MED12L (mediator complex subunit 12L)

Gene

• Entrez ID: 116931
• Gene name: Mediator complex subunit 12L
• Gene symbol: MED12L
• Synonyms (NCBI Gene): NIZIDS, NOPAR, TNRC11L, TRALP, TRALPUSH
• Chromosome: 3
• Chromosome location: 3q25.1
• Summary: The protein encoded by this gene is part of the Mediator complex, which is involved in transcriptional coactivation of nearly all RNA polymerase II-dependent genes. The Mediator complex links gene-specific transcriptional activators with the basal transcr

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs1559855453	->C	Pathogenic	Genic upstream transcript variant, frameshift variant, non coding transcript variant, coding sequence variant
rs1560115921	C>T	Pathogenic	Stop gained, genic downstream transcript variant, coding sequence variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT028147	hsa-miR-93-5p	Sequencing	20371350
MIRT042329	hsa-miR-484	CLASH	23622248
MIRT208722	hsa-miR-19a-3p	PAR-CLIP	20371350
MIRT208723	hsa-miR-19b-3p	PAR-CLIP	20371350
MIRT208731	hsa-miR-3662	PAR-CLIP	20371350
MIRT305596	hsa-miR-6750-3p	PAR-CLIP	20371350
MIRT208724	hsa-miR-580-5p	PAR-CLIP	20371350
MIRT506589	hsa-miR-32-3p	PAR-CLIP	20371350
MIRT208733	hsa-miR-4698	PAR-CLIP	20371350
MIRT506588	hsa-miR-3607-5p	PAR-CLIP	20371350
MIRT208732	hsa-miR-548aj-5p	PAR-CLIP	20371350
MIRT208726	hsa-miR-548f-5p	PAR-CLIP	20371350
MIRT208727	hsa-miR-548g-5p	PAR-CLIP	20371350
MIRT208729	hsa-miR-548x-5p	PAR-CLIP	20371350
MIRT208725	hsa-miR-1468-3p	PAR-CLIP	20371350
MIRT506587	hsa-miR-4764-3p	PAR-CLIP	20371350
MIRT506586	hsa-miR-6516-3p	PAR-CLIP	20371350
MIRT208734	hsa-miR-548aw	PAR-CLIP	20371350
MIRT208722	hsa-miR-19a-3p	PAR-CLIP	20371350
MIRT208723	hsa-miR-19b-3p	PAR-CLIP	20371350
MIRT208731	hsa-miR-3662	PAR-CLIP	20371350
MIRT305596	hsa-miR-6750-3p	PAR-CLIP	20371350
MIRT208724	hsa-miR-580-5p	PAR-CLIP	20371350
MIRT506589	hsa-miR-32-3p	PAR-CLIP	20371350
MIRT208733	hsa-miR-4698	PAR-CLIP	20371350
MIRT506588	hsa-miR-3607-5p	PAR-CLIP	20371350
MIRT506587	hsa-miR-4764-3p	PAR-CLIP	20371350
MIRT506586	hsa-miR-6516-3p	PAR-CLIP	20371350
MIRT208722	hsa-miR-19a-3p	PAR-CLIP	21572407
MIRT208723	hsa-miR-19b-3p	PAR-CLIP	21572407
MIRT208731	hsa-miR-3662	PAR-CLIP	21572407
MIRT305596	hsa-miR-6750-3p	PAR-CLIP	21572407
MIRT208724	hsa-miR-580-5p	PAR-CLIP	21572407
MIRT506589	hsa-miR-32-3p	PAR-CLIP	21572407
MIRT208733	hsa-miR-4698	PAR-CLIP	21572407
MIRT556146	hsa-miR-1306-5p	PAR-CLIP	21572407
MIRT506588	hsa-miR-3607-5p	PAR-CLIP	21572407
MIRT556145	hsa-miR-4772-3p	PAR-CLIP	21572407
MIRT556144	hsa-miR-2276-3p	PAR-CLIP	21572407
MIRT208732	hsa-miR-548aj-5p	PAR-CLIP	21572407
MIRT208726	hsa-miR-548f-5p	PAR-CLIP	21572407
MIRT208727	hsa-miR-548g-5p	PAR-CLIP	21572407
MIRT208729	hsa-miR-548x-5p	PAR-CLIP	21572407
MIRT208725	hsa-miR-1468-3p	PAR-CLIP	21572407
MIRT506587	hsa-miR-4764-3p	PAR-CLIP	21572407
MIRT506586	hsa-miR-6516-3p	PAR-CLIP	21572407
MIRT208734	hsa-miR-548aw	PAR-CLIP	21572407
MIRT208722	hsa-miR-19a-3p	PAR-CLIP	21572407
MIRT208723	hsa-miR-19b-3p	PAR-CLIP	21572407
MIRT208731	hsa-miR-3662	PAR-CLIP	21572407
MIRT305596	hsa-miR-6750-3p	PAR-CLIP	21572407
MIRT208724	hsa-miR-580-5p	PAR-CLIP	21572407
MIRT506589	hsa-miR-32-3p	PAR-CLIP	21572407
MIRT208733	hsa-miR-4698	PAR-CLIP	21572407
MIRT506588	hsa-miR-3607-5p	PAR-CLIP	21572407
MIRT208732	hsa-miR-548aj-5p	PAR-CLIP	21572407
MIRT208726	hsa-miR-548f-5p	PAR-CLIP	21572407
MIRT208727	hsa-miR-548g-5p	PAR-CLIP	21572407
MIRT208729	hsa-miR-548x-5p	PAR-CLIP	21572407
MIRT208725	hsa-miR-1468-3p	PAR-CLIP	21572407
MIRT506587	hsa-miR-4764-3p	PAR-CLIP	21572407
MIRT506586	hsa-miR-6516-3p	PAR-CLIP	21572407
MIRT208734	hsa-miR-548aw	PAR-CLIP	21572407
MIRT208722	hsa-miR-19a-3p	PAR-CLIP	23446348
MIRT208723	hsa-miR-19b-3p	PAR-CLIP	23446348
MIRT208731	hsa-miR-3662	PAR-CLIP	23446348
MIRT305596	hsa-miR-6750-3p	PAR-CLIP	23446348
MIRT208724	hsa-miR-580-5p	PAR-CLIP	23446348
MIRT506589	hsa-miR-32-3p	PAR-CLIP	23446348
MIRT208733	hsa-miR-4698	PAR-CLIP	23446348
MIRT506588	hsa-miR-3607-5p	PAR-CLIP	23446348
MIRT208732	hsa-miR-548aj-5p	PAR-CLIP	23446348
MIRT208726	hsa-miR-548f-5p	PAR-CLIP	23446348
MIRT208727	hsa-miR-548g-5p	PAR-CLIP	23446348
MIRT208729	hsa-miR-548x-5p	PAR-CLIP	23446348
MIRT208725	hsa-miR-1468-3p	PAR-CLIP	23446348
MIRT506587	hsa-miR-4764-3p	PAR-CLIP	23446348
MIRT506586	hsa-miR-6516-3p	PAR-CLIP	23446348
MIRT208734	hsa-miR-548aw	PAR-CLIP	23446348
MIRT208722	hsa-miR-19a-3p	PAR-CLIP	20371350
MIRT208723	hsa-miR-19b-3p	PAR-CLIP	20371350
MIRT208731	hsa-miR-3662	PAR-CLIP	20371350
MIRT305596	hsa-miR-6750-3p	PAR-CLIP	20371350
MIRT208724	hsa-miR-580-5p	PAR-CLIP	20371350
MIRT506589	hsa-miR-32-3p	PAR-CLIP	20371350
MIRT208733	hsa-miR-4698	PAR-CLIP	20371350
MIRT506588	hsa-miR-3607-5p	PAR-CLIP	20371350
MIRT208732	hsa-miR-548aj-5p	PAR-CLIP	20371350
MIRT208726	hsa-miR-548f-5p	PAR-CLIP	20371350
MIRT208727	hsa-miR-548g-5p	PAR-CLIP	20371350
MIRT208729	hsa-miR-548x-5p	PAR-CLIP	20371350
MIRT208725	hsa-miR-1468-3p	PAR-CLIP	20371350
MIRT506587	hsa-miR-4764-3p	PAR-CLIP	20371350
MIRT506586	hsa-miR-6516-3p	PAR-CLIP	20371350
MIRT208734	hsa-miR-548aw	PAR-CLIP	20371350
MIRT208722	hsa-miR-19a-3p	PAR-CLIP	20371350
MIRT208723	hsa-miR-19b-3p	PAR-CLIP	20371350
MIRT208731	hsa-miR-3662	PAR-CLIP	20371350
MIRT305596	hsa-miR-6750-3p	PAR-CLIP	20371350
MIRT208724	hsa-miR-580-5p	PAR-CLIP	20371350
MIRT506589	hsa-miR-32-3p	PAR-CLIP	20371350
MIRT208733	hsa-miR-4698	PAR-CLIP	20371350
MIRT506588	hsa-miR-3607-5p	PAR-CLIP	20371350
MIRT506587	hsa-miR-4764-3p	PAR-CLIP	20371350
MIRT506586	hsa-miR-6516-3p	PAR-CLIP	20371350
MIRT208722	hsa-miR-19a-3p	PAR-CLIP	21572407
MIRT208723	hsa-miR-19b-3p	PAR-CLIP	21572407
MIRT208731	hsa-miR-3662	PAR-CLIP	21572407
MIRT305596	hsa-miR-6750-3p	PAR-CLIP	21572407
MIRT208724	hsa-miR-580-5p	PAR-CLIP	21572407
MIRT506589	hsa-miR-32-3p	PAR-CLIP	21572407
MIRT208733	hsa-miR-4698	PAR-CLIP	21572407
MIRT556146	hsa-miR-1306-5p	PAR-CLIP	21572407
MIRT506588	hsa-miR-3607-5p	PAR-CLIP	21572407
MIRT556145	hsa-miR-4772-3p	PAR-CLIP	21572407
MIRT556144	hsa-miR-2276-3p	PAR-CLIP	21572407
MIRT208732	hsa-miR-548aj-5p	PAR-CLIP	21572407
MIRT208726	hsa-miR-548f-5p	PAR-CLIP	21572407
MIRT208727	hsa-miR-548g-5p	PAR-CLIP	21572407
MIRT208729	hsa-miR-548x-5p	PAR-CLIP	21572407
MIRT208725	hsa-miR-1468-3p	PAR-CLIP	21572407
MIRT506587	hsa-miR-4764-3p	PAR-CLIP	21572407
MIRT506586	hsa-miR-6516-3p	PAR-CLIP	21572407
MIRT208734	hsa-miR-548aw	PAR-CLIP	21572407
MIRT208722	hsa-miR-19a-3p	PAR-CLIP	21572407
MIRT208723	hsa-miR-19b-3p	PAR-CLIP	21572407
MIRT208731	hsa-miR-3662	PAR-CLIP	21572407
MIRT305596	hsa-miR-6750-3p	PAR-CLIP	21572407
MIRT208724	hsa-miR-580-5p	PAR-CLIP	21572407
MIRT506589	hsa-miR-32-3p	PAR-CLIP	21572407
MIRT208733	hsa-miR-4698	PAR-CLIP	21572407
MIRT506588	hsa-miR-3607-5p	PAR-CLIP	21572407
MIRT208732	hsa-miR-548aj-5p	PAR-CLIP	21572407
MIRT208726	hsa-miR-548f-5p	PAR-CLIP	21572407
MIRT208727	hsa-miR-548g-5p	PAR-CLIP	21572407
MIRT208729	hsa-miR-548x-5p	PAR-CLIP	21572407
MIRT208725	hsa-miR-1468-3p	PAR-CLIP	21572407
MIRT506587	hsa-miR-4764-3p	PAR-CLIP	21572407
MIRT506586	hsa-miR-6516-3p	PAR-CLIP	21572407
MIRT208734	hsa-miR-548aw	PAR-CLIP	21572407
MIRT208722	hsa-miR-19a-3p	PAR-CLIP	23446348
MIRT208723	hsa-miR-19b-3p	PAR-CLIP	23446348
MIRT208731	hsa-miR-3662	PAR-CLIP	23446348
MIRT305596	hsa-miR-6750-3p	PAR-CLIP	23446348
MIRT208724	hsa-miR-580-5p	PAR-CLIP	23446348
MIRT506589	hsa-miR-32-3p	PAR-CLIP	23446348
MIRT208733	hsa-miR-4698	PAR-CLIP	23446348
MIRT506588	hsa-miR-3607-5p	PAR-CLIP	23446348
MIRT208732	hsa-miR-548aj-5p	PAR-CLIP	23446348
MIRT208726	hsa-miR-548f-5p	PAR-CLIP	23446348
MIRT208727	hsa-miR-548g-5p	PAR-CLIP	23446348
MIRT208729	hsa-miR-548x-5p	PAR-CLIP	23446348
MIRT208725	hsa-miR-1468-3p	PAR-CLIP	23446348
MIRT506587	hsa-miR-4764-3p	PAR-CLIP	23446348
MIRT506586	hsa-miR-6516-3p	PAR-CLIP	23446348
MIRT208734	hsa-miR-548aw	PAR-CLIP	23446348
MIRT1140330	hsa-miR-105	CLIP-seq
MIRT1140331	hsa-miR-106a	CLIP-seq
MIRT1140332	hsa-miR-106b	CLIP-seq
MIRT1140333	hsa-miR-10a	CLIP-seq
MIRT1140334	hsa-miR-10b	CLIP-seq
MIRT1140335	hsa-miR-1182	CLIP-seq
MIRT1140336	hsa-miR-122	CLIP-seq
MIRT1140337	hsa-miR-1237	CLIP-seq
MIRT1140338	hsa-miR-1249	CLIP-seq
MIRT1140339	hsa-miR-1264	CLIP-seq
MIRT1140340	hsa-miR-1271	CLIP-seq
MIRT1140341	hsa-miR-128	CLIP-seq
MIRT1140342	hsa-miR-129-5p	CLIP-seq
MIRT1140343	hsa-miR-1296	CLIP-seq
MIRT1140344	hsa-miR-1299	CLIP-seq
MIRT1140345	hsa-miR-130a	CLIP-seq
MIRT1140346	hsa-miR-130b	CLIP-seq
MIRT1140347	hsa-miR-139-5p	CLIP-seq
MIRT1140348	hsa-miR-142-5p	CLIP-seq
MIRT1140349	hsa-miR-148a	CLIP-seq
MIRT1140350	hsa-miR-148b	CLIP-seq
MIRT1140351	hsa-miR-152	CLIP-seq
MIRT1140352	hsa-miR-17	CLIP-seq
MIRT1140353	hsa-miR-181a	CLIP-seq
MIRT1140354	hsa-miR-181b	CLIP-seq
MIRT1140355	hsa-miR-181c	CLIP-seq
MIRT1140356	hsa-miR-181d	CLIP-seq
MIRT1140357	hsa-miR-182	CLIP-seq
MIRT1140358	hsa-miR-186	CLIP-seq
MIRT1140359	hsa-miR-19a	CLIP-seq
MIRT1140360	hsa-miR-19b	CLIP-seq
MIRT1140361	hsa-miR-2052	CLIP-seq
MIRT1140362	hsa-miR-20a	CLIP-seq
MIRT1140363	hsa-miR-20b	CLIP-seq
MIRT1140364	hsa-miR-23a	CLIP-seq
MIRT1140365	hsa-miR-23b	CLIP-seq
MIRT1140366	hsa-miR-23c	CLIP-seq
MIRT1140367	hsa-miR-27a	CLIP-seq
MIRT1140368	hsa-miR-27b	CLIP-seq
MIRT1140369	hsa-miR-2909	CLIP-seq
MIRT1140370	hsa-miR-299-5p	CLIP-seq
MIRT1140371	hsa-miR-301a	CLIP-seq
MIRT1140372	hsa-miR-301b	CLIP-seq
MIRT1140373	hsa-miR-302a	CLIP-seq
MIRT1140374	hsa-miR-302b	CLIP-seq
MIRT1140375	hsa-miR-302c	CLIP-seq
MIRT1140376	hsa-miR-302d	CLIP-seq
MIRT1140377	hsa-miR-302e	CLIP-seq
MIRT1140378	hsa-miR-30a	CLIP-seq
MIRT1140379	hsa-miR-30b	CLIP-seq
MIRT1140380	hsa-miR-30c	CLIP-seq
MIRT1140381	hsa-miR-30d	CLIP-seq
MIRT1140382	hsa-miR-30e	CLIP-seq
MIRT1140383	hsa-miR-3134	CLIP-seq
MIRT1140384	hsa-miR-3135b	CLIP-seq
MIRT1140385	hsa-miR-3136-5p	CLIP-seq
MIRT1140386	hsa-miR-3141	CLIP-seq
MIRT1140387	hsa-miR-3159	CLIP-seq
MIRT1140388	hsa-miR-3177-5p	CLIP-seq
MIRT1140389	hsa-miR-3180-5p	CLIP-seq
MIRT1140390	hsa-miR-3185	CLIP-seq
MIRT1140391	hsa-miR-3190	CLIP-seq
MIRT1140392	hsa-miR-330-3p	CLIP-seq
MIRT1140393	hsa-miR-340	CLIP-seq
MIRT1140394	hsa-miR-3545-5p	CLIP-seq
MIRT1140395	hsa-miR-3609	CLIP-seq
MIRT1140396	hsa-miR-3613-5p	CLIP-seq
MIRT1140397	hsa-miR-3622a-5p	CLIP-seq
MIRT1140398	hsa-miR-3652	CLIP-seq
MIRT1140399	hsa-miR-3653	CLIP-seq
MIRT1140400	hsa-miR-3658	CLIP-seq
MIRT1140401	hsa-miR-3666	CLIP-seq
MIRT1140402	hsa-miR-3672	CLIP-seq
MIRT1140403	hsa-miR-3680	CLIP-seq
MIRT1140404	hsa-miR-3689a-3p	CLIP-seq
MIRT1140405	hsa-miR-3689c	CLIP-seq
MIRT1140406	hsa-miR-371-5p	CLIP-seq
MIRT1140407	hsa-miR-371b-5p	CLIP-seq
MIRT1140408	hsa-miR-372	CLIP-seq
MIRT1140409	hsa-miR-373	CLIP-seq
MIRT1140410	hsa-miR-378	CLIP-seq
MIRT1140411	hsa-miR-378b	CLIP-seq
MIRT1140412	hsa-miR-378c	CLIP-seq
MIRT1140413	hsa-miR-378d	CLIP-seq
MIRT1140414	hsa-miR-378e	CLIP-seq
MIRT1140415	hsa-miR-378f	CLIP-seq
MIRT1140416	hsa-miR-378h	CLIP-seq
MIRT1140417	hsa-miR-378i	CLIP-seq
MIRT1140418	hsa-miR-409-3p	CLIP-seq
MIRT1140419	hsa-miR-422a	CLIP-seq
MIRT1140420	hsa-miR-4260	CLIP-seq
MIRT1140421	hsa-miR-4262	CLIP-seq
MIRT1140422	hsa-miR-4264	CLIP-seq
MIRT1140423	hsa-miR-4276	CLIP-seq
MIRT1140424	hsa-miR-4295	CLIP-seq
MIRT1140425	hsa-miR-4307	CLIP-seq
MIRT1140426	hsa-miR-4423-3p	CLIP-seq
MIRT1140427	hsa-miR-4430	CLIP-seq
MIRT1140428	hsa-miR-4439	CLIP-seq
MIRT1140429	hsa-miR-4470	CLIP-seq
MIRT1140430	hsa-miR-4474-3p	CLIP-seq
MIRT1140431	hsa-miR-4477a	CLIP-seq
MIRT1140432	hsa-miR-4491	CLIP-seq
MIRT1140433	hsa-miR-4505	CLIP-seq
MIRT1140434	hsa-miR-450b-5p	CLIP-seq
MIRT1140435	hsa-miR-4513	CLIP-seq
MIRT1140436	hsa-miR-4534	CLIP-seq
MIRT1140437	hsa-miR-454	CLIP-seq
MIRT1140438	hsa-miR-4638-3p	CLIP-seq
MIRT1140439	hsa-miR-4640-5p	CLIP-seq
MIRT1140440	hsa-miR-4652-3p	CLIP-seq
MIRT1140441	hsa-miR-4657	CLIP-seq
MIRT1140442	hsa-miR-4666-5p	CLIP-seq
MIRT1140443	hsa-miR-4695-3p	CLIP-seq
MIRT1140444	hsa-miR-4712-3p	CLIP-seq
MIRT1140445	hsa-miR-4717-3p	CLIP-seq
MIRT1140446	hsa-miR-4724-3p	CLIP-seq
MIRT1140447	hsa-miR-4726-5p	CLIP-seq
MIRT1140448	hsa-miR-4728-5p	CLIP-seq
MIRT1140449	hsa-miR-4764-5p	CLIP-seq
MIRT1140450	hsa-miR-4782-5p	CLIP-seq
MIRT1140451	hsa-miR-4795-5p	CLIP-seq
MIRT1140452	hsa-miR-4796-3p	CLIP-seq
MIRT1140453	hsa-miR-4797-3p	CLIP-seq
MIRT1140454	hsa-miR-4802-3p	CLIP-seq
MIRT1140455	hsa-miR-4803	CLIP-seq
MIRT1140456	hsa-miR-490-5p	CLIP-seq
MIRT1140457	hsa-miR-5096	CLIP-seq
MIRT1140458	hsa-miR-513a-5p	CLIP-seq
MIRT1140459	hsa-miR-513b	CLIP-seq
MIRT1140460	hsa-miR-516b	CLIP-seq
MIRT1140461	hsa-miR-519d	CLIP-seq
MIRT1140462	hsa-miR-520a-3p	CLIP-seq
MIRT1140463	hsa-miR-520b	CLIP-seq
MIRT1140464	hsa-miR-520c-3p	CLIP-seq
MIRT1140465	hsa-miR-520d-3p	CLIP-seq
MIRT1140466	hsa-miR-520d-5p	CLIP-seq
MIRT1140467	hsa-miR-520e	CLIP-seq
MIRT1140468	hsa-miR-520f	CLIP-seq
MIRT1140469	hsa-miR-524-5p	CLIP-seq
MIRT1140470	hsa-miR-543	CLIP-seq
MIRT1140471	hsa-miR-548ah	CLIP-seq
MIRT1140472	hsa-miR-561	CLIP-seq
MIRT1140473	hsa-miR-601	CLIP-seq
MIRT1140474	hsa-miR-651	CLIP-seq
MIRT1140475	hsa-miR-7	CLIP-seq
MIRT1140476	hsa-miR-93	CLIP-seq
MIRT1140477	hsa-miR-96	CLIP-seq
MIRT2039818	hsa-miR-101	CLIP-seq
MIRT1140337	hsa-miR-1237	CLIP-seq
MIRT2039819	hsa-miR-1276	CLIP-seq
MIRT1140344	hsa-miR-1299	CLIP-seq
MIRT2039820	hsa-miR-144	CLIP-seq
MIRT1140353	hsa-miR-181a	CLIP-seq
MIRT1140354	hsa-miR-181b	CLIP-seq
MIRT1140355	hsa-miR-181c	CLIP-seq
MIRT1140356	hsa-miR-181d	CLIP-seq
MIRT2039821	hsa-miR-1972	CLIP-seq
MIRT1140364	hsa-miR-23a	CLIP-seq
MIRT1140365	hsa-miR-23b	CLIP-seq
MIRT1140366	hsa-miR-23c	CLIP-seq
MIRT2039822	hsa-miR-3065-5p	CLIP-seq
MIRT2039823	hsa-miR-3117-5p	CLIP-seq
MIRT1140391	hsa-miR-3190	CLIP-seq
MIRT1140393	hsa-miR-340	CLIP-seq
MIRT2039824	hsa-miR-3660	CLIP-seq
MIRT1140402	hsa-miR-3672	CLIP-seq
MIRT1140410	hsa-miR-378	CLIP-seq
MIRT1140411	hsa-miR-378b	CLIP-seq
MIRT1140412	hsa-miR-378c	CLIP-seq
MIRT1140413	hsa-miR-378d	CLIP-seq
MIRT1140414	hsa-miR-378e	CLIP-seq
MIRT1140415	hsa-miR-378f	CLIP-seq
MIRT1140416	hsa-miR-378h	CLIP-seq
MIRT1140417	hsa-miR-378i	CLIP-seq
MIRT1140419	hsa-miR-422a	CLIP-seq
MIRT1140420	hsa-miR-4260	CLIP-seq
MIRT1140421	hsa-miR-4262	CLIP-seq
MIRT2039825	hsa-miR-4272	CLIP-seq
MIRT2039826	hsa-miR-4279	CLIP-seq
MIRT1140432	hsa-miR-4491	CLIP-seq
MIRT2039827	hsa-miR-4499	CLIP-seq
MIRT1140434	hsa-miR-450b-5p	CLIP-seq
MIRT1140435	hsa-miR-4513	CLIP-seq
MIRT2039828	hsa-miR-4526	CLIP-seq
MIRT1140438	hsa-miR-4638-3p	CLIP-seq
MIRT1140439	hsa-miR-4640-5p	CLIP-seq
MIRT2039829	hsa-miR-4645-3p	CLIP-seq
MIRT1140441	hsa-miR-4657	CLIP-seq
MIRT1140442	hsa-miR-4666-5p	CLIP-seq
MIRT2039830	hsa-miR-4699-3p	CLIP-seq
MIRT1140447	hsa-miR-4726-5p	CLIP-seq
MIRT2039831	hsa-miR-4731-3p	CLIP-seq
MIRT1140450	hsa-miR-4782-5p	CLIP-seq
MIRT2039832	hsa-miR-4801	CLIP-seq
MIRT1140460	hsa-miR-516b	CLIP-seq
MIRT2039833	hsa-miR-545	CLIP-seq
MIRT2039834	hsa-miR-579	CLIP-seq
MIRT2269773	hsa-miR-1272	CLIP-seq
MIRT1140341	hsa-miR-128	CLIP-seq
MIRT1140345	hsa-miR-130a	CLIP-seq
MIRT1140346	hsa-miR-130b	CLIP-seq
MIRT2269774	hsa-miR-1322	CLIP-seq
MIRT2039820	hsa-miR-144	CLIP-seq
MIRT1140349	hsa-miR-148a	CLIP-seq
MIRT1140350	hsa-miR-148b	CLIP-seq
MIRT1140351	hsa-miR-152	CLIP-seq
MIRT1140353	hsa-miR-181a	CLIP-seq
MIRT1140354	hsa-miR-181b	CLIP-seq
MIRT1140355	hsa-miR-181c	CLIP-seq
MIRT1140356	hsa-miR-181d	CLIP-seq
MIRT1140359	hsa-miR-19a	CLIP-seq
MIRT1140360	hsa-miR-19b	CLIP-seq
MIRT2269775	hsa-miR-2276	CLIP-seq
MIRT1140364	hsa-miR-23a	CLIP-seq
MIRT1140365	hsa-miR-23b	CLIP-seq
MIRT1140366	hsa-miR-23c	CLIP-seq
MIRT1140367	hsa-miR-27a	CLIP-seq
MIRT1140368	hsa-miR-27b	CLIP-seq
MIRT1140371	hsa-miR-301a	CLIP-seq
MIRT1140372	hsa-miR-301b	CLIP-seq
MIRT2039822	hsa-miR-3065-5p	CLIP-seq
MIRT2269776	hsa-miR-3153	CLIP-seq
MIRT2269777	hsa-miR-3646	CLIP-seq
MIRT2039824	hsa-miR-3660	CLIP-seq
MIRT1140401	hsa-miR-3666	CLIP-seq
MIRT1140421	hsa-miR-4262	CLIP-seq
MIRT1140423	hsa-miR-4276	CLIP-seq
MIRT1140424	hsa-miR-4295	CLIP-seq
MIRT2269778	hsa-miR-4495	CLIP-seq
MIRT2039828	hsa-miR-4526	CLIP-seq
MIRT2269779	hsa-miR-4528	CLIP-seq
MIRT1140437	hsa-miR-454	CLIP-seq
MIRT2039829	hsa-miR-4645-3p	CLIP-seq
MIRT1140440	hsa-miR-4652-3p	CLIP-seq
MIRT2269780	hsa-miR-4668-5p	CLIP-seq
MIRT1140455	hsa-miR-4803	CLIP-seq
MIRT1140458	hsa-miR-513a-5p	CLIP-seq
MIRT2390764	hsa-miR-1290	CLIP-seq
MIRT2390765	hsa-miR-3127-3p	CLIP-seq
MIRT2390766	hsa-miR-3167	CLIP-seq
MIRT1140396	hsa-miR-3613-5p	CLIP-seq
MIRT2390767	hsa-miR-3679-3p	CLIP-seq
MIRT2390768	hsa-miR-4446-5p	CLIP-seq
MIRT2390769	hsa-miR-876-5p	CLIP-seq
MIRT2453889	hsa-miR-136	CLIP-seq
MIRT2453890	hsa-miR-345	CLIP-seq
MIRT2453891	hsa-miR-4761-5p	CLIP-seq
MIRT2453892	hsa-miR-498	CLIP-seq
MIRT2453889	hsa-miR-136	CLIP-seq
MIRT2453890	hsa-miR-345	CLIP-seq
MIRT2453891	hsa-miR-4761-5p	CLIP-seq
MIRT2453892	hsa-miR-498	CLIP-seq
MIRT1140330	hsa-miR-105	CLIP-seq
MIRT2453889	hsa-miR-136	CLIP-seq
MIRT1140347	hsa-miR-139-5p	CLIP-seq
MIRT2568851	hsa-miR-2110	CLIP-seq
MIRT2568852	hsa-miR-217	CLIP-seq
MIRT2568853	hsa-miR-3155	CLIP-seq
MIRT2568854	hsa-miR-3155b	CLIP-seq
MIRT2568855	hsa-miR-3647-3p	CLIP-seq
MIRT1140399	hsa-miR-3653	CLIP-seq
MIRT2568856	hsa-miR-3655	CLIP-seq
MIRT1140400	hsa-miR-3658	CLIP-seq
MIRT2568857	hsa-miR-3936	CLIP-seq
MIRT2568858	hsa-miR-4271	CLIP-seq
MIRT2568859	hsa-miR-4282	CLIP-seq
MIRT2568860	hsa-miR-4284	CLIP-seq
MIRT2568861	hsa-miR-4300	CLIP-seq
MIRT1140425	hsa-miR-4307	CLIP-seq
MIRT1140431	hsa-miR-4477a	CLIP-seq
MIRT2568862	hsa-miR-4477b	CLIP-seq
MIRT2568863	hsa-miR-4487	CLIP-seq
MIRT2568864	hsa-miR-4668-3p	CLIP-seq
MIRT2568865	hsa-miR-4725-3p	CLIP-seq
MIRT2568866	hsa-miR-4731-5p	CLIP-seq
MIRT2568867	hsa-miR-4738-3p	CLIP-seq
MIRT2453891	hsa-miR-4761-5p	CLIP-seq
MIRT2453892	hsa-miR-498	CLIP-seq
MIRT2568868	hsa-miR-511	CLIP-seq
MIRT2568869	hsa-miR-548c-3p	CLIP-seq
MIRT2568870	hsa-miR-615-5p	CLIP-seq
MIRT2568871	hsa-miR-720	CLIP-seq
MIRT2568872	hsa-miR-920	CLIP-seq
MIRT2568873	hsa-miR-939	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003712	Function	Transcription coregulator activity	IEA
GO:0003713	Function	Transcription coactivator activity	IBA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IEA
GO:0008013	Function	Beta-catenin binding	IEA
GO:0016592	Component	Mediator complex	IBA
GO:0016592	Component	Mediator complex	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IBA

Other IDs

• MIM: 611318
• HGNC: 16050
• e!Ensembl: ENSG00000144893

Protein

• UniProt ID: Q86YW9
• Protein name: Mediator of RNA polymerase II transcription subunit 12-like protein (Mediator complex subunit 12-like protein) (Thyroid hormone receptor-associated-like protein) (Trinucleotide repeat-containing gene 11 protein-like)
• Protein function: May be a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF09497	Med12	105 → 161	Transcription mediator complex subunit Med12	Domain
  PF12145	Med12-LCEWAV	283 → 730	Eukaryotic Mediator 12 subunit domain	Domain
  PF12144	Med12-PQL	1802 → 2019	Eukaryotic Mediator 12 catenin-binding domain	Domain

• Sequence:

  MAAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFTGDEHGSAR
  NIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDL
  AGNKPLSILAKKVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQA
  PDPNLEWTQISTRYLREQLAKISDFYHMASSTGDGPVPVPPEVEQAMKQWEYNEKLAFHM
  FQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQYSDEFVQSAYLSRRLAYFCAR
  RLSLLLSDSPNLLAAHSPHMMIGPNNSSIGAPSPGPPGPGMSPVQLAFSDFLSCAQHGPL
  VYGLSCMLQTVTLCCPSALVWNYSTNENKSANPGSPLDLLQVAPSSLPMPGGNTAFNQQV
  RARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSM
  ETLYHKIFWANQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIE
  AERCGESEVLDEKESISSSSLAGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLV
  LLFCEFIRHDVFSHDAYMCTLISRGDLSVTASTRPRSPVGENADEHYSKDHDVKMEIFSP
  MPGESCENANTSLGRRMSVNCEKLVKREKPRELIFPSNYDLLRHLQYATHFPIPLDESSS
  HECNQRTILLYGVGKERDEARHQLKKITKDILKILNKKSTTETGVGDEGQKARKNKQETF
  PTLETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPA
  LNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQ
  TAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQT
  IYNNVMPANSNLRWDPDFMMDFIENPSARSINYSMLGKILSDNAANRYSFVCNTLMNVCM
  GHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSF
  HDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQ
  ACFLPQATGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGNNSVSSLK
  NDDFTMRGLRCDGNADDIWTASQNPKSCGKSISIETANLREYARYVLRTICQQEWVGEHC
  LKEPERLCTDKELILDPVLSNMQAQKLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQ
  WTLRQSWLELQLMIKQCLKDPGSGSVAEMNNLLDNIAKATIEVFQQSADLNNSSNSGMSL
  FNPNSIGSADTSSTRQNGIKTFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKG
  QHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNW
  REERYQDDIKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHT
  NNELFTTVLDMLGVLINGTLASDLSNASPGGSEENKRAYMNLVKKLKKELGDKRSESIDK
  VRQLLPLPKQTCDVITCEPMGSLIDTKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLFEGQ
  KNPAPLSWAWFGTVRVDRRVIKYEEQHHLLLYHTHPMPKPRSYYLQPLPLPPEEEEEEPT
  SPVSQEPERKSAELSDQGKTTTDEEKKTKGRKRKTKSSSRVDEYPQSNIYRVPPNYSPIS
  SQMMHHPQSTLWGYNLVGQPQQPGFFLQNQSLTPGGSRLDPAGSFVPTNTKQALSNMLQR
  RSGAMMQPPSLHAITSQQQLIQMKLLQQQQQQRLLRQAQTRPFQQGQPGDQAALFAAQAR
  PSPQLPQYPGLQQAQTMPQGYTMYGTQMPLQQTSQQQAGSVVLSPSYNSRAYPAAHSNPV
  LMERLRQIQQQPSGYVQQQASPYLQPLTGSQRLNHQALQQSPLVGGGIDAVLTSAHPNLP
  SVPLPQDPMRPRQPQVRQQQRLLQMQQPQQPQPQQPPQPQQSSQSQSQTLGLQAMQPQQP
  LFPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVTPYGHPSHF

• Sequence length: 2145

Pathways

KEGG:

Thyroid hormone signaling pathway

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Intellectual disability	Pathogenic	rs1560115921, rs1560108090, rs1560103306, rs1559855453	RCV000779622 RCV000779623 RCV000779624 RCV000779625	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Nizon-Isidor syndrome	Likely pathogenic; Pathogenic	rs878982061, rs2149096532, rs1724263784, rs2473572861, rs2474008510, rs2473757315, rs2474225919, rs2473757305, rs1560069336, rs2530392269, rs1560108090, rs1723551652, rs1711989766	RCV001537880 RCV001724765 RCV002272608 RCV002283789 RCV002468850 RCV003147873 RCV003335899 RCV003387613 RCV003444083 RCV003492904 RCV001090066 RCV001090064 RCV001090065	★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
Acute myeloid leukemia	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ALZHEIMER DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTOSOMAL DOMINANT NON-SYNDROMIC INTELLECTUAL DISABILITY	—	Disgenet, GWAS catalog Disgenet, GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BLEEDING DISORDER DUE TO P2RY12 DEFECT	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEVELOPMENTAL DISABILITIES	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Developmental disorder	Likely benign; Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIGESTIVE SYSTEM DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIVERTICULAR DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INSOMNIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
IRRITABLE BOWEL SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MED12L-related disorder	Uncertain significance; Likely benign; Conflicting classifications of pathogenicity	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MED12L-related neurodevelopmental disorder	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Neurodevelopmental disorder	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEURODEVELOPMENTAL DISORDERS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NON-SPECIFIC SYNDROMIC INTELLECTUAL DISABILITY	—	Orphanet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PARKINSON DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
THROMBOCYTOPENIA	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Agenesis of Corpus Callosum	Corpus callosum agenesis	Pubtator	31155615	Associate	★☆☆☆☆ Found in Text Mining only
Alzheimer`s Disease	Alzheimer disease	GWASCAT_DG	30514930		★☆☆☆☆ Found in Text Mining only
Autism Spectrum Disorder	Autism	Pubtator	31155615	Associate	★☆☆☆☆ Found in Text Mining only
Autosomal dominant non-syndromic intellectual disability	Non-Syndromic Intellectual Disability	Orphanet			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Bleeding Disorder Due To P2RY12 Defect	Platelet-type bleeding disorder	CLINVAR_DG			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Clumsiness - motor delay	Motor delay	GENOMICS_ENGLAND_DG	31155615		★☆☆☆☆ Found in Text Mining only
Congenital Abnormalities	Congenital abnormalities	Pubtator	31155615	Associate	★☆☆☆☆ Found in Text Mining only
Developmental Disabilities	Developmental disability	Pubtator	31155615	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Diverticular Diseases	Diverticular Diseases	GWASCAT_DG	30177863		★☆☆☆☆ Found in Text Mining only
Epilepsy	Epilepsy	Pubtator	35175489	Associate	★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Mental retardation	BEFREE	31155615, 31267042		★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Intellectual Disability	Mental retardation	GENOMICS_ENGLAND_DG	31155615		★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Intellectual Disability	Intellectual developmental disorder	Pubtator	31155615	Associate	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Myocardial Infarction	Myocardial infarction	Pubtator	30143348	Associate	★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	28067867	Associate	★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	34034702	Associate	★☆☆☆☆ Found in Text Mining only