Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	116840
Gene name	Centrobin, centriole duplication and spindle assembly protein
Gene symbol	CNTROB
Synonyms (NCBI Gene)	LIP8PP1221
Chromosome	17
Chromosome location	17p13.1
Summary	This gene encodes a centrosomal protein that interacts with BRCA2, and is required for centriole duplication and cytokinesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug

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miRTarBase ID	miRNA	Experiments	Reference
MIRT045665	hsa-miR-149-5p	CLASH	23622248
MIRT661268	hsa-miR-6746-3p	HITS-CLIP	23824327
MIRT642522	hsa-miR-4762-5p	HITS-CLIP	23824327
MIRT642521	hsa-miR-6793-3p	HITS-CLIP	23824327
MIRT642520	hsa-miR-3655	HITS-CLIP	23824327
MIRT642519	hsa-miR-5699-5p	HITS-CLIP	23824327
MIRT661267	hsa-miR-4632-3p	HITS-CLIP	23824327
MIRT642518	hsa-miR-376a-3p	HITS-CLIP	23824327
MIRT642517	hsa-miR-376b-3p	HITS-CLIP	23824327
MIRT642522	hsa-miR-4762-5p	HITS-CLIP	23824327
MIRT642521	hsa-miR-6793-3p	HITS-CLIP	23824327
MIRT642520	hsa-miR-3655	HITS-CLIP	23824327
MIRT642519	hsa-miR-5699-5p	HITS-CLIP	23824327
MIRT642518	hsa-miR-376a-3p	HITS-CLIP	23824327
MIRT642517	hsa-miR-376b-3p	HITS-CLIP	23824327
MIRT661268	hsa-miR-6746-3p	HITS-CLIP	23824327
MIRT642522	hsa-miR-4762-5p	HITS-CLIP	23824327
MIRT642521	hsa-miR-6793-3p	HITS-CLIP	23824327
MIRT642520	hsa-miR-3655	HITS-CLIP	23824327
MIRT642519	hsa-miR-5699-5p	HITS-CLIP	23824327
MIRT661267	hsa-miR-4632-3p	HITS-CLIP	23824327
MIRT642518	hsa-miR-376a-3p	HITS-CLIP	23824327
MIRT642517	hsa-miR-376b-3p	HITS-CLIP	23824327
MIRT642522	hsa-miR-4762-5p	HITS-CLIP	23824327
MIRT642521	hsa-miR-6793-3p	HITS-CLIP	23824327
MIRT642520	hsa-miR-3655	HITS-CLIP	23824327
MIRT642519	hsa-miR-5699-5p	HITS-CLIP	23824327
MIRT642518	hsa-miR-376a-3p	HITS-CLIP	23824327
MIRT642517	hsa-miR-376b-3p	HITS-CLIP	23824327
MIRT901966	hsa-miR-4477a	CLIP-seq
MIRT901967	hsa-miR-4712-3p	CLIP-seq
MIRT901968	hsa-miR-4729	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16275750, 25416956, 32296183, 35709258
GO:0005737	Component	Cytoplasm	IEA
GO:0005813	Component	Centrosome	IBA
GO:0005813	Component	Centrosome	IDA	21399614
GO:0005813	Component	Centrosome	IMP	21576394
GO:0005814	Component	Centriole	IBA
GO:0005814	Component	Centriole	IDA	16275750, 27185865
GO:0005814	Component	Centriole	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005856	Component	Cytoskeleton	IEA
GO:0007099	Process	Centriole replication	IBA
GO:0007099	Process	Centriole replication	IEA
GO:0007099	Process	Centriole replication	IMP	16275750, 21576394
GO:0019904	Function	Protein domain specific binding	IPI	11984006
GO:0036064	Component	Ciliary basal body	IDA
GO:0051299	Process	Centrosome separation	IBA
GO:0051299	Process	Centrosome separation	IMP	16275750
GO:0051301	Process	Cell division	IEA
GO:1902017	Process	Regulation of cilium assembly	IEA
GO:1902410	Process	Mitotic cytokinetic process	IBA
GO:1902410	Process	Mitotic cytokinetic process	IMP	16275750

MIM	HGNC	e!Ensembl
611425	29616	ENSG00000170037

Q8N137

Protein name

Centrobin (Centrosomal BRCA2-interacting protein) (LYST-interacting protein 8)

Protein function

Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis.

Family and domains

Tissue specificity

TISSUE SPECIFICITY: Widely expressed (at protein level). Highly expressed in testis. Also expressed in spleen, thymus, prostate, small intestine, colon and peripheral blood leukocytes. {ECO:0000269|PubMed:16275750}.

Sequence

MATSADSPSSPLGAEDLLSDSSEPPGLNQVSSEVTSQLYASLRLSRQAEATARAQLYLPS
TSPPHEGLDGFAQELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQTMLQTSRDTAYRD
PLIPGAGSERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNP
PDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLA
RVVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESAR
LQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQ
TWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELD
TARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREH
HRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQ
QLEEQRVELVERLQAMLQAHWDEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKEERRVW
TMPPMAVALKPVLQQSREARDELPGAPPVLCSSSSDLSLLLGPSFQSQHSFQPLEPKPDL
TSSTAGAFSALGAFHPDHRAERPFPEEDPGPDGEGLLKQGLPPAQLEGLKNFLHQLLETV
PQNNENPSVDLLPPKSGPLTVPSWEEAPQVPRIPPPVHKTKVPLAMASSLFRVPEPPSSH
SQGSGPSSGSPERGGDGLTFPRQLMEVSQLLRLYQARGWGALPAEDLLLYLKRLEHSGTD
GRGDNVPRRNTDSRLGEIPRKEIPSQAVPRRLATAPKTEKPPARKKSGHPAPSSMRSRGG
VWR

Sequence length

903

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
OLIGODENDROGLIOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
POLYCYSTIC OVARY SYNDROME	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
POLYCYTHEMIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSORIASIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (7)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Breast Carcinoma	Breast Carcinoma	BEFREE	23001753		★★★★★ ★☆☆☆☆ Found in Text Mining only
Invasive Ductal Breast Carcinoma	Invasive Duct and Lobular Carcinoma	BEFREE	23001753		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	23001753		★★★★★ ★☆☆☆☆ Found in Text Mining only
Microcephaly	Microcephaly	BEFREE	29440264		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mulibrey Nanism	Mulibrey nanism	Pubtator	33983387	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Polycystic Ovary Syndrome	Polycystic Ovary Syndrome	CTD_human_DG	21411543		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sclerocystic Ovaries	Sclerocystic Ovaries	CTD_human_DG	21411543		★★★★★ ★☆☆☆☆ Found in Text Mining only

CNTROB (centrobin, centriole duplication and spindle assembly protein)