Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	117247
Gene name	Solute carrier family 16 member 10
Gene symbol	SLC16A10
Synonyms (NCBI Gene)	MCT10PRO0813TAT1
Chromosome	6
Chromosome location	6q21
Summary	SLC16A10 is a member of a family of plasma membrane amino acid transporters that mediate the Na(+)-independent transport of aromatic amino acids across the plasma membrane.[supplied by OMIM, Apr 2004]

164

Show/Hide all (164)

miRTarBase ID	miRNA	Experiments	Reference
MIRT002409	hsa-miR-21-5p	Microarray	18591254
MIRT666322	hsa-miR-140-3p	HITS-CLIP	21572407
MIRT706751	hsa-miR-4418	HITS-CLIP	21572407
MIRT706750	hsa-miR-509-3-5p	HITS-CLIP	21572407
MIRT706749	hsa-miR-509-5p	HITS-CLIP	21572407
MIRT666328	hsa-miR-6890-3p	HITS-CLIP	21572407
MIRT706748	hsa-miR-499b-5p	HITS-CLIP	21572407
MIRT666325	hsa-miR-1304-3p	HITS-CLIP	21572407
MIRT706747	hsa-miR-3158-5p	HITS-CLIP	21572407
MIRT706746	hsa-miR-3166	HITS-CLIP	21572407
MIRT706745	hsa-miR-4771	HITS-CLIP	21572407
MIRT666320	hsa-miR-6499-3p	HITS-CLIP	21572407
MIRT666318	hsa-miR-504-3p	HITS-CLIP	21572407
MIRT666314	hsa-miR-143-5p	HITS-CLIP	21572407
MIRT706744	hsa-miR-1273h-3p	HITS-CLIP	21572407
MIRT666313	hsa-miR-5698	HITS-CLIP	21572407
MIRT666328	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT666327	hsa-miR-5693	HITS-CLIP	23824327
MIRT666326	hsa-miR-1281	HITS-CLIP	23824327
MIRT666325	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT666324	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT666323	hsa-miR-6722-5p	HITS-CLIP	23824327
MIRT666322	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT666321	hsa-miR-500b-3p	HITS-CLIP	23824327
MIRT666320	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT666319	hsa-miR-3135b	HITS-CLIP	23824327
MIRT666318	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT666317	hsa-miR-3652	HITS-CLIP	23824327
MIRT666316	hsa-miR-4430	HITS-CLIP	23824327
MIRT666315	hsa-miR-6879-3p	HITS-CLIP	23824327
MIRT666314	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT666313	hsa-miR-5698	HITS-CLIP	23824327
MIRT653746	hsa-miR-624-3p	HITS-CLIP	23824327
MIRT653745	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT653744	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT653743	hsa-miR-6758-3p	HITS-CLIP	23824327
MIRT653742	hsa-miR-3674	HITS-CLIP	23824327
MIRT521119	hsa-miR-4643	PAR-CLIP	23446348
MIRT521118	hsa-miR-4438	PAR-CLIP	23446348
MIRT521117	hsa-miR-942-3p	PAR-CLIP	23446348
MIRT521115	hsa-miR-6746-3p	PAR-CLIP	23446348
MIRT521116	hsa-miR-6504-3p	PAR-CLIP	23446348
MIRT521114	hsa-miR-4717-3p	PAR-CLIP	23446348
MIRT521113	hsa-miR-4537	PAR-CLIP	23446348
MIRT521112	hsa-miR-5095	PAR-CLIP	23446348
MIRT521111	hsa-miR-7151-3p	PAR-CLIP	23446348
MIRT244041	hsa-miR-590-3p	PAR-CLIP	23446348
MIRT521110	hsa-miR-1273f	PAR-CLIP	23446348
MIRT315452	hsa-miR-4650-3p	PAR-CLIP	23446348
MIRT315453	hsa-miR-3529-5p	PAR-CLIP	23446348
MIRT315444	hsa-miR-379-5p	PAR-CLIP	23446348
MIRT315450	hsa-miR-4451	PAR-CLIP	23446348
MIRT521109	hsa-miR-6832-5p	PAR-CLIP	23446348
MIRT521108	hsa-miR-3149	PAR-CLIP	23446348
MIRT497443	hsa-miR-1825	PAR-CLIP	22291592
MIRT497442	hsa-miR-199a-5p	PAR-CLIP	22291592
MIRT497441	hsa-miR-199b-5p	PAR-CLIP	22291592
MIRT497440	hsa-miR-2115-5p	PAR-CLIP	22291592
MIRT497439	hsa-miR-145-5p	PAR-CLIP	22291592
MIRT497438	hsa-miR-5195-3p	PAR-CLIP	22291592
MIRT496810	hsa-miR-4428	PAR-CLIP	22291592
MIRT496809	hsa-miR-3190-5p	PAR-CLIP	22291592
MIRT496808	hsa-miR-6720-3p	PAR-CLIP	22291592
MIRT496807	hsa-miR-3926	PAR-CLIP	22291592
MIRT496806	hsa-miR-566	PAR-CLIP	22291592
MIRT496805	hsa-miR-6807-5p	PAR-CLIP	22291592
MIRT496804	hsa-miR-548s	PAR-CLIP	22291592
MIRT666324	hsa-miR-122-5p	HITS-CLIP	27418678
MIRT666326	hsa-miR-1281	HITS-CLIP	27418678
MIRT666325	hsa-miR-1304-3p	HITS-CLIP	27418678
MIRT666314	hsa-miR-143-5p	HITS-CLIP	27418678
MIRT666319	hsa-miR-3135b	HITS-CLIP	27418678
MIRT666317	hsa-miR-3652	HITS-CLIP	27418678
MIRT666316	hsa-miR-4430	HITS-CLIP	27418678
MIRT666318	hsa-miR-504-3p	HITS-CLIP	27418678
MIRT666327	hsa-miR-5693	HITS-CLIP	27418678
MIRT666313	hsa-miR-5698	HITS-CLIP	27418678
MIRT666320	hsa-miR-6499-3p	HITS-CLIP	27418678
MIRT666323	hsa-miR-6722-5p	HITS-CLIP	27418678
MIRT666328	hsa-miR-6890-3p	HITS-CLIP	27418678
MIRT666322	hsa-miR-140-3p	HITS-CLIP	21572407
MIRT706751	hsa-miR-4418	HITS-CLIP	21572407
MIRT706750	hsa-miR-509-3-5p	HITS-CLIP	21572407
MIRT706749	hsa-miR-509-5p	HITS-CLIP	21572407
MIRT666328	hsa-miR-6890-3p	HITS-CLIP	21572407
MIRT706748	hsa-miR-499b-5p	HITS-CLIP	21572407
MIRT666325	hsa-miR-1304-3p	HITS-CLIP	21572407
MIRT706747	hsa-miR-3158-5p	HITS-CLIP	21572407
MIRT706746	hsa-miR-3166	HITS-CLIP	21572407
MIRT706745	hsa-miR-4771	HITS-CLIP	21572407
MIRT666320	hsa-miR-6499-3p	HITS-CLIP	21572407
MIRT666318	hsa-miR-504-3p	HITS-CLIP	21572407
MIRT666314	hsa-miR-143-5p	HITS-CLIP	21572407
MIRT706744	hsa-miR-1273h-3p	HITS-CLIP	21572407
MIRT666313	hsa-miR-5698	HITS-CLIP	21572407
MIRT666328	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT666327	hsa-miR-5693	HITS-CLIP	23824327
MIRT666326	hsa-miR-1281	HITS-CLIP	23824327
MIRT666325	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT666324	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT666323	hsa-miR-6722-5p	HITS-CLIP	23824327
MIRT666322	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT666321	hsa-miR-500b-3p	HITS-CLIP	23824327
MIRT666320	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT666319	hsa-miR-3135b	HITS-CLIP	23824327
MIRT666318	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT666317	hsa-miR-3652	HITS-CLIP	23824327
MIRT666316	hsa-miR-4430	HITS-CLIP	23824327
MIRT666315	hsa-miR-6879-3p	HITS-CLIP	23824327
MIRT666314	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT666313	hsa-miR-5698	HITS-CLIP	23824327
MIRT653746	hsa-miR-624-3p	HITS-CLIP	23824327
MIRT653745	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT653744	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT653743	hsa-miR-6758-3p	HITS-CLIP	23824327
MIRT653742	hsa-miR-3674	HITS-CLIP	23824327
MIRT521119	hsa-miR-4643	PAR-CLIP	23446348
MIRT521118	hsa-miR-4438	PAR-CLIP	23446348
MIRT521117	hsa-miR-942-3p	PAR-CLIP	23446348
MIRT521115	hsa-miR-6746-3p	PAR-CLIP	23446348
MIRT521116	hsa-miR-6504-3p	PAR-CLIP	23446348
MIRT521114	hsa-miR-4717-3p	PAR-CLIP	23446348
MIRT521113	hsa-miR-4537	PAR-CLIP	23446348
MIRT521112	hsa-miR-5095	PAR-CLIP	23446348
MIRT521111	hsa-miR-7151-3p	PAR-CLIP	23446348
MIRT244041	hsa-miR-590-3p	PAR-CLIP	23446348
MIRT521110	hsa-miR-1273f	PAR-CLIP	23446348
MIRT315452	hsa-miR-4650-3p	PAR-CLIP	23446348
MIRT315453	hsa-miR-3529-5p	PAR-CLIP	23446348
MIRT315444	hsa-miR-379-5p	PAR-CLIP	23446348
MIRT315450	hsa-miR-4451	PAR-CLIP	23446348
MIRT521109	hsa-miR-6832-5p	PAR-CLIP	23446348
MIRT521108	hsa-miR-3149	PAR-CLIP	23446348
MIRT497443	hsa-miR-1825	PAR-CLIP	22291592
MIRT497442	hsa-miR-199a-5p	PAR-CLIP	22291592
MIRT497441	hsa-miR-199b-5p	PAR-CLIP	22291592
MIRT497440	hsa-miR-2115-5p	PAR-CLIP	22291592
MIRT497439	hsa-miR-145-5p	PAR-CLIP	22291592
MIRT497438	hsa-miR-5195-3p	PAR-CLIP	22291592
MIRT496810	hsa-miR-4428	PAR-CLIP	22291592
MIRT496809	hsa-miR-3190-5p	PAR-CLIP	22291592
MIRT496808	hsa-miR-6720-3p	PAR-CLIP	22291592
MIRT496807	hsa-miR-3926	PAR-CLIP	22291592
MIRT496806	hsa-miR-566	PAR-CLIP	22291592
MIRT496805	hsa-miR-6807-5p	PAR-CLIP	22291592
MIRT496804	hsa-miR-548s	PAR-CLIP	22291592
MIRT002409	hsa-miR-21-5p	Luciferase reporter assayWestern blottingqRT-PCR	38750066
MIRT1352786	hsa-miR-338-5p	CLIP-seq
MIRT1352787	hsa-miR-3671	CLIP-seq
MIRT1352788	hsa-miR-5096	CLIP-seq
MIRT1352789	hsa-miR-513b	CLIP-seq
MIRT1352790	hsa-miR-607	CLIP-seq
MIRT2104468	hsa-miR-22	CLIP-seq
MIRT2104469	hsa-miR-3143	CLIP-seq
MIRT2104470	hsa-miR-376c	CLIP-seq
MIRT2104471	hsa-miR-4252	CLIP-seq
MIRT2104472	hsa-miR-4803	CLIP-seq
MIRT2104473	hsa-miR-891b	CLIP-seq
MIRT2328893	hsa-miR-767-3p	CLIP-seq
MIRT2623272	hsa-miR-3613-3p	CLIP-seq
MIRT2623273	hsa-miR-4282	CLIP-seq
MIRT2623274	hsa-miR-622	CLIP-seq
MIRT2623272	hsa-miR-3613-3p	CLIP-seq
MIRT2623273	hsa-miR-4282	CLIP-seq

Show/Hide all (42)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003333	Process	Amino acid transmembrane transport	IEA
GO:0005302	Function	L-tyrosine transmembrane transporter activity	IDA	11827462
GO:0005302	Function	L-tyrosine transmembrane transporter activity	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	18337592
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006590	Process	Thyroid hormone generation	IEA
GO:0006865	Process	Amino acid transport	TAS
GO:0015171	Function	Amino acid transmembrane transporter activity	IEA
GO:0015171	Function	Amino acid transmembrane transporter activity	TAS
GO:0015173	Function	Aromatic amino acid transmembrane transporter activity	IDA	11827462
GO:0015173	Function	Aromatic amino acid transmembrane transporter activity	IEA
GO:0015192	Function	L-phenylalanine transmembrane transporter activity	IDA	11827462
GO:0015192	Function	L-phenylalanine transmembrane transporter activity	IEA
GO:0015196	Function	L-tryptophan transmembrane transporter activity	IDA	11827462
GO:0015196	Function	L-tryptophan transmembrane transporter activity	IEA
GO:0015349	Function	Thyroid hormone transmembrane transporter activity	IDA	18337592, 21315799
GO:0015349	Function	Thyroid hormone transmembrane transporter activity	IEA
GO:0015801	Process	Aromatic amino acid transport	IDA	11827462
GO:0015801	Process	Aromatic amino acid transport	IEA
GO:0015801	Process	Aromatic amino acid transport	TAS	15918515
GO:0015823	Process	Phenylalanine transport	IEA
GO:0015827	Process	Tryptophan transport	IEA
GO:0015828	Process	Tyrosine transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0016323	Component	Basolateral plasma membrane	IBA
GO:0016323	Component	Basolateral plasma membrane	IDA	15918515
GO:0016323	Component	Basolateral plasma membrane	IEA
GO:0016323	Component	Basolateral plasma membrane	ISS
GO:0016323	Component	Basolateral plasma membrane	TAS	15918515
GO:0022857	Function	Transmembrane transporter activity	IBA
GO:0022857	Function	Transmembrane transporter activity	IEA
GO:0030054	Component	Cell junction	IDA
GO:0046943	Function	Carboxylic acid transmembrane transporter activity	IEA
GO:0055085	Process	Transmembrane transport	IEA
GO:0070327	Process	Thyroid hormone transport	IBA
GO:0070327	Process	Thyroid hormone transport	IDA	18337592, 21315799
GO:0070327	Process	Thyroid hormone transport	IEA
GO:0070460	Process	Thyroid-stimulating hormone secretion	IEA
GO:1905039	Process	Carboxylic acid transmembrane transport	IEA

MIM	HGNC	e!Ensembl
607550	17027	ENSG00000112394

Q8TF71

Protein name

Monocarboxylate transporter 10 (MCT 10) (Aromatic amino acid transporter 1) (Solute carrier family 16 member 10) (T-type amino acid transporter 1)

Protein function

Sodium- and proton-independent thyroid hormones and aromatic acids transporter (PubMed:11827462, PubMed:18337592, PubMed:28754537). Mediates both uptake and efflux of 3,5,3'-triiodothyronine (T3) and 3,5,3',5'-tetraiodothyronine (T4) with high a

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07690	MFS_1	74 → 379	Major Facilitator Superfamily	Family
PF07690	MFS_1	303 → 509	Major Facilitator Superfamily	Family

Tissue specificity

TISSUE SPECIFICITY: Strongly expressed in kidney and skeletal muscle and at lower level in placenta and heart. {ECO:0000269|PubMed:11827462}.

Sequence

MVLSQEEPDSARGTSEAQPLGPAPTGAAPPPGPGPSDSPEAAVEKVEVELAGPATAEPHE
PPEPPEGGWGWLVMLAAMWCNGSVFGIQNACGVLFVSMLETFGSKDDDKMVFKTAWVGSL
SMGMIFFCCPIVSVFTDLFGCRKTAVVGAAVGFVGLMSSSFVSSIEPLYLTYGIIFACGC
SFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTILLPLLLRVLIDSVGLFYTLRVLCIF
MFVLFLAGFTYRPLATSTKDKESGGSGSSLFSRKKFSPPKKIFNFAIFKVTAYAVWAVGI
PLALFGYFVPYVHLMKHVNERFQDEKNKEVVLMCIGVTSGVGRLLFGRIADYVPGVKKVY
LQVLSFFFIGLMSMMIPLCSIFGALIAVCLIMGLFDGCFISIMAPIAFELVGAQDVSQAI
GFLLGFMSIPMTVGPPIAGLLRDKLGSYDVAFYLAGVPPLIGGAVLCFIPWIHSKKQREI
SKTTGKEKMEKMLENQNSLLSSSSGMFKKESDSII

Sequence length

515

Interactions

View interactions

	KEGG		Reactome
	Hormone signaling Thyroid hormone signaling pathway Protein digestion and absorption		Amino acid transport across the plasma membrane

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (7)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ATYPICAL FEMORAL FRACTURE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DENTAL CARIES	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GOUT	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatocellular carcinoma	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSORIASIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSORIATIC ARTHRITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (19)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Arthritis, Psoriatic	Psoriatic Arthritis	GWASCAT_DG	30552173		★★★★★ ★☆☆☆☆ Found in Text Mining only
Bladder Neoplasm	Bladder Neoplasm	BEFREE	23790536		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma	Carcinoma	BEFREE	12783972		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of bladder	Bladder carcinoma	BEFREE	23790536		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cataract	Cataract	BEFREE	31231240		★★★★★ ★☆☆☆☆ Found in Text Mining only
Depressive disorder	Mental Depression	BEFREE	28174547		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes mellitus	Pubtator	36340268	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypothyroidism	Hypothyroidism	BEFREE	29557697		★★★★★ ★☆☆☆☆ Found in Text Mining only
Kidney Failure Chronic	Kidney failure	Pubtator	35908957	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoma, Follicular	Lymphoma	BEFREE	11840295		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	15651064		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of urinary bladder	Urinary bladder cancer	BEFREE	23790536		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	12809927		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mental Depression	Mental Depression	BEFREE	28174547		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	15651064, 16566978		★★★★★ ★☆☆☆☆ Found in Text Mining only
nervous system disorder	Nervous System Disorder	BEFREE	17451964		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	15651064		★★★★★ ★☆☆☆☆ Found in Text Mining only
Septicemia	Septicemia	BEFREE	29118715		★★★★★ ★☆☆☆☆ Found in Text Mining only
Transitional cell carcinoma of bladder	Bladder carcinoma	BEFREE	16566978		★★★★★ ★☆☆☆☆ Found in Text Mining only

SLC16A10 (solute carrier family 16 member 10)