIP	22012620
MIRT212148	hsa-miR-4282	PAR-CLIP	22012620
MIRT212139	hsa-miR-548m	PAR-CLIP	22012620
MIRT212141	hsa-miR-548ag	PAR-CLIP	22012620
MIRT212142	hsa-miR-548ai	PAR-CLIP	22012620
MIRT212146	hsa-miR-548ba	PAR-CLIP	22012620
MIRT212136	hsa-miR-570-5p	PAR-CLIP	22012620
MIRT538527	hsa-miR-519a-3p	PAR-CLIP	22012620
MIRT538526	hsa-miR-519b-3p	PAR-CLIP	22012620
MIRT538525	hsa-miR-519c-3p	PAR-CLIP	22012620
MIRT538524	hsa-miR-302a-3p	PAR-CLIP	22012620
MIRT538523	hsa-miR-302b-3p	PAR-CLIP	22012620
MIRT538522	hsa-miR-302c-3p	PAR-CLIP	22012620
MIRT538521	hsa-miR-302d-3p	PAR-CLIP	22012620
MIRT538520	hsa-miR-302e	PAR-CLIP	22012620
MIRT538519	hsa-miR-372-3p	PAR-CLIP	22012620
MIRT538518	hsa-miR-373-3p	PAR-CLIP	22012620
MIRT538517	hsa-miR-520a-3p	PAR-CLIP	22012620
MIRT538516	hsa-miR-520b	PAR-CLIP	22012620
MIRT538515	hsa-miR-520c-3p	PAR-CLIP	22012620
MIRT538514	hsa-miR-520d-3p	PAR-CLIP	22012620
MIRT538513	hsa-miR-520e	PAR-CLIP	22012620
MIRT538512	hsa-miR-16-2-3p	PAR-CLIP	22012620
MIRT538511	hsa-miR-195-3p	PAR-CLIP	22012620
MIRT444300	hsa-miR-5582-3p	PAR-CLIP	22100165
MIRT444299	hsa-miR-4635	PAR-CLIP	22100165
MIRT444297	hsa-miR-3185	PAR-CLIP	22100165
MIRT444298	hsa-miR-3616-5p	PAR-CLIP	22100165
MIRT444296	hsa-miR-573	PAR-CLIP	22100165
MIRT444295	hsa-miR-3201	PAR-CLIP	22100165
MIRT444300	hsa-miR-5582-3p	PAR-CLIP	22100165
MIRT444299	hsa-miR-4635	PAR-CLIP	22100165
MIRT444297	hsa-miR-3185	PAR-CLIP	22100165
MIRT444298	hsa-miR-3616-5p	PAR-CLIP	22100165
MIRT444296	hsa-miR-573	PAR-CLIP	22100165
MIRT444295	hsa-miR-3201	PAR-CLIP	22100165
MIRT894546	hsa-miR-1	CLIP-seq
MIRT894547	hsa-miR-3673	CLIP-seq
MIRT894548	hsa-miR-516b	CLIP-seq
MIRT894549	hsa-miR-539	CLIP-seq
MIRT894550	hsa-miR-183	CLIP-seq
MIRT894551	hsa-miR-24	CLIP-seq
MIRT894552	hsa-miR-3200-3p	CLIP-seq
MIRT894553	hsa-miR-3973	CLIP-seq
MIRT894554	hsa-miR-4284	CLIP-seq
MIRT894555	hsa-miR-4328	CLIP-seq
MIRT894556	hsa-miR-4712-3p	CLIP-seq
MIRT894557	hsa-miR-4802-3p	CLIP-seq
MIRT894558	hsa-miR-520g	CLIP-seq
MIRT894559	hsa-miR-520h	CLIP-seq
MIRT894560	hsa-miR-548a-5p	CLIP-seq
MIRT894561	hsa-miR-548ab	CLIP-seq
MIRT894562	hsa-miR-548ak	CLIP-seq
MIRT894563	hsa-miR-548b-5p	CLIP-seq
MIRT894564	hsa-miR-548c-5p	CLIP-seq
MIRT894565	hsa-miR-548d-5p	CLIP-seq
MIRT894566	hsa-miR-548h	CLIP-seq
MIRT894567	hsa-miR-548i	CLIP-seq
MIRT894568	hsa-miR-548j	CLIP-seq
MIRT894569	hsa-miR-548w	CLIP-seq
MIRT894570	hsa-miR-548y	CLIP-seq
MIRT894571	hsa-miR-559	CLIP-seq
MIRT894572	hsa-miR-569	CLIP-seq
MIRT894573	hsa-miR-720	CLIP-seq
MIRT2201230	hsa-miR-103a	CLIP-seq
MIRT2201231	hsa-miR-107	CLIP-seq
MIRT2201232	hsa-miR-1207-3p	CLIP-seq
MIRT2201233	hsa-miR-1284	CLIP-seq
MIRT2201234	hsa-miR-148a	CLIP-seq
MIRT2201235	hsa-miR-148b	CLIP-seq
MIRT2201236	hsa-miR-152	CLIP-seq
MIRT2201237	hsa-miR-155	CLIP-seq
MIRT2201238	hsa-miR-15a	CLIP-seq
MIRT2201239	hsa-miR-15b	CLIP-seq
MIRT2201240	hsa-miR-16	CLIP-seq
MIRT2201241	hsa-miR-1825	CLIP-seq
MIRT2201242	hsa-miR-195	CLIP-seq
MIRT2201243	hsa-miR-199a-5p	CLIP-seq
MIRT2201244	hsa-miR-199b-5p	CLIP-seq
MIRT2201245	hsa-miR-219-1-3p	CLIP-seq
MIRT2201246	hsa-miR-298	CLIP-seq
MIRT2201247	hsa-miR-300	CLIP-seq
MIRT2201248	hsa-miR-3074-3p	CLIP-seq
MIRT2201249	hsa-miR-324-5p	CLIP-seq
MIRT2201250	hsa-miR-330-3p	CLIP-seq
MIRT2201251	hsa-miR-381	CLIP-seq
MIRT2201252	hsa-miR-421	CLIP-seq
MIRT2201253	hsa-miR-424	CLIP-seq
MIRT2201254	hsa-miR-4269	CLIP-seq
MIRT2201255	hsa-miR-4310	CLIP-seq
MIRT2201256	hsa-miR-4514	CLIP-seq
MIRT2201257	hsa-miR-4666-3p	CLIP-seq
MIRT2201258	hsa-miR-4692	CLIP-seq
MIRT2201259	hsa-miR-4693-5p	CLIP-seq
MIRT2201260	hsa-miR-4709-5p	CLIP-seq
MIRT2201261	hsa-miR-4720-3p	CLIP-seq
MIRT2201262	hsa-miR-4742-5p	CLIP-seq
MIRT2201263	hsa-miR-4753-3p	CLIP-seq
MIRT2201264	hsa-miR-4760-3p	CLIP-seq
MIRT2201265	hsa-miR-4804-3p	CLIP-seq
MIRT2201266	hsa-miR-497	CLIP-seq
MIRT2201267	hsa-miR-568	CLIP-seq
MIRT2201268	hsa-miR-643	CLIP-seq
MIRT2201269	hsa-miR-942	CLIP-seq
MIRT2201270	hsa-miR-944	CLIP-seq
MIRT2447121	hsa-miR-153	CLIP-seq
MIRT2447122	hsa-miR-23a	CLIP-seq
MIRT2447123	hsa-miR-23b	CLIP-seq
MIRT2447124	hsa-miR-23c	CLIP-seq
MIRT2447125	hsa-miR-3667-5p	CLIP-seq
MIRT2447126	hsa-miR-448	CLIP-seq
MIRT2201230	hsa-miR-103a	CLIP-seq
MIRT2201231	hsa-miR-107	CLIP-seq
MIRT2201232	hsa-miR-1207-3p	CLIP-seq
MIRT2504029	hsa-miR-1244	CLIP-seq
MIRT2504030	hsa-miR-1267	CLIP-seq
MIRT2504031	hsa-miR-1304	CLIP-seq
MIRT2504032	hsa-miR-142-5p	CLIP-seq
MIRT2201234	hsa-miR-148a	CLIP-seq
MIRT2201235	hsa-miR-148b	CLIP-seq
MIRT2504033	hsa-miR-151-5p	CLIP-seq
MIRT2504034	hsa-miR-151b	CLIP-seq
MIRT2201236	hsa-miR-152	CLIP-seq
MIRT2447121	hsa-miR-153	CLIP-seq
MIRT2201238	hsa-miR-15a	CLIP-seq
MIRT2201239	hsa-miR-15b	CLIP-seq
MIRT2201240	hsa-miR-16	CLIP-seq
MIRT2201241	hsa-miR-1825	CLIP-seq
MIRT2201242	hsa-miR-195	CLIP-seq
MIRT2504035	hsa-miR-1972	CLIP-seq
MIRT2201243	hsa-miR-199a-5p	CLIP-seq
MIRT2201244	hsa-miR-199b-5p	CLIP-seq
MIRT2447122	hsa-miR-23a	CLIP-seq
MIRT2447123	hsa-miR-23b	CLIP-seq
MIRT2447124	hsa-miR-23c	CLIP-seq
MIRT2201246	hsa-miR-298	CLIP-seq
MIRT2201248	hsa-miR-3074-3p	CLIP-seq
MIRT2504036	hsa-miR-3121-3p	CLIP-seq
MIRT2504037	hsa-miR-3125	CLIP-seq
MIRT2504038	hsa-miR-3131	CLIP-seq
MIRT2504039	hsa-miR-3197	CLIP-seq
MIRT2201249	hsa-miR-324-5p	CLIP-seq
MIRT2201250	hsa-miR-330-3p	CLIP-seq
MIRT2504040	hsa-miR-3613-3p	CLIP-seq
MIRT2504041	hsa-miR-3647-3p	CLIP-seq
MIRT2447125	hsa-miR-3667-5p	CLIP-seq
MIRT2504042	hsa-miR-3907	CLIP-seq
MIRT2504043	hsa-miR-3916	CLIP-seq
MIRT2504044	hsa-miR-409-3p	CLIP-seq
MIRT2201252	hsa-miR-421	CLIP-seq
MIRT2201253	hsa-miR-424	CLIP-seq
MIRT2504045	hsa-miR-4251	CLIP-seq
MIRT2201254	hsa-miR-4269	CLIP-seq
MIRT2201255	hsa-miR-4310	CLIP-seq
MIRT2504046	hsa-miR-4329	CLIP-seq
MIRT2447126	hsa-miR-448	CLIP-seq
MIRT2504047	hsa-miR-450b-5p	CLIP-seq
MIRT2201256	hsa-miR-4514	CLIP-seq
MIRT2504048	hsa-miR-4522	CLIP-seq
MIRT2201258	hsa-miR-4692	CLIP-seq
MIRT2201260	hsa-miR-4709-5p	CLIP-seq
MIRT2504049	hsa-miR-4711-3p	CLIP-seq
MIRT2201262	hsa-miR-4742-5p	CLIP-seq
MIRT2504050	hsa-miR-4781-3p	CLIP-seq
MIRT2504051	hsa-miR-4793-3p	CLIP-seq
MIRT2504052	hsa-miR-487a	CLIP-seq
MIRT2201266	hsa-miR-497	CLIP-seq
MIRT2504053	hsa-miR-511	CLIP-seq
MIRT2201267	hsa-miR-568	CLIP-seq
MIRT2504054	hsa-miR-570	CLIP-seq
MIRT2504055	hsa-miR-596	CLIP-seq
MIRT2504056	hsa-miR-611	CLIP-seq
MIRT2504057	hsa-miR-626	CLIP-seq
MIRT2201268	hsa-miR-643	CLIP-seq
MIRT2504058	hsa-miR-764	CLIP-seq
MIRT2201270	hsa-miR-944	CLIP-seq
MIRT2201232	hsa-miR-1207-3p	CLIP-seq
MIRT2504029	hsa-miR-1244	CLIP-seq
MIRT2504030	hsa-miR-1267	CLIP-seq
MIRT2504031	hsa-miR-1304	CLIP-seq
MIRT2201234	hsa-miR-148a	CLIP-seq
MIRT2201235	hsa-miR-148b	CLIP-seq
MIRT2504033	hsa-miR-151-5p	CLIP-seq
MIRT2504034	hsa-miR-151b	CLIP-seq
MIRT2201236	hsa-miR-152	CLIP-seq
MIRT2447121	hsa-miR-153	CLIP-seq
MIRT2201241	hsa-miR-1825	CLIP-seq
MIRT2504035	hsa-miR-1972	CLIP-seq
MIRT2678228	hsa-miR-199a-3p	CLIP-seq
MIRT2201243	hsa-miR-199a-5p	CLIP-seq
MIRT2678229	hsa-miR-199b-3p	CLIP-seq
MIRT2201244	hsa-miR-199b-5p	CLIP-seq
MIRT2447122	hsa-miR-23a	CLIP-seq
MIRT2447123	hsa-miR-23b	CLIP-seq
MIRT2447124	hsa-miR-23c	CLIP-seq
MIRT2201246	hsa-miR-298	CLIP-seq
MIRT2201248	hsa-miR-3074-3p	CLIP-seq
MIRT2504036	hsa-miR-3121-3p	CLIP-seq
MIRT2678230	hsa-miR-3129-5p	CLIP-seq
MIRT2504038	hsa-miR-3131	CLIP-seq
MIRT2504039	hsa-miR-3197	CLIP-seq
MIRT2201249	hsa-miR-324-5p	CLIP-seq
MIRT2504041	hsa-miR-3647-3p	CLIP-seq
MIRT2447125	hsa-miR-3667-5p	CLIP-seq
MIRT2504042	hsa-miR-3907	CLIP-seq
MIRT2504044	hsa-miR-409-3p	CLIP-seq
MIRT2201252	hsa-miR-421	CLIP-seq
MIRT2201254	hsa-miR-4269	CLIP-seq
MIRT2447126	hsa-miR-448	CLIP-seq
MIRT2201256	hsa-miR-4514	CLIP-seq
MIRT2504048	hsa-miR-4522	CLIP-seq
MIRT2201258	hsa-miR-4692	CLIP-seq
MIRT2201260	hsa-miR-4709-5p	CLIP-seq
MIRT2201262	hsa-miR-4742-5p	CLIP-seq
MIRT2504050	hsa-miR-4781-3p	CLIP-seq
MIRT2504051	hsa-miR-4793-3p	CLIP-seq
MIRT2678231	hsa-miR-4797-3p	CLIP-seq
MIRT2504052	hsa-miR-487a	CLIP-seq
MIRT2201267	hsa-miR-568	CLIP-seq
MIRT2504055	hsa-miR-596	CLIP-seq
MIRT2504056	hsa-miR-611	CLIP-seq
MIRT2504057	hsa-miR-626	CLIP-seq
MIRT2201268	hsa-miR-643	CLIP-seq
MIRT2504058	hsa-miR-764	CLIP-seq
MIRT2678232	hsa-miR-936	CLIP-seq
MIRT2201270	hsa-miR-944	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0000166	Function	Nucleotide binding	IEA
GO:0005247	Function	Voltage-gated chloride channel activity	IBA
GO:0005247	Function	Voltage-gated chloride channel activity	TAS	7665160
GO:0005254	Function	Chloride channel activity	IDA	11274166
GO:0005254	Function	Chloride channel activity	IEA
GO:0005254	Function	Chloride channel activity	TAS	12471024
GO:0005515	Function	Protein binding	IPI	12471024
GO:0005524	Function	ATP binding	IEA
GO:0005764	Component	Lysosome	IEA
GO:0005765	Component	Lysosomal membrane	IEA
GO:0005765	Component	Lysosomal membrane	ISS
GO:0005768	Component	Endosome	IEA
GO:0005769	Component	Early endosome	IBA
GO:0005769	Component	Early endosome	IDA	12471024
GO:0005770	Component	Late endosome	IDA	12471024
GO:0005794	Component	Golgi apparatus	IBA
GO:0005794	Component	Golgi apparatus	IDA	12471024
GO:0005794	Component	Golgi apparatus	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	11274166
GO:0005886	Component	Plasma membrane	IEA
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006821	Process	Chloride transport	IEA
GO:0006885	Process	Regulation of pH	TAS	12471024
GO:0006911	Process	Phagocytosis, engulfment	IEA
GO:0008021	Component	Synaptic vesicle	IBA
GO:0008021	Component	Synaptic vesicle	IDA	11182090
GO:0008021	Component	Synaptic vesicle	IEA
GO:0008344	Process	Adult locomotory behavior	IEA
GO:0009897	Component	External side of plasma membrane	IDA	11274166
GO:0009986	Component	Cell surface	NAS	12471024
GO:0010008	Component	Endosome membrane	IEA
GO:0010008	Component	Endosome membrane	ISS
GO:0012506	Component	Vesicle membrane	IDA	12471024
GO:0015108	Function	Chloride transmembrane transporter activity	IEA
GO:0015297	Function	Antiporter activity	IEA
GO:0015297	Function	Antiporter activity	ISS
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	TAS	12471024
GO:0030141	Component	Secretory granule	IDA	16522634
GO:0030165	Function	PDZ domain binding	IDA	12471024
GO:0030672	Component	Synaptic vesicle membrane	IDA	11182090
GO:0030672	Component	Synaptic vesicle membrane	IMP	11182090
GO:0031410	Component	Cytoplasmic vesicle	IDA	11274166
GO:0031901	Component	Early endosome membrane	IEA
GO:0031902	Component	Late endosome membrane	IEA
GO:0032587	Component	Ruffle membrane	IEA
GO:0035249	Process	Synaptic transmission, glutamatergic	IEA
GO:0042581	Component	Specific granule	IDA	16522634
GO:0042995	Component	Cell projection	IEA
GO:0043679	Component	Axon terminus	IEA
GO:0045335	Component	Phagocytic vesicle	IDA	16522634
GO:0045494	Process	Photoreceptor cell maintenance	IEA
GO:0045794	Process	Negative regulation of cell volume	IMP	12183454
GO:0048388	Process	Endosomal lumen acidification	TAS	12471024
GO:0051932	Process	Synaptic transmission, GABAergic	IEA
GO:0055037	Component	Recycling endosome	IEA
GO:0055037	Component	Recycling endosome	ISS
GO:0055085	Process	Transmembrane transport	IEA
GO:0062158	Function	Chloride:proton antiporter activity	IEA
GO:0070050	Process	Neuron cellular homeostasis	IEA
GO:0072320	Function	Volume-sensitive chloride channel activity	IMP	12183454
GO:0097401	Process	Synaptic vesicle lumen acidification	IEA
GO:0098978	Component	Glutamatergic synapse	IDA	11182090
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0098978	Component	Glutamatergic synapse	IMP	11182090
GO:0098982	Component	GABA-ergic synapse	IDA	11182090
GO:0098982	Component	GABA-ergic synapse	IMP	11182090
GO:1902476	Process	Chloride transmembrane transport	IDA	11274166
GO:1903428	Process	Positive regulation of reactive oxygen species biosynthetic process	IEA

Other IDs

• MIM: 600580
• HGNC: 2021
• e!Ensembl: ENSG00000109572

Protein

• UniProt ID: P51790
• Protein name: H(+)/Cl(-) exchange transporter 3 (Chloride channel protein 3) (ClC-3) (Chloride transporter ClC-3)
• Protein function: [Isoform 1]: Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons (By similarity). The CLC channel family contains both chloride channels and proton-coupled anion transporte
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00654	Voltage_CLC	220 → 623	Voltage gated chloride channel	Family
  PF00571	CBS	654 → 718	CBS domain	Domain
  PF00571	CBS	751 → 806	CBS domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed primarily in tissues derived from neuroectoderm. Within the brain, its expression is particularly evident in the hippocampus, olfactory cortex, and olfactory bulb. Highly expressed in aortic and coronary vascular smooth muscl
• Sequence:

  MESEQLFHRGYYRNSYNSITSASSDEELLDGAGVIMDFQTSEDDNLLDGDTAVGTHYTMT
  NGGSINSSTHLLDLLDEPIPGVGTYDDFHTIDWVREKCKDRERHRRINSKKKESAWEMTK
  SLYDAWSGWLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETT
  FEERDKCPQWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSG
  IPEIKTILSGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCGNIFSYLF
  PKYSTNEAKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAA
  FVLRSINPFGNSRLVLFYVEYHTPWYLFELFPFILLGVFGGLWGAFFIRANIAWCRRRKS
  TKFGKYPVLEVIIVAAITAVIAFPNPYTRLNTSELIKELFTDCGPLESSSLCDYRNDMNA
  SKIVDDIPDRPAGIGVYSAIWQLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAIAGRI
  VGIAVEQLAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFEL
  TGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDAKEEFTHTTLAADVMRP
  RRNDPPLAVLTQDNMTVDDIENMINETSYNGFPVIMSKESQRLVGFALRRDLTIAIESAR
  KKQEGIVGSSRVCFAQHTPSLPAESPRPLKLRSILDMSPFTVTDHTPMEIVVDIFRKLGL
  RQCLVTHNGRLLGIITKKDILRHMAQTANQDPASIMFN

• Sequence length: 818

Pathways

KEGG:

Neutrophil extracellular trap formation

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Autism, susceptiblity to	Pathogenic	rs1733026743	RCV003313025	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Neurodevelopmental delay	Likely pathogenic; Pathogenic	rs2150238934, rs2150246636, rs2150254146, rs201059509, rs2150267036, rs2150274994, rs1732900321, rs1732397227	RCV001553771 RCV001553778 RCV001553773 RCV001553772 RCV001553776 RCV001553777 RCV001553775 RCV001289539	★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Neurodevelopmental disorder	Likely pathogenic	rs1732900321	RCV001195290	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Neurodevelopmental disorder with hypotonia and brain abnormalities	Likely pathogenic	rs2150238934, rs2150254146, rs201059509, rs2150267036, rs2150274994, rs2477120199, rs1732900321, rs1732397227	RCV002051945 RCV002051947 RCV002051946 RCV001597308 RCV002051949 RCV003319580 RCV001597254 RCV002051932	★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Neurodevelopmental disorder with seizures and brain abnormalities	Pathogenic	rs2150246636	RCV001597309	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
AMYOTROPHIC LATERAL SCLEROSIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISTIC DISORDER	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CLCN3-related disorder	Uncertain significance; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CLCN3-related neurodevelopmental disorders	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COMPLEX NEURODEVELOPMENTAL DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOMA	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NASOPHARYNGEAL CARCINOMA	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEURODEVELOPMENTAL DISORDERS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NON-SPECIFIC SYNDROMIC INTELLECTUAL DISABILITY	—	Disgenet, Orphanet Disgenet, Orphanet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PARKINSON DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Progressive sensorineural hearing impairment	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
STOMACH NEOPLASMS	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Adenocarcinoma of lung (disorder)	Lung adenocarcinoma	BEFREE	30230544		★☆☆☆☆ Found in Text Mining only
Amyloidosis	Amyloidosis	BEFREE	22207005		★☆☆☆☆ Found in Text Mining only
Asthenozoospermia	Asthenozoospermia	BEFREE	27270342		★☆☆☆☆ Found in Text Mining only
Asthenozoospermia	Asthenozoospermia	Pubtator	27270342	Associate	★☆☆☆☆ Found in Text Mining only
Asthma	Asthma	Pubtator	25514499	Associate	★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	28419445, 29949674, 29963105, 30230544, 31608175		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	29949674	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Ovarian Epithelial	Epithelial ovarian carcinoma	Pubtator	33765585	Associate	★☆☆☆☆ Found in Text Mining only
Cardiomyopathy Dilated	Dilated cardiomyopathy	Pubtator	24339868	Associate	★☆☆☆☆ Found in Text Mining only
Cardiovascular Diseases	Cardiovascular Diseases	BEFREE	21602838		★☆☆☆☆ Found in Text Mining only
Cervix carcinoma	Cervix carcinoma	BEFREE	30636929		★☆☆☆☆ Found in Text Mining only
Child Development Disorders, Pervasive	Development Disorder	GWASCAT_DG	28540026		★☆☆☆☆ Found in Text Mining only
Chondrosarcoma	Chondrosarcoma	BEFREE	31281178		★☆☆☆☆ Found in Text Mining only
Cognition Disorders	Cognitive disorder	BEFREE	30468668		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	35817785	Associate	★☆☆☆☆ Found in Text Mining only
Congestive heart failure	Congestive Heart Failure	BEFREE	21602838		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	31165783		★☆☆☆☆ Found in Text Mining only
Endometriosis	Endometriosis	BEFREE	26965430		★☆☆☆☆ Found in Text Mining only
Familial Primary Pulmonary Hypertension	Pulmonary hypertension	Pubtator	35989293	Associate	★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	11146166		★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	11146166		★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	12843258, 23408563, 28969029, 29963152		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Glioma	Glioma	LHGDN	12843258		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Glioma	Glioma	CTD_human_DG	12843258		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Glioma	Glioma	Pubtator	12843258, 20139089, 22049206, 23261316	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Global developmental delay	Developmental Delay	BEFREE	12059962		★☆☆☆☆ Found in Text Mining only
Heart failure	Heart Failure	BEFREE	21602838		★☆☆☆☆ Found in Text Mining only
Hereditary Diffuse Gastric Cancer	Gastric Cancer	CTD_human_DG	21364753		★☆☆☆☆ Found in Text Mining only
Hypereosinophilic Syndrome	Hypereosinophilic syndrome	Pubtator	25514499	Associate	★☆☆☆☆ Found in Text Mining only
Hypertensive disease	Hypertension	BEFREE	21602838		★☆☆☆☆ Found in Text Mining only
Hypertrophic Cardiomyopathy	Hypertrophic cardiomyopathy	BEFREE	29885652		★☆☆☆☆ Found in Text Mining only
Impaired cognition	Impaired Cognition	BEFREE	30468668		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	11997263, 29749557, 30678806		★☆☆☆☆ Found in Text Mining only
Liver neoplasms	Liver neoplasms	BEFREE	11997263		★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic Metastasis	BEFREE	30636929		★☆☆☆☆ Found in Text Mining only
Malignant Glioma	Glioma	CTD_human_DG	12843258		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	28419445, 29949674, 29963105, 30230544, 31608175		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	15256454		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	CTD_human_DG	21364753		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	29795988, 30217218		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	18359479, 25537517, 30230544, 30636929		★☆☆☆☆ Found in Text Mining only
mixed gliomas	Glioma	CTD_human_DG	12843258		★☆☆☆☆ Found in Text Mining only
Nasal Polyps	Nasal polyposis	LHGDN	17882904		★☆☆☆☆ Found in Text Mining only
Nasopharyngeal Carcinoma	Nasopharyngeal carcinoma	Pubtator	15127135, 22496242, 27451945	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Nasopharyngeal carcinoma	Nasopharyngeal Carcinoma	BEFREE	18359479, 21792908, 22108225, 22496242, 23270726, 25450461, 26794461, 30171707, 30992317, 31606620		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Nasopharyngeal carcinoma	Nasopharyngeal Carcinoma	CTD_human_DG	22108225		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Neoplasms	Neoplasms	BEFREE	29749557, 29795988, 29963105, 30636929, 30678806, 31281178, 31606620		★☆☆☆☆ Found in Text Mining only
Neuronal Ceroid-Lipofuscinoses	Neuronal Ceroid Lipofuscinosis	BEFREE	12059962		★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	BEFREE	31165783		★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	Pubtator	25973047	Associate	★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	33765585	Associate	★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	15256454		★☆☆☆☆ Found in Text Mining only
Pulmonary Arterial Hypertension	Pulmonary arterial hypertension	Pubtator	35989293	Associate	★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	GWASCAT_DG	25056061, 26198764, 28540026, 28991256, 29483656, 30285260		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Schizophrenia	Schizophrenia	Pubtator	27668389	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Schizophrenia	Schizophrenia	BEFREE	31548722		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Stomach Carcinoma	Stomach Carcinoma	BEFREE	29795988, 30217218		★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach Neoplasms	CTD_human_DG	21364753		★★☆☆☆ Found in Text Mining + Unknown/Other Associations